1. Increased numbers of suppressor-cytotoxic cells in a patient with carbamazepine hypersensitivity.
- Author
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Blijham GH, Blaauw I, Schutte B, and Mendes de Leon DE
- Subjects
- Antibodies, Monoclonal immunology, Cell Division drug effects, Drug Hypersensitivity blood, Histocompatibility Antigens Class II immunology, Humans, Leukocyte Count, Lymphocyte Activation drug effects, Male, Middle Aged, T-Lymphocytes, Cytotoxic pathology, T-Lymphocytes, Regulatory pathology, Carbamazepine adverse effects, Drug Hypersensitivity immunology, T-Lymphocytes, Cytotoxic immunology, T-Lymphocytes, Regulatory immunology
- Abstract
A patient is presented with a clinical syndrome of erythroderma, fever, liver function abnormalities, eosinophilia and atypical lymphocytosis due to carbamazepine hypersensitivity. Immunological analysis of peripheral blood mononuclear cells was performed using mouse monoclonal antibodies against T-cell and Ia antigens. A 12-fold increase in the absolute numbers of suppressor-cytotoxic T-cells was found, resulting in a reversed helper/suppressor ratio. Also the number of Ia-positive cells was greatly increased. Carbamazepine may induce a reversible proliferation and activation of the suppressor-cytotoxic subset of T-cells. Implications and pathogenetic possibilities are briefly discussed.
- Published
- 1984
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