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1. E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, Marlow, Rebecca, van de Ven, Marieke, Brough, Rachel, Pemberton, Helen N, Frankum, Jessica, Song, Feifei, Rafiq, Rumana, Konde, Asha, Krastev, Dragomir B, Menon, Malini, Campbell, James, Gulati, Aditi, Kumar, Rahul, Pettitt, Stephen J, Gurden, Mark D, Cardenosa, Marta Llorca, Chong, Irene, Gazinska, Patrycja, Wallberg, Fredrik, Sawyer, Elinor J, Martin, Lesley-Ann, Dowsett, Mitch, Linardopoulos, Spiros, Natrajan, Rachael, Ryan, Colm J, Derksen, Patrick WB, Jonkers, Jos, Tutt, Andrew NJ, Ashworth, Alan, and Lord, Christopher J

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Cancer, Brain Disorders, Breast Cancer, Good Health and Well Being, Anilides, Animals, Antigens, CD, Antineoplastic Agents, Breast Neoplasms, Cadherins, Cell Line, Tumor, Crizotinib, Female, Humans, Mice, Mutation, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Quinolines, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered CDH1 mutations, we identified synthetic lethality between E-cadherin deficiency and inhibition of the tyrosine kinase ROS1. Data from large-scale genetic screens in molecularly diverse breast tumor cell lines established that the E-cadherin/ROS1 synthetic lethality was not only robust in the face of considerable molecular heterogeneity but was also elicited with clinical ROS1 inhibitors, including foretinib and crizotinib. ROS1 inhibitors induced mitotic abnormalities and multinucleation in E-cadherin-defective cells, phenotypes associated with a defect in cytokinesis and aberrant p120 catenin phosphorylation and localization. In vivo, ROS1 inhibitors produced profound antitumor effects in multiple models of E-cadherin-defective breast cancer. These data therefore provide the preclinical rationale for assessing ROS1 inhibitors, such as the licensed drug crizotinib, in appropriately stratified patients.Significance: E-cadherin defects are common in breast cancer but are currently not targeted with a precision medicine approach. Our preclinical data indicate that licensed ROS1 inhibitors, including crizotinib, should be repurposed to target E-cadherin-defective breast cancers, thus providing the rationale for the assessment of these agents in molecularly stratified phase II clinical trials. Cancer Discov; 8(4); 498-515. ©2018 AACR.This article is highlighted in the In This Issue feature, p. 371.

Published
2018

2. Data from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, primary, van de Ven, Marieke, primary, Brough, Rachel, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Song, Feifei, primary, Rafiq, Rumana, primary, Konde, Asha, primary, Krastev, Dragomir B., primary, Menon, Malini, primary, Campbell, James, primary, Gulati, Aditi, primary, Kumar, Rahul, primary, Pettitt, Stephen J., primary, Gurden, Mark D., primary, Cardenosa, Marta Llorca, primary, Chong, Irene, primary, Gazinska, Patrycja, primary, Wallberg, Fredrik, primary, Sawyer, Elinor J., primary, Martin, Lesley-Ann, primary, Dowsett, Mitch, primary, Linardopoulos, Spiros, primary, Natrajan, Rachael, primary, Ryan, Colm J., primary, Derksen, Patrick W.B., primary, Jonkers, Jos, primary, Tutt, Andrew N.J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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3. Supplementary Table 2 from Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

Author

Dréan, Amy, primary, Williamson, Chris T., primary, Brough, Rachel, primary, Brandsma, Inger, primary, Menon, Malini, primary, Konde, Asha, primary, Garcia-Murillas, Isaac, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Rafiq, Rumana, primary, Badham, Nicholas, primary, Campbell, James, primary, Gulati, Aditi, primary, Turner, Nicholas C., primary, Pettitt, Stephen J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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4. Data from Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

Author

Dréan, Amy, primary, Williamson, Chris T., primary, Brough, Rachel, primary, Brandsma, Inger, primary, Menon, Malini, primary, Konde, Asha, primary, Garcia-Murillas, Isaac, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Rafiq, Rumana, primary, Badham, Nicholas, primary, Campbell, James, primary, Gulati, Aditi, primary, Turner, Nicholas C., primary, Pettitt, Stephen J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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5. Supplementary Video S1 from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, primary, van de Ven, Marieke, primary, Brough, Rachel, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Song, Feifei, primary, Rafiq, Rumana, primary, Konde, Asha, primary, Krastev, Dragomir B., primary, Menon, Malini, primary, Campbell, James, primary, Gulati, Aditi, primary, Kumar, Rahul, primary, Pettitt, Stephen J., primary, Gurden, Mark D., primary, Cardenosa, Marta Llorca, primary, Chong, Irene, primary, Gazinska, Patrycja, primary, Wallberg, Fredrik, primary, Sawyer, Elinor J., primary, Martin, Lesley-Ann, primary, Dowsett, Mitch, primary, Linardopoulos, Spiros, primary, Natrajan, Rachael, primary, Ryan, Colm J., primary, Derksen, Patrick W.B., primary, Jonkers, Jos, primary, Tutt, Andrew N.J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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6. Supplementary Figures 1-10 from Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

Author

Dréan, Amy, primary, Williamson, Chris T., primary, Brough, Rachel, primary, Brandsma, Inger, primary, Menon, Malini, primary, Konde, Asha, primary, Garcia-Murillas, Isaac, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Rafiq, Rumana, primary, Badham, Nicholas, primary, Campbell, James, primary, Gulati, Aditi, primary, Turner, Nicholas C., primary, Pettitt, Stephen J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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7. Supplementary Table 1 from Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

Author

Dréan, Amy, primary, Williamson, Chris T., primary, Brough, Rachel, primary, Brandsma, Inger, primary, Menon, Malini, primary, Konde, Asha, primary, Garcia-Murillas, Isaac, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Rafiq, Rumana, primary, Badham, Nicholas, primary, Campbell, James, primary, Gulati, Aditi, primary, Turner, Nicholas C., primary, Pettitt, Stephen J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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8. Supplementary Information from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, primary, van de Ven, Marieke, primary, Brough, Rachel, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Song, Feifei, primary, Rafiq, Rumana, primary, Konde, Asha, primary, Krastev, Dragomir B., primary, Menon, Malini, primary, Campbell, James, primary, Gulati, Aditi, primary, Kumar, Rahul, primary, Pettitt, Stephen J., primary, Gurden, Mark D., primary, Cardenosa, Marta Llorca, primary, Chong, Irene, primary, Gazinska, Patrycja, primary, Wallberg, Fredrik, primary, Sawyer, Elinor J., primary, Martin, Lesley-Ann, primary, Dowsett, Mitch, primary, Linardopoulos, Spiros, primary, Natrajan, Rachael, primary, Ryan, Colm J., primary, Derksen, Patrick W.B., primary, Jonkers, Jos, primary, Tutt, Andrew N.J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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9. Supplementary Figures S1-S20 from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, primary, van de Ven, Marieke, primary, Brough, Rachel, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Song, Feifei, primary, Rafiq, Rumana, primary, Konde, Asha, primary, Krastev, Dragomir B., primary, Menon, Malini, primary, Campbell, James, primary, Gulati, Aditi, primary, Kumar, Rahul, primary, Pettitt, Stephen J., primary, Gurden, Mark D., primary, Cardenosa, Marta Llorca, primary, Chong, Irene, primary, Gazinska, Patrycja, primary, Wallberg, Fredrik, primary, Sawyer, Elinor J., primary, Martin, Lesley-Ann, primary, Dowsett, Mitch, primary, Linardopoulos, Spiros, primary, Natrajan, Rachael, primary, Ryan, Colm J., primary, Derksen, Patrick W.B., primary, Jonkers, Jos, primary, Tutt, Andrew N.J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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10. Supplementary Tables S1-S11 from E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, primary, van de Ven, Marieke, primary, Brough, Rachel, primary, Pemberton, Helen N., primary, Frankum, Jessica, primary, Song, Feifei, primary, Rafiq, Rumana, primary, Konde, Asha, primary, Krastev, Dragomir B., primary, Menon, Malini, primary, Campbell, James, primary, Gulati, Aditi, primary, Kumar, Rahul, primary, Pettitt, Stephen J., primary, Gurden, Mark D., primary, Cardenosa, Marta Llorca, primary, Chong, Irene, primary, Gazinska, Patrycja, primary, Wallberg, Fredrik, primary, Sawyer, Elinor J., primary, Martin, Lesley-Ann, primary, Dowsett, Mitch, primary, Linardopoulos, Spiros, primary, Natrajan, Rachael, primary, Ryan, Colm J., primary, Derksen, Patrick W.B., primary, Jonkers, Jos, primary, Tutt, Andrew N.J., primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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11. A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors

Author

Menon, Malini, Elliott, Richard, Bowers, Leandra, Balan, Nicolae, Rafiq, Rumana, Costa-Cabral, Sara, Munkonge, Felix, Trinidade, Ines, Porter, Roderick, Campbell, Andrew D., Johnson, Emma R., Esdar, Christina, Buchstaller, Hans-Peter, Leuthner, Birgitta, Rohdich, Felix, Schneider, Richard, Sansom, Owen, Wienke, Dirk, Ashworth, Alan, and Lord, Christopher J.

Published
2019
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13. Supplementary Table 1 from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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14. Supplementary Figures from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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15. Data from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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16. Supplementary Table 2 from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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17. Supplementary Table 5 from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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18. Supplementary Table 4 from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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19. Supplementary Table 3 from ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., primary, Frankum, Jessica, primary, Konde, Asha, primary, Williamson, Chris T., primary, Krastev, Dragomir B., primary, Pemberton, Helen N., primary, Campbell, James, primary, Gulati, Aditi, primary, Elliott, Richard, primary, Menon, Malini, primary, Selfe, Joanna L., primary, Brough, Rachel, primary, Pettitt, Stephen J., primary, Niedzwiedz, Wojciech, primary, van der Graaf, Winette T.A., primary, Shipley, Janet, primary, Ashworth, Alan, primary, and Lord, Christopher J., primary

Published
2023
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20. Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

Author

Holme, Harriett, Gulati, Aditi, Brough, Rachel, Fleuren, Emmy D. G., Bajrami, Ilirjana, Campbell, James, Chong, Irene Y., Costa-Cabral, Sara, Elliott, Richard, Fenton, Tim, Frankum, Jessica, Jones, Samuel E., Menon, Malini, Miller, Rowan, Pemberton, Helen N., Postel-Vinay, Sophie, Rafiq, Rumana, Selfe, Joanna L., von Kriegsheim, Alex, Munoz, Amaya Garcia, Rodriguez, Javier, Shipley, Janet, van der Graaf, Winette T. A., Williamson, Chris T., Ryan, Colm J., Pettitt, Stephen, Ashworth, Alan, Strauss, Sandra J., and Lord, Christopher J.

Published
2018
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21. Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

Author

Holme, Harriett, Gulati, Aditi, Brough, Rachel, Fleuren, Emmy D. G., Bajrami, Ilirjana, Campbell, James, Chong, Irene Y., Costa-Cabral, Sara, Elliott, Richard, Fenton, Tim, Frankum, Jessica, Jones, Samuel E., Menon, Malini, Miller, Rowan, Pemberton, Helen N., Postel-Vinay, Sophie, Rafiq, Rumana, Selfe, Joanna L., von Kriegsheim, Alex, Munoz, Amaya Garcia, Rodriguez, Javier, Shipley, Janet, van der Graaf, Winette T. A., Williamson, Chris T., Ryan, Colm J., Pettitt, Stephen, Ashworth, Alan, Strauss, Sandra J., and Lord, Christopher J.

Published
2018
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28. Abstract 2986: E-cadherin/ROS1 inhibitor synthetic lethality in breast cancer

Author

Bajrami, Ilirjana, primary, Marlow, Rebecca, additional, Ven, Marieke van de, additional, Brough, Rachel, additional, Pemberton, Helen N., additional, Frankum, Jessica, additional, Song, Fei Fei, additional, Rafiq, Rumana, additional, Konde, Asha, additional, Menon, Malini, additional, Campbell, James, additional, Gulati, Aditi, additional, Kumar, Rahul, additional, Pettitt, Stephen J., additional, Gurden, Mark D., additional, Cardenosa, Marta Llorca, additional, Chong, Irene, additional, Gazinska, Patrycja, additional, Wallberg, Fredrik, additional, Sawyer, Elinor J., additional, Martin, Lesley-Ann, additional, Dowsett, Mitch, additional, Linardopoulos, Spiros, additional, Ryan, Colm, additional, Derksen, Patrick W., additional, Jonkers, Jos, additional, Tutt, Andrew N.J., additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2018
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29. PTAP motif duplication in the p6 Gag protein confers a replication advantage on HIV-1 subtype C

Author

Sharma, Shilpee, primary, Arunachalam, Prabhu S., additional, Menon, Malini, additional, Ragupathy, Viswanath, additional, Satya, Ravi Vijaya, additional, Jebaraj, Joshua, additional, Aralaguppe, Shambhu Ganeshappa, additional, Rao, Chaitra, additional, Pal, Sreshtha, additional, Saravanan, Shanmugam, additional, Murugavel, Kailapuri G., additional, Balakrishnan, Pachamuthu, additional, Solomon, Suniti, additional, Hewlett, Indira, additional, and Ranga, Udaykumar, additional

Published
2018
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30. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Author

Pettitt, Stephen J., primary, Krastev, Dragomir B., additional, Brandsma, Inger, additional, Dréan, Amy, additional, Song, Feifei, additional, Aleksandrov, Radoslav, additional, Harrell, Maria I., additional, Menon, Malini, additional, Brough, Rachel, additional, Campbell, James, additional, Frankum, Jessica, additional, Ranes, Michael, additional, Pemberton, Helen N., additional, Rafiq, Rumana, additional, Fenwick, Kerry, additional, Swain, Amanda, additional, Guettler, Sebastian, additional, Lee, Jung-Min, additional, Swisher, Elizabeth M., additional, Stoynov, Stoyno, additional, Yusa, Kosuke, additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2018
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31. ATR Is a Therapeutic Target in Synovial Sarcoma

Author

Jones, Samuel E., primary, Fleuren, Emmy D.G., additional, Frankum, Jessica, additional, Konde, Asha, additional, Williamson, Chris T., additional, Krastev, Dragomir B., additional, Pemberton, Helen N., additional, Campbell, James, additional, Gulati, Aditi, additional, Elliott, Richard, additional, Menon, Malini, additional, Selfe, Joanna L., additional, Brough, Rachel, additional, Pettitt, Stephen J., additional, Niedzwiedz, Wojciech, additional, van der Graaf, Winette T.A., additional, Shipley, Janet, additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2017
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32. Genome-wide and high-density CRISPR-Cas9 screens identify point mutations inPARP1causing PARP inhibitor resistance

Author

Pettitt, Stephen J., primary, Krastev, Dragomir B., additional, Brandsma, Inger, additional, Drean, Amy, additional, Song, Feifei, additional, Aleksandrov, Radoslav, additional, Harrell, Maria I., additional, Menon, Malini, additional, Brough, Rachel, additional, Campbell, James, additional, Frankum, Jessica, additional, Ranes, Michael, additional, Pemberton, Helen N., additional, Rafiq, Rumana, additional, Fenwick, Kerry, additional, Swain, Amanda, additional, Guettler, Sebastian, additional, Lee, Jung-Min, additional, Swisher, Elizabeth M., additional, Stoynov, Stoyno, additional, Yusa, Kosuke, additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2017
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33. Modeling Therapy Resistance in BRCA1/2-Mutant Cancers

Author

Dréan, Amy, primary, Williamson, Chris T., additional, Brough, Rachel, additional, Brandsma, Inger, additional, Menon, Malini, additional, Konde, Asha, additional, Garcia-Murillas, Isaac, additional, Pemberton, Helen N., additional, Frankum, Jessica, additional, Rafiq, Rumana, additional, Badham, Nicholas, additional, Campbell, James, additional, Gulati, Aditi, additional, Turner, Nicholas C., additional, Pettitt, Stephen J., additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2017
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37. Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors

Author

Elliott, Richard J. R., primary, Jarvis, Ashley, additional, Rajasekaran, Mohan B., additional, Menon, Malini, additional, Bowers, Leandra, additional, Boffey, Ray, additional, Bayford, Melanie, additional, Firth-Clark, Stuart, additional, Key, Rebekah, additional, Aqil, Rehan, additional, Kirton, Stewart B., additional, Niculescu-Duvaz, Dan, additional, Fish, Laura, additional, Lopes, Filipa, additional, McLeary, Robert, additional, Trindade, Ines, additional, Vendrell, Elisenda, additional, Munkonge, Felix, additional, Porter, Rod, additional, Perrior, Trevor, additional, Springer, Caroline, additional, Oliver, Antony W., additional, Pearl, Laurence H., additional, Ashworth, Alan, additional, and Lord, Christopher J., additional

Published
2015
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41. Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

Author

Jarvis, Ashley, primary, Allerston, Charles K., additional, Jia, Haiyan, additional, Herzog, Birger, additional, Garza-Garcia, Acely, additional, Winfield, Natalie, additional, Ellard, Katie, additional, Aqil, Rehan, additional, Lynch, Rosemary, additional, Chapman, Chris, additional, Hartzoulakis, Basil, additional, Nally, James, additional, Stewart, Mark, additional, Cheng, Lili, additional, Menon, Malini, additional, Tickner, Michelle, additional, Djordjevic, Snezana, additional, Driscoll, Paul C., additional, Zachary, Ian, additional, and Selwood, David L., additional

Published
2010
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43. Influence of dietary fat on fecal mutagenicity in premenopausal women

Author

Nair, P. P., primary, Shami, Samina, additional, Sainz, Eduardo, additional, Menon, Malini, additional, Jerabek, Lois B., additional, Yvonne Jones, D., additional, Judd, Joseph T., additional, Campbell, William S., additional, Schiffman, Mark H., additional, Taylor, Philip R., additional, Schatzkin, Arthur, additional, Guidry, Catherine, additional, and Brown, Charles C., additional

Published
1990
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46. Dumfries plans full review of scheme

Author

Menon, Malini

Subjects
Company business planning, Banking, finance and accounting industries, Business
Abstract

The Dumfries & Galloway Council Pension Fund plans to overhaul its GBP335 million scheme following its termination of balanced manager Deutsche Asset Management, which handled approximately 70% of the fund. [...]

Published
2005

47. Icelandic funds plan merger

Author

Menon, Malini

Subjects
Company acquisition/merger, Company business planning, Banking, finance and accounting industries, Business
Abstract

Iceland's Southern and Western province pension funds--Lifeyrissjodur Sudurlands and Vesturlands Lifeyrissjodur, respectively--are in the final stage of negotiations for a possible merger. The move would enable economies of scale, both [...]

Published
2005

48. Swedish fund to tender GBP510m in equity

Author

Menon, Malini

Subjects
Banking, finance and accounting industries, Business
Abstract

Sweden's AP-Fonden 7 will put out to tender three equity mandates totaling SEK6.9 billion (GBP510 million) this December. The SEK51 billion (GBP3.7 billion) fund will tender Japanese, European and Pacific-basin [...]

Published
2005

49. Dutch scheme to invest in commodities

Author

Menon, Malini

Subjects
Company investment, Banking, finance and accounting industries, Business
Abstract

The Dutch industry-wide pension scheme Pensioenfonds Horeca & Catering will search for a commodities manager early next year following a review. The fund opted for a maiden allocation to the [...]

Published
2005

50. Swiss fund considers international real estate

Author

Menon, Malini

Subjects
Real property, Banking, finance and accounting industries, Business
Abstract

Pensionskasse des Bundes PUBLICA, the CHF31 billion (GBP13.6 billion) Swiss scheme for government employees, could search for international real estate managers to diversify its real estate portfolio and boost returns. [...]

Published
2005

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