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244 results on '"Mengel, Annerose"'

3. Outcomes After Decompressive Surgery for Severe Cerebral Venous Sinus Thrombosis Associated or Not Associated with Vaccine-Induced Immune Thrombosis with Thrombocytopenia: A Multicenter Cohort Study

Author

Pelz, Johann Otto, Kenda, Martin, Alonso, Angelika, Etminan, Nima, Wittstock, Matthias, Niesen, Wolf-Dirk, Lambeck, Johann, Güresir, Erdem, Wach, Johannes, Lampmannn, Tim, Dziewas, Rainer, Wiedmann, Markus, Schneider, Hauke, Bayas, Antonios, Christ, Monika, Mengel, Annerose, Poli, Sven, Brämer, Dirk, Lindner, Dirk, Pfrepper, Christian, Roth, Christian, Salih, Farid, Günther, Albrecht, and Michalski, Dominik

Published
2024
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5. Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)

Author

Hofmann, Anna, Blum, Corinna, Single, Constanze, Adeyemi, Kamal, Schwarz, Patricia, Siokas, Vasileios, Rattay, Tim W., Häberle, Helene A., Riessen, Reimer, Brendel, Bettina, Haug, Iris, Bösel, Ruth, Zago, Manola, Martus, Peter, Ziemann, Ulf, Mengel, Annerose, and Feil, Katharina

Published
2023
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7. Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19: Results of a retrospective multicenter neuroimaging-based study from three central European countries

Author

Jensen-Kondering, Ulf, Maurer, Christoph J., Brudermann, Hanna C. B., Ernst, Marielle, Sedaghat, Sam, Margraf, Nils G., Bahmer, Thomas, Jansen, Olav, Nawabi, Jawed, Vogt, Estelle, Büttner, Laura, Siebert, Eberhard, Bartl, Michael, Maus, Volker, Werding, Gregor, Schlamann, Marc, Abdullayev, Nuran, Bender, Benjamin, Richter, Vivien, Mengel, Annerose, Göpel, Siri, Berlis, Ansgar, Grams, Astrid, Ladenhauf, Valentin, Gizewski, Elke R., Kindl, Philipp, Schulze-Zachau, Victor, Psychogios, Marios, König, Inke R., Sondermann, Stefan, Wallis, Sönke, Brüggemann, Norbert, Schramm, Peter, and Neumann, Alexander

Published
2023
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8. Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design

Author

Wachter, Rolf, Gröschel, Klaus, Wasser, Katrin, Uhe, Tobias, Schäbitz, Wolf-Rüdiger, Köhrmann, Martin, Dichgans, Martin, Gröschel, Sonja, Uphaus, Timo, Hahn, Marianne, Zuhorn, Frederic, Wulff, Leonard, Plümer, Jorge, Kok, Lena, Janz, Marcel, Kitsiou, Alkisti, Gehmeyr, Julian, Dabbagh, Alhuda, Huber, Charlotte, Pelz, Johann, Wartenberg, Katja, Michalski, Dominik, Seidel, Mirko, Flissakowski, Oscar, Goschenhofer, Anna, Hussain, Rabia-Basari, Kim, Ina, Kinze, Stephan, Kroneberger, Christian, Lingnau, Michale, Lischewski, Dennis, Muhn, Florian, Rogge, Witold, Schieffer, Miriam, Setayesh-Roonizi, Anuscheh, Sparenberg, Paul, Schertel, Jill Marie, Ringleb, Peter, Purrucker, Jan, Berberich, Anne, Heyse, Miriam, Ungerer, Matthias, Bauer, Gregor, Reichardt, Christine, Etgen, Thorleif, Ebel, Bernhard, Milanković-Eberl, Dragana, Schwarte, Olav, Höcherl, Constanze, Asch, Eric-Manuel, Bojtschuk, Luisa, Frey, Maximilian, Dlouhy, Tomas, Ertl, Michael, Zickler, Philipp Patrick, Beier, Barbara, Braadt, Lino-Dominic, Gabrielyan, Inessa, Kermer, Pawel, Kaste, Matthias, Anter, Ahmed, Stirbulescu, Corina, Meleshchenco, Nataliia, Burgholte, Friederike, Lüers, Claus, Steiner, Thorsten, Cierpinski, Mari-Carmen, Lichti, Bethke, Florian, Bonowski, Lars, Eid, Hassan Abou, Vajda-Medina, Esteban, Probst, Mareike, Essa, Hisham, Frank, Benedikt, Stolte, Benjamin, Milles, Lennart, Soda, Hassan, Hiermann, Erich, Rascher, Renate Weinhardt Alexandra, Stan, Marius, Kääb, Stefan, Kellert, Lars, Dimitriadis, Konstantinos, Kopczak, Anna, Küster, Bettina, Sinner, Moritz, Steiger, Ignaz, Kaffe, Maria, Clauß, Sebastian, Janowitz, Daniel, Thaler, Raffael, Schellinger, Peter, Glahn, Jörg, Schubert, Jan, Jenniges, Simone, Markmann-Boenke, Silke, Putzer, Anne-Sophie, Straeten, Michael Schwarze Vera, Wiemer, Marcus, Kallmünzer, Bernd, Macha, Kosmas, Haupenthal, David, Balk, Stefanie, Kossel, Clara-Sophie, Häusler, Georg, Lehrieder, Dominik, Cidlinsky, Peter, Hametner, Christian, Vogl, Christine, Fischer, Thomas, Huttelmaier, Moritz, Nordbeck, Octavian Maniuc Peter, von Hardenberg, Albrecht, Jünemann, Martin, Braun, Tobias, Viard, Maxime, Gerner, Stefan, Omar, AlHaj, Genau, Sonja, Olbricht, Linus, Wassenberg, Matthias, Langguth, Niklas, Fräbel, Christian, Baumgart, Romy, Kalra, Love-Preet, Diel, Norma, Hoffmann, Frank, Kraft, Andrea, Schönmuth, Bettine, Giebler, Anja, Weber, Lorenz, Grond, Martin, Birringer, Jan, Lichte-Schneider, Sandra, Hütwohl, Daniela, Krause, Lars Udo, Petersen, Martina, Althaus, Katharina, Kirchmeier, Konstantin, Novikova, Liubov, Müller, Susanne, Schellong, Sebastian, Brudzinski, Mirko, Gerk, Ulrich, Palisch, Holger, Heinzel, Frank R., Fett, Jana, Suntha, Avinash, Burian, Katja, Schmitz, Bettina, Gutwinski, Anna, Angermüller, Veronika, Alhammoud, Tameem, Cakiroglu, Hüsniye, Bach, Ullrich, Nabavi, Darius, Offermann, Jens, Crome, Olaf, Dimitrijeski, Boris, Meincke, Carsten, Hamann, Gerhard, Alber, Burkhard, Müller, Robert, Pallesen, Lars-Peder, Pütz, Volker, Hartmann, Christian, Berrouschot, Jörg, Stoll, Anett, Keilitz, Janina, Klunk, Dietrich, Voigt, Roman, Kastrup, Andreas, Schröter, Andreas, Schmucker, Johannes, Pfeilschifter, Waltraud, Krämer, Christoffer, Wiemers, Milena, Simon, Micha, Finke, Alexander, Weiß, Christian, Hobohm, Carsten, Naupold, Katrin, Bley-Renning, Karen, Winter, Sabrina, Poli, Sven, Mengel, Annerose, Poli, Khouloud, Expósito, Alexandra Gómez, Mbroh, Joshua, Tieck, Maria, Rosenkranz, Michael, Boskamp, Stefan, Ritter, Nicolas, Seibel, Lena, Schöps, Christian, Ketzler, Rebecca, Nägele, Herbert, Sydow, Karsten, Kurka, Natalia, Schäfer, Jan Hendrik, Charisse, Daniel, Gruber, Katharina, Kohlhase, Konstantin, Lieschke, Franziska, Operhalski, Felix, Seiler, Alexander, Petzold, Gabor, Bode, Felix Jürgen, Stösser, Sebastian, Meißner, Julius, Ebrahimi, Taraneh, Nordsiek, Julia, Beckonert, Niklas, Weissenborn, Karin, Große, Gerrit Maximilian, Worthmann, Hans, Hennemann, Ann-Katrin, Jochmann, Svenja, Gründahl, Julius, Al-Ayoubi, Jana, Ernst, Johanna, Bähr, Oliver, Gruber, Herbert, Benesch, Sonka, Pollinger, Thomas, Alachkar, Nawar, Busch, Sonia, Butz, Steffi, Forkmann, Mathias, Mahnkopf, Christian, Mischke, Thomas, Schnupp, Steffen, Thomalla, Götz, Deb-Chatterji, Milani, Cheng, Bastian, Gelderblom, Mathias, Hoppe, Julia, Jensen, Märit, Schell, Maximilian, Schlemm, Eckhard, Marquardt, Lars, Kazarians, Haiko, Rheingans, Pia Franziska, Hötzer, Kai, Rose, Dietmar, Neumann-Haefelin, Tobias, Berthel, Jörg, Alijaj, Lirim, Krug, Joachim, Niethammer, Margit, Szöllösi, Géza-Attila, Obermann, Marc, Adochitei, Nicoletta, Strik, Herwig, Lenz, Arne, Steigerwald, Frank, Müller, Jörg, Honermann, Martin, Burgstaller, Marian Christoph, Kollmar, Rainer, Rashid, Maryam, Ganai, Ahmad Ajaz, Ossendorf, Saric, Majda, Tischer, Karl-Heinz, Toluli, Adela, Wollenweber, Frank Arne, Rahban, Laya, Silva, Thais Portugal, Lee, Miri, Grosch, Matthias Julius, Minnerup, Jens, Liman, Jan, Nückel, Martin, Böhm, Magdalena, Weber-Krüger, Mark, Brachmann, Johannes, Laufs, Ulrich, Gelbrich, Götz, Petroff, David, Prettin, Christiane, Schellinger, Peter D., Hamann, Gerhard F., Mende, Meinhard, and Wagner, Marcus

Published
2023
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12. Angioinvasive Rhino-Orbital-Cerebral Mucormycosis in a Patient with Type 2 Diabetes Mellitus: A Complex and Lethal Cause of Stroke.

Author

Weissert, Nadine, Mengel, Annerose, Bader, Katharina, Hennersdorf, Florian, and Feil, Katharina

Subjects
*INTERNAL carotid artery, *TYPE 2 diabetes, *MAGNETIC resonance angiography, *MYCOSES, *MUCORMYCOSIS, CAROTID artery stenosis
Abstract

Rhino-orbital-cerebral mucormycosis is a rapidly progressive and often fatal fungal infection caused by molds of the order Mucorales, particularly affecting immunocompromised individuals. This infection is notorious for its angioinvasive properties, enabling the fungi to invade blood vessels and leading to tissue necrosis. We report the clinical course of a 59-year-old Caucasian man with poorly controlled type 2 diabetes (HbA1c 16.8%) who presented with unilateral headache, left-sided facial numbness, and incomplete left ocular motor paresis. Initial presentation raised suspicion of orbital phlegmon, leading to antibiotic and later corticosteroid pulse therapy, which worsened the patient's condition. Subsequent imaging demonstrated extensive inflammatory changes, including wall irregularities of the left intracranial internal carotid artery, accompanied by ocular protrusion and periorbital enhancement. New palatal lesions indicated mucormycosis, which was confirmed by molecular analysis of a palatal biopsy, leading to Amphotericin B treatment. Pre-surgery imaging revealed a malignant middle cerebral artery infarction, and the patient died 16 days after symptom onset and 12 days after initial presentation under palliative care due to a poor prognosis. This case of angioinvasive mucormycosis underscores the severe and often fatal course of rhino-orbital-cerebral mucormycosis in an immunocompromised individual. The rapid progression from initially vague and unspecific symptoms to extensive vascular involvement and stroke highlights the critical need for early and accurate diagnosis, as well as prompt intervention to prevent further disease progression. Additionally, this case also illustrates the potential risks associated with corticosteroid therapy in the presence of undiagnosed fungal infections, which can exacerbate the condition and lead to serious complications. Clinicians should maintain a high index of suspicion for mucormycosis in similar clinical scenarios, prioritizing adequate antifungal treatment and careful monitoring to improve patient outcomes. Early interdisciplinary collaboration is essential for the effective management of such complex cases. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Cerebrovascular Reactivity Assessed by Breath-Hold Functional MRI in Patients with Neurological Post-COVID-19 Syndrome—A Pilot Study.

Author

Zerweck, Leonie, Klose, Uwe, Mengel, Annerose, Hoheisel, Tobias, Eikemeier, Melinda, Richter, Vivien, Joos, Natalie Sophie, Ernemann, Ulrike, Bender, Benjamin, and Hauser, Till-Karsten

Subjects
FUNCTIONAL magnetic resonance imaging, FATIGUE (Physiology), COVID-19 pandemic, SYMPTOMS, SARS-CoV-2
Abstract

Endothelial dysfunction represents a potential pathomechanism of neurological post-COVID-19 syndrome (PCS). A recent study demonstrated reduced cerebrovascular reactivity (CVR) in patients with PCS. The aim of this pilot study was to prospectively assess CVR in patients with PCS using breath-hold functional MRI (bh-fMRI). Fourteen patients with neurological PCS and leading symptoms of fatigue/memory issues/concentration disorder (PCSfmc), 11 patients with PCS and leading symptoms of myopathy/neuropathy (PCSmn), and 17 healthy controls underwent bh-fMRI. Signal change and time to peak (TTP) were assessed globally and in seven regions of interest and compared between the subgroups using one-way ANCOVA adjusting for age, time since infection, Fazekas score, and sex. No significant differences were observed. In PCS patients, the global CVR exhibited a slight, non-significant tendency to be lower compared to healthy controls (PCSfmc: 0.78 ± 0.11%, PCSmn: 0.84 ± 0.10% and 0.87 ± 0.07%). There was a non-significant trend towards lower global TTP values in the PCS subgroups than in the control group (PCSfmc: 26.41 ± 1.39 s, PCSmn: 26.32 ± 1.36 s versus 29.52 ± 0.93 s). Endothelial dysfunction does not seem to be the sole pathomechanism of neurological symptoms in PCS. Further studies in larger cohorts are required. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase

Author

van de Munckhof, Anita, Lindgren, Erik, Kleinig, Timothy J., Field, Thalia S., Cordonnier, Charlotte, Krzywicka, Katarzyna, Poli, Sven, Sánchez van Kammen, Mayte, Borhani-Haghighi, Afshin, Lemmens, Robin, Scutelnic, Adrian, Ciccone, Alfonso, Gattringer, Thomas, Wittstock, Matthias, Dizonno, Vanessa, Devroye, Annemie, Elkady, Ahmed, Günther, Albrecht, Cervera, Alvaro, Mengel, Annerose, Chew, Beng Lim Alvin, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Jacobi, Christian, Soriano, Cristina, Michalski, Dominik, Zamani, Zohreh, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Vuillier, Fabrice, Bode, Felix J., Caparros, François, Maier, Frank, Tsivgoulis, Georgios, Katzberg, Hans D., Duan, Jiangang, Burrow, Jim, Pelz, Johann, Mbroh, Joshua, Oen, Joyce, Schouten, Judith, Zimmermann, Julian, Ng, Karl, Garambois, Katia, Petruzzellis, Marco, Carvalho Dias, Mariana, Ghiasian, Masoud, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Skjelland, Mona, Almasi-Dooghaee, Mostafa, Cuisenier, Pauline, Murphy, Seán, Timsit, Serge, Coutts, Shelagh B., Schönenberger, Silvia, Nagel, Simon, Hiltunen, Sini, Chatterton, Sophie, Cox, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Mirzaasgari, Zahra, Middeldorp, Saskia, Levi, Marcel M., Kremer Hovinga, Johanna A., Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, Aguiar de Sousa, Diana, Ferro, José M., and Coutinho, Jonathan M.

Published
2022
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16. Heart Rate Variability and Functional Outcomes of Patients with Spontaneous Intracerebral Hemorrhage.

Author

Laichinger, Kornelia, Mengel, Annerose, Buesink, Rebecca, Roesch, Sara, Stefanou, Maria-Ioanna, Single, Constanze, Hauser, Till-Karsten, Krumbholz, Markus, Ziemann, Ulf, and Feil, Katharina

Subjects
HEART beat, CEREBRAL hemorrhage, DYSAUTONOMIA, STROKE, FUNCTIONAL status
Abstract

Background: The relationship between heart rate variability (HRV) changes potentially indicating autonomic dysregulation following spontaneous intracerebral hemorrhage (ICH) and functional outcome has not yet been fully elucidated. This study investigated the effects of HRV during the initial 96 h after admission on 90-day functional outcome in ICH patients. Methods: We included patients with spontaneous ICH in a prospective cohort single-center study. Continuous HR data were retrieved from the Intellispace Critical Care and Anesthesia information system (Philips Healthcare) and analyzed within the following time intervals: 0–2, 0–8, 0–12, 0–24, 0–48, 0–72, and 8–16, 16–24, 24–48, 48–72, 72–96 h after admission. HRV was determined from all available HR values by calculating the successive variability (SV), standard deviation (SD), and coefficient of variation (CV). Low HRV was set as SD ≤ 11.4 ms, and high HRV as SD > 11.4 ms. The clinical severity of ICH was assessed using the National Institutes of Health Stroke Scale (NIHSS) and functional outcome using the modified Rankin Scale (mRS). Good functional outcome was defined as mRS 0–2. Results: The cohort included 261 ICH patients (mean age ± SD 69.6 ± 16.5 years, 48.7% female, median NIHSS 6 (2, 12), median ICH score 1 (0, 2), of whom 106 (40.6%) had good functional outcome. All patients had the lowest HRV at admission, which increased during the first two days. Comparing ICH patients with low HRV (n = 141) and high HRV (n = 118), those with good outcome showed significantly lower HRV during the first three days (0–72 h: HRV SD good outcome 10.6 ± 3.5 ms vs. poor outcome 12.0 ± 4.0 ms; p = 0.004). Logistic regression revealed that advanced age, high premorbid mRS, and high NIHSS at admission were significant predictors of poor functional outcome, while reduced SD of HRV showed a non-significant trend towards good functional outcome (0–72 h: OR 0.898; CI 0.800–1.008; p = 0.067). Conclusions: Our results indicate autonomic dysfunction with sympathetic hyperactivity after spontaneous ICH, as reflected by the evidence of the lower HRV in the first days. Initially increased sympathetic tone appears to have a protective effect, as suggested by the comparatively lower HRV in patients with good functional outcome at the first days. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Type 1 Myocardial Infarction in Patients With Acute Ischemic Stroke.

Author

Nolte, Christian H., von Rennenberg, Regina, Litmeier, Simon, Leistner, David M., Szabo, Kristina, Baumann, Stefan, Mengel, Annerose, Michalski, Dominik, Siepmann, Timo, Blankenberg, Stephan, Petzold, Gabor C., Dichgans, Martin, Katus, Hugo, Pieske, Burkert, Regitz-Zagrosek, Vera, Braemswig, Tim Bastian, Rangus, Ida, Pepic, Amra, Vettorazzi, Eik, and Zeiher, Andreas M.

Published
2024
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23. Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial

Author

Poli, Sven, primary, Mbroh, Joshua, additional, Baron, Jean-Claude, additional, Singhal, Aneesh B, additional, Strbian, Daniel, additional, Molina, Carlos, additional, Lemmens, Robin, additional, Turc, Guillaume, additional, Mikulik, Robert, additional, Michel, Patrik, additional, Tatlisumak, Turgut, additional, Audebert, Heinrich J, additional, Dichgans, Martin, additional, Veltkamp, Roland, additional, Hüsing, Johannes, additional, Graessner, Holm, additional, Fiehler, Jens, additional, Montaner, Joan, additional, Adeyemi, Adedolapo Kamaldeen, additional, Althaus, Katharina, additional, Arenillas, Juan F, additional, Bender, Benjamin, additional, Benedikt, Frank, additional, Broocks, Gabriel, additional, Burghaus, Ina, additional, Cardona, Pere, additional, Deb-Chatterji, Milani, additional, Cviková, Martina, additional, Defreyne, Luc, additional, De Herdt, Veerle, additional, Detante, Olivier, additional, Ernemann, Ulrike, additional, Flottmann, Fabian, additional, García Guillamón, Lídia, additional, Glauch, Monika, additional, Gomez-Exposito, Alexandra, additional, Gory, Benjamin, additional, Sylvie Grand, Sylvie, additional, Haršány, Michal, additional, Hauser, Till Karsten, additional, Heck, Olivier, additional, Hemelsoet, Dimitri, additional, Hennersdorf, Florian, additional, Hoppe, Julia, additional, Kalmbach, Pia, additional, Kellert, Lars, additional, Köhrmann, Martin, additional, Kowarik, Markus, additional, Lara-Rodríguez, Blanca, additional, Legris, Loic, additional, Lindig, Tobias, additional, Luntz, Steffen, additional, Lusk, Jay, additional, Mac Grory, Brian, additional, Manger, Andreas, additional, Martinez-Majander, Nicolas, additional, Mengel, Annerose, additional, Meyne, Johannes, additional, Müller, Susanne, additional, Mundiyanapurath, Sibu, additional, Naggara, Olivier, additional, Nedeltchev, Krassen, additional, Nguyen, Thanh N, additional, Nilsson, Maike A, additional, Obadia, Michael, additional, Poli, Khouloud, additional, Purrucker, Jan C, additional, Räty, Silja, additional, Richard, Sebastien, additional, Richter, Hardy, additional, Schilte, Clotilde, additional, Schlemm, Eckhard, additional, Stöhr, Linda, additional, Stolte, Benjamin, additional, Sykora, Marek, additional, Thomalla, Götz, additional, Tomppo, Liisa, additional, van Horn, Noel, additional, Zeller, Julia, additional, Ziemann, Ulf, additional, Zuern, Christine S, additional, Härtig, Florian, additional, Tuennerhoff, Johannes, additional, Hassen, Wagih Ben, additional, Benz, Thorsten, additional, Brandhorst, Ansgar, additional, Cendrero, Judith, additional, Cheng, Bastian, additional, Cuisenier, Pauline, additional, Favre-Wiki, Isabelle, additional, Garambois, Katia, additional, Jensen, Märit, additional, Guillen, Ana Nuñez, additional, Merchan, Andres Paipa, additional, Pala, Elena, additional, Pancorbo, Olalla, additional, Morenilla, Ana Penalba, additional, Garcia, Helena Quesada, additional, Richter, Vivien, additional, Schell, Maximilian, additional, Schirmer, Andrea, additional, Sibolt, Gerli, additional, Stoop, Wendy, additional, Wischmann, Johannes, additional, and Zanolini, Umberto, additional

Published
2023
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25. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Author

Scutelnic, Adrian, primary, van de Munckhof, Anita, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Lindgren, Erik, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Middeldorp, Saskia, additional, Aaron, Sanjith, additional, Borhani-Haghighi, Afshin, additional, Arauz, Antonio, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Putaala, Jukka, additional, Wasay, Mohammad, additional, Conforto, Adriana Bastos, additional, de Sousa, Diana Aguiar, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Arnold, Marcel, additional, Heldner, Mirjam R, additional, Antonenko, Kateryna, additional, Mbroh, Joshua, additional, Brodard, Justine, additional, Hooshmandi, Etrat, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J., additional, Skjelland, Mona, additional, Duan, Jiangang, additional, Hiltunen, Sini, additional, Zuurbier, Susanna M., additional, Petruzzellis, Marco, additional, Sharma, Aarti R., additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Puthuppallil, Anemon, additional, Tuladhar, Anil M., additional, Mengel, Annerose, additional, Medina, Antonio, additional, Hellström Vogel, Åslög, additional, Tawa, Audrey, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Lim Alvin Chew, Beng, additional, Ziaadini, Bentalhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Zanferrari, Carla, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Legault, Catherine, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Pelz, Johann, additional, Wahl, Christoph, additional, Kern, Rolf, additional, Tracol, Clement, additional, Soriano, Cristina, additional, Guisado-Alonso, Daniel, additional, Bougon, David, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, De Maistre, Emmanuel, additional, Saxhaug Kristoffersen, Espen, additional, Bonneville, Fabrice, additional, Geeraerts, Thomas, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Grillo, Francesco, additional, Caparros, François, additional, Susen, Sophie, additional, Maier, Frank, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Frisullo, Giovanni, additional, Franchineau, Guillaume, additional, Cangür, Hakan, additional, Katzberg, Hans, additional, Mozhdehipanah, Hossein, additional, Sibon, Igor, additional, Baharoglu, M. Irem, additional, Masjuan, Jaime, additional, Brar, Jaskiran, additional, Payen, Jean-Francois, additional, Burrow, Jim, additional, Fernandes, João, additional, Octavio López Esparza, Jorge, additional, Oen, Joyce, additional, Schouten, Judith, additional, Ng, Karl, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Althaus, Katharina, additional, Garambois, Katia, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Humbertjean, Lisa, additional, Lebrato Hernandez, Lucia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Dubois, Marie-Cecile, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Kumar Karunakaran, Ravi, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Scholz, Moritz J., additional, Kahnis, Robert, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R., additional, Kumar Paramasivan, Naveen, additional, Erat Sreedharan, Sapna, additional, Sylaja, PN, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Cuisenier, Pauline, additional, Huet, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Nemati, Reza, additional, Vieira, Ricardo, additional, Goh, Rudy, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S., additional, Bal, Simerpreet, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Cox, Thomas, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Shaygannejad, Vahid, additional, Garcia-Talavera, Veronica, additional, Palma, Vincenzo, additional, Arslan, Yıldız, additional, Mirzaasgari, Zahra, additional, Yavari, Zeinab, additional, Zamani, Zohreh, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, and van Gorp, Eric C.M., additional

Published
2023
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26. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Author

van de Munckhof, Anita, primary, Borhani-Haghighi, Afshin, additional, Aaron, Sanjith, additional, Krzywicka, Katarzyna, additional, van Kammen, Mayte Sánchez, additional, Cordonnier, Charlotte, additional, Kleinig, Timothy J, additional, Field, Thalia S, additional, Poli, Sven, additional, Lemmens, Robin, additional, Scutelnic, Adrian, additional, Lindgren, Erik, additional, Duan, Jiangang, additional, Arslan, Yıldız, additional, van Gorp, Eric CM, additional, Kremer Hovinga, Johanna A, additional, Günther, Albrecht, additional, Jood, Katarina, additional, Tatlisumak, Turgut, additional, Putaala, Jukka, additional, Heldner, Mirjam R, additional, Arnold, Marcel, additional, de Sousa, Diana Aguiar, additional, Wasay, Mohammad, additional, Arauz, Antonio, additional, Conforto, Adriana Bastos, additional, Ferro, José M, additional, Coutinho, Jonathan M, additional, Mbroh, Joshua, additional, Ciccone, Alfonso, additional, Wittstock, Matthias, additional, Zimmermann, Julian, additional, Bode, Felix J, additional, Skjelland, Mona, additional, Dizonno, Vanessa, additional, Devroye, Annemie, additional, Hiltunen, Sini, additional, Petruzzellis, Marco, additional, Bakchoul, Tamam, additional, Levi, Marcel, additional, Middeldorp, Saskia, additional, Sharma, Aarti R, additional, Ghoreishi, Abdoreza, additional, Elkady, Ahmed, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Buture, Alina, additional, Cervera, Alvaro, additional, Paiva Nunes, Ana, additional, Romina Montané Baños, Ana, additional, Tiede, Andreas, additional, Tuladhar, Anil M, additional, Mengel, Annerose, additional, Medina, Antonio, additional, Aujayeb, Avinash, additional, Ramasamy, Balakrishnan, additional, Casolla, Barbara, additional, Spratt, Neil, additional, Ziaadini, Bentolhoda, additional, Varkey Maramattom, Boby, additional, Buck, Brian, additional, Garcia-Esperon, Carlos, additional, Vayne, Caroline, additional, Jacobi, Christian, additional, Pfrepper, Christian, additional, Bal, Deepti, additional, Sergio Zimatore, Domenico, additional, Michalski, Dominik, additional, Blacquiere, Dylan, additional, Johansson, Elias, additional, Cuadrado-Godia, Elisa, additional, Sadeghi-Hokmabadi, Elyar, additional, Carrera, Emmanuel, additional, Maistre, Emmanuel De, additional, Saxhaug Kristoffersen, Espen, additional, Hooshmandi, Etrat, additional, Bonneville, Fabrice, additional, Vuillier, Fabrice, additional, Giammello, Fabrizio, additional, D’Onofrio, Florindo, additional, Tsivgoulis, Georgios, additional, Gulli, Giosue, additional, Katzberg, Hans, additional, Sibon, Igor, additional, Baharoglu, Irem, additional, Masjuan, Jaime, additional, Fernandes, João, additional, Pelz, Johann, additional, Octavio López Esparza, Jorge, additional, Schouten, Judith, additional, Ng, Karl, additional, Derex, Laurent, additional, Puy, Laurent, additional, Poorsaadat, Leila, additional, Valler, Lenise, additional, Januzi de Almeida Rocha, Letícia, additional, Murillo-Bonilla, Luis, additional, Kellermair, Lukas, additional, Morin Martin, Mar, additional, Sofia Cotelli, Maria, additional, Hernandez Perez, Maria, additional, Zedde, Marialuisa, additional, Carvalho Dias, Mariana, additional, Carvalho, Marta, additional, Ghiasian, Masoud, additional, Umaiorubahan, Meenakshisundaram, additional, Roozbeh, Mehrdad, additional, Romoli, Michele, additional, Miranda, Miguel, additional, Wronski, Miriam, additional, Saadatnia, Mohammad, additional, Bandettini di Poggio, Monica, additional, Almasi-Dooghaee, Mostafa, additional, Hoseininejad Mir, Nahid, additional, Ichaporia, Nasli R, additional, Kumar Paramasivan, Naveen, additional, Raposo, Nicolas, additional, Fadakar, Nima, additional, Kruyt, Nyika, additional, Detante, Olivier, additional, Sharma, Pankaj, additional, Candelaresi, Paolo, additional, Scoppettuolo, Pasquale, additional, Reiner, Peggy, additional, Sylaja, PN, additional, Kumar Karunakaran, Ravi, additional, Vieira, Ricardo, additional, Kern, Rolf, additional, Goh, Rudy, additional, Erat Sreedharan, Sapna, additional, Murphy, Seán, additional, Timsit, Serge, additional, Coutts, Shelagh, additional, Sharma, Shyam S, additional, Schoenenberger, Silvia, additional, Nagel, Simon, additional, Kaul, Subhash, additional, Karapanayiotides, Theodoros, additional, Gattringer, Thomas, additional, Mathew, Thomas, additional, Bartsch, Thorsten, additional, Palma, Vincenzo, additional, Mirzaasgari, Zahra, additional, Zamani, Zohreh, additional, Mirahmadizadeh, Alireza, additional, Gutierrez-Romero, Alonso, additional, Iván Valdes-Ferrer, Ivan, additional, Elizabeth Ceballos-Liceaga, Santa, additional, and Maria Santibañez-Copado, Ana, additional

Published
2023
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27. ABO blood group associated with cerebral venous thrombosis after Oxford-AstraZeneca COVID-19 vaccination: a case–control study.

Author

Ken-Dror, Gie, Sharma, Pankaj, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Ghoreishi, Abdoreza, Borhani-Haghighi, Afshin, Negro, Alberto, Günther, Albrecht, Cervera, Alvaro, Tuladhar, Anil Man, Devroye, Annemie, Mengel, Annerose, Aujayeb, Avinash, Casolla, Barbara, Chew, Beng Lim Alvin, Zanferrari, Carla, Garcia-Esperon, Carlos, Wahl, Christoph M., and Alonso, Daniel Guisado

Abstract

Objectives: To determine whether blood group influences development of cerebral venous thrombosis (CVT) after administration of the coronavirus disease 2019 (COVID-19) AstraZeneca ChAdOx1-S vaccine. Design: A case–control study. Univariate and multivariate logistic regression was used to determine the association between blood type and COVID-19 vaccination status. Setting: Vaccinated and unvaccinated patients recruited from the international Bio-Repository to Establish the Aetiology of Sinovenous Thrombosis study and the Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group. Participants: All patients were of European descent and age and sex matched. Cases (n = 82) were patients ≥18 years old who suffered a CVT within 28 days of a first dose of ChAdOx1-S vaccine. Controls (n = 441) were unvaccinated CVT patients ≥18 years old. All patients were of European descent. Main outcome measures: Frequency of blood type and ABO allele distribution by vaccination status. Results: Blood group O was found to be more prevalent among CVT patients with vaccine-induced thrombotic thrombocytopenia (VITT-CVT) after ChAdOx1-S vaccination compared with unvaccinated CVT cases (43% vs. 17%, respectively, p < 0.001). Blood group A was less prevalent, though still high, in the vaccinated group compared with the unvaccinated group (47% vs. 71%, respectively, p < 0.001). No significant differences were observed in the VITT-CVT non-ChAdOx1-S vaccine group and unvaccinated pre-COVID-19 CVT group for blood group. Conclusions: Blood group O is more prevalent among patients with VITT-CVT after ChAdOx1-S vaccination compared with unvaccinated cases, independent of well-established CVT risk factors. A larger dataset may be able to determine whether those of blood groups B and/or AB may be safely vaccinated with the low cost, readily available and easily transported ChAdOx1-S rather than adopting a complete ban. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Shear Wave Elastography for the Assessment of Carotid Plaque Vulnerability: A Systematic Review

Author

Mbroh, Joshua, primary, Tünnerhoff, Johannes, additional, Poli, Khouloud, additional, Bender, Benjamin, additional, Schwarz, Patricia, additional, Mengel, Annerose, additional, Gomez-Exposito, Alexandra, additional, Kowarik, Markus, additional, Feil, Katharina, additional, Wisslicen, Marco, additional, Wang, Yi, additional, Ernemann, Ulrike, additional, Ziemann, Ulf, additional, and Poli, Sven, additional

Published
2023
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30. No evidence of oligoclonal bands, intrathecal immunoglobulin synthesis and B cell recruitment in acute ischemic stroke

Author

Laichinger, Kornelia, primary, Bombach, Paula, additional, Dünschede, Jutta, additional, Ruschil, Christoph, additional, Stefanou, Maria-Ioanna, additional, Dubois, Evelyn, additional, Poli, Sven, additional, Feil, Katharina, additional, Ziemann, Ulf, additional, Kowarik, Markus, additional, and Mengel, Annerose, additional

Published
2023
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31. Effects of Melatonin Administration on Post-Stroke Delirium in Patients with Intracerebral Hemorrhage

Author

Siokas, Vasileios, primary, Roesch, Sara, additional, Stefanou, Maria-Ioanna, additional, Buesink, Rebecca, additional, Wilke, Vera, additional, Sartor-Pfeiffer, Jennifer, additional, Adeyemi, Kamaldeen, additional, Poli, Sven, additional, Dardiotis, Efthimios, additional, Ziemann, Ulf, additional, Feil, Katharina, additional, and Mengel, Annerose, additional

Published
2023
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32. Correction to: Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

Author

Marx, Gernot, Litmathe, Jens, Schulz, Jörg B., Dafotakis, Manuel, Möllhoff, Thomas, Stalljohann, Carolin, Engels, Jonas, Sauerzapfe, Barbara, Stolzenberg, Barbara, Jonas, Engels, Möllhoff, Thomas, Carolin, Stalljohann, Thorben, Beeker, Gernot, Marx, Melanie, Schäfer, Tobias, Schürholz, Ertunc, Altiok, Marx, Nikolaus, Alexander, Kersten, Hannah, Dückers, Alexander, Koch, Trautwein, Christian, Scharf, Alexander, Kreuzer, Ilse, Jaschinski, Ulrich, Kreuzer, Ilse, Jaschinski, Ulrich, Niklas, Markus, Kulzer, Michael, Schlott, Martin, Iberer, Thomas, Stella, Oelert, Thorsten, Löhr, Vandana, Pillai, Praeger, Damaris, Knebel, Fabian, Baumann, Gert, Rosseau, Simone, Schlenk, Florian, Hoffmeister, Bodo, Compton, Friederike, Hoffmann, Clemens, Rademacher, Sibylle, Vietzke, Michael, Jörres, Achim, Meisel, Andreas, Hotter, Benjamin, Mengel, Annerose, Goldmann, Anton, Nöther, Frank, Keh, Didier, Schmidt, Katrin, Angermair, Stefan, Kaffarnik, Magnus, Bubser, Florian, Gummelt, Immo, Vedder, Ina, Bach, Friedhelm, Winter, Markus, Weißer, Frank, Roederer, Marc, Martini, Stefan, Bergmann, Lars, Adamzik, Michael, Baumann, Andreas, Wolf, Britta, Zahn, Peter K., Lehnhardt, Marcus, Daigeler, Adrien, Andreas, Andreas Hohn, Reinhold, Katrin, Adolf, Michael, Altenbeck, Nicole, Gussone, Christoph, Dietrich, Johannes Wolfgang, Köditz, Roland, Putensen, Christian, Schewe, Jens-Christian, Muders, Thomas, Soukup, Jens, Skitek, Kornel, Geisser, Wolfgang, Alber, Andreas, Düthorn, Ludwig, Demund, Josef, Düthorn, Ludwig, Criegern, Isabel v., Nowak, Andreas, Morgenstern, Toralf, Gliniorz, Christoph, Meisner, Michael, Dexel, Melanie, Schütte, Jan Karl, Huppertz-Thyssen, Markus H., Schröder, Stefan, Kowalzik, Ralf, Guel, Cansu, Terhorst, Rainer, Nießen, Peter, Hauschild, Rolf, Mutzek, Elisabeth-Maria, Kogelmann, Klaus, Drüner, Matthias, Jarczak, Dominik, Forster, Christian, Willam, Carsten, Eckardt, K. U., Clemenz, Rüdiger, Siemonsen, Sven, Pauschinger, Matthias, Baumgärtel, Matthias, Muschner, Dorothea, Christ, Michael, Wenzl, Martin, Höhl, Rainer, Junger, Axel, Wöhrle, Armin, Kanthak, Henry, Leschke, Matthias, Kanthak, Henry, Wöhrle, Armin, Leschke, Matthias, Kessler, Paul, Souquet, Jochen, Holfeld, Andreas, Habler, Oliver, Thörner, Markus, Vogt, Oliver, Meybohm, Patrick, Zacharowski, Kai, Lindau, Simone, Lenk, Marcus, Weis, Florian, Schubert, Hermann, Kemnitz, Jürgen, Reckort, Sven, Weikert, Martina, Sudhues, Ulrich, Möller, Stefan, Stefan, Pinger, Domke, Andrea, Wiesenack, Christoph, Schmidt, Florian, Döbel, Kai-Uwe, Moerer, Onnen, Schäper, Jörn, Kernchen, Andrea, Gründling, Matthias, Bollmann, Jan, Kuhn, Sven-Olaf, Kemming, Gregor, Einfeld, Carsten, Sommerer, Thomas, Kemming, Gregor, Einfeld, Carsten, Sommerer, Thomas, Köntges, Philipp, Hinz, Burkhard, Jauch, Lars-Oliver, Selonke, Lutz, Kluge, Stefan, Nierhaus, Axel, de Heer, Geraldine, Gruß, Marco, Köhler, Katja, Brinkmann, Alexander, Fuchs, Thomas, Köberer, Andreas, Geuting, Markus, Weigt, Henry, Baltus, Thomas, Scheltz, Claudia, Bloos, Frank, Reinhart, Konrad, Jegen, Rudolf, Flucht, Marcus, Jürgen, Gburek, Flucht, Marcus, Jegen, Rudolf, Stumm, Anne, Rossenbach, Jannik, Stumm, Anne, Haller, Mathias, Stumm, Anne, Rossenbach, Jannik, Lynch, John, Kempkens, Martin, Buechner, Volkmar, Molitor, Dieter, Klasen, Gerda, Rahmen, Bruno, Muhr, Petra, Canaviri, Patricia, Fiedler, Fritz, Lutz, Jürgen, Kaiser, Marc, Klünter, Simon, Krep, Henning, Anders, Helge, Aduckathil, Sanjay, Sakka, Samir, Reessing, Jan Hinnerk, Aabaid, Sabrina, Löbe, Mathias, Bogatsch, Holger, Löffler, Marcus, Engels, Christoph, Molter, Gerd Peter, Stunz, Michael, Mitrenga, Anja, Geldner, Götz, Bürle, Monica, Klasen, Robert, Werner, Steffanie, Wilhelm, Wolfram, Silke, Frenzel, Juliane, Illert, Jana, Schuttpelz, Briegel, Josef, Möhnle, Patrick, Knorr, Adrian, Hartl, Wolfgang, Ney, Ludwig, Stemmler, Hans-Joachim, Pfister, Hans-Walter, Angstwurm, Matthias, Frey, Lorenz, Irlbeck, Michael, Huge, Volker, Weis, Marion, Kilger, Erich, Hofmann-Kiefer, Klaus, Felbinger, Thomas, Kaufmann, Ines, Goeschl, Julia, Brettner, Franz, Hamm, Heiner, Eife, Claudia, Peckelsen, Claus, Findeisen, Michael, Schmidt-Schridde, Patrick, Kuner, Andreas, Walz, Thomas, Kuner, Barbara, Schrauzer, Thomas, Nentwich, Jens, John, Stefan, Byhahn, Christian, Kretschmer, Thomas, Bergold, Martin N., Weyland, Andreas, Jelschen, Florian, Diers, Anja, Knebel, Frieder G., Kupfer, Thomas, Oppert, Michael, Rohde, Steffen, Möllemann, Angela, Oehmichen, Uwe, Renner, Theresa, Bone, Hans-Georg, Freyhoff, Jörg, Holst, Dana, Birken, Thomas, Henschel, Jörg, Gloger, Martin, Brock, Peter, Klösel, Stephan, Albuszies, Gerd, Schumacher, Detlef, Meierhenrich, Rainer, Schöpp, Alexej, Kuhn, Harald, Riessen, Reimer, Haap, Michael, Ziegler, Silvia, Fastnacht-Böttcher, Jana, Schröder, Rolf Jürgen, Weiss, Manfred, Frank, Katrin, Georgieff, Michael, Weiss, Manfred, Barth, Eberhard, Bracht, Henrik, Ehmcke, Heidrun, Francke, Astrid, Ott, Stefan, Köpcke, Jens, Meyer, Andreas, Jokiel, Gunnar, Freund, Thomas, Schick, Guido, Karassimos, Evagelos, and SepNet Critical Care Trials Group

Published
2017
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33. Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Author

Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A., Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Heldner, Mirjam R., Antonenko, Kateryna, Mbroh, Joshua, Brodard, Justine, Hooshmandi, Etrat, Dizonno, Vanessa, Devroye, Annemie, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Duan, Jiangang, Hiltunen, Sini, Zuurbier, Susanna M., Petruzzellis, Marco, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Schoenenberger, Silvia, Nagel, Simon, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Puthuppallil, Anemon, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Hellström Vogel, Åslög, Tawa, Audrey, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Lim Alvin Chew, Beng, Ziaadini, Bentalhoda, Varkey Maramattom, Boby, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Vayne, Caroline, Legault, Catherine, Jacobi, Christian, Pfrepper, Christian, Pelz, Johann, Wahl, Christoph, Kern, Rolf, Tracol, Clement, Soriano, Cristina, Guisado-Alonso, Daniel, Bougon, David, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, De Maistre, Emmanuel, Saxhaug Kristoffersen, Espen, Bonneville, Fabrice, Geeraerts, Thomas, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Grillo, Francesco, Caparros, François, Susen, Sophie, Maier, Frank, Tsivgoulis, Georgios, Gulli, Giosue, Frisullo, Giovanni, Franchineau, Guillaume, Cangür, Hakan, Katzberg, Hans, Mozhdehipanah, Hossein, Sibon, Igor, Baharoglu, M. Irem, Masjuan, Jaime, Brar, Jaskiran, Payen, Jean Francois, Burrow, Jim, Fernandes, João, Octavio López Esparza, Jorge, Oen, Joyce, Schouten, Judith, Ng, Karl, Chatterton, Sophie, Wronski, Miriam, Althaus, Katharina, Garambois, Katia, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Humbertjean, Lisa, Lebrato Hernandez, Lucia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Dubois, Marie Cecile, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Kumar Karunakaran, Ravi, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Scholz, Moritz J., Kahnis, Robert, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Erat Sreedharan, Sapna, Sylaja, P. N., Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Cuisenier, Pauline, Huet, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Nemati, Reza, Vieira, Ricardo, Goh, Rudy, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Bal, Simerpreet, Kaul, Subhash, Karapanayiotides, Theodoros, Cox, Thomas, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Garcia-Talavera, Veronica, Palma, Vincenzo, Arslan, Yıldız, Mirzaasgari, Zahra, Yavari, Zeinab, Zamani, Zohreh, Bakchoul, Tamam, Levi, Marcel, van Gorp, Eric C.M., Scutelnic, Adrian, van de Munckhof, Anita, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Lindgren, Erik, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Middeldorp, Saskia, Aaron, Sanjith, Borhani-Haghighi, Afshin, Arauz, Antonio, Kremer Hovinga, Johanna A., Günther, Albrecht, Putaala, Jukka, Wasay, Mohammad, Conforto, Adriana Bastos, de Sousa, Diana Aguiar, Jood, Katarina, Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Heldner, Mirjam R., Antonenko, Kateryna, Mbroh, Joshua, Brodard, Justine, Hooshmandi, Etrat, Dizonno, Vanessa, Devroye, Annemie, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Duan, Jiangang, Hiltunen, Sini, Zuurbier, Susanna M., Petruzzellis, Marco, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Schoenenberger, Silvia, Nagel, Simon, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Puthuppallil, Anemon, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Hellström Vogel, Åslög, Tawa, Audrey, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Lim Alvin Chew, Beng, Ziaadini, Bentalhoda, Varkey Maramattom, Boby, Buck, Brian, Zanferrari, Carla, Garcia-Esperon, Carlos, Vayne, Caroline, Legault, Catherine, Jacobi, Christian, Pfrepper, Christian, Pelz, Johann, Wahl, Christoph, Kern, Rolf, Tracol, Clement, Soriano, Cristina, Guisado-Alonso, Daniel, Bougon, David, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, De Maistre, Emmanuel, Saxhaug Kristoffersen, Espen, Bonneville, Fabrice, Geeraerts, Thomas, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Grillo, Francesco, Caparros, François, Susen, Sophie, Maier, Frank, Tsivgoulis, Georgios, Gulli, Giosue, Frisullo, Giovanni, Franchineau, Guillaume, Cangür, Hakan, Katzberg, Hans, Mozhdehipanah, Hossein, Sibon, Igor, Baharoglu, M. Irem, Masjuan, Jaime, Brar, Jaskiran, Payen, Jean Francois, Burrow, Jim, Fernandes, João, Octavio López Esparza, Jorge, Oen, Joyce, Schouten, Judith, Ng, Karl, Chatterton, Sophie, Wronski, Miriam, Althaus, Katharina, Garambois, Katia, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Humbertjean, Lisa, Lebrato Hernandez, Lucia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Dubois, Marie Cecile, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Kumar Karunakaran, Ravi, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Scholz, Moritz J., Kahnis, Robert, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Erat Sreedharan, Sapna, Sylaja, P. N., Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Cuisenier, Pauline, Huet, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Nemati, Reza, Vieira, Ricardo, Goh, Rudy, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Bal, Simerpreet, Kaul, Subhash, Karapanayiotides, Theodoros, Cox, Thomas, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Shaygannejad, Vahid, Garcia-Talavera, Veronica, Palma, Vincenzo, Arslan, Yıldız, Mirzaasgari, Zahra, Yavari, Zeinab, Zamani, Zohreh, Bakchoul, Tamam, Levi, Marcel, and van Gorp, Eric C.M.

Abstract

Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.

Published
2023

34. Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries

Author

van de Munckhof, Anita, Borhani-Haghighi, Afshin, Aaron, Sanjith, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Scutelnic, Adrian, Lindgren, Erik, Duan, Jiangang, Arslan, Yıldız, van Gorp, Eric C.M., Kremer Hovinga, Johanna A., Günther, Albrecht, Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, de Sousa, Diana Aguiar, Wasay, Mohammad, Arauz, Antonio, Conforto, Adriana Bastos, Ferro, José M., Coutinho, Jonathan M., Mbroh, Joshua, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Dizonno, Vanessa, Devroye, Annemie, Hiltunen, Sini, Petruzzellis, Marco, Bakchoul, Tamam, Levi, Marcel, Middeldorp, Saskia, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Spratt, Neil, Ziaadini, Bentolhoda, Varkey Maramattom, Boby, Buck, Brian, Garcia-Esperon, Carlos, Vayne, Caroline, Jacobi, Christian, Pfrepper, Christian, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, Maistre, Emmanuel De, Saxhaug Kristoffersen, Espen, Hooshmandi, Etrat, Bonneville, Fabrice, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Tsivgoulis, Georgios, Gulli, Giosue, Katzberg, Hans, Sibon, Igor, Baharoglu, Irem, Masjuan, Jaime, Fernandes, João, Pelz, Johann, Octavio López Esparza, Jorge, Schouten, Judith, Ng, Karl, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Sylaja, P. N., Kumar Karunakaran, Ravi, Vieira, Ricardo, Kern, Rolf, Goh, Rudy, Erat Sreedharan, Sapna, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Schoenenberger, Silvia, Nagel, Simon, Kaul, Subhash, Karapanayiotides, Theodoros, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Palma, Vincenzo, Mirzaasgari, Zahra, Zamani, Zohreh, Mirahmadizadeh, Alireza, Gutierrez-Romero, Alonso, Iván Valdes-Ferrer, Ivan, Elizabeth Ceballos-Liceaga, Santa, Maria Santibañez-Copado, Ana, van de Munckhof, Anita, Borhani-Haghighi, Afshin, Aaron, Sanjith, Krzywicka, Katarzyna, van Kammen, Mayte Sánchez, Cordonnier, Charlotte, Kleinig, Timothy J., Field, Thalia S., Poli, Sven, Lemmens, Robin, Scutelnic, Adrian, Lindgren, Erik, Duan, Jiangang, Arslan, Yıldız, van Gorp, Eric C.M., Kremer Hovinga, Johanna A., Günther, Albrecht, Jood, Katarina, Tatlisumak, Turgut, Putaala, Jukka, Heldner, Mirjam R., Arnold, Marcel, de Sousa, Diana Aguiar, Wasay, Mohammad, Arauz, Antonio, Conforto, Adriana Bastos, Ferro, José M., Coutinho, Jonathan M., Mbroh, Joshua, Ciccone, Alfonso, Wittstock, Matthias, Zimmermann, Julian, Bode, Felix J., Skjelland, Mona, Dizonno, Vanessa, Devroye, Annemie, Hiltunen, Sini, Petruzzellis, Marco, Bakchoul, Tamam, Levi, Marcel, Middeldorp, Saskia, Sharma, Aarti R., Ghoreishi, Abdoreza, Elkady, Ahmed, Negro, Alberto, Gutschalk, Alexander, Buture, Alina, Cervera, Alvaro, Paiva Nunes, Ana, Romina Montané Baños, Ana, Tiede, Andreas, Tuladhar, Anil M., Mengel, Annerose, Medina, Antonio, Aujayeb, Avinash, Ramasamy, Balakrishnan, Casolla, Barbara, Spratt, Neil, Ziaadini, Bentolhoda, Varkey Maramattom, Boby, Buck, Brian, Garcia-Esperon, Carlos, Vayne, Caroline, Jacobi, Christian, Pfrepper, Christian, Bal, Deepti, Sergio Zimatore, Domenico, Michalski, Dominik, Blacquiere, Dylan, Johansson, Elias, Cuadrado-Godia, Elisa, Sadeghi-Hokmabadi, Elyar, Carrera, Emmanuel, Maistre, Emmanuel De, Saxhaug Kristoffersen, Espen, Hooshmandi, Etrat, Bonneville, Fabrice, Vuillier, Fabrice, Giammello, Fabrizio, D’Onofrio, Florindo, Tsivgoulis, Georgios, Gulli, Giosue, Katzberg, Hans, Sibon, Igor, Baharoglu, Irem, Masjuan, Jaime, Fernandes, João, Pelz, Johann, Octavio López Esparza, Jorge, Schouten, Judith, Ng, Karl, Derex, Laurent, Puy, Laurent, Poorsaadat, Leila, Valler, Lenise, Januzi de Almeida Rocha, Letícia, Murillo-Bonilla, Luis, Kellermair, Lukas, Morin Martin, Mar, Sofia Cotelli, Maria, Hernandez Perez, Maria, Zedde, Marialuisa, Carvalho Dias, Mariana, Carvalho, Marta, Ghiasian, Masoud, Umaiorubahan, Meenakshisundaram, Roozbeh, Mehrdad, Romoli, Michele, Miranda, Miguel, Wronski, Miriam, Saadatnia, Mohammad, Bandettini di Poggio, Monica, Almasi-Dooghaee, Mostafa, Hoseininejad Mir, Nahid, Ichaporia, Nasli R., Kumar Paramasivan, Naveen, Raposo, Nicolas, Fadakar, Nima, Kruyt, Nyika, Detante, Olivier, Sharma, Pankaj, Candelaresi, Paolo, Scoppettuolo, Pasquale, Reiner, Peggy, Sylaja, P. N., Kumar Karunakaran, Ravi, Vieira, Ricardo, Kern, Rolf, Goh, Rudy, Erat Sreedharan, Sapna, Murphy, Seán, Timsit, Serge, Coutts, Shelagh, Sharma, Shyam S., Schoenenberger, Silvia, Nagel, Simon, Kaul, Subhash, Karapanayiotides, Theodoros, Gattringer, Thomas, Mathew, Thomas, Bartsch, Thorsten, Palma, Vincenzo, Mirzaasgari, Zahra, Zamani, Zohreh, Mirahmadizadeh, Alireza, Gutierrez-Romero, Alonso, Iván Valdes-Ferrer, Ivan, Elizabeth Ceballos-Liceaga, Santa, and Maria Santibañez-Copado, Ana

Abstract

Background: Adenovirus-based COVID-19 vaccines are extensively used in low- and middle-income countries (LMICs). Remarkably, cases of cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) have rarely been reported from LMICs. Aims: We studied the frequency, manifestations, treatment, and outcomes of CVST-VITT in LMICs. Methods: We report data from an international registry on CVST after COVID-19 vaccination. VITT was classified according to the Pavord criteria. We compared CVST-VITT cases from LMICs to cases from high-income countries (HICs). Results: Until August 2022, 228 CVST cases were reported, of which 63 were from LMICs (all middle-income countries [MICs]: Brazil, China, India, Iran, Mexico, Pakistan, Turkey). Of these 63, 32 (51%) met the VITT criteria, compared to 103 of 165 (62%) from HICs. Only 5 of the 32 (16%) CVST-VITT cases from MICs had definite VITT, mostly because anti-platelet factor 4 antibodies were often not tested. The median age was 26 (interquartile range [IQR] 20–37) versus 47 (IQR 32–58) years, and the proportion of women was 25 of 32 (78%) versus 77 of 103 (75%) in MICs versus HICs, respectively. Patients from MICs were diagnosed later than patients from HICs (1/32 [3%] vs. 65/103 [63%] diagnosed before May 2021). Clinical manifestations, including intracranial hemorrhage, were largely similar as was intravenous immunoglobulin use. In-hospital mortality was lower in MICs (7/31 [23%, 95% confidence interval (CI) 11–40]) than in HICs (44/102 [43%, 95% CI 34–53], p = 0.039). Conclusions: The number of CVST-VITT cases reported from LMICs was small despite the widespread use of adenoviral vaccines. Clinical manifestations and treatment of CVST-VITT cases were largely similar in MICs and HICs, while mortality was lower in patients from MICs.

Published
2023

37. Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome

Author

Wilke, Vera, primary, Sulyok, Mihaly, additional, Stefanou, Maria-Ioanna, additional, Richter, Vivien, additional, Bender, Benjamin, additional, Ernemann, Ulrike, additional, Ziemann, Ulf, additional, Malek, Nisar, additional, Kienzle, Katharina, additional, Klein, Constantin, additional, Bunk, Stefanie, additional, Goepel, Siri, additional, and Mengel, Annerose, additional

Published
2022
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38. Rapid Diagnosis of Central Nervous System Scedosporiosis by Specific Quantitative Polymerase Chain Reaction Applied to Formalin-Fixed, Paraffin-Embedded Tissue

Author

Lauerer, Robert J., Rosenow, Emely, Beschorner, Rudi, Hempel, Johann-Martin, Naros, Georgios, Hofmann, Anna, Berger, Katharina, Sartor-Pfeiffer, Jennifer, Mengel, Annerose, Ziemann, Ulf, Rickerts, Volker, and Feil, Katharina

Subjects
brain abscess, specific qPCR, Scedosporium apiospermum, QH301-705.5, Communication, Biology (General)
Abstract

Scedosporium (S.) apiospermum is a typical mold causing cerebral abscesses, often after near-drowning. Infections are associated with high morbidity and mortality due to diagnostic challenges including the need for prolonged incubation of cultures. In addition, histopathological differentiation from other filamentous fungi, including Aspergillus fumigatus, may not be possible, excluding early specific diagnosis and targeted therapy. Polymerase chain reaction (PCR) on tissue samples can rapidly identify fungi, leading to an earlier adequate treatment. Due to an extensive spectrum of causative fungi, broad-range PCRs with amplicon sequencing have been endorsed as the best DNA amplification strategy. We herein describe a case with brain abscesses due to S. apiospermum in a 66-year-old immunocompromised female patient. While broad-range PCR failed to identify a fungal pathogen from a cerebral biopsy demonstrating hyaline mold hyphae, specific quantitative PCR (qPCR) identified Scedosporium and ruled out Aspergillus, the most prevalent agent of central nervous system mold infection. A panel of specific qPCR assays, guided by the morphology of fungal elements in tissue or as a multiplex assay, may be a successful molecular approach to identify fungal agents of brain abscesses. This also applies in the presence of negative broad-range fungal PCR, therefore providing diagnostic and therapeutic potential for early specific management and improvement of patient clinical outcome.

Published
2022

39. TRoponin of Unknown origin in STroke evaluated by multi-component cardiac Magnetic resonance Imaging – The TRUST-MI study

Author

Mengel, Annerose, Nenova, Lilyana, Müller, Karin A. L., Poli, Sven, Kowarik, Markus C., Feil, Katharina, Mizera, Lars, Geisler, Tobias, Kübler, Jens, Mahrholdt, Heiko, Ernemann, Ulrike, Hennersdorf, Florian, Ziemann, Ulf, Nikolaou, Konstantin, Gawaz, Meinrad, Krumm, Patrick, and Greulich, Simon

Subjects
Cardiology and Cardiovascular Medicine
Published
2022
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43. <scp>COVID</scp> ‐19 Vaccine‐Associated Cerebral Venous Thrombosis in Germany

Author

Schulz, Jörg B, Berlit, Peter, Steinmetz, Helmuth, Thiele, Thomas, Kurth, Tobias, Group, German Society of Neurology SARS-CoV-2 Vaccination Study, Alonso, Angelika, Bartsch, Thorsten, Baumsteiger, Christoph, Bode, Felix, Cangür, Hakan, Daffertshofer, Michael, Diener, Hans-Christoph, Dafotakis, Manuel, Dieterich, Marianne, Fabian, Friederike, Fousse, Mathias, Godau, Jana, Grond, Martin, Günther, Albrecht, Gutschalk, Alexander, Hagemann, Georg, Hartmann, Corinna, Gerloff, Christian, Hilker-Roggendorf, Rüdiger, Höglinger, Günter, Ikenberg, Benno, Ismail, Fatme Seval, Jesse, Sarah, Kallmünzer, Bernd, Kern, Rolf, Klietz, Martin, Knauß, Samuel, Knier, Benjamin, Greinacher, Andreas, Limmroth, Volker, Mengel, Annerose, Meyne, Johannes, Morgenthaler, Martin, Müller, Matthias, Nagel, Simon, Niels, Ralf Dittrich, Onur, Oezguer A, Pelz, Johann, Plenge, Johannes, Klein, Christine, Poli, Sven, Roth, Christian, Röther, Joachim, Saß, Christian, Schönenberger, Silvia, Schubert, Roger, Simon, Ole, Agaplesion, Ina Specht, Sperfeld, Anne, Spreer, Annette, Petzold, Gabor C, Steinbrecher, Andreas, Steiner, Jochen, Stetefeld, Henning, Trendelenburg, George, Vatankhah, Nils Bijan, Wahl, Christoph Michael, Wartenberg, Katja, Witt, Karsten, Wittstock, Matthias, Wolf, Björn, Piccininni, Marco, Wolf, Joachim, Zimmermann, Julian, and Röhrig, Rainer

Subjects
Male, Pediatrics, Neurology, Medizin, etiology [Intracranial Thrombosis], BNT162 vaccine, epidemiology [Cerebral Hemorrhage], Rate ratio, etiology [Ischemic Stroke], Germany, Surveys and Questionnaires, epidemiology [Ischemic Stroke], epidemiology [Venous Thrombosis], Research Articles, etiology [Venous Thrombosis], Venous Thrombosis, Aged, 80 and over, education.field_of_study, Incidence, Incidence (epidemiology), Age Factors, Middle Aged, etiology [Cerebral Hemorrhage], Vaccination, Venous thrombosis, Female, Research Article, Adult, medicine.medical_specialty, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Population, epidemiology [Germany], Young Adult, Sex Factors, ChAdOx1 nCoV-19, medicine, adverse effects [COVID-19 Vaccines], Humans, ddc:610, education, BNT162 Vaccine, Cerebral Hemorrhage, Ischemic Stroke, Aged, epidemiology [Intracranial Thrombosis], business.industry, medicine.disease, Confidence interval, ChAdOx1 COVID-19 vaccine, Neurology (clinical), Intracranial Thrombosis, business
Abstract

OBJECTIVE We aimed to estimate the incidence of cerebral sinus and venous thrombosis (CVT) within 1 month from first dose administration and the frequency of vaccine-induced immune thrombotic thrombocytopenia (VITT) as the underlying mechanism after vaccination with BNT162b2, ChAdOx1, and mRNA-1273, in Germany. METHODS A web-based questionnaire was e-mailed to all departments of neurology. We requested a report of cases of CVT occurring within 1 month of a COVID-19 vaccination. Other cerebral events could also be reported. Incidence rates of CVT were calculated by using official statistics of 9 German states. RESULTS A total of 45 CVT cases were reported. In addition, 9 primary ischemic strokes, 4 primary intracerebral hemorrhages, and 4 other neurological events were recorded. Of the CVT patients, 35 (77.8%) were female, and 36 (80.0%) were younger than 60 years. Fifty-three events were observed after vaccination with ChAdOx1 (85.5%), 9 after BNT162b2 (14.5%) vaccination, and none after mRNA-1273 vaccination. After 7,126,434 first vaccine doses, the incidence rate of CVT within 1 month from first dose administration was 0.55 (95% confidence interval [CI] = 0.38-0.78) per 100,000 person-months (which corresponds to a risk of CVT within the first 31 days of 0.55 per 100,000 individuals) for all vaccines and 1.52 (95% CI = 1.00-2.21) for ChAdOx1 (after 2,320,535 ChAdOx1 first doses). The adjusted incidence rate ratio was 9.68 (95% CI = 3.46-34.98) for ChAdOx1 compared to mRNA-based vaccines and 3.14 (95% CI = 1.22-10.65) for females compared to non-females. In 26 of 45 patients with CVT (57.8%), VITT was graded highly probable. INTERPRETATION Given an incidence of 0.02 to 0.15 per 100,000 person-months for CVT in the general population, these findings point toward a higher risk for CVT after ChAdOx1 vaccination, especially for women. ANN NEUROL 2021;90:627-639.

Published
2021
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44. Predictors of post-stroke delirium incidence and duration: Results of a prospective observational study using high-frequency delirium screening

Author

Fleischmann, Robert, primary, Andrasch, Tina, additional, Warwas, Sina, additional, Kunz, Rhina, additional, Gross, Stefan, additional, Witt, Carl, additional, Ruhnau, Johanna, additional, Vogelgesang, Antje, additional, Ulm, Lena, additional, Mengel, Annerose, additional, and von Sarnowski, Bettina, additional

Published
2022
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45. Management of Cerebral Venous Thrombosis Due to Adenoviral COVID‐19 Vaccination

Author

Scutelnic, Adrian, primary, Krzywicka, Katarzyna, additional, Mbroh, Joshua, additional, van de Munckhof, Anita, additional, van Kammen, Mayte Sánchez, additional, de Sousa, Diana Aguiar, additional, Lindgren, Erik, additional, Jood, Katarina, additional, Günther, Albrecht, additional, Hiltunen, Sini, additional, Putaala, Jukka, additional, Tiede, Andreas, additional, Maier, Frank, additional, Kern, Rolf, additional, Bartsch, Thorsten, additional, Althaus, Katharina, additional, Ciccone, Alfonso, additional, Wiedmann, Markus, additional, Skjelland, Mona, additional, Medina, Antonio, additional, Cuadrado‐Godia, Elisa, additional, Cox, Thomas, additional, Aujayeb, Avinash, additional, Raposo, Nicolas, additional, Garambois, Katia, additional, Payen, Jean‐Francois, additional, Vuillier, Fabrice, additional, Franchineau, Guillaume, additional, Timsit, Serge, additional, Bougon, David, additional, Dubois, Marie‐Cécile, additional, Tawa, Audrey, additional, Tracol, Clement, additional, De Maistre, Emmanuel, additional, Bonneville, Fabrice, additional, Vayne, Caroline, additional, Mengel, Annerose, additional, Michalski, Dominik, additional, Pelz, Johann, additional, Wittstock, Matthias, additional, Bode, Felix, additional, Zimmermann, Julian, additional, Schouten, Judith, additional, Buture, Alina, additional, Murphy, Sean, additional, Palma, Vincenzo, additional, Negro, Alberto, additional, Gutschalk, Alexander, additional, Nagel, Simon, additional, Schoenenberger, Silvia, additional, Frisullo, Giovanni, additional, Zanferrari, Carla, additional, Grillo, Francesco, additional, Giammello, Fabrizio, additional, Martin, Mar Morin, additional, Cervera, Alvaro, additional, Burrow, Jim, additional, Esperon, Carlos Garcia, additional, Chew, Beng Lim Alvin, additional, Kleinig, Timothy J., additional, Soriano, Cristina, additional, Zimatore, Domenico S., additional, Petruzzellis, Marco, additional, Elkady, Ahmed, additional, Miranda, Miguel S., additional, Fernandes, João, additional, Vogel, Åslög Hellström, additional, Johansson, Elias, additional, Philip, Anemon Puthuppallil, additional, Coutts, Shelagh B., additional, Bal, Simerpreet, additional, Buck, Brian, additional, Legault, Catherine, additional, Blacquiere, Dylan, additional, Katzberg, Hans D., additional, Field, Thalia S., additional, Dizonno, Vanessa, additional, Gattringer, Thomas, additional, Jacobi, Christian, additional, Devroye, Annemie, additional, Lemmens, Robin, additional, Kristoffersen, Espen Saxhaug, additional, di Poggio, Monica Bandettini, additional, Ghiasian, Masoud, additional, Karapanayiotides, Theodoros, additional, Chatterton, Sophie, additional, Wronski, Miriam, additional, Ng, Karl, additional, Kahnis, Robert, additional, Geeraerts, Thomas, additional, Reiner, Peggy, additional, Cordonnier, Charlotte, additional, Middeldorp, Saskia, additional, Levi, Marcel, additional, van Gorp, Eric C. M., additional, van de Beek, Diederik, additional, Brodard, Justine, additional, Kremer Hovinga, Johanna A., additional, Kruip, Marieke J. H. A., additional, Tatlisumak, Turgut, additional, Ferro, José M., additional, Coutinho, Jonathan M., additional, Arnold, Marcel, additional, Poli, Sven, additional, and Heldner, Mirjam R., additional

Published
2022
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46. Simulation-based training improves process times in acute stroke care (STREAM)

Author

Bohmann, Ferdinand O., Gruber, Katharina, Kurka, Natalia, Willems, Laurent M., Herrmann, Eva, du Mesnil de Rochemont, Richard, Scholz, Peter, Rai, Heike, Zickler, Philipp, Ertl, Michael, Berlis, Ansgar, Poli, Sven, Mengel, Annerose, Ringleb, Peter, Nagel, Simon, Pfaff, Johannes, Wollenweber, Frank A., Kellert, Lars, Herzberg, Moriz, Koehler, Luzie, Haeusler, Karl Georg, Alegiani, Anna, Schubert, Charlotte, Brekenfeld, Caspar, Doppler, Christopher E. J., Onur, Ozgur A., Kabbasch, Christoph, Manser, Tanja, Steinmetz, Helmuth, Pfeilschifter, Waltraud, Bohmann, Ferdinand O., Gruber, Katharina, Kurka, Natalia, Willems, Laurent M., Herrmann, Eva, du Mesnil de Rochemont, Richard, Scholz, Peter, Rai, Heike, Zickler, Philipp, Ertl, Michael, Berlis, Ansgar, Poli, Sven, Mengel, Annerose, Ringleb, Peter, Nagel, Simon, Pfaff, Johannes, Wollenweber, Frank A., Kellert, Lars, Herzberg, Moriz, Koehler, Luzie, Haeusler, Karl Georg, Alegiani, Anna, Schubert, Charlotte, Brekenfeld, Caspar, Doppler, Christopher E. J., Onur, Ozgur A., Kabbasch, Christoph, Manser, Tanja, Steinmetz, Helmuth, and Pfeilschifter, Waltraud

Abstract

Background The objective of the STREAM Trial was to evaluate the effect of simulation training on process times in acute stroke care. Methods The multicenter prospective interventional STREAM Trial was conducted between 10/2017 and 04/2019 at seven tertiary care neurocenters in Germany with a pre- and post-interventional observation phase. We recorded patient characteristics, acute stroke care process times, stroke team composition and simulation experience for consecutive direct-to-center patients receiving intravenous thrombolysis (IVT) and/or endovascular therapy (EVT). The intervention consisted of a composite intervention centered around stroke-specific in situ simulation training. Primary outcome measure was the 'door-to-needle' time (DTN) for IVT. Secondary outcome measures included process times of EVT and measures taken to streamline the pre-existing treatment algorithm. Results The effect of the STREAM intervention on the process times of all acute stroke operations was neutral. However, secondary analyses showed a DTN reduction of 5 min from 38 min pre-intervention (interquartile range [IQR] 25-43 min) to 33 min (IQR 23-39 min, p = 0.03) post-intervention achieved by simulation-experienced stroke teams. Concerning EVT, we found significantly shorter door-to-groin times in patients who were treated by teams with simulation experience as compared to simulation-naive teams in the post-interventional phase (-21 min, simulation-naive: 95 min, IQR 69-111 vs. simulation-experienced: 74 min, IQR 51-92, p = 0.04). Conclusion An intervention combining workflow refinement and simulation-based stroke team training has the potential to improve process times in acute stroke care.

Published
2022

47. Management of cerebral venous thrombosis due to adenoviral covid-19 vaccination

Author

Scutelnic, Adrian, Krzywicka, Katarzyna, Mbroh, Joshua, van de Munckhof, Anita, van Kammen, Mayte Sánchez, de Sousa, Diana Aguiar, Lindgren, Erik, Jood, Katarina, Günther, Albrecht, Hiltunen, Sini, Putaala, Jukka, Tiede, Andreas, Maier, Frank, Kern, Rolf, Bartsch, Thorsten, Althaus, Katharina, Ciccone, Alfonso, Wiedmann, Markus, Skjelland, Mona, Medina, Antonio, Cuadrado-Godia, Elisa, Cox, Thomas, Aujayeb, Avinash, Raposo, Nicolas, Garambois, Katia, Payen, Jean-Francois, Vuillier, Fabrice, Franchineau, Guillaume, Timsit, Serge, Bougon, David, Dubois, Marie-Cécile, Tawa, Audrey, Tracol, Clement, De Maistre, Emmanuel, Bonneville, Fabrice, Vayne, Caroline, Mengel, Annerose, Michalski, Dominik, Pelz, Johann, Wittstock, Matthias, Bode, Felix, Zimmermann, Julian, Schouten, Judith, Buture, Alina, Murphy, Sean, Palma, Vincenzo, Negro, Alberto, Gutschalk, Alexander, Nagel, Simon, Schoenenberger, Silvia, Frisullo, Giovanni, Zanferrari, Carla, Grillo, Francesco, Giammello, Fabrizio, Martin, Mar Morin, Cervera, Alvaro, Burrow, Jim, Esperon, Carlos Garcia, Chew, Beng Lim Alvin, Kleinig, Timothy J., Soriano, Cristina, Zimatore, Domenico S., Petruzzellis, Marco, Elkady, Ahmed, Miranda, Miguel S., Fernandes, João, Vogel, Åslög Hellström, Johansson, Elias, Philip, Anemon Puthuppallil, Coutts, Shelagh B., Bal, Simerpreet, Buck, Brian, Legault, Catherine, Blacquiere, Dylan, Katzberg, Hans D., Field, Thalia S., Dizonno, Vanessa, Gattringer, Thomas, Jacobi, Christian, Devroye, Annemie, Lemmens, Robin, Kristoffersen, Espen Saxhaug, di Poggio, Monica Bandettini, Ghiasian, Masoud, Karapanayiotides, Theodoros, Chatterton, Sophie, Wronski, Miriam, Ng, Karl, Kahnis, Robert, Geeraerts, Thomas, Reiner, Peggy, Cordonnier, Charlotte, Middeldorp, Saskia, Levi, Marcel, van Gorp, Eric C. M., van de Beek, Diederik, Brodard, Justine, Kremer Hovinga, Johanna A., Kruip, Marieke J. H. A., Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Poli, Sven, Heldner, Mirjam R., Scutelnic, Adrian, Krzywicka, Katarzyna, Mbroh, Joshua, van de Munckhof, Anita, van Kammen, Mayte Sánchez, de Sousa, Diana Aguiar, Lindgren, Erik, Jood, Katarina, Günther, Albrecht, Hiltunen, Sini, Putaala, Jukka, Tiede, Andreas, Maier, Frank, Kern, Rolf, Bartsch, Thorsten, Althaus, Katharina, Ciccone, Alfonso, Wiedmann, Markus, Skjelland, Mona, Medina, Antonio, Cuadrado-Godia, Elisa, Cox, Thomas, Aujayeb, Avinash, Raposo, Nicolas, Garambois, Katia, Payen, Jean-Francois, Vuillier, Fabrice, Franchineau, Guillaume, Timsit, Serge, Bougon, David, Dubois, Marie-Cécile, Tawa, Audrey, Tracol, Clement, De Maistre, Emmanuel, Bonneville, Fabrice, Vayne, Caroline, Mengel, Annerose, Michalski, Dominik, Pelz, Johann, Wittstock, Matthias, Bode, Felix, Zimmermann, Julian, Schouten, Judith, Buture, Alina, Murphy, Sean, Palma, Vincenzo, Negro, Alberto, Gutschalk, Alexander, Nagel, Simon, Schoenenberger, Silvia, Frisullo, Giovanni, Zanferrari, Carla, Grillo, Francesco, Giammello, Fabrizio, Martin, Mar Morin, Cervera, Alvaro, Burrow, Jim, Esperon, Carlos Garcia, Chew, Beng Lim Alvin, Kleinig, Timothy J., Soriano, Cristina, Zimatore, Domenico S., Petruzzellis, Marco, Elkady, Ahmed, Miranda, Miguel S., Fernandes, João, Vogel, Åslög Hellström, Johansson, Elias, Philip, Anemon Puthuppallil, Coutts, Shelagh B., Bal, Simerpreet, Buck, Brian, Legault, Catherine, Blacquiere, Dylan, Katzberg, Hans D., Field, Thalia S., Dizonno, Vanessa, Gattringer, Thomas, Jacobi, Christian, Devroye, Annemie, Lemmens, Robin, Kristoffersen, Espen Saxhaug, di Poggio, Monica Bandettini, Ghiasian, Masoud, Karapanayiotides, Theodoros, Chatterton, Sophie, Wronski, Miriam, Ng, Karl, Kahnis, Robert, Geeraerts, Thomas, Reiner, Peggy, Cordonnier, Charlotte, Middeldorp, Saskia, Levi, Marcel, van Gorp, Eric C. M., van de Beek, Diederik, Brodard, Justine, Kremer Hovinga, Johanna A., Kruip, Marieke J. H. A., Tatlisumak, Turgut, Ferro, José M., Coutinho, Jonathan M., Arnold, Marcel, Poli, Sven, and Heldner, Mirjam R.

Abstract

Objective: Cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality. Methods: We used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis. Results: Ninety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p < 0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR] = 0.43, 95% confidence interval [CI] = 0.16–1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR = 0.19, 95% CI = 0.06–0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR = 0.70, 95% CI = 0.24–2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR = 2.19, 95% CI = 0.74–6.54). Conclusions: In patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT., DEAL

Published
2022
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48. Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and [15O]water PET

Author

Zerweck, Leonie; https://orcid.org/0000-0003-4105-5131, Roder, Constantin; https://orcid.org/0000-0003-4487-2807, Hauser, Till-Karsten; https://orcid.org/0000-0001-7604-3419, Thurow, Johannes; https://orcid.org/0000-0001-6703-6030, Mengel, Annerose; https://orcid.org/0000-0002-2399-3020, Tatagiba, Marcos; https://orcid.org/0000-0002-1627-9937, Khan, Nadia; https://orcid.org/0000-0001-5179-5243, Meyer, Philipp T; https://orcid.org/0000-0001-8336-750X, Ernemann, Ulrike; https://orcid.org/0000-0003-1330-1235, Klose, Uwe; https://orcid.org/0000-0001-5236-3450, Zerweck, Leonie; https://orcid.org/0000-0003-4105-5131, Roder, Constantin; https://orcid.org/0000-0003-4487-2807, Hauser, Till-Karsten; https://orcid.org/0000-0001-7604-3419, Thurow, Johannes; https://orcid.org/0000-0001-6703-6030, Mengel, Annerose; https://orcid.org/0000-0002-2399-3020, Tatagiba, Marcos; https://orcid.org/0000-0002-1627-9937, Khan, Nadia; https://orcid.org/0000-0001-5179-5243, Meyer, Philipp T; https://orcid.org/0000-0001-8336-750X, Ernemann, Ulrike; https://orcid.org/0000-0003-1330-1235, and Klose, Uwe; https://orcid.org/0000-0001-5236-3450

Abstract

Purpose Patients with Moyamoya Angiopathy (MMA) require hemodynamic evaluation to assess the risk of stroke. Assessment of cerebral blood flow with [15O]water PET and acetazolamide challenge is the diagnostic standard for the evaluation of the cerebral perfusion reserve (CPR). Estimation of the cerebrovascular reactivity (CVR) by use of breath-hold-triggered fMRI (bh-fMRI) as an index of CPR has been proposed as a reliable and more readily available approach. Recent findings suggest the use of resting-state fMRI (rs-fMRI) which requires minimum patient compliance. The aim of this study was to compare rs-fMRI to bh-fMRI and [15O]water PET in patients with MMA. Methods Patients with MMA underwent rs-fMRI and bh-fMRI in the same MRI session. Maps of the CVR gained by both modalities were compared retrospectively by calculating the correlation between the mean CVR of 12 volumes of interest. Additionally, the rs-maps of a subgroup of patients were compared to CPR-maps gained by [15O]water PET. Results The comparison of the rs-maps and the bh-maps of 24 patients revealed a good correlation (Pearson’s r = 0.71 ± 0.13; preoperative patients: Pearson’s r = 0.71 ± 0.17; postoperative patients: Pearson’s r = 0.71 ± 0.11). The comparison of 7 rs-fMRI data sets to the corresponding [15O]water PET data sets also revealed a high level of agreement (Pearson’s r = 0.80 ± 0.19). Conclusion The present analysis indicates that rs-fMRI might be a promising non-invasive method with almost no patient cooperation needed to evaluate the CVR. Further prospective studies are required.

Published
2022

50. Predictors of post-stroke delirium incidence and duration: Results of a prospective observational study using high-frequency delirium screening.

Author

Fleischmann, Robert, Andrasch, Tina, Warwas, Sina, Kunz, Rhina, Gross, Stefan, Witt, Carl, Ruhnau, Johanna, Vogelgesang, Antje, Ulm, Lena, Mengel, Annerose, and von Sarnowski, Bettina

Subjects
MEDICAL screening, DELIRIUM, LONGITUDINAL method, URINARY catheters, ISCHEMIC stroke
Abstract

Background: Post-stroke delirium (PSD) is a modifiable predictor for worse outcome in stroke. Knowledge of its risk factors would facilitate clinical management of affected patients, but recently updated national guidelines consider available evidence insufficient. Aims: The study aimed to establish risk factors for PSD incidence and duration using high-frequency screening. Methods: We prospectively investigated patients with ischemic stroke admitted within 24 h. Patients were screened twice daily for the presence of PSD throughout the treatment period. Sociodemographic, treatment-related, and neuroimaging characteristics were evaluated as predictors of either PSD incidence (odds ratios (OR)) or duration (PSD days/unit of the predictor, b), using logistic and linear regression models, respectively. Results: PSD occurred in 55/141 patients (age = 73.8 ± 10.4 years, 61 female, National Institutes of Health Stroke Scale (NIHSS) = 6.4 ± 6.5). Age (odds ratio (OR) = 1.06 (95% confidence interval (CI): 1.02–1.10), b = 0.08 (95% CI = 0.04–0.13)), and male gender (b = 0.99 (95% CI = 0.05–1.93)) were significant non-modifiable risk factors. In a multivariable model adjusted for age and gender, presence of pain (OR < sub > mvar = 1.75 (95% CI = 1.12–2.74)), urinary catheter (OR < sub > mvar = 3.16 (95% CI = 1.10–9.14)) and post-stroke infection (PSI; OR < sub > mvar = 4.43 (95% CI = 1.09–18.01)) were predictors of PSD incidence. PSD duration was impacted by presence of pain (b < sub > mvar = 0.49 (95% CI = 0.19–0.81)), urinary catheter (b < sub > mvar = 1.03 (95% CI = 0.01–2.07)), intravenous line (b < sub > mvar = 0.36 (95% CI = 0.16–0.57)), and PSI (b < sub > mvar = 1.60 (95% CI = 0.42–2.78)). PSD (OR = 3.53 (95% CI = 1.48–5.57)) and PSI (OR = 5.29 (95% CI = 2.92–7.66)) independently predicted inferior NIHSS at discharge. Insular and basal ganglia lesions increased the PSD risk about four- to eight-fold. Discussion/Conclusion: This study identified modifiable risk factors, the management of which might reduce the negative impact PSD has on outcome. [ABSTRACT FROM AUTHOR]

Published
2023
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