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2. Multirecombinant Enterovirus A71 Subgenogroup C1 Isolates Associated with Neurologic Disease, France, 2016-2017

Author

Ngangas, Stephanie Tomba, Lukashev, Alexander, Jugie, Gwendoline, Ivanova, Olga, Mansuy, Jean-Michel, Mengelle, Catherine, Izopet, Jacques, Lhonneur, Anne-Sophie, Rozenberg, Flore, Leyssene, David, Hecquet, Denise, Marque-Juillet, Stephanie, Boutolleau, David, Burrel, Sonia, Peigue-Lafeuille, Helene, Archimbaud, Christine, Benschop, Kimberley, Henquell, Cecile, Mirand, Audrey, and Bailly, Jean-Luc

Subjects
Diseases -- France -- Health aspects, Genomics -- Health aspects, Enterovirus infections, Genomes, Neurologic manifestations, Infection, Pediatric diseases, Nervous system diseases, Health
Abstract

Enterovirus A71 (EV-A71) comprises 7 genogroups (A-G) and various subgenogroups (e.g., B0-B5, C1-C5) (1). B4, B5, and C4 viruses circulate mainly in Asia, and C1 and C2 viruses have been [...]

Published
2019
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3. Effectiveness of Immune Checkpoint Inhibitors in Transplant Recipients with Progressive Multifocal Leukoencephalopathy

Author

Medrano, Chloe, Vergez, Francois, Mengelle, Catherine, Faguer, Stanislas, Kamar, Nassim, and Del Bello, Arnaud

Subjects
HIV infections -- Care and treatment -- Health aspects, Belatacept -- Health aspects, Progressive multifocal leukoencephalopathy -- Care and treatment -- Health aspects, Nivolumab -- Health aspects, Kidney transplantation -- Health aspects, Organ transplant recipients -- Care and treatment -- Health aspects, Pembrolizumab -- Health aspects, T cells -- Health aspects, HIV, Hematologic diseases, Antibodies, Infection, Leukoencephalopathy, Organ transplantation, Health
Abstract

The role of T-cell exhaustion in the development of progressive multifocal leukoencephalopathy (PML), a rare brain disease caused by JC virus, has prompted clinicians to use immune checkpoint inhibitor molecules [...]

Published
2019
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4. Peripheral Plasma and Semen Cytokine Response to Zika Virus in Humans

Author

Mansuy, Jean-Michel, Costa, Hicham El, Gouilly, Jordi, Mengelle, Catherine, Pasquier, Christophe, Martin-Blondel, Guillaume, Izopet, Jacques, and Jabrane-Ferrat, Nabila

Subjects
Disease transmission, Cytokines, Zika virus, Infection, Ethics, Testosterone, Newborn infants, RNA, Viremia, Health
Abstract

Before the 2015-2016 outbreak, Zika virus infection had been associated with only mild symptoms. However, the outbreak revealed infection could cause severe clinical manifestations, particularly for fetuses and newborns (1). [...]

Published
2019

8. Zika virus infection and prolonged viremia in whole-blood specimens

Author

Mansuy, Jean Michel, Mengelle, Catherine, Pasquier, Christophe, Chapuy-Regaud, Sabine, Delobel, Pierre, Martin-Blondel, Guillaume, and Izopet, Jacques

Subjects
Ebola virus -- Health aspects, Public health -- Health aspects, Zika virus -- Health aspects, Virus diseases -- Prevention -- Health aspects, Infection -- Prevention -- Health aspects, Blood donation -- Health aspects, RNA -- Health aspects, Health
Abstract

Since cases of severe neurologic disorders among adults (1) and fetal abnormalities (2) linked to Zika virus infections were initially reported, the World Health Organization has deemed the Zika virus [...]

Published
2017

14. Drug-resistant cytomegalovirus in transplant recipients: a French cohort study

Author

Hantz, Sébastien, Garnier-Geoffroy, Françoise, Mazeron, Marie-Christine, Garrigue, Isabelle, Merville, Pierre, Mengelle, Catherine, Rostaing, Lionel, Saint Marcoux, Franck, Essig, Marie, Rerolle, Jean-Philippe, Cotin, Sébastien, Germi, Raphaëlle, Pillet, Sylvie, Lebranchu, Yvon, Turlure, Pascal, Alain, Sophie, Herbein, Georges, Coaquette, Alain, Lafon, Marie Edith, Garrigue, Isabelle, Archimbaud, Christine, Henquell, Cécile, Peigue-Lafeuille, Hélène, Pothier, Pierre, Bour, Jean Baptiste, Cesaire, Raymond, Majioullah, Fatimah, Morand, Patrice, Germi, Raphaëlle, Morel-Baccard, Christine, Signori-Schmuck, Anne, Alain, Sophie, Hantz, Sébastien, Grosjean, Jérôme, Morfin-Sherpa, Florence, Billaud, Geneviève, Domenach, Vinca, Andre, Patrice, Milon, Marie Paule, Segondy, Michel, Foulongne, Vincent, Agius, Gérard, Beby-Defaux, Agnès, Pozzetto, Bruno, Pillet, Sylvie, Mansuy, Jean Michel, Mengelle, Catherine, Gaudio-Castelain, Sandrine, Ducancelle, Alexandra, Lunel, Françoise, Payan, Christopher, Gouarin, Stéphanie, Dewilde, Anny, Bressolette, Céline, Coste-Burel, Marianne, Imbert-Marcille, Berthe-Marie, Andreoletti, Laurent, Leveque, Nicolas, Venard, Véronique, Jeulin, Hélène, Minjolle, Sophie, Gueudin, Marie, Colimon, Ronald, Stoll-Keller, Françoise, Fafi-Kremer, Samira, Dubois, F., Gaudy, Catherine, Deny, Paul, Vezinet, Françoise Brun, Houhou, Nadira, Honderlick, Patrick, Mazeron, Marie Christine, Leruez-Ville, Marianne, Vaghefi, Parissa, Dussaix, Elisabeth, Agut, Henri, Boutolleau, David, Deback, Claire, Scieux, Catherine, Le Goff, Jérôme, Ducloux, Didier, Vanlemmens, Claire, Larosa, Fabrice, Neau-Cransac, M., Dromer, C., Rosier, Emmanuelle, Merville, Pierre, Douillet, Marine, Morel, Delphine, Moreau, Karine, Martin, Séverine, Billes, Marc-Alain, Milpied, Noel, Tabrizi, Reza, Vigouroux, Stéphane, Melot, Cyril, Deteix, Patrice, Heng, Anne-Elisabeth, Mackaya, Léandre, Casanova, Sandrine, Bay, Jacques-Olivier, Demeocq, François, Duee, Frédéric, Mousson, Christiane, Hillon, Patrick, Minello, Anne, Charve, Philippe, Tanter, Yves, Bayle, François, Janbon, Bénédicte, Borrel, Elisabeth, Boignard, Aude, Neron, Linda, Pison, Christophe, Saint-Raymond, Christel, Brion, Jean Paul, Cahn, Jean Yves, Bordessoule, Dominique, Turlure, Pascal, Bompart, Frédérica, Philippon, Céline, Essig, Marie, Aldigier, Jean-Claude, Rerolle, Jean Philippe, Dickson, Zarah, Leprivey, Valérie, Roger-Rolle, Florence, Piguet, Christophe, Marquet, Pierre, Francois, Bruno, Pouteil-Noble, Claire, Mialou, Valérie, Mourad, Georges, Mariat, Christophe, Cornillon, Jérôme, Tavernie-Tardy, Emmanuelle, Attal, M., Huynh, Anne, Rostaing, Lionel, Kamar, Nassim, Mencia, Danièle, Crognier, Laure, de Ligny, Bruno Hurault, Hazzan, Marc, Bordigoni, Pierre, Pall-Kondolff, Sandrine, Salmon, Alexandra, Clement, Laurence, Chevallier, Patrice, Le Gouill, Steven, Gastinne, Thomas, Delaunay, Jacques, Ayari, Sameh, Guillaume, Thierry, Mohty, Mohammed, Moreau, Philippe, Robin, Marie-Aude, Le Houerou, Claire, Giral, Magali, Papuchon, Emmanuelle, Pattier, Sabine, Treilhaud, Michèle, Camus, Christophe, Etienne, Isabelle, Moulin, Bruno, Caillard-Ohlmann, Sophie, Lioure, Bruno, Cojean, Nadine, Lutz, Patrick, Uettwiller, Françoise, Entz-Werle, Natacha, Laplace, Annegret, Buchler, Matthias, Lebranchu, Yvon, Barbet, Christelle, Fourchy, Dominique, Stern, Marc, Grenet, Dominique, Delahousse, Michel, Karras, Alexandre, Saliba, Faouzi, Ichai, Philippe, Dhedin, Nathalie, Vernant, Jean-Paul, Uzunov, Madalina, Barrou, Benoît, Glotz, Denis, Peraldi, Marie-Noëlle, Langner, Nathalie, and Ribaud, Patricia

Published
2010
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16. Ebola 2014-2015 and SARS-CoV-2 2019-2020

Author

Mansuy, Jean-Michel, Martin-Blondel, Guillaume, Mengelle, Catherine, Izopet, Jacques, Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and PINIER, CHRISTINE

Subjects
SARS-CoV-2, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Ebola, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, virus diseases
Abstract

International audience; A 42-year-old woman was admitted to A & E at the Toulouse University Hospital for asthenia, pyrexia and frontal headache on May 6, 2020. She was diagnosed as suffering from a classical meningitis syndrome. This patient had been infected with HIV-1in 2013 and had since been effectively treated. Her HIV-1 viremia was undetectable when last checked in December 2019.She reached the end of her antiretroviral treatment on March 16, during the lockdown in France. As she was afraid of getting the SARS-CoV 2 virus outside her home, she stopped her treatment and did not renewed it until she was admitted to A & E

Published
2020

18. Chikungunya in the Caribbean as threat to Europe

Author

Mansuy, Jean-Michel, Grouteau, Erick, Mengelle, Catherine, Claudet, Isabelle, and Izopet, Jacques

Subjects
Chikungunya fever -- Distribution, Public health administration, Company distribution practices, Health
Abstract

To the Editor: The first evidence of chikungunya virus in the Western Hemisphere was its detection in December 2013 in the French West Indies (1). One month later, the virus [...]

Published
2014

31. Zoster after Cyclophosphamide for Systemic Lupus Erythematosus or Vasculitis: Incidence, Risk Factors, and Effect of Antiviral Prophylaxis

Author

Garnier, Camille, primary, Ribes, David, additional, Chauveau, Dominique, additional, Huart, Antoine, additional, Pugnet, Grégory, additional, Adoue, Daniel, additional, Prevot, Grégoire, additional, Alric, Laurent, additional, Delobel, Pierre, additional, Derumeaux, Hélène, additional, Mengelle, Catherine, additional, Sailler, Laurent, additional, and Moulis, Guillaume, additional

Published
2018
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35. Prognostic impact of viral reactivations in acute myeloid leukemia patients undergoing allogeneic stem cell transplantation in first complete response

Author

Guenounou, Sarah, primary, Borel, Cécile, additional, Bérard, Emilie, additional, Yon, Edwige, additional, Fort, Marylise, additional, Mengelle, Catherine, additional, Bertoli, Sarah, additional, Sarry, Audrey, additional, Tavitian, Suzanne, additional, Huguet, Françoise, additional, Attal, Michel, additional, Récher, Christian, additional, and Huynh, Anne, additional

Published
2016
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37. Zika virus in semen and spermatozoa

Author

Mansuy, Jean Michel, primary, Suberbielle, Elsa, additional, Chapuy-Regaud, Sabine, additional, Mengelle, Catherine, additional, Bujan, Louis, additional, Marchou, Bruno, additional, Delobel, Pierre, additional, Gonzalez-Dunia, Daniel, additional, Malnou, Cécile E, additional, Izopet, Jacques, additional, and Martin-Blondel, Guillaume, additional

Published
2016
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38. Toscana virus meningitis in Southwestern France

Author

Chagneau, Camille, primary, Mansuy, Jean-Michel, additional, Barthe, Carole, additional, Oliveira-Mendes, Kévin, additional, Izopet, Jacques, additional, Charrel, Rémi, additional, and Mengelle, Catherine, additional

Published
2016
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42. Prophylaxis versus pre-emptive treatment for prevention of cytomegalovirus infection in CMV-seropositive orthotopic liver-transplant recipients

Author

Mengelle, Catherine, Rostaing, Lionel, Weclawiak, Hugo, Rossignol, Cécile, Kamar, Nassim, Izopet, Jacques, Laboratoire de Virologie [Toulouse], CHU Toulouse [Toulouse], Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation, CHU Toulouse [Toulouse]-Hôpital de Rangueil, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Herrada, Anthony, Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Graft Rejection, Male, Time Factors, Cytomegalovirus, Antiviral Agents, Chemoprevention, Young Adult, CMV-DNAemia, CMV-infection prevention strategies, Humans, Valganciclovir, Viremia, Ganciclovir, Aged, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Incidence, virus diseases, Middle Aged, Viral Load, Survival Analysis, Transplant Recipients, Liver Transplantation, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cytomegalovirus Infections, DNA, Viral, Female, Immunosuppressive Agents
Abstract

International audience; This study compared the pre-emptive and the prophylactic strategies used to prevent cytomegalovirus (CMV) infection and disease in CMV-seropositive orthotopic liver-transplant recipients and searched for associated predictive factors. Seventy-three orthotopic liver-transplant recipients who had received a transplant before November 2005 were given ganciclovir IV pre-emptively (group I) and 56 recipients who had received a transplant after November 2005 were given prophylactic valganciclovir for 3 months (group II). Demographic and biochemical parameters did not statistically vary between the groups at baseline. Monitoring of CMV DNAemia was similar in both groups. Forty-two (57.5%) patients presented with CMV infection in group I and 18 (32.1%) in group II (P

Published
2014

46. Pilot conversion trial from mycophenolic acid to everolimus in ABO-incompatible kidney-transplant recipients with BK viruria and/or viremia

Author

Belliere, Julie, primary, Kamar, Nassim, additional, Mengelle, Catherine, additional, Allal, Asma, additional, Sallusto, Federico, additional, Doumerc, Nicolas, additional, Game, Xavier, additional, Congy-Jolivet, Nicolas, additional, Esposito, Laure, additional, Debiol, Benedicte, additional, and Rostaing, Lionel, additional

Published
2015
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47. JC VIRUS DNA IN THE PERIPHERAL BLOOD OF RENAL TRANSPLANT PATIENTS: A ONE-YEAR PROSPECTIVE FOLLOW-UP IN FRANCE

Author

Mengelle, Catherine, Kamar, Nassim, MANSUY, Jean Michel, Sandres-Sauné, Karine, Legrand-Abravanel, Florence, Miédougé, Marcel, Rostaing, Lionel, Izopet, Jacques, Virology, University Hospital, Nephrology, Dialysis, and Multi-Organ Transplantation, CHU Rangueil, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
viruses, Medicine
Abstract

International audience; There is little information on JC virus (JCV) infection in renal transplant patients. A long-term prospective follow-up study was conducted to assess the incidence of JCV DNA in the blood of 103 adult renal transplant patients enrolled prospectively between 1 January and 31 December, 2006. Patients were monitored until April, 2008. JCV DNA was quantified by a real-time polymerase chain reaction in whole blood samples collected regularly for at least one year post-transplant. JCV was detected in seven patients (6.8 %) (31/1487 whole blood samples) at a median time of 139 days post-transplant. The median JC virus load of the first positive DNA blood sample was 3.4 log10 copies/mL (1.9 - 5.7 log10 copies/mL). Induction therapy were either anti-CD25 monoclonal antibodies (n=5) or antithymocyte globulins (n=2). Post-transplant immunosuppressive treatment included steroids with tacrolimus/mycophenolate mofetil (MMF) (n=2), or ciclosporin/MMF (n=1), or belatacept/MMF (n=4). Two patients were also treated with rituximab. All seven patients infected with JCV had other viral infections(s): BK virus (3), Epstein-Barr virus (2), Cytomegalovirus (1) or both BK virus and Epstein-Barr virus (1). Three patients had BKV-associated nephropathy and decoy cells shedding. JCV infection was not associated with acute rejection episodes or nephropathy, regardless of the virus load. No patient developed progressive multifocal leukoencephalopathy during follow-up. Thus the incidence of JCV infection in renal transplant patients was low and not associated with any specific clinical manifestations. JCV replication must still be diagnosed and differentiated from BK virus infection because of its non-aggressive course.

Published
2010

49. Monitoring human cytomegalovirus (HCMV) in HCMV-seropositive orthotopic liver-transplant recipients by means of quantitative real-time polymerase chain reaction

Author

Mengelle, Catherine, Legrand-Abravanel, Florence, Kamar, Nassim, Alain, Sophie, Basse, Grégoire, Pillet, Adèle, Lavayssière, Laurence, Suc, Bertrand, Izopet, Jacques, Rostaing, Lionel, Université de Limoges (UNILIM), Biologie moléculaire et cellulaire des microorganismes (EA3175), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Bucek, Ingrid

Subjects
Graft Rejection, MESH: Cytomegalovirus, MESH: Liver Transplantation, Time Factors, Cytomegalovirus, MESH: Graft Rejection, MESH: Creatinine, Polymerase Chain Reaction, Postoperative Complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Postoperative Complications, Humans, Retrospective Studies, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Humans, MESH: Time Factors, virus diseases, MESH: Polymerase Chain Reaction, MESH: Retrospective Studies, MESH: Cytomegalovirus Infections, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Liver Transplantation, Creatinine, Cytomegalovirus Infections, Epidemiological Monitoring, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Environmental Monitoring, Environmental Monitoring
Abstract

International audience; OBJECTIVE: Human cytomegalovirus can be reactivated after orthotopic liver transplantation in patients who are seropositive for cytomegalovirus. Whether those cytomegalovirus-seropositive patients require immediate posttransplant (anti)- cytomegalovirus prophylactic therapy or preemptive treatment as opposed to deferred treatment remains controversial. The aims of our study were to evaluate the relevance of cytomegalovirus monitoring with quantitative real-time polymerase chain reaction in whole blood and to analyze the factors that determine the treatment of the first episode of cytomegalovirus infection with intravenous ganciclovir in seropositive liver-transplant patients. PATIENTS AND METHODS: Forty-two cytomegalovirus-seropositive liver-transplant patients were assessed for cytomegalovirus DNAemia every 2 weeks until posttransplant day 90 and every 3 to 4 weeks until day 180. Biochemical and hematologic parameters were also prospectively monitored. RESULTS: Cytomegalovirus DNAemia was detected at least once in 27 patients (64%). Treatment was initiated in 12 patients (group 1) but not in 15 others (group 2). Median HCMV viral loads of the first positive and the highest DNAemia were statistically higher in group 1 than in group 2 (P = 0.01). Univariate analysis of DNAemia showed that alkaline phosphatase levels were significantly higher in group 1 than in group 2 (P = .0011) and that hemoglobin levels were significantly lower in group 1 than in group 2 (P = .0443). The results of multivariate analysis showed that the only factor that predicted the treatment of the first episode of HCMV DNAemia was a level of alkaline phosphatase greater than 150 IU/L [odds ratio, 20; range, 1.97-203.32; P = .01]. CONCLUSIONS: A combination of criteria, including viral-load kinetics, clinical factors, alkaline phosphatase levels (in particular), and the patient's immune condition, is required to efficiently monitor patients who are seropositive for cytomegalovirus after orthotopic liver transplantation.

Published
2006

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