8,721 results on '"Meng, J."'
Search Results
2. Charge radii of $^{11-16}$C, $^{13-17}$N and $^{15-18}$O determined from their charge-changing cross-sections and the mirror-difference charge radii
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Zhao, J. W., Sun, B. -H., Tanihata, I., Xu, J. Y., Zhang, K. Y., Prochazka, A., Zhu, L. H., Terashima, S., Meng, J., He, L. C., Liu, C. Y., Li, G. S., Lu, C. G., Lin, W. J., Lin, W. P., Liu, Z., Ren, P. P, Sun, Z. Y., Wang, F., Wang, J., Wang, M., Wang, S. T., Wei, X. L., Xu, X. D., Zhang, J. C., Zhang, M. X, and Zhang, X. H.
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Nuclear Experiment ,Nuclear Theory - Abstract
Charge-changing cross-sections of $^{11-16}$C, $^{13-17}$N and $^{15-18}$O on a carbon target have been determined at energies around 300 MeV/nucleon. A nucleon separation energy-dependent correction factor has been introduced to the Glauber model calculation for extracting the nuclear charge radii from the experimental CCCSs. The charge radii of $^{11}$C, $^{13,16}$N and $^{15}$O thus were determined for the first time. With the new radii, we studied the experimental mirror-difference charge radii ($\Delta R_{\text {ch}}^{\text {mirror}}$) of $^{11}$B-$^{11}$C, $^{13}$C-$^{13}$N, $^{15}$N-$^{15}$O, $^{17}$N-$^{17}$Ne pairs for the first time. We find that the $\Delta R_{\text {ch}}^{\text {mirror}}$ values of $^{13}$C-$^{13}$N and $^{15}$N-$^{15}$O pairs follow well the empirical relation to the isospin asymmetry predicted by the $ab$ $initio$ calculations, while $\Delta R_{\text {ch}}^{\text {mirror}}$ of $^{11}$B-$^{11}$C and $^{17}$N-$^{17}$Ne pairs deviate from such relation by more than two standard deviations., Comment: 3 figures, submitted to Physics Letters B
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- 2024
3. Time-dependent density functional theory study of induced-fission dynamics of $^{226}$Th
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Li, B., Vretenar, D., Nikšić, T., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
A microscopic finite-temperature model based on time-dependent nuclear density functional theory (TDDFT), is employed to study the induced-fission process of $^{226}$Th. The saddle-to-scission dynamics of this process is explored, starting from various points on the deformation surface of Helmholtz free energy at a temperature that corresponds to the experimental excitation energy, and following self-consistent isentropic fission trajectories as they evolve toward scission. Dissipation effects and the formation of excited fragments are investigated and, in particular, the difference in the evolution of the local temperature along asymmetric and symmetric fission trajectories. The relative entropies and entanglement between fission fragments emerging at scission are analyzed., Comment: 23 pages, 5 figures. arXiv admin note: text overlap with arXiv:2209.02419
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- 2024
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4. The 25th anniversary for nuclear chirality
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Meng, J. and Wang, Y. P.
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Nuclear Theory ,Nuclear Experiment - Abstract
The brief history for the prediction of the nuclear chirality is provided. The theoretical and experimental investigations of the nuclear chirality are reviewed, including the verification of chiral doublet bands, the chiral conundrum and its resolution, and the prediction and observation of the multiple chiral doublets (M$\chi$D). Some recent theoretical progresses are highlighted, including the chiral collective Hamiltonian, the A-plot and the K-plot, the nuclear chirality-parity (ChP) violation, the chiral rotation induced by the pairing correlations, as well as the chiral dynamics. The possibly emerging area, challenges that lie ahead, and opportunities for progress in the context of the nuclear chirality are discussed., Comment: 19 papes,10 figures
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- 2024
5. Entanglement in multinucleon transfer reactions
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Li, B., Vretenar, D., Nikšić, T., Zhang, D. D., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
Nuclear reactions present an interesting case for studies of the time-evolution of entanglement between complex quantum systems. In this work, the time-dependent nuclear density functional theory is employed to explore entanglement in multinucleon transfer reactions. As an illustrative example, for the reaction $^{40}$Ca $+$ $^{208}$Pb at $E_{\rm lab} = 249$ MeV, in the interval of impact parameters $4.65-7.40$ fm, and the relativistic density functional PC-PK1, we compute the von Neumann entropies, entanglement between fragments, nucleon-number fluctuations, and Shannon entropy for the nucleon-number observable. A simple linear correlation is established between the entanglement and nucleon-number fluctuation of the final fragments. The entanglement between the fragments can be related to the corresponding excitation energies and angular momenta. The relationship between the von Neumann entropy and the Shannon entropy for the nucleon-number observable is analyzed, as well as the time-evolution of the entanglement (nucleon-number fluctuation). The entanglement is also calculated for a range of incident energies and it is shown how, depending on the impact parameter, the entanglement increases with the collision energy., Comment: 22 pages, 7 figures
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- 2024
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6. Neutrinoless double-$\beta$ decay and double Gamow-Teller transitions
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Wang, Y. K., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The neutrinoless double-$\beta$ ($0\nu\beta\beta$) decay and the double Gamow-Teller (DGT) transition are investigated with the state-of-the-art Relativistic Configuration-interaction Density functional theory. A strong linear correlation between the nuclear matrix elements (NMEs) of the $0\nu\beta\beta$ decay and the DGT transition is demonstrated. This linear correlation is found to originate from the similarity of the leading-order term of the $0\nu\beta\beta$-decay operator and the DGT-transition one, as revealed by expanding the $0\nu\beta\beta$-decay operator in terms of the spherical harmonics. The present results provide a strong support to constrain the $0\nu\beta\beta$-decay NMEs through the double charge-exchange reactions., Comment: 13 pages, 5 figures
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- 2024
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7. Abnormal Bifurcation of the Double Binding Energy Differences and Proton-Neutron Pairing: Nuclei Close to $N=Z$ Line from Ni to Rb
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Wang, Y. P., Wang, Y. K., Xu, F. F., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The recently observed abnormal bifurcation of the double binding energy differences $\delta V_{pn}$ between the odd-odd and even-even nuclei along the $N=Z$ line from Ni to Rb has challenged the nuclear theories. To solve this problem, a shell-model-like approach based on the relativistic density functional theory is established, by treating simultaneously the neutron-neutron, proton-neutron, and proton-proton pairing correlations both microscopically and self-consistently. Without any \textit{ad hoc} parameters, the calculated results well reproduce the observations, and the mechanism for this abnormal bifurcation is found to be due to the enhanced proton-neutron pairing correlations in the odd-odd $N=Z$ nuclei, compared with the even-even ones. The present results provide an excellent interpretation for the abnormal $\delta V_{pn}$ bifurcation, and provide a clear signal for the existence of the proton-neutron pairing correlations for nuclei close to the $N=Z$ line., Comment: 6 pages, 4 figures
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- 2024
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8. Multinucleon transfer with time-dependent covariant density functional theory
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Zhang, D. D., Vretenar, D., NikšIć, T., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The microscopic framework of time-dependent covariant density functional theory is applied to study multinucleon transfer reactions, with transfer probabilities calculated using the particle number projection method. It is found that similar total cross sections are obtained with two different relativistic density functionals, PC-PK1 and DD-ME2, as well as with the Skyrme functional SLy5 in a previous study, for multinucleon transfer in the reactions: $^{40}{\rm Ca}+{}^{124}{\rm Sn}$ at $E_{\rm lab} = 170$ MeV, $^{40}{\rm Ca}+{}^{208}{\rm Pb}$ at $E_{\rm lab} = 249$ MeV, and $^{58}{\rm Ni}+{}^{208}{\rm Pb}$ at $E_{\rm lab} = 328.4$ MeV. We report the first microscopic calculation of total cross sections for the reactions: $^{40}{\rm Ar}+{}^{208}{\rm Pb}$ at $E_{\rm lab} = 256$ MeV and $^{206}{\rm Pb}+{}^{118}{\rm Sn}$ at $E_{\rm lab} = 1200$ MeV. Compared to the results obtained with the GRAZING model, the cross sections predicted by the time-dependent covariant density functional theory are in much better agreement with data, and demonstrate the potential of microscopic models based on relativistic density functionals for the description of reaction dynamics., Comment: 20 pages, 5 figures
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- 2024
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9. Longitudinal Analysis of Risk Factors for Pulmonary Function Decline in Chronic Lung Diseases Over Five Years
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Li L, Meng J, and Chen J
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chronic lung diseases ,pulmonary function decline ,latent class growth modeling ,random forest model ,health services ,machine learning in healthcare ,Diseases of the respiratory system ,RC705-779 - Abstract
Lu Li,* Jiaqi Meng,* Jiquan Chen Department of Pulmonary and Critical Care Medicine, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiquan Chen, Department of Pulmonary and Critical Care Medicine, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China, Tel +86-13065135302, Email chenjq9932@163.comObjective: Chronic lung diseases (CLDs) are a major global health concern, characterized by a progressive decline in pulmonary function that severely impacts quality of life. It is essential to identify and predict the primary risk factors for CLDs. This study aims to establish a predictive model to assist healthcare providers in the early identification of high-risk patients and timely interventions and treatment options.Methods: This study utilized questionnaire data from the China Health and Retirement Longitudinal Study (CHARLS) collected in 2011, 2013, and 2015. A latent class growth model (LCGM) was established using CLDs as the baseline sample. This model stratified the patients based on the extent of the decline in Δpeak expiratory flow (ΔPEF), which served as the target variable. Independent variables included age, gender, smoking status, body mass index, education level, and comorbidities. A random forest model was developed using Python, and the importance of the feature was visualized through the SHAP method. The predictive performance of the model was evaluated using receiver operating characteristic (ROC) curve analysis, calibration curve analysis, and decision curve analysis.Results: After screening, a total of 553 patients with CLDs were included in the study. The random forest model pinpointed grip strength, age, education level, gender, and asthma as the top five risk factors for pulmonary function decline. Specifically, the model demonstrated robust predictive performance with an area under the ROC curve (AUC) value of 0.77, affirming its accuracy and clinical applicability. Both calibration and decision curves further substantiated the reliability of the model in identifying patients at increased risk for pulmonary function decline.Conclusion: The predictive model developed in this study serves as a valuable tool for clinicians to target early interventions and optimize treatment strategies to enhance the quality of care and patient outcomes in the management of CLDs.Keywords: chronic lung diseases, pulmonary function decline, latent class growth modeling, random forest model, health services, machine learning in healthcare
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- 2024
10. Isospin-dependence of the charge-changing cross-section shaped by the charged-particle evaporation process
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Zhao, J. W., Sun, B. -H., Tanihata, I., Terashima, S., Prochazka, A., Xu, J. Y., Zhu, L. H., Meng, J., Su, J., Zhang, K. Y., Geng, L. S., He, L. C., Liu, C. Y., Li, G. S., Lu, C. G., Lin, W. J., Lin, W. P., Liu, Z., Ren, P. P, Sun, Z. Y., Wang, F., Wang, J., Wang, M., Wang, S. T., Wei, X. L., Xu, X. D., Zhang, J. C., Zhang, M. X, and Zhang, X. H.
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Nuclear Experiment ,Nuclear Theory - Abstract
We present the charge-changing cross sections (CCCS) of $^{11-15}$C, $^{13-17}$N, and $^{15,17-18}$O at around 300 MeV/nucleon on a carbon target, which extends to $p$-shell isotopes with $N < Z$ for the first time. The Glauber model, which considers only the proton distribution of projectile nuclei, underestimates the cross sections by more than 10\%. We show that this discrepancy can be resolved by considering the contribution from the charged-particle evaporation process (CPEP) following projectile neutron removal. Using nucleon densities from the deformed relativistic Hartree-Bogoliubov theory in continuum, we investigate the isospin-dependent CPEP contribution to the CCCS for a wide range of neutron-to-proton separation energy asymmetry. Our calculations, which include the CPEP contribution, agree well with existing systematic data and reveal an ``evaporation peak" at the isospin symmetric region where the neutron-to-proton separation energy is close to zero. These results suggest that analysis beyond the Glauber model is crucial for accurately determining nuclear charge radii from CCCSs., Comment: 5 figures
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- 2023
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11. Ternary quasifission in collisions of actinide nuclei
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Zhang, D. D., Li, B., Vretenar, D., Nikšić, T., Ren, Z. X., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The microscopic framework of time-dependent covariant density functional theory is applied to a systematic study of ternary quasifission in collisions of pairs of $^{238}$U nuclei. It is shown that the inclusion of octupole degree of freedom in the case of head-to-head collisions, extends the energy window in which ternary quasifission occurs, and greatly enhances the number of nucleons contained in a middle fragment. Dynamical pairing correlations, included here in the time-dependent BCS approximation, prevent the occurrence of ternary quasifission in head-to-head collisions, and have an effect on the location of the energy window in which a middle fragment is formed in tail-to-tail collisions. In the latter case, as well as for tail-to-side collisions, the formation of very heavy neutron-rich systems in certain energy intervals is predicted., Comment: 23 pages, 13 figures
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- 2023
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12. Generalized time-dependent generator coordinate method for induced fission dynamics
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Li, B., Vretenar, D., Nikšić, T., Zhao, J., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The generalized time-dependent generator coordinate method (TD-GCM) is extended to include pairing correlations. The correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and weight functions. The particle-hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional, while pairing is treated dynamically in the standard BCS approximation with time-dependent pairing tensor and single-particle occupation probabilities. With the inclusion of pairing correlations, various time-dependent phenomena in open-shell nuclei can be described more realistically. The model is applied to the description of saddle-to-scission dynamics of induced fission. The generalized TDGCM charge yields and total kinetic energy distribution for the fission of 240Pu, are compared to those obtained using the standard time-dependent density functional theory (TD-DFT) approach, and with available data., Comment: 25 pages,9 figures. arXiv admin note: text overlap with arXiv:2304.13369
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- 2023
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13. Fully-gapped superconductivity and topological aspects of the noncentrosymmetric TaReSi superconductor
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Shang, T., Zhao, J. Z., Hu, Lun-Hui, Gawryluk, D. J., Zhu, X. Y., Zhang, H., Meng, J., Zhen, Z. X., Yu, B. C., Zhou, Z., Xu, Y., Zhan, Q. F., Pomjakushina, E., and Shiroka, T.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
We report a study of the noncentrosymmetric TaReSi superconductor by means of muon-spin rotation and relaxation ($\mu$SR) technique, complemented by electronic band-structure calculations. Its superconductivity, with $T_c$ = 5.5 K and upper critical field $\mu_0H_\mathrm{c2}(0)$ $\sim$ 3.4 T, was characterized via electrical-resistivity- and magnetic-susceptibility measurements. The temperature-dependent superfluid density, obtained from transverse-field $\mu$SR, suggests a fully-gapped superconducting state in TaReSi, with an energy gap $\Delta_0$ = 0.79 meV and a magnetic penetration depth $\lambda_0$ = 562 nm. The absence of a spontaneous magnetization below $T_c$, as confirmed by zero-field $\mu$SR, indicates a preserved time-reversal symmetry in the superconducting state. The density of states near the Fermi level is dominated by the Ta- and Re-5$d$ orbitals, which account for the relatively large band splitting due to the antisymmetric spin-orbit coupling. In its normal state, TaReSi behaves as a three-dimensional Kramers nodal-line semimetal, characterized by an hourglass-shaped dispersion protected by glide reflection. By combining non\-triv\-i\-al electronic bands with intrinsic superconductivity, TaReSi is a promising material for investigating the topological aspects of noncentrosymmetric superconductors., Comment: 9 pages, 9 figures; accepted by Phys. Rev. B
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- 2023
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14. Fully-gapped superconductivity with preserved time-reversal symmetry in NiBi$_3$ single crystals
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Shang, T., Meng, J., Zhu, X. Y., Zhang, H., Yu, B. C., Zhen, Z. X., Wang, Y. H., Xu, Y., Zhan, Q. F., Gawryluk, D. J., and Shiroka, T.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
We report a study of NiBi$_3$ single crystals by means of electrical-resistivity-, magnetization-, and muon-spin rotation and relaxation ($\mu$SR) measurements. As a single crystal, NiBi$_3$ adopts a needle-like shape and exhibits bulk superconductivity with $T_c \approx 4.1$ K. By applying magnetic fields parallel and perpendicular to the $b$-axis of NiBi$_3$, we establish that its lower- and upper critical fields, as well as the magnetic penetration depths show slightly different values, suggesting a weakly anisotropic superconductivity. In both cases, the zero-temperature upper critical fields are much smaller than the Pauli-limit value, indicating that the superconducting state is constrained by the orbital pair breaking. The temperature evolution of the superfluid density, obtained from transverse-field $\mu$SR, reveals a fully-gapped superconductivity in NiBi$_3$, with a shared superconducting gap $\Delta_0$ = 2.1 $k_\mathrm{B}$$T_c$ and magnetic penetration depths $\lambda_0$ = 223 and 210 nm for $H \parallel b$- and $H \perp b$, respectively. The lack of spontaneous fields below $T_c$ indicates that time-reversal symmetry is preserved in NiBi$_3$. The absence of a fast muon-spin relaxation and/or precession in the zero-field $\mu$SR spectra definitely rules out any type of magnetic ordering in NiBi$_3$ single crystals. Overall, our investigation suggests that NiBi$_3$ behaves as a conventional $s$-type superconductor., Comment: 8 pages, 8 figures, accepted by Phys. Rev. B
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- 2023
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15. Impact of isovector pairing fluctuation on neutrinoless double-beta decay in multi-reference covariant density functional theory
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Ding, C. R., Zhang, X., Yao, J. M., Ring, P., and Meng, J.
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Nuclear Theory ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
We extend the multi-reference covariant density functional theory (MR-CDFT) by including fluctuations in quadrupole deformations and average isovector pairing gaps simultaneously for the nuclear matrix elements (NMEs) of neutrinoless double-beta $(0\nu\beta\beta)$ decay in the candidate nuclei $^{76}$Ge, $^{82}$Se, $^{100}$Mo, $^{130}$Te, and $^{136}$Xe assuming the exchange of either light or heavy neutrinos. The results indicate a linear correlation between the predicted NMEs and the isovector pairing strengths, as well as the excitation energies of $2^{+}_1$ and $4^{+}_1$ states. By adjusting the pairing strengths based on the excitation energies of the $2^{+}_1$ states, we calculate the NMEs for $0\nu\beta\beta$ decay, which are reduced by approximately $12\%$ to $62\%$ compared to the results obtained in the previous studies by Song et al. [Phys. Rev. C95, 024305 (2017)]. Additionally, upon introducing the average isovector pairing gap as an additional generator coordinate in the calculation, the NMEs increase by a factor ranging from $56\%$ to $218\%$., Comment: 11 pages with 4 tables and 8 figures
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- 2023
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16. A Novel Scale System Based on the Frailty Index and Laboratory Indicators for the Short-Term Prognosis of Patients with Acute Myocardial Infarction: A Retrospective Cohort Study
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Cao T, Liu F, Yao Y, Sun D, Wang R, Cao J, Meng J, Zhang L, and Li W
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myocardial infarction ,frailty index ,major adverse cardiac events ,prognosis ,cohort study ,Geriatrics ,RC952-954.6 - Abstract
Tianqing Cao,1,* Fei Liu,2,* Yan Yao,2 Danghong Sun,2 Rong Wang,3 Junxia Cao,3 Jie Meng,2 Ling Zhang,4 Weiming Li1 1Shanghai Tenth People’s Hospital, Clinical Medical College of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Cardiology, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China; 3Department of Pulmonology, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, People’s Republic of China; 4Department of Nursing, Changshu No.2 People’s Hospital/Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weiming Li; Ling Zhang, Email 18917683469@189.cn; nancy120312@163.comObjective: Current scoring systems for short-term prognosis in patients with acute myocardial infarction (AMI) lack coverage of risk factors and have limitations in risk stratification. The aim of this study was to develop a novel assessment system based on laboratory indicators and frailty quantification to better infer short-term prognosis and risk indication in patients with AMI.Methods: A total of 365 patients with MI from January 2022 to June 2023 in Northern Jiangsu Province Hospital were included. The primary endpoint was all-cause mortality and major adverse cardiac events (MACE) during follow-up. A novel scoring model ranging from 0 to 12 was constructed, and the predictive ability of this scoring system was evaluated using the area under the receiver operating characteristic curve (AUC).Results: During follow-up, 68 patients experienced MACE. Five scoring indicators were selected through multivariate logistic regression analysis, resulting in a composite score with an AUC of 0.925, demonstrating good prognostic accuracy.Conclusion: The novel prognostic assessment system, which integrates age, Stress Hyperglycemia Ratio (SHR), Neutrophil to Lymphocyte Ratio (NLR), lactate, and frailty score, exhibits good predictive value for short-term MACE in patients with acute myocardial infarction and may enable more accurate risk classification for future use in MI patient risk management.Keywords: myocardial infarction, frailty index, major adverse cardiac events, prognosis, cohort study
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- 2024
17. Relationship of Glymphatic Function with Cognitive Impairment, Sleep Disorders, Anxiety and Depression in Patients with Parkinson’s Disease
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Gui Q, Meng J, Shen M, Feng H, Dong X, Xu D, Zhu W, Cheng Q, Wang L, Wu G, and Lu Y
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glymphatic system ,parkinson’s disease ,non-motor symptoms ,cognition ,sleep ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Qian Gui,1,* Jingcai Meng,2,* Mingqiang Shen,1 Hongxuan Feng,1 Xiaofeng Dong,1 Daqiang Xu,3 Wenxin Zhu,2 Qingzhang Cheng,1 Linhui Wang,2 Guanhui Wu,1 Yanli Lu3 1Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Suzhou, Jiangsu, 215002, People’s Republic of China; 2Department of Physiology and Neurobiology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of China; 3Department of Radiology, the Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Suzhou, Jiangsu, 215002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanli Lu, Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), 26 Daoqian Street, Suzhou City, Jiangsu Province, People’s Republic of China, Tel +8618251135654, Email luyanli.2009@163.com Guanhui Wu, Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), 26 Daoqian Street, Suzhou City, Jiangsu Province, People’s Republic of China, Email ghwusz26@njmu.edu.cnIntroduction: Previous studies have predominantly explored the relationship of the glymphatic system with motor symptoms in Parkinson’s disease (PD); however, research on non-motor symptoms remains limited. Therefore, this study investigated the association between glymphatic function and non-motor symptoms, including cognitive impairment and sleep disorders, in PD patients.Methods: This study recruited 49 PD patients and 38 healthy controls (HC). Glymphatic function was evaluated using enlarged perivascular spaces (EPVS) in the basal ganglia (BG) region and diffusion tensor image analysis along the perivascular space (DTI-ALPS) index. Cognition, sleep, anxiety, and depression scales were assessed in all participants. According to the scale scores, PD patients were further divided into several groups to identify the presence of non-motor symptoms. Differences in EPVS numbers and ALPS index between PD subgroups and HC group were compared. Spearman correlation analysis was performed to investigate the association between the PD non-motor symptoms and ALPS index. Additionally, receiver operating characteristic (ROC) curves analysis was conducted for ALPS index to predict cognitive impairment and insomnia in PD patients.Results: PD patients with and without non-motor symptoms all showed more EPVS numbers than the controls, and the EPVS numbers in PD patients with cognitive impairment were also greater than those without. Notably, except for the depression subgroup, PD patients with non-motor symptoms showed significantly lower ALPS index than the controls. The Montreal Cognitive Assessment (MoCA) scores were positively correlated, whereas the Parkinson’s Disease Sleep Scale (PDSS)-2 and REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) scores were negatively correlated with the ALPS index in PD patients (r=0.3618, P=0.0053; r=− 0.4146, P=0.0015; r=− 0.2655, P=0.0326, respectively). The ALPS index proved to be predictive of cognitive impairment and insomnia in PD patients (AUC=0.7733, P=0.001; AUC=0.7993, P=0.0004, respectively).Conclusion: Glymphatic function is closely associated with cognition and sleep of PD patients.Keywords: glymphatic system, parkinson’s disease, non-motor symptoms, cognition, sleep
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- 2024
18. ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma
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Huang X, Wang M, Zhang D, Meng J, and Liu P
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hepatocellular carcinoma ,zdhhc20 ,pi3k-akt pathway ,cell proliferation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Xiaoju Huang,1– 3 Mengmeng Wang,1– 3 Dan Zhang,1– 3 Junpeng Meng,4,5 Pian Liu1– 3 1Cancer Center Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, 430022, People’s Republic of China; 3Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 4Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 5Department of General Surgery, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, People’s Republic of ChinaCorrespondence: Pian Liu; Junpeng Meng, Email liupianamazing@126.com; mengjunpeng1981@163.comBackground: Liver cancer is the sixth most common cancer worldwide, and hepatocellular carcinoma (HCC) presents one of the most challenging global health issues. ZDHHC20, a member of the ZDHHC palmitoyltransferase (ZDHHC-PAT) family, is involved in a reversible lipid modification known as palmitoylation, which contributes to the occurrence and progression of various tumors. However, the specific mechanisms underlying the involvement of ZDHHC20 in this process are unclear.Methods: The effects of both ZDHHC20 knockdown and overexpression on hepatocellular carcinoma cell proliferation were evaluated using PCR, Western blotting, CCK-8 assay, colony formation assay, cell cycle analysis, apoptosis analysis, and EDU assay. The TCGA-LIHC dataset was analyzed bioinformatically, and the phosphorylation level of PI3K and AKT in SK-Hep1 and Huh7 cells was assessed using Western blotting. Nude mouse subcutaneous xenograft experiments were conducted to evaluate the effects of different treatment conditions on mouse tumor growth.Results: ZDHHC20 knockdown inhibited cell proliferation and promoted apoptosis, while overexpression of ZDHHC20 promoted cell proliferation and inhibited apoptosis. Knockdown of ZDHHC20 also decreased phosphorylation of PI3K and AKT in HCC, whereas overexpression of ZDHHC20 increased phosphorylation of PI3K and AKT. The PI3K-AKT pathway inhibitors, LY294002 and MK2206, effectively inhibited the promotional effects of ZDHHC20 on the proliferation and growth of HCC.Conclusion: High expression of ZDHHC20 promotes the proliferation and tumor growth of HCC by activating the PI3K-AKT signaling pathway. The PI3K inhibitor LY294002 and the AKT inhibitor MK2206 inhibit the promotional effects of ZDHHC20 on the proliferation of HCC and the growth of tumors.Keywords: hepatocellular carcinoma, ZDHHC20, PI3K-AKT pathway, cell proliferation
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- 2024
19. Carrimycin, as One of the Drugs in Combination Therapy, for the Treatment of Carbapenem-Resistant Acinetobacter Baumannii Infection
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Du N, You D, Tenzing D, Qu D, Meng J, Wang Y, and He J
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carrimycin ,carbapenem-resistant acinetobacter baumannii ,crab ,case report ,Infectious and parasitic diseases ,RC109-216 - Abstract
Ning Du,1,* Dan You,2,* Dava Tenzing,3 Dongxiang Qu,2 Jun Meng,1,* Yihui Wang,4,* Juan He5,* 1Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong Province, People’s Republic of China; 2Department of Pharmacy, The First Hospital of Qiqihar, Qiqihar, Heilongjiang Province, People’s Republic of China; 3Department of Emergency, People’s Hospital of Shigatse City, Shigatse, Xizang Autonomous Region, People’s Republic of China; 4Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 5Department of Pharmacy, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan He, Department of Pharmacy, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email hejuanwin@126.com Yihui Wang, Department of Emergency, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email wangyihui581@163.comPurpose: Infection with carbapenem-resistant Acinetobacter baumannii (CRAB) is a tough nut to crack. Carrimycin is a novel recombinant macrolide antibiotic, and has good anti-infection effects in vivo. At present, it is rarely reported for treatment of CRAB infection. We present a case where a patient with COVID-19 complicated by CRAB infection was successfully treated with a combination therapy including carrimycin, offering clinical insights and experience.Patients and Methods: The patient infected with CRAB was cured by carrimycin combined with tigecycline and amikacin ultimately. We analyzed and summarized the therapeutic regimen and disease feature to provide reference for clinical treatment.Results: The patient was admitted to emergency observation wards with fever and was diagnosed with COVID-19 pneumonia. During the treatment, his condition worsened. He had a fever, cough, and expectoration. After 3 days of empirical treatment with meropenem, tested positive for A. baumannii infection by the next-generation sequencing, and CRAB was detected in blood and sputum culture. Then, he was administered with tigecycline and amikacin immediately for 5 days, however the therapeutic effect was not significant. The patient still remained in a high inflammatory response. Ultimately, the treatment regimen was changed to carrimycin combined with tigecycline and amikacin for 7 days, and then carrimycin combined with tigecycline for 10 days, the patient’s clinical condition gradually improved. The patient received carrimycin monotherapy for 7 days, then discharged.Conclusion: Carrimycin may be a bright alternative for CRAB infection as one of the drugs in combination therapy, especially in a patient with hyperinflammatory response.Keywords: Carrimycin, Carbapenem-resistant Acinetobacter baumannii, CRAB, case report
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- 2024
20. Generalized time-dependent generator coordinate method for induced fission dynamics
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Li, B., Vretenar, D., Nikšić, T., Zhao, J., Zhao, P. W., and Meng, J.
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- 2024
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21. Generalized time-dependent generator coordinate method for small and large amplitude collective motion
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Li, B., Vretenar, D., Nikšić, T., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
An implementation of the generalized time-dependent generator coordinated method (TD-GCM) is developed, that can be applied to the dynamics of small- and large-amplitude collective motion of atomic nuclei. Both the generator states and weight functions of the GCM correlated wave function depend on time. The initial generator states are obtained as solutions of deformation-constrained self-consistent mean-field equations, and are evolved in time by the standard mean-field equations of nuclear density functional theory (TD-DFT). The TD-DFT trajectories are used as a generally non-orthogonal and overcomplete basis in which the TD-GCM wave function is expanded. The weights, expressed in terms of a collective wave function, obey a TD-GCM (integral) equation. In this explorative paper, the generalized TD-GCM is applied to the excitation energies and spreading width of giant resonances, and to the dynamics of induced fission. The necessity of including pairing correlations in the basis of TD-DFT trajectories is demonstrated in the latter example., Comment: 30 pages,11 figures
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- 2023
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22. Coexisting single-particle excitations and octupole correlations in transitional nucleus $\mathbf{^{217}Ra}$
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Madhu, Deo, A. Y., Yadav, Khamosh, Sahoo, Dhananjaya, Wang, Y. Y., Wang, Y. K., Meng, J., Suman, Saket, Tandel, S. K., Sharma, A., Ahmed, I., Katre, K., Devi, K. Rojeeta, Dutt, S., Kumar, S., Yashraj, Muralithar, S., and Singh, R. P.
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Nuclear Experiment ,Nuclear Theory - Abstract
The level structure of the transitional nucleus $\mathrm{^{217}Ra}$ has been extended with the addition of around 20 new transitions. The discrepancies between the placements of several transitions reported in the earlier studies are resolved. The newly-established negative-parity sequence at low excitation energies hints at the expected parity-doublet structures in this nucleus. The properties of the observed simplex bands are compared with that of similar bands in neighboring nuclei. Since the presence of parity-doublet structures reflect octupole correlations, theoretical calculations using reflection-asymmetric triaxial particle rotor model (RAT-PRM) have been performed. A comparison of the observed features of the simplex bands with the predictions of the RAT-PRM calculations suggests that $\mathrm{^{217}Ra}$ exhibits an intermediate the behavior between the extremes of spherical and octupole-deformed nuclei. The termination of the simplex bands at intermediate energies and the structures lying above reflect the dominance of the single-particle excitations at higher excitation energies., Comment: 15 pages, 16 figures
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- 2023
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23. Relativistic Configuration-interaction Density Functional Theory: Nuclear Matrix Elements for $\beta\beta$ Decay
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Wang, Y. K., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The relativistic configuration-interaction density functional theory is developed for even-even and odd-odd nuclei and is used to predict the nuclear matrix element of the neutrinoless $\beta\beta$ ($0\nu\beta\beta$) decay in $^{76}$Ge, amongst the most promising $\beta\beta$-decay candidates. The spectroscopic properties of the $\beta\beta$-decay partners $^{76}$Ge and $^{76}$Se, and the nuclear matrix element governing the two-neutrino $\beta\beta$ ($2\nu\beta\beta$) decay in $^{76}$Ge are well reproduced, providing solid benchmarks for the theoretical calculations. The inclusion of the triaxial degree of freedom slightly enhances the nuclear matrix element of the $2\nu\beta\beta$ decay while raises that of the $0\nu\beta\beta$ decay significantly by a factor around two. The present results highlight the importance of nuclear triaxial deformation for a better prediction of the $0\nu\beta\beta$-decay nuclear matrix element., Comment: 14 pages, 4 figures
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- 2023
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24. $0\nu\beta\beta$-decay nuclear matrix elements in self-consistent Skyrme quasiparticle random phase approximation: uncertainty from pairing interaction
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Lv, W. -L., Niu, Y. -F., Fang, D. -L., Yao, J. -M., Bai, C. -L., and Meng, J.
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Nuclear Theory - Abstract
The uncertainty in the nuclear matrix elements (NMEs) of $0\nu\beta\beta$ decay for $^{76}$Ge, $^{82}$Se, $^{128}$Te, $^{130}$Te, and $^{136}$Xe in the self-consistent quasiparticle random phase approximation (QRPA) method is investigated by using eighteen Skyrme interactions supplemented with either a volume- or surface-type of pairing interactions. The NMEs for the isotopes concerned (except $^{136}$Xe) are less sensitive to the particle-hole ($ph$) interactions, while strongly dependent on the employed isovector particle-particle ($pp$) pairing interactions even though the pairing strengths are optimized to the same pairing gap. The results indicate that a precise determination of the isovector $pp$ pairing interaction in the Skyrme energy density functional is of importance to reduce the uncertainty in the NMEs within the QRPA framework., Comment: 7 pages, 5 figures
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- 2023
25. Very early warning of a moderate-to-strong El Ni\~no in 2023
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Ludescher, J., Meng, J., Fan, J., Bunde, A., and Schellnhuber, H. J.
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Physics - Atmospheric and Oceanic Physics - Abstract
The El Ni\~no Southern Oscillation (ENSO) is the strongest driver of year-to-year variations of the global climate and can lead to extreme weather conditions and disasters in various regions around the world. Here, we review two different approaches for the early forecast of El Ni\~no that we have developed recently: the climate network-based approach allows forecasting the onset of an El Ni\~no event about 1 year ahead, while the complexity-based approach allows additionally to estimate the magnitude of an upcoming El Ni\~no event in the calendar year before. For 2023, both approaches predict the onset of an El Ni\~no event, with a combined onset probability of about 89%. The complexity-based approach predicts a moderate-to-strong El Ni\~no with a magnitude of $1.49\pm0.37${\deg}C. Since El Ni\~no events temporarily increase the global temperature, we expect that the coming El Ni\~no will increase the global temperature by about +0.2{\deg}C, likely making 2024 the hottest year since the beginning of instrumental observations. It is possible that as a consequence of this El Ni\~no, the +1.5{\deg}C target (compared to pre-industrial levels) will be temporarily breached already in 2024., Comment: 11 pages, 6 figures. arXiv admin note: substantial text overlap with arXiv:2102.02192; text overlap with arXiv:2212.14025
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- 2023
26. Possible neutron halo in triaxial nucleus 42Al
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Zhang, K. Y., Zhang, S. Q., and Meng, J.
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Nuclear Theory ,Nuclear Experiment - Abstract
A microscopic self-consistent triaxial relativistic Hartree-Bogoliubov theory in continuum (TRHBc), which simultaneously takes into account the triaxiality and pairing correlations as well as continuum effects, is established and applied to explore the novel halo phenomenon in aluminum isotopes. The experimental proton drip line and the available data of neutron separation energies and charge radii are reproduced well without any free parameters. The neutron-richest odd-odd aluminum isotope observed so far, 42Al, is predicted to be triaxially deformed with beta=0.35 and gamma=42. Its one-neutron separation energy is predicted to be 0.68 MeV, in agreement with the AME2020, and the neutron rms radius is 3.94 fm, remarkably larger than the empirical value. The density distribution of the valance neutron, which extends much farther in space than the core, suggests a possible neutron halo in 42Al. The dominant components responsible for the spatial extension of the halo are revealed by the single-neutron orbitals around the Fermi energy. A novel phenomenon, the exchange of the intermediate and short axes between the triaxial core with beta=0.38 and gamma=50, and the triaxial halo with beta=0.79 and gamma=-23, is found. Future experiments to explore the halo phenomenon and the novel shape decoupling in 42Al are highly demanded., Comment: 6 pages, 5 figures
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- 2022
27. Nuclear chiral rotation induced by superfluidity
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Wang, Y. P. and Meng, J.
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Nuclear Theory ,Nuclear Experiment - Abstract
The microscopic understanding on the influence of the pairing correlations or the superfluidity on the nuclear chiral rotation has been a longstanding and challenging problem. Based on the three-dimensional cranking covariant density functional theory, a shell-model-like approach with exact particle number conservation is implemented to take into account the pairing correlations and applied for the chiral doublet bands in Nd135. The data available are well reproduced. It is found that the superfluidity can reduce the critical frequency and make the chiral rotation easier. The mechanism is that the particle/hole alignments along the short/long axis are reduced by the pairing correlations, resulting in the enhanced preference of the collective rotation along the intermediate axis, and inducing the early appearance of the chiral rotation., Comment: 8 pages, 4 figures, final version appeared in PLB
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- 2022
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28. Prevalence of Chronic Obstructive Pulmonary Disease and Its Associated Risk Factors in Yunnan Province, China: A Population Based Cross-Sectional Study
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Wen G, Meng J, Peng P, Xu Y, Wang R, Cui W, Wen A, Luo G, Zhang Y, and Tang S
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chronic obstructive pulmonary disease ,epidemiological characteristics ,influencing factors ,high-risk population ,china ,Diseases of the respiratory system ,RC705-779 - Abstract
Geyi Wen,1,* Jinliang Meng,1,* Puxian Peng,2,* Yanyan Xu,1 Ruiqi Wang,1 Wenlong Cui,2 Aihan Wen,2 Guohong Luo,2 Yunhui Zhang,1 Songyuan Tang2 1Department of Pulmonary and Critical Care Medicine, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, People’s Republic of China; 2Institute of Health Studies, School of Public Health, Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunhui Zhang, Department of Pulmonary and Critical Care Medicine, the First People’s Hospital of Yunnan Province, No. 157 Jinbi Road, Xishan District, Kunming, Yunnan, 650032, People’s Republic of China, Email yunhuizhang3188@126.com Songyuan Tang, Institute of Health Studies, School of Public Health, Kunming Medical University, 1168 West Chunrong Road, Yuhua Street, Chenggong District, Kunming, Yunnan, 650500, People’s Republic of China, Email tsythailand@hotmail.comPurpose: Chronic obstructive pulmonary disease (COPD) is a significant disease impacting health and quality of life. Yunnan Province, a major tobacco producer, lacks comprehensive COPD studies. The purpose of this study is to describe the epidemic situation of COPD in Yunnan province and explore its influencing factors.Methods: This study is a cross-sectional research conducted in a representative sample of adults aged 20 and older from 13 prefectures and cities in Yunnan Province, China. COPD was diagnosed using post-bronchodilator pulmonary function tests. Demographics were analyzed with descriptive statistics. The influencing factors of COPD were examined by using the multivariate logistic regression models.Results: Our study found that high-risk individuals for COPD accounted for 20.30% of the screened population aged 20 and above, with a COPD prevalence of 27.18% among this high-risk group. Male had a higher prevalence (33.01%) than did female (16.35%; p< 0.001 for sex difference). Additionally, the proportion of severe and extremely severe COPD cases in Yunnan Province was higher than the national average and other provinces. After considering the potential confounding variables, male (OR=2.291, 95% CI: 1.584– 3.313), age (OR=1.501, 95% CI: 1.338– 1.685), underweight (OR=1.747, 95% CI: 1.225– 2.491), previous smoking (OR=1.712, 95% CI: 1.182– 2.478), passive smoking (OR=1.444, 95% CI: 1.159– 1.800), and a history of respiratory system diseases in childhood (OR=2.010, 95% CI: 1.346– 3.001) were significantly associated with an increased risk of COPD. Conversely, being overweight (OR=0.636, 95% CI: 0.489– 0.828), and residing in high-altitude counties (OR=0.445, 95% CI: 0.263– 0.754) were negatively correlated with the risk of COPD.Conclusion: There is significant prevalence of COPD (27.18%) among high-risk population aged 20 and above in Yunnan Province, China. Apart from male, smoking, BMI and other known risk factors for COPD. We found that high-altitude residence had a lower prevalence of COPD. There is no significant difference in COPD prevalence between Han and ethnic minority populations.Keywords: chronic obstructive pulmonary disease, epidemiological characteristics, influencing factors, high-risk population, China
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- 2024
29. Risk Management for Whole-Process Safe Disposal of Medical Waste: Progress and Challenges
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Yang T, Du Y, Sun M, Meng J, and Li Y
- Subjects
medical waste ,safe disposal ,major infectious diseases ,progress and challenges ,Public aspects of medicine ,RA1-1270 - Abstract
Ting Yang,1,2 Yanan Du,1 Mingzhen Sun,1 Jingjing Meng,1 Yiyi Li1 1School of Health Services Management, Anhui Medical University, Hefei, Anhui, 230032, People’s Republic of China; 2Intelligent Interconnected Systems Laboratory of Anhui Province (Hefei University of Technology), Hefei, Anhui, 230009, People’s Republic of ChinaCorrespondence: Ting Yang, Email yangting@ahmu.edu.cnAbstract: Over the past decade, the global outbreaks of SARS, influenza A (H1N1), COVID-19, and other major infectious diseases have exposed the insufficient capacity for emergency disposal of medical waste in numerous countries and regions. Particularly during epidemics of major infectious diseases, medical waste exhibits new characteristics such as accelerated growth rate, heightened risk level, and more stringent disposal requirements. Consequently, there is an urgent need for advanced theoretical approaches that can perceive, predict, evaluate, and control risks associated with safe disposal throughout the entire process in a timely, accurate, efficient, and comprehensive manner. This article provides a systematic review of relevant research on collection, storage, transportation, and disposal of medical waste throughout its entirety to illustrate the current state of safe disposal practices. Building upon this foundation and leveraging emerging information technologies like Internet of Things (IoT), cloud computing, big data analytics, and artificial intelligence (AI), we deeply contemplate future research directions with an aim to minimize risks across all stages of medical waste disposal while offering valuable references and decision support to further advance safe disposal practices.Keywords: medical waste, safe disposal, major infectious diseases, progress and challenges
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- 2024
30. The Pan-Cancer Analysis Uncovers the Prognostic and Immunotherapeutic Significance of CD19 as an Immune Marker in Tumor
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Wei L, Meng J, Xiang D, Yang Q, Zhou Y, Xu L, Chen J, and Han Y
- Subjects
cd19 ,pan-cancer ,prognosis ,immune infiltration ,biomarker ,Medicine (General) ,R5-920 - Abstract
Lanyi Wei, Jingjing Meng, Danfeng Xiang, Quanjun Yang, Yangyun Zhou, Lingyan Xu, Junjun Chen,* Yonglong Han* Department of Pharmacy, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junjun Chen; Yonglong Han, Department of Pharmacy, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China, Email chenjunjun8812@sina.com; yonglongh@126.comBackground: The specific cytotoxic effects of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy have led to impressive outcomes in individuals previously treated for B-cell malignancies. However, the specific biological role of CD19(+) target cells, which exert antitumor immunity against some solid tumors, remains to be elucidated.Methods: We collected information regarding the level of CD19 mRNA and protein expression from various databases including The Cancer Genome Atlas (TCGA), Tumor Immune Estimation Resource (TIMER), Genotype-Tissue Expression (GTEx), and Human Protein Atlas (HPA) for both tumor and normal samples. To evaluate the patient’s prognosis according to CD19 expression, a Kaplan-Meier (KM) analysis and univariate Cox regression were performed. Furthermore, using the Estimation of Stromal and Immune Cells in Malignant Tumor Tissues Using the Expression Data (ESTIMATE) algorithm, we estimated the ratio of immune cells infiltrating malignant tumor tissues. Afterward, the GSCALite repository was employed to evaluate the vulnerability of tumors expressing CD19 to drugs used in chemotherapy. To validate the results in clinical samples of certain cancer types, immunohistochemistry was then performed.Results: Most tumor types exhibited CD19 expression differently, apart from colon adenocarcinoma (COAD). The early diagnostic value of CD19 has been demonstrated in 9 different tumor types, and the overexpression of CD19 has the potential to extend the survival duration of patients. Multiple tumors showed a positive correlation between CD19 expression and tumor mutation burden (TMB), microsatellite instability (MSI), and ESTIMATE score. Furthermore, a direct association was discovered between the expression of CD19 and the infiltration of immune cells, particularly in cases of breast invasive carcinoma (BRCA). Moreover, CD19 is highly sensitive to a variety of chemotherapy drugs.Conclusion: The study reveals the potential of CD19 as both a predictive biomarker and a target for different cancer immunotherapies.Keywords: CD19, pan-cancer, prognosis, immune infiltration, biomarker
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- 2024
31. Fission dynamics, dissipation and clustering at finite temperature
- Author
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Li, B., Vretenar, D., Ren, Z. X., Nikšić, T., Zhao, J., Zhao, P. W., and Meng, J.
- Subjects
Nuclear Theory - Abstract
The saddle-to-scission dynamics of the induced fission process is explored using a microscopic finite-temperature model based on time-dependent nuclear density functional theory (TDDFT), that allows to follow the evolution of local temperature along fission trajectories. Starting from a temperature that corresponds to the experimental excitation energy of the compound system, the model propagates the nucleons along isentropic paths toward scission. For the four illustrative cases of induced fission of $^{240}$Pu, $^{234}$U, $^{244}$Cm, and $^{250}$Cf, characteristic fission trajectories are considered, and the partition of the total energy into various kinetic and potential energy contributions at scission is analyzed, with special emphasis on the energy dissipated along the fission path and the prescission kinetic energy. The model is also applied to the dynamics of neck formation and rupture, characterized by the formation of few-nucleon clusters in the low-density region between the nascent fragments., Comment: 31 pages, 10 figures
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- 2022
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32. The performance of ultraviolet solar-blind detection of p-Si/n-Ga2O3 heterojunctions with/without hole-blocking layer
- Author
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Zhang, Q., Gao, H. L., Deng, J. X., Meng, X., Tian, K., Xu, J. W., Yang, X. L., Kong, L., Meng, L. J., Du, J., Yang, Q. Q., Wang, G. S., Meng, J. H., and Wang, X. L.
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- 2024
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33. Stability and interpolation properties for Stokes-like virtual element spaces
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da Veiga, L. Beirão, Mascotto, L., and Meng, J.
- Subjects
Mathematics - Numerical Analysis ,65N12, 65N30, 65N50 - Abstract
We prove stability bounds for Stokes-like virtual element spaces in two and three dimensions. Such bounds are also instrumental in deriving optimal interpolation estimates. Furthermore, we develop some numerical tests in order to investigate the behaviour of the stability constants also from the practical side.
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- 2022
34. Enhancement of creep properties with trace nitrogen in a low-cost nickel-based single crystal superalloy
- Author
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Zhang, G.Q., Wang, L., Pang, Y.Y., Meng, J., Zhou, Y.Z., and Sun, X.F.
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- 2024
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35. Characterizing CD8+ TEMRA Cells in CP/CPPS Patients: Insights from Targeted Single-Cell Transcriptomic and Functional Investigations
- Author
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Zhang F, Ge Q, Meng J, Chen J, Liang C, and Zhang M
- Subjects
chronic prostatitis/chronic pelvic pain syndrome ,targeted single-cell rna sequencing ,cd8+ temra ,periblood memory t-cell ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Fei Zhang,* Qintao Ge,* Jialin Meng, Jia Chen, Chaozhao Liang, Meng Zhang Department of Urology, The First Affiliated Hospital of Anhui Medical University; Institute of Urology, Anhui Medical University; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, 230022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chaozhao Liang; Meng Zhang, Department of Urology, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Shushan District, Hefei City, Anhui Province, 230022, People’s Republic of China, Tel/Fax +86 55162922034, Email liang_chaozhao@ahmu.edu.cn; zhangmeng1930@126.comBackground: The specific involvement of the CD8+ T effector memory RA (TEMRA) subset in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has largely not been explored in the literature.Methods: Targeted single-cell RNA sequencing (scRNA-seq) profiles were generated from peripheral blood mononuclear cells (PBMCs) obtained from two CP/CPPS patients and two healthy controls (HCs) in our recent study. Pseudotime series algorithms were used to reveal the differentiation trajectory, CellChat analysis was used to explore the communication between individual cells, and the SCENIC program was used to identify potential transcription factors (TFs). Based on the cosine similarity, clusters of differentially expressed genes (DEGs) were considered to be further enriched in different pathways. To confirm the functional role of the critical clusters, flow cytometry was employed.Results: The results revealed the molecular landscape of these clusters, with TEMRA cells exhibiting pronounced cytokine-mediated signaling pathway enrichment. Pseudotime trajectory analysis further mapped the evolution from naïve T cells to that of TEMRA cells, elucidating the developmental pathways involved in the immune context. A significant finding from CellChat analysis was the differential expression of ligands and receptors, with CD8+ TEMRA cells showing enhanced signaling, particularly in the CP/CPPS context, compared to HCs. Flow cytometry confirmed these results, revealing a heightened proinflammatory cytokine profile in patients with chronic prostatitis-like symptoms (CP-LS), suggesting that TEMRA cells play a significant role in disease pathogenesis. TF profiling across the T-cell clusters identified key regulators of cellular identity, identifying novel therapeutic targets. Elevated TNF signaling activity in CD8+ TEMRA cells underscored the involvement of these cells in disease mechanisms.Conclusion: This study elucidates the pivotal role of the CD8+ TEMRA cell subset in CP/CPPS, which is characterized by increased TNF signaling and proinflammatory factor expression, highlighting potential biomarkers and opening new avenues for therapeutic intervention.Keywords: chronic prostatitis/chronic pelvic pain syndrome, targeted single-cell RNA sequencing, CD8+ TEMRA, periblood memory T-cell
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- 2024
36. Configuration interaction projected density functional theory: effects of four-quasiparticle configurations and time-odd interactions
- Author
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Wang, Y. K., Zhao, P. W., and Meng, J.
- Subjects
Nuclear Theory - Abstract
The effects of four-quasiparticle configurations and time-odd interactions are investigated in the framework of configuration interaction projected density functional theory by taking the yrast states of 60Fe as examples. Based on the universal PC-PK1 density functional, the energies of the yrast states with spin up to 20\hbar and the available B(E2) transition probabilities are well reproduced. The yrast states are predicted to be of four-quasiparticle structure above spin I = 16\hbar. The inclusion of the time-odd interactions increases the kinetic moments of inertia and delays the appearance of the first band crossing, and, thus, improves the description of the data., Comment: 14 pages,5 figures
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- 2022
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37. Computing eigenvalues of semi-infinite quasi-Toeplitz matrices
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Bini, D. A., Iannazzo, B., Meini, B., Meng, J., and Robol, L.
- Subjects
Mathematics - Numerical Analysis - Abstract
A quasi-Toeplitz (QT) matrix is a semi-infinite matrix of the form $A=T(a)+E$ where $T(a)$ is the Toeplitz matrix with entries $(T(a))_{i,j}=a_{j-i}$, for $a_{j-i}\in\mathbb C$, $i,j\ge 1$, while $E$ is a matrix representing a compact operator in $\ell^2$. The matrix $A$ is finitely representable if $a_k=0$ for $k<-m$ and for $k>n$, given $m,n>0$, and if $E$ has a finite number of nonzero entries. The problem of numerically computing eigenpairs of a finitely representable QT matrix is investigated, i.e., pairs $(\lambda,{\bf v})$ such that $A{\bf v}=\lambda {\bf v}$, with $\lambda\in\mathbb C$, ${\bf v}=(v_j)_{j\in\mathbb Z^+}$, ${\bf v}\ne 0$, and $\sum_{j=1}^\infty |v_j|^2<\infty$. It is shown that the problem is reduced to a finite nonlinear eigenvalue problem of the kind $ WU(\lambda){\pmb \beta}=0$, where $W$ is a constant matrix and $U$ depends on $\lambda$ and can be given in terms of either a Vandermonde matrix or a companion matrix. Algorithms relying on Newton's method applied to the equation $\det WU(\lambda)=0$ are analyzed. Numerical experiments show the effectiveness of this approach. The algorithms have been included in the CQT-Toolbox [Numer. Algorithms 81 (2019), no. 2, 741--769].
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- 2022
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38. Dynamics of rotation in chiral nuclei
- Author
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Ren, Z. X., Zhao, P. W., and Meng, J.
- Subjects
Nuclear Theory ,Nuclear Experiment - Abstract
The dynamics of chiral nuclei is investigated for the first time with the time-dependent and tilted axis cranking covariant density functional theories on a three-dimensional space lattice in a microscopic and self-consistent way. The experimental energies of the two pairs of the chiral doublet bands in $^{135}$Nd are well reproduced without any adjustable parameters beyond the well-defined density functional. A novel mechanism, i.e., chiral precession, is revealed from the microscopic dynamics of the total angular momentum in the body-fixed frame, whose harmonicity is associated with a transition from the planar into aplanar rotations with the increasing spin. This provides a fully microscopic and dynamical view to understand the chiral excitations in nuclei., Comment: 7 pages, 5 figures
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- 2022
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39. Beyond-mean-field approaches for nuclear neutrinoless double beta decay in the standard mechanism
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Yao, J. M., Meng, J., Niu, Y. F., and Ring, P.
- Subjects
Nuclear Theory ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Nuclear Experiment - Abstract
Nuclear weak decays provide important probes to fundamental symmetries in nature. A precise description of these processes in atomic nuclei requires comprehensive knowledge on both the strong and weak interactions in the nuclear medium and on the dynamics of quantum many-body systems. In particular, an observation of the hypothetical double beta decay without emission of neutrinos ($0\nu\beta\beta$) would unambiguously demonstrate the Majorana nature of neutrinos and the existence of the lepton-number-violation process. It would also provide unique information on the ordering and absolute scale of neutrino masses. The next-generation tonne-scale experiments with sensitivity up to $10^{28}$ years after a few years of running will probably provide a definite answer to these fundamental questions based on our current knowledge on the nuclear matrix element (NME), the precise determination of which is a challenge to nuclear theory. Beyond-mean-field approaches have been frequently adapted for the study of nuclear structure and decay throughout the nuclear chart for several decades. In this review, we summarize the status of beyond-mean-field calculations of the NMEs of $0\nu\beta\beta$ decay assuming the standard mechanism of an exchange of light Majorana neutrinos. The challenges and prospects in the extension and application of beyond-mean-field approaches for $0\nu\beta\beta$ decay are discussed., Comment: 82 pages, 29 figures. Version to appear in Progress in Particle and Nuclear Physics (2022)
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- 2021
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40. Microscopic analysis of induced nuclear fission dynamics
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Ren, Z. X., Zhao, J., Vretenar, D., Niksic, T., Zhao, P. W., and Meng, J.
- Subjects
Nuclear Theory ,Nuclear Experiment - Abstract
The dynamics of low-energy induced fission is explored using a consistent microscopic framework that combines the time-dependent generator coordinate method (TDGCM) and time-dependent nuclear density functional theory (TDDFT). While the former presents a fully quantum mechanical approach that describes the entire fission process as an adiabatic evolution of collective degrees of freedom, the latter models the dissipative dynamics of the final stage of fission by propagating the nucleons independently toward scission and beyond. By combining the two methods, based on the same nuclear energy density functional and pairing interaction, we perform an illustrative calculation of the charge distribution of yields and total kinetic energy for induced fission of $^{240}$Pu. For the saddle-to-scission phase a set of initial points for the TDDFT evolution is selected along an iso-energy curve beyond the outer fission barrier on the deformation energy surface, and the TDGCM is used to calculate the probability that the collective wave function reaches these points at different times. Fission observables are computed with both methods and compared with available data. The relative merits of including quantum fluctuations (TDGCM) and the one-body dissipation mechanism (TDDFT) are discussed., Comment: 7 pages,6 figures
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- 2021
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41. Effects of rotation and valence nucleons in molecular-like ${\alpha}$-chain nuclei
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Zhang, D. D., Ren, Z. X., Zhao, P. W., Vretenar, D., Nikšić, T., and Meng, J.
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Nuclear Theory - Abstract
Effects of rotation and valence nucleons in molecular-like linear $\alpha$-chain nuclei are analyzed using a three-dimensional lattice cranking model based on covariant density functional theory. The structure of $^{16}$C and $^{16}$Ne is investigated as a function of rotational frequency. The valence nucleons, with respect to the 3$\alpha$ linear chain core of $^{12}$C, at low frequency occupy the $\pi$ molecular orbital. With increasing rotational frequency these nucleons transition from the $\pi$ orbital to the $\sigma$ molecular orbital, thus stabilizing the 3$\alpha$ linear chain structure. It is predicted that the valence protons in $^{16}$Ne change occupation from the $\pi$ to the $\sigma$ molecular orbital at $\hbar\omega \approx 1.3$ MeV, a lower rotational frequency compared to $\hbar\omega \approx 1.7$ MeV for the valence neutrons in $^{16}$C. The same effects of valence protons are found in $^{20}$Mg, compared to the four valence neutrons in $^{20}$O. The model is also used to examine the effect of alignment of valence nucleons on the relative positions and size of the three $\alpha$-clusters in $^{16}$C and $^{16}$Ne., Comment: 20 pages, 9 figures
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- 2021
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42. Dynamical synthesis of 4He in the scission phase of nuclear fission
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Ren, Z. X., Vretenar, D., Niksic, T., Zhao, P. W., Zhao, J., and Meng, J.
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Nuclear Theory ,Nuclear Experiment - Abstract
In the exothermic process of fission decay, an atomic nucleus splits into two or more independent fragments. Several aspects of nuclear fission are not properly understood, in particular the formation of the neck between the nascent fragments, and the subsequent mechanism of scission into two or more independent fragments. Using an implementation of time-dependent density functional theory, based on a relativistic energy density functional and including pairing correlations, we analyze the final phase of the process of induced fission of $^{240}$Pu, and show that the time-scale of neck formation coincides with the assembly of two $\alpha$-like clusters (less than 1 zs = 10$^{-21}$ s). Because of its much larger binding energy, the dynamical synthesis of 4He in the neck predominates over other light clusters, e.g., $^3$H and $^6$He. At the instant of scission the neck ruptures exactly between the two $\alpha$-like clusters, which separate because of the Coulomb repulsion and are eventually absorbed by the two emerging fragments. The newly proposed mechanism of light charged clusters formation at scission provides a natural explanation of ternary fission., Comment: 5 pages, 4 figures, Final version for publication
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- 2021
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43. Multidimensional King-plot analysis for accurate extraction of Cd nuclear charge radii: a challenge for nuclear structure theory
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Han, J. Z., Pan, C., Zhang, K. Y., Yang, X. F., Zhang, S. Q., Berengut, J. C., Goriely, S., Wang, H., Yu, Y. M., Meng, J., Zhang, J. W., and Wang, L. J.
- Subjects
Physics - Atomic Physics - Abstract
High-accuracy determination of isotope shift factors, which plays a crucial role in accurate extraction of nuclear charge radius, is well-known to be challenging experimentally and theoretically. Nonetheless, based on an accurate measurement of the isotope shifts for the Cd$^+$ $5s~^2S_{1/2}-5p~^2P_{3/2}$ and the Cd $5s^2~^1S_0-5s5p~^1P_1$ transition, a multidimensional King-plot analysis is performed to extract the atomic field shift and mass shift factors accurately. The results are further cross-checked against results from atomic structure calculations using a high-accuracy configuration interaction and many-body perturbation theory. Combined with previous isotope shifts, nuclear charge radii for $^{100-130}$Cd of the highest accuracy are reported. For the neutron-rich region, accuracies for the charge radii are improved by nearly one order of magnitude. This work provides a coherent and systematic extraction of Cd nuclear charge radii from isotope shifts. The results offer stringent testing and possible challenges to the latest advances in nuclear theory and excellent benchmarking to the atomic structure calculations.
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- 2021
44. Achieving net-zero power supply in China needs better cost uncertainty quantification
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Hu, P.Y., Zhao, M.S., Xu, Y.T., Hu, L.T., Liang, J.W., Meng, J., and Zhang, C.
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- 2024
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45. High-precision nuclear chronometer for the cosmos
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Wu, X. H., Zhao, P. W., Zhang, S. Q., and Meng, J.
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Nuclear Theory ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Nuclear Experiment - Abstract
Nuclear chronometer, which predicts the ages of the oldest stars by comparing the present and initial abundances of long-lived radioactive nuclides, provides an independent dating technique for the cosmos. A new nuclear chronometer called Th-U-X chronometer is proposed, which imposes stringent constraints on the astrophysical conditions in the $r$-process simulation by synchronizing the previous Th/X, U/X and Th/U chronometers. The astrophysical uncertainties of nuclear chronometer are significantly reduced from more than $\pm2$ billion years to within 0:3 billion years by the Th-U-X chronometer. The proposed chronometer is then applied to estimate the ages of the six metal-poor stars with observed uranium abundances, and the predicted ages are compatible with the cosmic age 13.8 billion years predicted from the cosmic microwave background radiation, but in contradictory with the new cosmic age 11.4 billion years from the gravitational lenses measurement., Comment: 5 pages, 4 figures
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- 2021
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46. ApoA1, ApoB, ApoA1/B for Pathogenic Prediction of Chronic Obstructive Pulmonary Disease Complicated by Acute Lower Respiratory Tract Infection: A Cross-Sectional Study
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Meng J, Yang W, Chen Z, Pei C, Peng X, Li C, and Li F
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apoa1 ,apob ,apoa1/b ,copd ,acute lower respiratory tract infection ,pathogens ,Diseases of the respiratory system ,RC705-779 - Abstract
Jiaqi Meng,1 Weichang Yang,2 Ziyong Chen,1 Caixia Pei,1 Xinmin Peng,1 Can Li,1 Fengyuan Li1 1Department of Respiratory and Critical Care Medicine, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330008, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Can Li; Fengyuan Li, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China, Email 407329399@qq.com; lifengyuan@126.comPurpose: To investigate the value of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ApoA1/B ratio in pathogenic diagnosis of chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infection, assisting comprehensive disease assessment.Patients and Methods: The study enrolled 171 COPD patients with acute lower respiratory tract infections, 35 COPD patients without acute lower respiratory tract infections, and 41 healthy controls. Correlation analysis and binary logistic regression were used to assess the roles of various factors in COPD with acute lower respiratory tract infections. Receiver operating characteristic (ROC) curves were plotted and area under curves (AUC) values were calculated to evaluate the predictive performance.Results: Infections were the cause of alterations in ApoA1, ApoB and ApoA1/B index. In correlation analysis for pathogenic diagnosis of COPD complicated by acute lower respiratory infections, age, ApoA1, ApoA1/B ratio, lymphocyte count (LYMPH), neutrophil count (NEUT), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and endotoxin were significantly correlated. For predicting COPD complicated by acute lower respiratory tract bacterial infection, ApoA1 had the highest area under the ROC curve (AUC: 0.889), with sensitivity and specificity of 82.9% and 83.9%, respectively. The combination of NEUT and ApoA1 improved the prediction efficacy (AUC: 0.909; sensitivity/specificity: 85.1%/85.7%).Conclusion: ApoA1, ApoB, and ApoA1/B ratio are good indicators for predicting pathogens in COPD complicated by acute lower respiratory tract infection, especially ApoA1 which has high predictive value.Keywords: ApoA1, ApoB, ApoA1/B, COPD, Acute lower respiratory tract infection, pathogens
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- 2024
47. Nuclear matrix elements of neutrinoless double-$\beta$ decay in the triaxial projected shell model
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Wang, Y. K., Zhao, P. W., and Meng, J.
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Nuclear Theory - Abstract
The nuclear matrix elements of neutrinoless double-$\beta$ decay for nuclei $^{76}$Ge, $^{82}$Se, $^{100}$Mo, $^{130}$Te, and $^{150}$Nd are studied within the triaxial projected shell model, which incorporates simultaneously the triaxial deformation and quasiparticle configuration mixing. The low-lying spectra and the $B(E2:0^+\rightarrow2^+)$ values are reproduced well. The effects of the quasiparticles configuration mixing, the triaxial deformation, and the closure approximation on the nuclear matrix elements are studied in detail. For nuclei $^{76}$Ge, $^{82}$Se, $^{100}$Mo, $^{130}$Te, and $^{150}$Nd, the nuclear matrix elements are respectively reduced by the quasiparticle configuration mixing by 6%, 7%, 2%, 3%, and 4%, and enhanced by the odd-odd intermediate states by 7%, 4%, 11%, 20%, and 14%. Varying the triaxial deformation $\gamma$ from $0^\circ$ to $60^\circ$ for the mother and daughter nuclei, the nuclear matrix elements change by 41%, 17%, 68%, 14%, and 511% respectively for $^{76}$Ge, $^{82}$Se, $^{100}$Mo, $^{130}$Te, and $^{150}$Nd, which indicates the importance of treating the triaxial deformation consistently in calculating the nuclear matrix elements., Comment: 17 pages, 5 figures
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- 2021
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48. Application of deep learning in radiation therapy for cancer
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Wen, X., Zhao, C., Zhao, B., Yuan, M., Chang, J., Liu, W., Meng, J., Shi, L., Yang, S., Zeng, J., and Yang, Y.
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- 2024
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49. Corporate social responsibility dimensions and stock price crash risk: Evidence from the management's self-interest perspective
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Wu, Chunying, Xiong, Xiong, Gao, Ya, and Meng, J. Ginger
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- 2024
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50. Visible spectra of W8+ in an electron-beam ion trap
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Lu, Q., Yan, C. L., Meng, J., Xu, G. Q., Yang, Y., Chen, C. Y., Xiao, J., Li, J. G., Wang, J. G., and Zou, Y.
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Physics - Atomic Physics - Abstract
To provide spectroscopic data for lowly charged tungsten ions relevant to fusion research, this work focuses on the W8+ ion. Six visible spectra lines in the range of 420-660 nm are observed with a compact electron-beam ion trap in Shanghai. These lines are assigned to W8+ based on their intensity variations as increasing electron-beam energy and the M1 line from the ground configuration in W7+. Furthermore, transition energies are calculated for the 30 lowest levels of the 4f14 5s2 5p4, 4f13 5s2 5p5 and 4f12 5s2 5p6 configurations of W8+ by using the flexible atomic code (FAC) and GRASP package, respectively. Reasonably good agreement is found between our two independent atomic-structure calculations. The resulting atomic parameters are adopted to simulate the spectra based on the collisional-radiative model implemented in the FAC code. This assists us with identification of six strong M1 transitions in 4f13 5s2 5p5 and 4f12 5s2 5p6 configurations from our experiments
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- 2021
- Full Text
- View/download PDF
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