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222 results on '"Mendoza-Santiesteban, Carlos"'

1. XOLARIS: A 24-Month, Prospective, Natural History Study of 201 Participants with Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa

Author

Gregory-Evans, Kevin, Koenekoop, Robert, Sankila, Eeva-Marja K., Bygglin, Henrik, Seitsonen, Sanna, Riikonen, Antti, Meunier, Isabelle, Fischer, M. Dominik, Ochakovski, Alex, Stingl, Katarina, Vaheb, Yousof, Richter, Paul, Wozar, Fabian, Reichel, Felix, Gassel, Caroline, Wolfram, Lasse, Fischer, Nora, Peters, Tobias, Wilhelm, Barbara, Seitz, Immanuel, Holz, Frank, Reinking, Katharina, Clemens, Amelie, Völker, Desiree, Herrmann, Philipp, Birtel, Johannes, Schipper, Pascal, Weber, Constance, Bulirsch, Louisa, Hoyng, Carel, Klaver, Caroline, Phan, T.M.L., Van Huet, Ramon, Boon, Camiel, Nguyen, X.T., Talib, M., Trzcionkowska, Kasia, Tussenbroek, Thomas, MacLaren, Robert E., Taylor, Laura J., Cehajic-Kapetanovic, Jasmina, Josan, Amandeep S., Yusuf, Imran H., Jasani, Kirti, Menghini, Moreno, Nanda, Anika, Rehman, Salwah, Jolly, Jasleen K., Buckley, Thomas M.W., Lotery, Andrew, Thulsidharan, Suresh, Khandhadia, Samir, Tsokolas, Georgios, Black, Graeme, Megaw, Roly, Bishop, Paul, Mukherjee, Rajarshi, Mohla, Aditi, McKibbin, Martin, Mukherjee, Raj, Lam, Byron L., Mendoza-Santiesteban, Carlos, Horowitz, Jason, Tsang, Stephen, Pennesi, Mark E., Yang, Paul, Lauer, Andreas K., Weleber, Richard G., Birch, David, Coors, Lori, Spencer, Rand, Csaky, Karl, Anand, Rajiv, Wang, Yi-Zhong, Gorin, Michael, Stepien, Kimberly, Duncan, Jacque L., Stewart, Jay, Moore, Anthony, Stout, J. Timothy, Weng, Christina, Leung, Ella, Schlle, Tahira, Bakall, Benjamin, Klein, Kendra, Bernstein, Paul, Hartnett, Mary Elizabeth, Mathias, Marc, Siringo, Frank, Pecen, Paula, Aleman, Tomas, McGuire, Albert, Nagiel, Aaron, Larsen, Michael, Ferraz Sallum, Juliana Maria, Ribeiro, Lucas, de Azevedo Amaral, Rebeca, Gow, James A., Li, Jiang, and Tsang, So-Fai

Published
2025
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3. The Effect of Self-Reported Visual Impairment and Sleep on Cognitive Decline: Results of the Hispanic Community Health Study/Study of Latinos

Author

Mahanna-Gabrielli, Elizabeth, Kuwayama, Sayaka, Tarraf, Wassim, Kaur, Sonya, DeBuc, Delia Cabrera, Cai, Jianwen, Daviglus, Martha L, Joslin, Charlotte E, Lee, David J, Mendoza-Santiesteban, Carlos, Stickel, Ariana M, Zheng, Diane, González, Hector M, and Ramos, Alberto R

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Psychology, Neurosciences, Eye Disease and Disorders of Vision, Health Disparities, Brain Disorders, Mental Health, Minority Health, Behavioral and Social Science, Sleep Research, Clinical Research, Acquired Cognitive Impairment, Neurodegenerative, Aging, Lung, Basic Behavioral and Social Science, Mental health, Aged, Humans, Cognitive Dysfunction, Hispanic or Latino, Self Report, Sleep, Sleep Apnea, Obstructive, Sleep Initiation and Maintenance Disorders, Sleepiness, Vision Disorders, Middle Aged, Sleep Duration, Speech Disorders, Cognitive decline, health disparities, Hispanic/Latinos, sleep disorders, visual impairment, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

BackgroundVisual impairment could worsen sleep/wake disorders and cognitive decline.ObjectiveTo examine interrelations among self-reported visual impairment, sleep, and cognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Miami-site.MethodHCHS/SOL Miami-site participants ages 45-74 years (n = 665) at Visit-1, who returned for cognitive test 7-years later (SOL-INCA). Participants completed the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ), validated sleep questionnaires and test for obstructive sleep apnea (OSA) at Visit-1. We obtained verbal episodic learning and memory, verbal fluency, processing speed, and executive functioning at Visit-1 and at SOL-INCA. Processing speed/executive functioning were added to SOL-INCA. We examined global cognition and change using a regression-based reliable change index, adjusting for the time lapse between Visit-1 and SOL-INCA. We used regression models to test whether 1) persons with OSA, self-reported sleep duration, insomnia, and sleepiness have an increased risk for visual impairment, 2a) visual impairment is associated with worse cognitive function and/or decline, and 2b) sleep disorders attenuate these associations.ResultSleepiness (β= 0.04; p

Published
2023

4. Assessment of Visual Function with Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study

Author

MacLaren, Robert, Aleman, Tomas, Birch, David, Jalil, Assad, Lotery, Andrew, Lam, Byron, Pennesi, Mark, Kay, Christine N., Yusuf, Imram H., Cehajic Kapetanovic, Jasmina, Jolly, Jasleen K., Josan, Amandeep S., Taylor, Laura J., Xue, Kanmin, Nanda, Anika, Buckley, Thomas, Salvetti, Anna Paola, Thulasidharan, Suresh, Kurc, Miguel, Khandhadia, Samir, Dias, Karla Orsine Murta, Baltmr, Abeir, Mandal, Nakul, Tsokolas, Georgios, Ivanova, Tsveta, EL-Faouri, Muhannd, Shaarawy, Sherif, Black, Graeme, Davis, Janet L., Gregori, Ninel Z., Mendoza-Santiesteban, Carlos E., Lauer, Andreas K., Yang, Paul, Bailey, Steven, Spencer, Rand, Fish, Gary E., Wang, Robert, Chong, Deborah, Abbey, Ashkan, Anand, Rajiv, MaGuire, Albert A., Roseman, Robert L., Hazariwala, Kaushik M., Parrott, Brandon, Lam, Byron L., Pennesi, Mark E., Panda, Sushil, Gow, James A., Zhao, Guolin, and MacLaren, Robert E.

Published
2024
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10. Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy

Author

Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Schultz, Anastasia, Albertos Arranz, Henar, Sánchez-Sáez, Xavier, Morgan, Jamie, Darland, Diane C., Gonzalez-Duarte, Alejandra, Kaufmann, Horacio, Mendoza-Santiesteban, Carlos E., Cuenca, Nicolás, Lefcort, Frances, Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología, Schultz, Anastasia, Albertos Arranz, Henar, Sánchez-Sáez, Xavier, Morgan, Jamie, Darland, Diane C., Gonzalez-Duarte, Alejandra, Kaufmann, Horacio, Mendoza-Santiesteban, Carlos E., Cuenca, Nicolás, and Lefcort, Frances

Abstract

Familial dysautonomia (FD) is a rare genetic neurodevelopmental and neurodegenerative disorder. In addition to the autonomic and peripheral sensory neuropathies that challenge patient survival, one of the most debilitating symptoms affecting patients' quality of life is progressive blindness resulting from the steady loss of retinal ganglion cells (RGCs). Within the FD community, there is a concerted effort to develop treatments to prevent the loss of RGCs. However, the mechanisms underlying the death of RGCs are not well understood. To study the mechanisms underlying RGC death, Pax6-cre;Elp1loxp/loxp male and female mice and postmortem retinal tissue from an FD patient were used to explore the neuronal and non-neuronal cellular pathology associated with the FD optic neuropathy. Neurons, astrocytes, microglia, Müller glia, and endothelial cells were investigated using a combination of histological analyses. We identified a novel disruption of cellular homeostasis and gliosis in the FD retina. Beginning shortly after birth and progressing with age, the FD retina is marked by astrogliosis and perturbations in microglia, which coincide with vascular remodeling. These changes begin before the onset of RGC death, suggesting alterations in the retinal neurovascular unit may contribute to and exacerbate RGC death. We reveal for the first time that the FD retina pathology includes reactive gliosis, increased microglial recruitment to the ganglion cell layer (GCL), disruptions in the deep and superficial vascular plexuses, and alterations in signaling pathways. These studies implicate the neurovascular unit as a disease-modifying target for therapeutic interventions in FD.

Published
2024

11. Assessment of Visual Function with Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa in the Randomized XIRIUS Phase 2/3 Study

Author

Lam, Byron L., primary, Pennesi, Mark E., additional, Kay, Christine N., additional, Panda, Sushil, additional, Gow, James A., additional, Zhao, Guolin, additional, MacLaren, Robert E., additional, MacLaren, Robert, additional, Aleman, Tomas, additional, Birch, David, additional, Jalil, Assad, additional, Lotery, Andrew, additional, Lam, Byron, additional, Pennesi, Mark, additional, Yusuf, Imram H., additional, Cehajic Kapetanovic, Jasmina, additional, Jolly, Jasleen K., additional, Josan, Amandeep S., additional, Taylor, Laura J., additional, Xue, Kanmin, additional, Nanda, Anika, additional, Buckley, Thomas, additional, Salvetti, Anna Paola, additional, Thulasidharan, Suresh, additional, Kurc, Miguel, additional, Khandhadia, Samir, additional, Dias, Karla Orsine Murta, additional, Baltmr, Abeir, additional, Mandal, Nakul, additional, Tsokolas, Georgios, additional, Ivanova, Tsveta, additional, EL-Faouri, Muhannd, additional, Shaarawy, Sherif, additional, Black, Graeme, additional, Davis, Janet L., additional, Gregori, Ninel Z., additional, Mendoza-Santiesteban, Carlos E., additional, Lauer, Andreas K., additional, Yang, Paul, additional, Bailey, Steven, additional, Spencer, Rand, additional, Fish, Gary E., additional, Wang, Robert, additional, Chong, Deborah, additional, Abbey, Ashkan, additional, Anand, Rajiv, additional, MaGuire, Albert A., additional, Roseman, Robert L., additional, Hazariwala, Kaushik M., additional, and Parrott, Brandon, additional

Published
2024
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19. Sleep, self‐reported ocular health, and cognition in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL‐Investigation of Neurocognitive Aging (SOL‐INCA)

Author

Mahanna‐Gabrielli, Elizabeth, primary, Kuwayama, Sayaka, additional, Tarraf, Wassim, additional, DeBuc, Delia Cabrera, additional, Cai, Jianwen, additional, Daviglus, Martha L, additional, Joslin, Charlotte, additional, Lee, David J, additional, Mendoza‐Santiesteban, Carlos, additional, Stickel, Ariana M, additional, Zheng, Diane, additional, González, Hector M, additional, and Ramos, Alberto R, additional

Published
2022
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28. Laser speckle‐based retinal imager as a potential screening tool for mild cognitive impairment

Author

DeBuc, Delia Cabrera, primary, Kandukuri, Jayanth, additional, Sinha, Avigyan, additional, Lee, Wen‐Hsiang, additional, Crocco, Elizabeth, additional, Sapahia, Rishav, additional, Mendoza‐Santiesteban, Carlos, additional, Smiddy, William E., additional, Garg, Rajesh K., additional, Kostic, Maja, additional, Alfonso, Michelle Marrero, additional, Baumel, Bernard, additional, and Rege, Abhishek, additional

Published
2021
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37. Longitudinal changes in the macula and optic nerve in familial dysautonomia

Author

Kfir, Jonathan, primary, Wu, Mengfei, additional, Liu, Mengling, additional, Raju, Leela, additional, Schuman, Joel S., additional, Ishikawa, Hiroshi, additional, Vanegas, Isabel M., additional, Mendoza-Santiesteban, Carlos E., additional, Palma, Jose-Alberto, additional, Norcliffe-Kaufmann, Lucy, additional, Morgenstein, Barr, additional, Kaufmann, Horacio, additional, and Wollstein, Gadi, additional

Published
2020
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