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136 results on '"Meng, Fanben"'

2. Two‐Photon Polymerized Shape Memory Microfibers: A New Mechanical Characterization Method in Liquid (Adv. Funct. Mater. 3/2023)

Author

Minnick, Grayson, primary, Safa, Bahareh Tajvidi, additional, Rosenbohm, Jordan, additional, Lavrik, Nickolay V., additional, Brooks, Justin, additional, Esfahani, Amir M., additional, Samaniego, Alberto, additional, Meng, Fanben, additional, Richter, Benjamin, additional, Gao, Wei, additional, and Yang, Ruiguo, additional

Published
2023
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9. Electric communication between the inner part of a cell and an electrode: the way to look inside a cell

Author

Meng, Fanben, Yang, Jinghua, Liu, Tao, Zhu, Xiaoli, and Li, Genxi

Subjects
Electrochemical analysis -- Methods, Electrophysiology -- Research, Cell physiology -- Observations, Chemistry
Abstract

A strategy to assemble cells on a solid support surface, here the surface of a gold electrode, is developed by transfecting cells with thiolated DNA molecules which have been immobilized on the gold electrode surface in advance. This strategy to assemble cells can present a general and convenient method for cell assembly on a solid support surface. What is more interesting, since efficient electric communication via the thiolated DNA between the electroactive species inside the cells and the substrate electrode can be achieved, an approach to 'look' into the inner part of the cells is proposed. For the test in this work, one drug, kaempferol, and one dye molecule, methylene blue, inside the cells have been detected by the commonly used electrochemical method linear scan voltammetry, and satisfactory results have been obtained. 10.1021/ac901455n

Published
2009

10. Electrochemical approach to detect apoptosis

Author

Xiao, Han, Liu, Lei, Meng, Fanben, Huang, Junyi, and Li, Genxi

Subjects
Apoptosis -- Research, Electrochemistry -- Methods, Electrodes -- Properties, Chemistry
Abstract

This paper reports an electrochemical approach for detection of apoptosis. Here we prepare a gold electrode modified with a helix peptide ferrocene (Fc)--GDGDEVDGC. Fc is used as an electroactive reporter and the peptide as a recognition and cleavage site of caspase-3, which is a special proteinase to apoptosis. Results show that this method may sensitively and specifically detect apoptotic cells with signal decline of 85%. This approach is different from the previous methods for apoptosis detection, because it does not need any fluorescent materials, expensive biological instruments, or complicated procedures.

Published
2008

11. Functional molecular transport junctions based on nanogap structures

Author

Meng, Fanben, Chen Xiaodong, and School of Materials Science & Engineering

Subjects
Engineering::Materials::Nanostructured materials [DRNTU], Engineering::Electrical and electronic engineering::Molecular electronics [DRNTU], Engineering::Nanotechnology [DRNTU]
Abstract

The use of individual molecules as functional components in electronic circuits offers the great opportunity to improve and revolutionize electronic systems. With the rapid achievement of nanofabrication, molecular electronic devices have been realized based on the investigation of electron properties of molecules. However, the study to build molecular architectures with electronic functions still leaves us a lot of room for improvement and optimization. Hence, this dissertation focuses on the exploration of hybridized electronic systems with judiciously designed molecules and metal nanostructures, to undertake advanced and complex functions. Herein, the newly-developed on-wire lithography (OWL) is employed to fabricate nanogaps as nanoelectrode pairs for the formation of molecular transport junctions (MTJs), the most essential structures in molecular electronics. In order to obtain more complex nanodevices with advanced functions, rationally designed or selected molecules are utilized to functionalize the nanogap structure, while several external stimulations are also introduced to modulate the device performance. Firstly, photo-modulable MTJs are developed via OWL-generated nanogaps functionalized by rationally designed and synthesized complexes with the photochromic dithienylethene unit(s) bearing the electro-active ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light is distinctly observed. Then, more external stimulations are introduced and orthogonally modulated MTJs are further achieved. The addressable and stepwise control of molecular isomerization is repeatedly and reversibly completed with a judicious use of the orthogonal optical and electrochemical. Through the rational design, these photo-/electro-cooperative nanodevices can be applied as resettable electronic logic gates for Boolean computing. Besides chemically synthesized organometallic complexes, natural biomolecules are also used to functionalize nanogap structures. A programmable controllable and reproducible memristive behavior is achieved by natural ferritin-based MTJs, which can be applied for nonvolatile memory. Additionally, the rapid development of biotechnology provides us another option to improve the device function or performance. By tuning the amount of iron inside an engineered ferritin, the ON/OFF ratio of conductance switching of such protein-based nanodevices is modulated accordingly, suggesting that protein molecules can be tailored using biotechnology to suit the specific requirements of molecular devices. These works provide direct proof that natural biomolecules as a parallel choice of chemically synthesized complex can be used to fabricate functional nanodevices. In conclusion, we develop advanced molecular nanodevices based on the feasible platform of precise nanogap structures fabricated by OWL, under various external controls. Both the synthetic chemistry and natural biosystem have been demonstrated to present enormous resources that fulfill the requirement of molecular devices. With chemical or biological modification of molecular architectures, the function and performance can be obviously improved. Therefore, after optimizing fabrication and operative conditions, such functional MTJs show promising applications in multifunctional nanocircuits. DOCTOR OF PHILOSOPHY (MSE)

Published
2019
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14. Spinal Cord Scaffolds: 3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds (Adv. Funct. Mater. 39/2018)

Author

Joung, Daeha, primary, Truong, Vincent, additional, Neitzke, Colin C., additional, Guo, Shuang-Zhuang, additional, Walsh, Patrick J., additional, Monat, Joseph R., additional, Meng, Fanben, additional, Park, Sung Hyun, additional, Dutton, James R., additional, Parr, Ann M., additional, and McAlpine, Michael C., additional

Published
2018
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15. 3D Printed Polymer Photodetectors

Author

Park, Sung Hyun, primary, Su, Ruitao, additional, Jeong, Jaewoo, additional, Guo, Shuang‐Zhuang, additional, Qiu, Kaiyan, additional, Joung, Daeha, additional, Meng, Fanben, additional, and McAlpine, Michael C., additional

Published
2018
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17. Bioprinting: 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors (Adv. Mater. Technol. 3/2018)

Author

Qiu, Kaiyan, primary, Zhao, Zichen, additional, Haghiashtiani, Ghazaleh, additional, Guo, Shuang‐Zhuang, additional, He, Mingyu, additional, Su, Ruitao, additional, Zhu, Zhijie, additional, Bhuiyan, Didarul B., additional, Murugan, Paari, additional, Meng, Fanben, additional, Park, Sung Hyun, additional, Chu, Chih‐Chang, additional, Ogle, Brenda M., additional, Saltzman, Daniel A., additional, Konety, Badrinath R., additional, Sweet, Robert M., additional, and McAlpine, Michael C., additional

Published
2018
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18. 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors

Author

Qiu, Kaiyan, primary, Zhao, Zichen, additional, Haghiashtiani, Ghazaleh, additional, Guo, Shuang‐Zhuang, additional, He, Mingyu, additional, Su, Ruitao, additional, Zhu, Zhijie, additional, Bhuiyan, Didarul B., additional, Murugan, Paari, additional, Meng, Fanben, additional, Park, Sung Hyun, additional, Chu, Chih‐Chang, additional, Ogle, Brenda M., additional, Saltzman, Daniel A., additional, Konety, Badrinath R., additional, Sweet, Robert M., additional, and McAlpine, Michael C., additional

Published
2017
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24. 3D printed nervous system on a chip

Author

Johnson, Blake N., primary, Lancaster, Karen Z., additional, Hogue, Ian B., additional, Meng, Fanben, additional, Kong, Yong Lin, additional, Enquist, Lynn W., additional, and McAlpine, Michael C., additional

Published
2016
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25. 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors.

Author

Qiu, Kaiyan, Zhao, Zichen, Haghiashtiani, Ghazaleh, Guo, Shuang‐Zhuang, He, Mingyu, Su, Ruitao, Zhu, Zhijie, Bhuiyan, Didarul B., Murugan, Paari, Meng, Fanben, Park, Sung Hyun, Chu, Chih‐Chang, Ogle, Brenda M., Saltzman, Daniel A., Konety, Badrinath R., Sweet, Robert M., and McAlpine, Michael C.

Subjects
DETECTORS, TISSUES, THREE-dimensional printing
Abstract

The design and development of novel methodologies and customized materials to fabricate patient‐specific 3D printed organ models with integrated sensing capabilities can yield advances in smart surgical aids for preoperative planning and rehearsal. Here, 3D printed prostate models are demonstrated with physical properties of tissue and integrated soft electronic sensors using custom‐formulated polymeric inks. The models show high quantitative fidelity in static and dynamic mechanical properties, optical characteristics, and anatomical geometries to patient tissues and organs. The models offer tissue‐mimicking tactile sensation and behavior and thus can be used for the prediction of organ physical behavior under deformation. The prediction results show good agreement with values obtained from simulations. The models also allow the application of surgical and diagnostic tools to their surface and inner channels. Finally, via the conformal integration of 3D printed soft electronic sensors, pressure applied to the models with surgical tools can be quantitatively measured. [ABSTRACT FROM AUTHOR]

Published
2018
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27. 3D Printed Anatomical Nerve Regeneration Pathways

Author

Johnson, Blake N., primary, Lancaster, Karen Z., additional, Zhen, Gehua, additional, He, Junyun, additional, Gupta, Maneesh K., additional, Kong, Yong Lin, additional, Engel, Esteban A., additional, Krick, Kellin D., additional, Ju, Alex, additional, Meng, Fanben, additional, Enquist, Lynn W., additional, Jia, Xiaofeng, additional, and McAlpine, Michael C., additional

Published
2015
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29. 3D Printed Programmable Release Capsules

Author

Gupta, Maneesh K., primary, Meng, Fanben, additional, Johnson, Blake N., additional, Kong, Yong Lin, additional, Tian, Limei, additional, Yeh, Yao-Wen, additional, Masters, Nina, additional, Singamaneni, Srikanth, additional, and McAlpine, Michael C., additional

Published
2015
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40. Functional Free-Standing Graphene Honeycomb Films

Author

Yin, Shengyan, primary, Goldovsky, Yulia, additional, Herzberg, Moshe, additional, Liu, Lei, additional, Sun, Hang, additional, Zhang, Yanyan, additional, Meng, Fanben, additional, Cao, Xuebo, additional, Sun, Darren D., additional, Chen, Hongyu, additional, Kushmaro, Ariel, additional, and Chen, Xiaodong, additional

Published
2013
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43. Protein‐Based Memristive Nanodevices

Author

Meng, Fanben, primary, Jiang, Lin, additional, Zheng, Kaihong, additional, Goh, Chin Foo, additional, Lim, Sierin, additional, Hng, Huey Hoon, additional, Ma, Jan, additional, Boey, Freddy, additional, and Chen, Xiaodong, additional

Published
2011
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49. Distinguishing Tumor Cells viaAnalyzing Intracellular Telomerase Activity

Author

Chen, Lin, Huang, Junyi, Meng, Fanben, and Zhou, Nandi

Abstract

Two strategies to identify tumor cells were developed in this research viaanalyzing the activity of telomerase inside the cells, which is regarded as the mark enzyme of tumors. The lysate of cells was used to assay directly. In the electrochemical assay, the substrate of telomerase was incubated with the lysate, followed by PCR amplification of the elongated products. Then the oxidation peak current of guanine that existed in the hydrolyte of PCR products was used as a target to identify tumor cells. In the spectral assay, the lysate of cells was used to catalyze the elongation of the substrate of telomerase modified on the surface of gold nanoparticles. Due to the formation of G-quadruple structures after elongation and subsequent aggregation of gold nanoparticles, the changes in UV-visible spectra can also be utilized to identify tumor cells.

Published
2010
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50. Data-Driven Image Analysis to Determine Antibody-Induced Dissociation of Cell-Cell Adhesion and Antibody Pathogenicity in Pemphigus Vulgaris.

Author

Moghaddam AO, Jin X, Zhai H, Safa BT, Seiffert-Sinha K, Leiker M, Rosenbohm J, Meng F, Sinha AA, and Yang R

Abstract

Pemphigus vulgaris (PV) is a blistering autoimmune disease that affects the skin and mucous membranes. The precise mechanisms by which PV antibodies induce a complete loss of cohesion of keratinocytes are not fully understood. But it is accepted that the process starts with antibody binding to desmosomal targets which leads to its disassembly and subsequent structural changes to cell-cell adhesions. In vitro immunofluorescence imaging of desmosome molecules has been used to characterize this initial phase, often qualitatively. However, there remains an untapped potential of image analysis in providing us more in-depth knowledge regarding ultrastructural changes after antibody binding. Currently, there is no such effort to establish a quantitative framework from immunofluorescence images in PV pathology. We take on this effort here in a comprehensive study to examine the effects of antibodies on key adhesion molecules and the cytoskeletal network, aiming to establish a correlation of ultrastructural changes in cell-cell adhesion with antibody pathogenicity. Specifically, we introduced a data-driven approach to quantitatively evaluate perturbations in adhesion molecules, including desmoglein 3, E-cadherin, as well as the cytoskeleton, following antibody treatment. We identify distinct immunofluorescence imaging signatures that mark the impact of antibody binding on the remodeling of the adhesion molecules and introduce a pathogenicity score to compare the relative effects of different antibodies. From this analysis, we showed that the biophysical response of keratinocytes to distinct PV associated antibodies is highly specific, allowing for accurate prediction of their pathogenicity. For instance, the high pathogenicity scores of the PVIgG and AK23 antibodies show strong agreement with their reported PV pathology. Our data-driven approach offers a more detailed framework for the action of autoantibodies in pemphigus and has the potential to pave the way for the development of effective novel diagnostic methods and therapeutic strategies., Competing Interests: COMPETING INTERESTS None to declare.

Published
2024
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