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3. The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS

Author

Tintoré, Mar, Arrambide, Georgina, Otero-Romero, Susana, Carbonell-Mirabent, Pere, Río, Jordi, Tur, Carmen, Comabella, Manuel, Nos, Carlos, Arévalo, María Jesús, Anglada, Elisenda, Menendez, Rebeca, Midaglia, Luciana, Galán, Ingrid, Vidal-Jordana, Angela, Castilló, Joaquin, Mulero, P, Zabalza, Ana, Rodríguez-Acevedo, Breogan, Rodriguez, Marta, Espejo, Carmen, Sequeira, Joao, Mitjana, Raquel, de Barros, Andrea, Pareto, Deborah, Auger, Cristina, Pérez-Hoyos, Santiago, Sastre-Garriga, Jaume, Rovira, Alex, Montalban, Xavier, and Universitat Autònoma de Barcelona

Subjects
Pediatrics, medicine.medical_specialty, Multiple Sclerosis, 030218 nuclear medicine & medical imaging, Multiple sclerosis, Cohort Studies, 03 medical and health sciences, Disability Evaluation, 0302 clinical medicine, medicine, Long term outcomes, Humans, Disease-modifying treatment, business.industry, disease-modifying treatment, Brain, prediction, medicine.disease, Prognosis, INCEPTION COHORT, Clinically isolated syndromes, Magnetic Resonance Imaging, Neurology, Disease Progression, Neurology (clinical), prognosis, business, Prediction, Original Research Papers, 030217 neurology & neurosurgery, MRI, Demyelinating Diseases
Abstract

Altres ajuts: This study has been funded by European Regional Development Fund and co-funded by Instituto Carlos III. It has also received support by a grant from Genzyme foundation (GENZYME-2015-01) granted to M.T. and from the 'Red Española de Esclerosis Múltiple (REEM)', which is sponsored by FIS, the Instituto de Salud Carlos III, the Ministry of Economy and Competitiveness in Spain, and the 'Ajuts per donar Suport als Grups de Recerca de Catalunya', which is sponsored by the 'Agència de Gestió d'Ajuts Universitaris i de Recerca' (AGAUR) of the Generalitat de Catalunya in Spain. To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years). In all, 401 patients were included (mean follow-up of 14.4 (standard deviation of 2.9) years). A higher number of T2 lesions was associated with an earlier MS diagnosis and an earlier risk of irreversible disability. Early treatment was associated with a decreased risk of EDSS of 3.0: adjusted hazard ratio = 0.4, 95% confidence interval = (0.2, 0.7). Patients with aggressive MS differed in their baseline brain magnetic resonance images: The median (interquartile range) number of T2 lesions and contrast-enhancing lesions (CEL) was 71 (28-95) versus 7 (1-19) and 3 (1-24) versus 0 (0-1), respectively. The cut-offs that better classified patients with aggressive MS were 20 for T2 lesions and 2 for CEL. Although MS natural history is changing, a high lesion load at onset is helpful to identify patients at risk of presenting an aggressive MS.

Published
2019

4. MSJ877810_supplementary_table_2 – Supplemental material for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS

Author

Tintore, Mar, Arrambide, Georgina, Otero-Romero, Susana, Carbonell-Mirabent, Pere, Río, Jordi, Tur, Carmen, Comabella, Manuel, Nos, Carlos, Arévalo, María Jesús, Anglada, Elisenda, Menendez, Rebeca, Midaglia, Luciana, Galán, Ingrid, Vidal-Jordana, Angela, Joaquin Castilló, Mulero, Patricia, Zabalza, Ana, Breogan Rodríguez-Acevedo, Rodriguez, Marta, Espejo, Carmen, Joao Sequeira, Mitjana, Raquel, Barros, Andrea De, Pareto, Deborah, Auger, Cristina, Pérez-Hoyos, Santiago, Sastre-Garriga, Jaume, Rovira, Alex, and Montalban, Xavier

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ877810_supplementary_table_2 for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS by Mar Tintore, Georgina Arrambide, Susana Otero-Romero, Pere Carbonell-Mirabent, Jordi Río, Carmen Tur, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Elisenda Anglada, Rebeca Menendez, Luciana Midaglia, Ingrid Galán, Angela Vidal-Jordana, Joaquin Castilló, Patricia Mulero, Ana Zabalza, Breogan Rodríguez-Acevedo, Marta Rodriguez, Carmen Espejo, Joao Sequeira, Raquel Mitjana, Andrea de Barros, Deborah Pareto, Cristina Auger, Santiago Pérez-Hoyos, Jaume Sastre-Garriga, Alex Rovira and Xavier Montalban in Multiple Sclerosis Journal

Published
2019
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5. The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

Author

Tintore, Mar, Arrambide, Georgina, Otero-Romero, Susana, Carbonell-Mirabent, Pere, Río, Jordi, Tur, Carmen, Comabella, Manuel, Nos, Carlos, Arévalo, María Jesús, Anglada, Elisenda, Menendez, Rebeca, Midaglia, Luciana, Galán, Ingrid, Vidal-Jordana, Angela, Castilló, Joaquin, Mulero, Patricia, Zabalza, Ana, Rodríguez-Acevedo, Breogan, Rodriguez, Marta, and Espejo, Carmen

Subjects
MAGNETIC resonance imaging, STANDARD deviations, MULTIPLE sclerosis
Abstract

Objective: To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. Methods: We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years). Results: In all, 401 patients were included (mean follow-up of 14.4 (standard deviation of 2.9) years). A higher number of T2 lesions was associated with an earlier MS diagnosis and an earlier risk of irreversible disability. Early treatment was associated with a decreased risk of EDSS of 3.0: adjusted hazard ratio = 0.4, 95% confidence interval = (0.2, 0.7). Patients with aggressive MS differed in their baseline brain magnetic resonance images: The median (interquartile range) number of T2 lesions and contrast-enhancing lesions (CEL) was 71 (28–95) versus 7 (1–19) and 3 (1–24) versus 0 (0–1), respectively. The cut-offs that better classified patients with aggressive MS were 20 for T2 lesions and 2 for CEL. Conclusion: Although MS natural history is changing, a high lesion load at onset is helpful to identify patients at risk of presenting an aggressive MS. [ABSTRACT FROM AUTHOR]

Published
2020
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6. The role of self-monitoring in adult learning in online context

Author

Goulão, Maria de Fátima, Cerezo Menendez, Rebeca, Goulão, Maria de Fátima, and Cerezo Menendez, Rebeca

Abstract

[EN] This paper examines the reflexions made by a set of online students regarding the results obtained in an assessment task and its consequences for the future. The sample included 43 students in continuous assessment, from both sexes. After knowing the results they were asked to indicate the implications of this exercise to their future studies. The content analysis revealed the existence of two categories - Causality (intrinsic / extrinsic) and Influence (Generics/ Specifics/No consequences) - regardless of the approach to real evaluation. The reflection that students can make about their learning process and the difficulties in developing their tasks is of great relevance to achieve success. This was evident in the analysis that our students made on the completion of the assessment work, as well as the consequences for their future study. This process of reflection and awareness in the teaching learning process is particularly relevant in online education where the role of metacognitive monitoring and control system gains a prominent role. Allowing students to reflect on these issues permits them to be more effective learners.

Published
2015

10. The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

Author

Tintore M, Arrambide G, Otero-Romero S, Carbonell-Mirabent P, Río J, Tur C, Comabella M, Nos C, Arévalo MJ, Anglada E, Menendez R, Midaglia L, Galán I, Vidal-Jordana A, Castilló J, Mulero P, Zabalza A, Rodríguez-Acevedo B, Rodriguez M, Espejo C, Sequeira J, Mitjana R, de Barros A, Pareto D, Auger C, Pérez-Hoyos S, Sastre-Garriga J, Rovira A, and Montalban X

Subjects
Brain, Cohort Studies, Disability Evaluation, Disease Progression, Humans, Magnetic Resonance Imaging, Demyelinating Diseases, Multiple Sclerosis diagnosis, Multiple Sclerosis epidemiology
Abstract

Objective: To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort., Methods: We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years)., Results: In all, 401 patients were included (mean follow-up of 14.4 (standard deviation of 2.9) years). A higher number of T2 lesions was associated with an earlier MS diagnosis and an earlier risk of irreversible disability. Early treatment was associated with a decreased risk of EDSS of 3.0: adjusted hazard ratio = 0.4, 95% confidence interval = (0.2, 0.7). Patients with aggressive MS differed in their baseline brain magnetic resonance images: The median (interquartile range) number of T2 lesions and contrast-enhancing lesions (CEL) was 71 (28-95) versus 7 (1-19) and 3 (1-24) versus 0 (0-1), respectively. The cut-offs that better classified patients with aggressive MS were 20 for T2 lesions and 2 for CEL., Conclusion: Although MS natural history is changing, a high lesion load at onset is helpful to identify patients at risk of presenting an aggressive MS.

Published
2020
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