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The presence of philosophy in the texts of Russian writers is quite natural. Many researchers in their works focus on the peculiarities of the formation of the creative path of authors from Russia, emphasizing the proximity and understanding of eternal problems, motives, and the meaning of life. A.A. Fet is one of such authors. The personality is attractive from the point of view of the analysis of creativity and the foundations of the ideological meaning of the formation of the creative path and the presence of a philosophical orientation in poetry. Whether this is a natural phenomenon in this particular author and in what exactly the world of the East manifests itself in Fet's work is to be found out in this article. A number of examples are collected here – excerpts from Fet's poetry as a sign of proof of the eastern philosophical orientation of the texts. Among the main tasks of the work is: analysis of the historical time in which Fet lived and worked from the position of the influence of philosophy on various spheres of life of Russian society; a detailed examination of the presence of Eastern philosophical motives in the work of the Russian writer using excerpts of texts.The main conclusions are made: there are philosophical motives in the poetic speech under consideration, in particular regarding the expression of conceptual worldview foundations: the presence of unity and integrity of all living things, the infinity of being, the divine origin of life, reflections on death, symbolic transmission of secret meaning and the urge to reflect on eternal categories in the reader of the work of A.A. Fet. The images show the presence of a deep level of semantics of the poetic text, translating the topics touched upon in poetry into the sacred plane. In our opinion, A.A. Fet's appeal to the motives of Eastern philosophy is due, on the one hand, to the depth and capacity of the author's own reflections due to his education and his own emerging writing style, and, on the other hand, to the popularity of symbolism, love and craving for philosophy in society.

Previous research on the link between CMTM6 expression dysregulation and tumor prognosis has been conflicting. In this study, the predictive effect of CMTM6 in malignant tumors was carefully evaluated using meta-analysis. The literature on the relationship between CMTM6 expression level and malignant tumor prognosis was searched in PubMed, Medline, Embase, and Web of Science databases until April 2021. Data were extracted from eligible studies and analyzed using RevMan5.3 and STATA 12.0 software. The HR and 95%CI were used to analyze the link between CMTM6 expression and OS. And the correlation between CMTM6 expression and clinicopathological features LNM and DM was evaluated by OR and 95%CI. Literature screening eventually included 12 studies involving 2133 patients with malignant tumors. High CMTM6 expression was found to be strongly linked with shorter OS and PFS in cancer patients (HR = 1.84,95%CI: 1.28-2.63, P = 0.001). High CMTM6 expression in gastrointestinal cancers was found to be significantly related with a shorter OS (HR = 2.21, 95%CI: 1.75-2.78, P 0.001). PFS was observed to be related with high CMTM6 expression in cancer patients (HR = 2.029, 95%CI: 1.263-3.26, P = 0.003). Meanwhile, high CMTM6 expression was highly associated to LNM (OR = 1.64, 95%CI: 1.02-2.64, P = 0.043) and DM (OR = 4.07, 95%CI: 1.73-9.56, P = 0.001). However, the expression level of CMTM6 in non-gastrointestinal tumors was not statistically significant with OS or LNM. High CMTM6 expression in gastrointestinal cancers is linked to shorter OS and PFS, as well as LNM and DM, suggesting that high CMTM6 expression could be employed as a new diagnosis for poor prognosis and metastasis.

As individuals interested in clinical and medical research, we have observed an increasing need for methodological research skills by grassroots, not-for-profit, and for-profit organizations. However, research methodology skills and resources are often available only in post-secondary institutions (i.e., graduate programs and communities of practice). Undergraduate learners often face the challenge of accessing post-graduate research training. This guest editorial de-scribes the Research Empowerment & Development (RED) Fellowship, a six-week collaborative program that aims to build capacity in individuals to conduct, develop, and implement high-quality research. This editorial will discuss the rationale for this program, the program plan, program design process, target audience, program timeline, future goals, and contact information.

RATIONALE Accurate measurement of trace compounds in blood samples is important in clinical diagnosis and life science. Ambient ionization mass spectrometry, however, suffers from the matrix effect when dealing with complex samples such as blood. Therefore, it is important to reduce the matrix effects in blood samples. METHODS A low-cost and disposable Teflon tube was used as a platform to precipitate the protein in blood. The analytes are extracted into organic solvent, and the precipitated protein can be adsorbed by the chromatography paper inserted. Therefore, the Teflon tube after precipitation can be directly subjected to paper spray ionization mass spectrometry, achieving one-step analysis of blood. RESULTS High sensitivity and satisfactory stability were achieved for pharmaceuticals, acids, and endogenic metabolites in blood. The absolute signal intensities of characteristic product ions of the tested analytes were 8-20 times higher after protein precipitation than those obtained using paper spray. Detection limits and quantitative performance were evaluated for three drugs: carbamazepine, metformin, and tioconazole. In addition, the limits of detection and quantitation were improved 9-14- and 8-12-fold, respectively. CONCLUSIONS Protein precipitation coupled to paper spray with a tube and then to mass spectrometry was successfully achieved and applied in the one-step analysis of trace compounds in blood samples. The experimental results showed that this method was sensitive, stable, convenient, and economic for the direct analysis of blood.