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Objective: To determine association of Serum Uric Acid levels (SUA) in subjects suffering Systemic Blood Pressure and to determine its association with systolic and diastolic blood pressure. Study Design: Cross Sectional Study. Setting: Department of Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan. Period: January 2018 to September 2019. Material & Methods: 150 diagnosed cases of systemic hypertension and 150 controls were selected though non-probability purposive sampling according to inclusion and exclusion criteria. 2 ml venous blood was taken, centrifuged and sera were used for uric acid. Data was saved in a pre-structured Performa. Statistical software (SPSS v 21.0, IBM, Incorporation, USA) of data variables was analyzed at 95% CI (P = 0.05). Results: Serum uric acid in controls was 2.93±0.72 compared to cases 4.25±1.44 mg/dl (P=0.0001). Hyperuricemia was observed in 58 (38.6%) cases compared to 23 (15.3%) controls. Uric acid shows strong positive association with Systolic BP (r= 0.52*, p=0.0001) and Diastolic BP (r= 0.46**, p=0.0001). Conclusion: We found hyperuricemia in 58 (38.6%) of systemic hypertension cases. Systolic and Diastolic Blood pressure show positive association with uric acid. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to determine the platelet count in diagnosed chronic renal failure patients and to find out the association of platelet count with glomerular filtration rate. Study Design: Case control study. Place of study: Diagnostic and research laboratory Liaquat University Hospital Hyderabad and Nephrology Unit, Isra University Hospital Hyderabad. Duration of study: January 2015 to July 2015. Materials and methods: Total of one hundred and twenty subjects (n=120) were divided into two groups. The healthy controls (n=60) were included in group-I whereas patients with chronic renal failure (n=60) were kept in group-II. 5 ml of blood was drawn and sent to laboratory for estimation of serum platelet count, blood urea nitrogen and serum creatinine levels. Results: The present study showed highly significant difference with marked decrease in the platelet counts seen in the CRF patients with 223.9±89.1 million/μL in comparison to the 347.60±55.9 million/μl platelets in control individuals. Also the results of BUN in CRF patients showed highly significant differences with 27.67±7.68 mg/dl when compared to controls having BUN 8.95±1.02 mg/dl. The comparison between GFR with mean platelet count showed negative correlation (r = -0.27) in CRF patients. Conclusion: The present study shows weak negative correlation of platelet count with GFR. [ABSTRACT FROM AUTHOR]