16 results on '"Menk, Ralf H."'
Search Results
2. Edge-illumination spectral phase-contrast tomography
- Author
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Brombal, Luca, Arfelli, Fulvia, Brun, Francesco, Di Trapani, Vittorio, Endrizzi, Marco, Menk, Ralf H., Perion, Paola, Rigon, Luigi, Saccomano, Mara, Tromba, Giuliana, Olivo, Alessandro, Brombal, Luca, Arfelli, Fulvia, Brun, Francesco, Di Trapani, Vittorio, Endrizzi, Marco, Menk, Ralf H., Perion, Paola, Rigon, Luigi, Saccomano, Mara, Tromba, Giuliana, and Olivo, Alessandro
- Abstract
Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 mu m) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 mu m voxel size) on an iodine-perfused ex vivo murine model is reported. The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high-Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional x-ray tubes.
- Published
- 2024
- Full Text
- View/download PDF
3. A high dynamic Micro Strips Ionization Chamber featuring Embedded Multi DSP Processing
- Author
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Voltolina, Francesco, Menk, Ralf H., and Carrato, Sergio
- Subjects
Physics - Instrumentation and Detectors - Abstract
An X-ray detector will be presented that is the combination of a segmented ionization chamber featuring one-dimensional spatial resolution integrated with an intelligent ADC front-end, multi DSP processing and embedded PC platform. This detector is optimized to fan beam geometry with an active area of 192 mm (horizontal) and a vertical acceptance of 6 mm. Spatial resolution is obtained by subdividing the anode into readout strips, having pitch of 150 micrometers, which are connected to 20 custom made integrating VLSI chips (each capable of 64-channel read-out and multiplexing) and read out by 14 bits 10 MHz ADCs and fast adaptive PGAs into DSP boards. A bandwidth reaching 3.2Gbit/s of raw data, generated from the real time sampling of the 1280 micro strips, is cascaded processed with FPGA and DSP to allow data compression resulting in several days of uninterrupted acquisition capability. Fast acquisition rates reaching 10 kHz are allowed due to the MicroCAT structure utilized not only as a shielding grid in ionization chamber mode but also to provide active electron amplification in the gas., Comment: 5 pages, 7 figures, distilled by AFPL Ghostscript 7.04
- Published
- 2010
- Full Text
- View/download PDF
4. Analysis of Intracellular Magnesium and Mineral Depositions during Osteogenic Commitment of 3D Cultured Saos2 Cells
- Author
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Stefano Iotti, Sandro Donato, Marilisa Cortesi, Joseph Lovecchio, Giovanna Picone, Giovanna Farruggia, Marco Lombardo, Menk Ralf H, Emanuele Giordano, Emil Malucelli, Alessandra Gianoncelli, Lucia Mancini, Concettina Cappadone, Alice Pasini, Picone G., Cappadone C., Pasini A., Lovecchio J., Cortesi M., Farruggia G., Lombardo M., Gianoncelli A., Mancini L., Menk Ralf H., Donato S., Giordano E., Malucelli E., and Iotti S.
- Subjects
0301 basic medicine ,Cellular differentiation ,0206 medical engineering ,Cell Culture Techniques ,chemistry.chemical_element ,02 engineering and technology ,Catalysis ,Article ,osteogenesis ,Inorganic Chemistry ,lcsh:Chemistry ,03 medical and health sciences ,Cell Line, Tumor ,osteosarcoma ,medicine ,Humans ,Magnesium ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Mineral ,Chemistry ,Osteogenesi ,Organic Chemistry ,Cell model ,Cell Differentiation ,Phosphorus ,General Medicine ,medicine.disease ,biomineralization ,020601 biomedical engineering ,Computer Science Applications ,Cell biology ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Osteosarcoma ,Bone forming ,osteoblastic differentiation ,Intracellular ,Biomineralization - Abstract
In this study, we explore the behaviour of intracellular magnesium during bone phenotype modulation in a 3D cell model built to mimic osteogenesis. In addition, we measured the amount of magnesium in the mineral depositions generated during osteogenic induction. A two-fold increase of intracellular magnesium content was found, both at three and seven days from the induction of differentiation. By X-ray microscopy, we characterized the morphology and chemical composition of the mineral depositions secreted by 3D cultured differentiated cells finding a marked co-localization of Mg with P at seven days of differentiation. This is the first experimental evidence on the presence of Mg in the mineral depositions generated during biomineralization, suggesting that Mg incorporation occurs during the bone forming process. In conclusion, this study on the one hand attests to an evident involvement of Mg in the process of cell differentiation, and, on the other hand, indicates that its multifaceted role needs further investigation.
- Published
- 2020
5. Fast beam monitor diamond-based devices for VUV and X-ray synchrotron radiation applications
- Author
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Di Fraia, Michele, De Sio, Antonio, Antonelli, Matias, Nesti, Renzo, Panella, Dario, Menk, Ralf H., Cautero, Giuseppe, Coreno, Marcello, Catone, Daniele, Zema, Nicola, Callegari, Carlo, and Pace, Emanuele
- Subjects
Nuclear and High Energy Physics ,Photon ,Materials science ,030303 biophysics ,Synchrotron radiation ,CVD diamond ,engineering.material ,Radiation ,01 natural sciences ,Synchrotron ,law.invention ,010309 optics ,03 medical and health sciences ,Optics ,law ,0103 physical sciences ,Instrumentation ,0303 health sciences ,business.industry ,Diamond ,Detectors ,Laser ,Beamline ,Beam monitor ,Picosecond ,engineering ,Physics::Accelerator Physics ,business - Abstract
The improved performance of third-generation light sources and the advent of next-generation synchrotron radiation facilities require the use of extremely precise monitoring of the main photon-beam parameters, such as position, absolute and relative intensity, and temporal structure. These parameters, and associated real-time feedbacks, are fundamental at the beamline control level and at the machine control level, to improve the stability of the photon beams and to provide bunch-to-bunch quantitative information. Fast response time, high radiation hardness and visible–blind response are main features of photon-beam monitors for VUV and X-ray synchrotron radiation beamlines; hence diamond-based detectors are outstanding candidates. Here, results are presented of an extensive measurement campaign aiming at optimizing the capabilities of diamond detectors to discern time structures below the 100 ps timescale. A custom-built device has been fabricated and tested at the Italian Synchrotron Radiation Laboratory Elettra in Trieste. The results obtained show that diamond is an excellent material for ultra-fast photon pulses with picosecond time resolution; finally the possibilities for application at free-electron laser sources are discussed.
- Published
- 2019
- Full Text
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6. Trace-element XAFS sensitivity: a stress test for a new XRF multi-detector
- Author
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Carlomagno, Ilaria, primary, Antonelli, Matias, additional, Aquilanti, Giuliana, additional, Bellutti, Pierluigi, additional, Bertuccio, Giuseppe, additional, Borghi, Giacomo, additional, Cautero, Giuseppe, additional, Cirrincione, Daniela, additional, de Giudici, Giovanni, additional, Ficorella, Francesco, additional, Gandola, Massimo, additional, Giuressi, Dario, additional, Medas, Daniela, additional, Mele, Filippo, additional, Menk, Ralf H., additional, Olivi, Luca, additional, Orzan, Giulio, additional, Picciotto, Antonino, additional, Podda, Francesca, additional, Rachevski, Alexandre, additional, Rashevskaya, Irina, additional, Stebel, Luigi, additional, Vacchi, Andrea, additional, Zampa, Gianluigi, additional, Zampa, Nicola, additional, Zorzi, Nicola, additional, and Meneghini, Carlo, additional
- Published
- 2021
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7. Characterization of the Percival detector with soft X-rays
- Author
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Marras, Alessandro, Correa, Jonathan, Lange, Sabine, Vardanyan, Vahagn, Gerhardt, Tim, Kuhn, Manuela, Krivan, Frantisek, Shevyakov, Igor, Zimmer, Manfred, Hoesch, Moritz, Bagschik, Kai, Scholz, Frank, Guerrini, Nicola, Marsh, Ben, Sedgwick, Iain, Cautero, Giuseppe, Giuressi, Dario, Iztok, Gregori, Menk, Ralf H., Scarcia, Martin, Stebel, Luigi, Nicholls, Tim, Nichols, William, Pedersen, Ulrik K., Shikhaliev, Polad, Tartoni, Nicola, Hyun, HyoJung, Kim, SeongHan, Kim, KyungSook, Rah, SeungYu, Dawiec, Arkadiusz, Orsini, Fabienne, Pinaroli, Giovanni, Greer, Alan, Aplin, Steve, Jewell, April D., Jones, Todd J., Nikzad, Shouleh, Hoenk, Michael E., Okrent, Frank, Graafsma, Heinz, Wunderer, Cornelia B., Marras, Alessandro, Correa, Jonathan, Lange, Sabine, Vardanyan, Vahagn, Gerhardt, Tim, Kuhn, Manuela, Krivan, Frantisek, Shevyakov, Igor, Zimmer, Manfred, Hoesch, Moritz, Bagschik, Kai, Scholz, Frank, Guerrini, Nicola, Marsh, Ben, Sedgwick, Iain, Cautero, Giuseppe, Giuressi, Dario, Iztok, Gregori, Menk, Ralf H., Scarcia, Martin, Stebel, Luigi, Nicholls, Tim, Nichols, William, Pedersen, Ulrik K., Shikhaliev, Polad, Tartoni, Nicola, Hyun, HyoJung, Kim, SeongHan, Kim, KyungSook, Rah, SeungYu, Dawiec, Arkadiusz, Orsini, Fabienne, Pinaroli, Giovanni, Greer, Alan, Aplin, Steve, Jewell, April D., Jones, Todd J., Nikzad, Shouleh, Hoenk, Michael E., Okrent, Frank, Graafsma, Heinz, and Wunderer, Cornelia B.
- Abstract
In this paper the back-side-illuminated Percival 2-Megapixel (P2M) detector is presented, along with its characterization by means of optical and X-ray photons. For the first time, the response of the system to soft X-rays (250 eV to 1 keV) is presented. The main performance parameters of the first detector are measured, assessing the capabilities in terms of noise, dynamic range and single-photon discrimination capability. Present limitations and coming improvements are discussed.
- Published
- 2021
- Full Text
- View/download PDF
8. Characterization of the Percival detector with soft X-rays
- Author
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Marras, Alessandro, primary, Correa, Jonathan, additional, Lange, Sabine, additional, Vardanyan, Vahagn, additional, Gerhardt, Tim, additional, Kuhn, Manuela, additional, Krivan, Frantisek, additional, Shevyakov, Igor, additional, Zimmer, Manfred, additional, Hoesch, Moritz, additional, Bagschik, Kai, additional, Scholz, Frank, additional, Guerrini, Nicola, additional, Marsh, Ben, additional, Sedgwick, Iain, additional, Cautero, Giuseppe, additional, Giuressi, Dario, additional, Iztok, Gregori, additional, Menk, Ralf H., additional, Scarcia, Martin, additional, Stebel, Luigi, additional, Nicholls, Tim, additional, Nichols, William, additional, Pedersen, Ulrik K., additional, Shikhaliev, Polad, additional, Tartoni, Nicola, additional, Hyun, HyoJung, additional, Kim, SeongHan, additional, Kim, KyungSook, additional, Rah, SeungYu, additional, Dawiec, Arkadiusz, additional, Orsini, Fabienne, additional, Pinaroli, Giovanni, additional, Greer, Alan, additional, Aplin, Steve, additional, Jewell, April D., additional, Jones, Todd J., additional, Nikzad, Shouleh, additional, Hoenk, Michael E., additional, Okrent, Frank, additional, Graafsma, Heinz, additional, and Wunderer, Cornelia B., additional
- Published
- 2021
- Full Text
- View/download PDF
9. An Improved Random Path Length Algorithm for p-i-n and Staircase Avalanche Photodiodes
- Author
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Pilotto, Alessandro, primary, Palestri, Pierpaolo, additional, Selmi, Luca, additional, Antonelli, Matias, additional, Arfelli, Fulvia, additional, Biasiol, Giorgio, additional, Cautero, Giuseppe, additional, Driussi, Francesco, additional, Menk, Ralf H., additional, Nichetti, Camilla, additional, and Steinhartova, Tereza, additional
- Published
- 2018
- Full Text
- View/download PDF
10. Multipurpose modular experimental station for the DiProI beamline of Fermi@Elettra free electron laser
- Author
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Pedersoli, Emanuele, Capotondi, Flavio, Cocco, Daniele, Zangrando, Marco, Kaulich, Burkhard, Menk, Ralf H., Locatelli, Andrea, Mentes, Tevfik O., Spezzani, Carlo, Sandrin, Gilio, Bacescu, Daniel M., Kiskinova, Maya, Bajt, Sasa, Barthelmess, Miriam, Barty, Anton, Schulz, Joachim, Gumprecht, Lars, Chapman, Henry N., Nelson, A. J., Frank, Matthias, Pivovaroff, Michael J., Woods, Bruce W., Bogan, Michael J., Hajdu, Janos, Pedersoli, Emanuele, Capotondi, Flavio, Cocco, Daniele, Zangrando, Marco, Kaulich, Burkhard, Menk, Ralf H., Locatelli, Andrea, Mentes, Tevfik O., Spezzani, Carlo, Sandrin, Gilio, Bacescu, Daniel M., Kiskinova, Maya, Bajt, Sasa, Barthelmess, Miriam, Barty, Anton, Schulz, Joachim, Gumprecht, Lars, Chapman, Henry N., Nelson, A. J., Frank, Matthias, Pivovaroff, Michael J., Woods, Bruce W., Bogan, Michael J., and Hajdu, Janos
- Abstract
We present a compact modular apparatus with a flexible design that will be operated at the DiProI beamline of the Fermi@Elettra free electron laser (FEL) for performing static and time-resolved coherent diffraction imaging experiments, taking advantage of the full coherence and variable polarization of the short seeded FEL pulses. The apparatus has been assembled and the potential of the experimental setup is demonstrated by commissioning tests with coherent synchrotron radiation. This multipurpose experimental station will be open to general users after installation at the Fermi@Elettra free electron laser in 2011.
- Published
- 2011
- Full Text
- View/download PDF
11. Multipurpose modular experimental station for the DiProI beamline of Fermi@Elettra free electron laser
- Author
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Pedersoli, Emanuele, primary, Capotondi, Flavio, additional, Cocco, Daniele, additional, Zangrando, Marco, additional, Kaulich, Burkhard, additional, Menk, Ralf H., additional, Locatelli, Andrea, additional, Mentes, Tevfik O., additional, Spezzani, Carlo, additional, Sandrin, Gilio, additional, Bacescu, Daniel M., additional, Kiskinova, Maya, additional, Bajt, Saša, additional, Barthelmess, Miriam, additional, Barty, Anton, additional, Schulz, Joachim, additional, Gumprecht, Lars, additional, Chapman, Henry N., additional, Nelson, A. J., additional, Frank, Matthias, additional, Pivovaroff, Michael J., additional, Woods, Bruce W., additional, Bogan, Michael J., additional, and Hajdu, Janos, additional
- Published
- 2011
- Full Text
- View/download PDF
12. CLESSIDRA: Focusing Hard X-Rays Efficiently with Arrays Composed of Small Prisms
- Author
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Jark, Werner, primary, Perennes, Frederic, additional, Matteucci, Marco, additional, Mancini, Lucia, additional, Menk, Ralf H., additional, and Rigon, Luigi, additional
- Published
- 2007
- Full Text
- View/download PDF
13. Quantitative and qualitative studies on high-contrast X-ray radiography with an asymmetrical crystal set-up at Elettra
- Author
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Hönnicke, Marcelo Gonçalves, primary, Rigon, Luigi, additional, Menk, Ralf-H., additional, and Cusatis, Cesar, additional
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- 2005
- Full Text
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14. Biological X-ray diffraction measurements with a novel two-dimensional gaseous pixel detector
- Author
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Sarvestani, Amir, primary, Amenitsch, Heinz, additional, Bernstorff, Sigrid, additional, Besch, Hans-Jürgen, additional, Menk, Ralf H., additional, Orthen, Andre, additional, Pavel, Nikolaj, additional, Rappolt, Michael, additional, Sauer, Norbert, additional, and Walenta, Albert H., additional
- Published
- 1999
- Full Text
- View/download PDF
15. Development and validation of a simulation tool for K-edge Subtraction imaging with polychromatic spectra and X-ray photon counting detectors
- Author
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Vittorio Di Trapani, Piernicola Oliva, Fulvia Arfelli, Luca Brombal, Ralf H. Menk, Pasquale Delogu, Di Trapani, Vittorio, Oliva, Piernicola, Arfelli, Fulvia, Brombal, Luca, Menk, Ralf H., and Delogu, Pasquale
- Subjects
Nuclear and High Energy Physics ,K-edge imaging ,Simulator ,XPCD ,Instrumentation - Abstract
In K-Edge Subtraction (KES) imaging the K-edge of a high-Z contrast medium is used to generate a differential image in which, in principle, only the contrast agent is visible, suppressing any background. A possible approach to KES imaging is by using polychromatic spectra and spectral X-ray photon counting detectors (XPCD). In this paper we present the development and validation of a simulation tool for KES imaging with spectral XPCD. In addition an analytical formula, based on theoretical considerations, is derived, that further supports the simulation results. The validation is made on experimental data obtained with an X-ray tube, an iodine-based contrast agent, and Pixirad-1/Pixie-III detection system.
- Published
- 2023
16. Edge-illumination spectral phase-contrast tomography.
- Author
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Brombal L, Arfelli F, Brun F, Di Trapani V, Endrizzi M, Menk RH, Perion P, Rigon L, Saccomano M, Tromba G, and Olivo A
- Subjects
- Mice, Animals, Lighting, Photons, Tellurium, Tomography, X-Ray Computed methods, Phantoms, Imaging, Cadmium Compounds, Quantum Dots, Iodine
- Abstract
Following the rapid, but independent, diffusion of x-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 μ m) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 μ m voxel size) on an iodine-perfused ex vivo murine model is reported. The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high- Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional x-ray tubes., (Creative Commons Attribution license.)
- Published
- 2024
- Full Text
- View/download PDF
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