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3 results on '"Mengpan Wang"'

1. Identification of key genes and pathways in duck fatty liver syndrome using gene set enrichment analysis

Author

Xue Yang, Hao Lin, Mengpan Wang, Xuebing Huang, Kaichao Li, Weiguang Xia, Yanan Zhang, Shuang Wang, Wei Chen, and Chuntian Zheng

Subjects
fatty liver syndrome, RNA-seq, GSEA, self-constructed gene set, duck, Animal culture, SF1-1100
Abstract

ABSTRACT: High-laying ducks are often fed high-energy, nutritious feeds to maintain high productivity, which predisposes them to lipid metabolism disorders and the development of fatty liver syndrome (FLS), which seriously affects production performance and has a substantial economic impact on the poultry industry. Therefore, it is necessary to elucidate the mechanisms underlying the development of fatty liver syndrome. In this study, seven Shan Partridge ducks, each with fatty liver syndrome and normal laying ducks, were selected, and Hematoxylin Eosin staining (HE staining), Masson staining, and transcriptome sequencing were performed on liver tissue. In addition to exploring key genes and pathways using conventional analysis methods, we constructed the first Kyoto Encyclopedia of Genes and Genomes (KEGG) database-based predefined gene set containing 12,764 pathways and 16,836 genes and further performed gene set enrichment analysis (GSEA) on the liver transcriptome data. Finally, key nodes and biological processes were identified via the protein-protein interaction (PPI) network. The results showed that the liver in the FL group exhibited steatosis and fibrosis, and a total of 3,663 genes with upregulated expression versus 2,296 downregulated genes were screened by conventional analysis. GSEA analysis and PPI network analysis revealed that the liver in the FL group exhibited disruption of the mitochondrial electron transport chain, leading to decreased oxidative phosphorylation and the secretion of excessive proinflammatory factors amid the continuous accumulation of lipids. Under continuous chronic inflammation, cell cycle arrest triggers apoptosis, while fibrosis becomes more severe, and procarcinogenic genes are activated, leading to the continuous development and deterioration of the liver. In conclusion, the predefined gene set constructed in this study can be used for GSEA, and the identified hub genes provide useful reference data and a solid foundation for the study of the genetic regulatory mechanism of fatty liver syndrome in ducks.

Published
2024
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2. Carboxymethyl cellulose supported ionic liquid as a heterogeneous catalyst for the cycloaddition of CO2 to cyclic carbonate

Author

Chen Chen, Mengpan Wang, Zhenshan Hou, Kun Li, Mingming Yuan, Xiuge Zhao, Xie Yinzheng, and Xiaohui Wu

Subjects
010405 organic chemistry, Chemistry, Process Chemistry and Technology, 010402 general chemistry, Heterogeneous catalysis, 01 natural sciences, Chloride, Catalysis, Cycloaddition, 0104 chemical sciences, Carboxymethyl cellulose, chemistry.chemical_compound, Polymer chemistry, Ionic liquid, medicine, Organic chemistry, Lewis acids and bases, Selectivity, medicine.drug
Abstract

The non-toxic biologic material carboxymethyl cellulose (CMC) supported imidazolium-based ionic liquids (ILs), coupling with a series of Lewis acids has been prepared and used as heterogeneous catalysts for the cycloaddition of CO2 to cyclic carbonate. The as-synthesized catalysts have been characterized by FT-IR, XRD, TGA, SEM etc. Especially, the protonated CMC (HCMC) supporting both the hydroxyl group functionalized IL (1-hydroxypropyl-3-n-butylimidazolium chloride, HBimCl) and NbCl5 (HBimCl-NbCl5/HCMC) exhibited the best catalytic performance. It was indicated that HBimCl on HBimCl-NbCl5/HCMC catalyst was highly leaching-resistant even if it was immobilized through non-covalent interaction. The IL and Lewis acid exhibited strong synergistic effects for the cycloaddition reaction. Additionally, the HBimCl-NbCl5/HCMC catalyst exhibited a high activity and excellent selectivity for a wide scope of substrates under optimum conditions and also it was further extended to application in the continuous fixed-bed flow reactor and showed an excellent catalytic stability. No loss of catalytic activity was observed even after 120 h on stream.

Published
2016

3. A pH-Responsive Soluble-Polymer-Based Homogeneous Ruthenium Catalyst for Highly Efficient Asymmetric Transfer Hydrogenation (ATH)

Author

Xiaohui Wu, Mengpan Wang, Qifeng Dong, Chen Chen, Xie Yinzheng, Zhenshan Hou, Wenbo Ma, and Mingming Yuan

Subjects
chemistry.chemical_classification, Aqueous solution, 010405 organic chemistry, Inorganic chemistry, Noyori asymmetric hydrogenation, chemistry.chemical_element, Homogeneous catalysis, General Chemistry, Polymer, 010402 general chemistry, Transfer hydrogenation, 01 natural sciences, 0104 chemical sciences, Catalysis, Ruthenium, chemistry, Chemical engineering, Copolymer
Abstract

A pH-responsive polymer has been synthesized successfully by means of copolymerization of dimethyl aminopropyl acrylamide (DMAPA) and N-p-styrenesulfonyl-1,2-diphenylethylenediamine (V-TsDPEN). The pH-responsive polymer coordination ruthenium complex was thus prepared and employed as an efficient catalyst for the asymmetric transfer hydrogenation (ATH) of various ketones. The polymer catalyst exhibited an attractive pH-induced phase-separable behavior in water: it could be dissolved in water when the pH of the solution was lower than 6.5 at the beginning of the reaction, but was precipitated completely from water when the pH of the solution was above 8.5 after reaction. Additionally, the catalysts were highly efficient for the ATH of a wide range of substrates that bore different functional groups and could be recycled easily from the aqueous solution by means of self-separation. They could be recycled eight times without significant changes in catalytic activity and enantioselectivity.

Published
2016

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