1. Human Pleural Fluid Elicits Pyruvate and Phenylalanine Metabolism in Acinetobacter baumannii to Enhance Cytotoxicity and Immune Evasion
- Author
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Nyah, Rodman, Martinez, Jasmine, Fung, Sammie, Nakanouchi, Jun, Myers, Amber L., Harris, Caitlin M., Dang, Emily, Fernandez, Jennifer, Liu, Christine, Mendoza, Anthony M., Jimenez, Verónica, Nikolaidis, Nikolas, Brennan, Catherine A., Bonomo, Robert A., Sieira, Rodrigo, and Ramirez, Maria Soledad
- Subjects
purl.org/becyt/ford/1 [https] ,Ciencias Biológicas ,Biología Celular, Microbiología ,IRON HOMEOSTASIS ,HAP COMPLEX ,CYTOTOXICITY ,YEAST ,REACTIVE OXYGEN SPECIES ,purl.org/becyt/ford/1.6 [https] ,CCAAT BOX ,CIENCIAS NATURALES Y EXACTAS - Abstract
The CCAAT box-harboring proteins represent a family of heterotrimeric transcription factors which is highly conserved in eukaryotes. In fungi, one of the particularly important homologs of this family is the Hap complex that separates the DNA-binding domain from the activation domain and imposes essential impacts on regulation of a wide range of cellular functions. So far, a comprehensive summary of this complex has been described in filamentous fungi but not in the yeast. In this review, we summarize a number of studies related to the structure and assembly mode of the Hap complex in a list of representative yeasts. Furthermore, we emphasize recent advances in understanding the regulatory functions of this complex, with a special focus on its role in regulating respiration, production of reactive oxygen species (ROS) and iron homeostasis. Fil: Nyah, Rodman. California State University; Estados Unidos Fil: Martinez, Jasmine. California State University; Estados Unidos Fil: Fung, Sammie. California State University; Estados Unidos Fil: Nakanouchi, Jun. California State University; Estados Unidos Fil: Myers, Amber L.. California State University; Estados Unidos Fil: Harris, Caitlin M.. California State University; Estados Unidos Fil: Dang, Emily. California State University; Estados Unidos Fil: Fernandez, Jennifer. California State University; Estados Unidos Fil: Liu, Christine. California State University; Estados Unidos Fil: Mendoza, Anthony M.. California State University; Estados Unidos Fil: Jimenez, Verónica. California State University; Estados Unidos Fil: Nikolaidis, Nikolas. California State University; Estados Unidos Fil: Brennan, Catherine A.. California State University; Estados Unidos Fil: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Cente; Estados Unidos. Center for Antimicrobial Resistance and Epidemiology; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Ramirez, Maria Soledad. California State University; Estados Unidos
- Published
- 2019
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