Search

Your search keyword '"Mengling Yuan"' showing total 3 results
Start Over Author "Mengling Yuan"
3 results on '"Mengling Yuan"'

1. AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma

Author

Diwei Zheng, Weihai Liu, Wenlin Xie, Guanyu Huang, Qiwei Jiang, Yang Yang, Jiarong Huang, Zihao Xing, Mengling Yuan, Mengning Wei, Yao Li, Junqiang Yin, Jingnan Shen, and Zhi Shi

Subjects
Medicine, Biology (General), QH301-705.5
Abstract

Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Although activator of HSP90 ATPase activity 1 (AHA1) is reported to be a potential oncogene, its role in osteosarcoma progression remains largely unclear. Since metabolism reprogramming is involved in tumorigenesis and cancer metastasis, the relationship between AHA1 and cancer metabolism is unknown. In this study, we found that AHA1 is significantly overexpressed in osteosarcoma and related to the prognosis of osteosarcoma patients. AHA1 promotes the growth and metastasis of osteosarcoma both in vitro and in vivo. Mechanistically, AHA1 upregulates the metabolic activity to meet cellular bioenergetic needs in osteosarcoma. Notably, we identified that isocitrate dehydrogenase 1 (IDH1) is a novel client protein of Hsp90-AHA1. Furthermore, the IDH1 protein level was positively correlated with AHA1 in osteosarcoma. And IDH1 overexpression could partially reverse the effect of AHA1 knockdown on cell growth and migration of osteosarcoma. Moreover, high IDH1 level was also associated with poor prognosis of osteosarcoma patients. This study demonstrates that AHA1 positively regulates IDH1 and metabolic activity to promote osteosarcoma growth and metastasis, which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.

Published
2021
Full Text
View/download PDF

2. De novo transcriptome assembly for pericarp in Litchi chinesis Sonn. cv. Feizixiao and identification of differentially expressed genes in response to Mg Foliar Nutrient

Author

Shijun Li, Kaibing Zhou, Zhan Wang, and Mengling Yuan

Subjects
0301 basic medicine, De novo transcriptome assembly, Horticulture, Biology, Crop, Transcriptome, 03 medical and health sciences, 030104 developmental biology, Differentially expressed genes, Nutrient, Flavonoid biosynthesis, Gene expression, Botany, Gene
Abstract

Litchi is a subtropical fruit crop indigenous to South China. The pericarp of the variety Feizixiao does not display the overall bright red hue at harvest, i.e. “stay-green” phenomenon. This phenomenon could be solved by Mg foliar nutrient sprays. This study will attempt to discover the molecular mechanisms in litchi pericarp under Mg treatment by sequencing and de novo assembling the transcriptome. We assembled 50809 unigenes with an average length of 735.47 bp; approximately 55.11% (28005) of unigenes could be annotated using the NCBI (National Center of Biotechnology Information) non-redundant (nr) database. Five DGE libraries have been generated from litchi pericarp, and approximately 20 million filtered reads per library were generated. A total of 1226 unigenes were found to be differently expressed in the pair-wise comparisons between any two periods of Mg-treated, and genes encoding key enzymes involved in flavonoid biosynthesis, anthocyanin biosynthesis, ABA signal pathway were identified.

Published
2017

3. The study of the inclining-load method of the landslide model based on numerical calculation

Author

Jian Wu, Mengling Yuan, and Huabin Yan

Subjects
Stress field, Stress (mechanics), Engineering, Centrifuge, Tilt (optics), Coincident, business.industry, Fracture (geology), Landslide, Strength reduction, Structural engineering, business
Abstract

In landslide model test, it is more commonly used the inclining-load method to realize imitating the destruction state of the slope. This paper will analysis the fracture morphology of the inclining-load method and the strength reduction method based on numerical calculation. Then it can be seen that the destruction state of the inclining-load method and the strength reduction method is coincident. Because of the constraints caused by the similar material, traditional model test is hard to make the stress level of the model be coincident with the prototype. This paper propose the relative stress field to study the similarity of the stress field of the inclining-load method and the centrifuge model test. The results show that the relative stress state of the model is similar with the centrifuge model test when the tilt angle is less than 9°.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results