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6. The JUMPFOOD study:additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper’s knee) in athletes—study protocol for a double-blind randomized controlled trial

Author

van Dam, L., Terink, R., Mensink, M., de Vos, R. J., Zwerver, J., van Dam, L., Terink, R., Mensink, M., de Vos, R. J., and Zwerver, J.

Abstract

Background: Patellar tendinopathy (PT) is a common problem in jumping athletes. Management can be challenging and treatment outcome is not always successful. In combination with tendon loading exercises, hydrolyzed collagen/vitamin C supplementation appears to have a promising effect on the recovery of tendinopathy. The aim of this study is to evaluate whether the use of oral supplementation of hydrolyzed collagen and vitamin C in combination with progressive tendon loading exercises (PTLE) is superior to PTLE and placebo on VISA-P score (which rates pain, function, sports participation) after 24 weeks for athletes with PT. Methods: The JUMPFOOD study is a double-blinded, two-armed randomized controlled trial, in which the effectiveness of oral supplementation of hydrolyzed collagen/vitamin C combined with PTLE compared to PTLE with placebo on pain and recovery of function in athletes with PT will be investigated. Seventy-six athletes aged 16–40 years, with symptoms of PT for at least 12 weeks, who play sports at least once a week will be included. All participants will receive education, advice with regard to load management and a PTLE program according to the Dutch guidelines for anterior knee pain. In addition, the intervention group will receive daily 10 g hydrolyzed collagen and 40 mg vitamin C supplementation for 24 weeks whereas the control group receives 10 g maltodextrin placebo supplementation. Measurements will take place at baseline and at 12 and 24 weeks’ follow-up. Primary outcome is the VISA-P score, which evaluates pain, function, and sports participation. For secondary outcome measures, data with regard to pain during functional tests, flexibility measurements, blood withdrawals, imaging characteristics of the tendon, and health questionnaires will be collected. During the follow-up period, participants will register sports participation, amount of training and tendon load, pain during sports, co-medication, and

Published
2023

9. A global experiment on motivating social distancing during the COVID-19 pandemic

Author

Legate, N, Nguyen, T, Weinstein, N, Moller, A, Legault, L, Vally, Z, Tajchman, Z, Zsido, A, Zrimsek, M, Chen, Z, Ziano, I, Gialitaki, Z, Ceary, C, Jang, Y, Lin, Y, Kunisato, Y, Yamada, Y, Xiao, Q, Jiang, X, Du, X, Yao, E, Ryan, W, Wilson, J, Cyrus-Lai, W, Jimenez-Leal, W, Law, W, Unanue, W, Collins, W, Richard, K, Vranka, M, Ankushev, V, Schei, V, Lerche, V, Kovic, V, Krizanic, V, Kadreva, V, Adoric, V, Tran, U, Yeung, S, Hassan, W, Houston, R, Machin, M, Lima, T, Ostermann, T, Frizzo, T, Sverdrup, T, House, T, Gill, T, Fedotov, M, Paltrow, T, Jernsather, T, Rahman, T, Machin, T, Koptjevskaja-Tamm, M, Hostler, T, Ishii, T, Szaszi, B, Adamus, S, Suter, L, von Bormann, S, Habib, S, Studzinska, A, Stojanovska, D, Janssen, S, Stieger, S, Schulenberg, S, Tatachari, S, Azouaghe, S, Sorokowski, P, Sorokowska, A, Song, X, Morbee, S, Lewis, S, Sinkolova, S, Grigoryev, D, Drexler, S, Daches, S, Levine, S, Geniole, S, Akter, S, Vracar, S, Massoni, S, Costa, S, Zorjan, S, Sarioguz, E, Izquierdo, S, Tshonda, S, Alves, S, Pontinen, S, Solas, S, Ordonez-Riano, S, Ocovaj, S, Onie, S, Lins, S, Biberauer, T, Coksan, S, Khumkom, S, Sacakli, A, Ruiz-Fernandez, S, Geiger, S, Modares, S, Walczak, R, Betlehem, R, Vilar, R, Carcamo, R, Ross, R, Mccarthy, R, Ballantyne, T, Westgate, E, Ryan, R, Gargurevich, R, Afhami, R, Ren, D, Monteiro, R, Reips, U, Reggev, N, Calin-Jagema, R, Pourafshari, R, Oliveira, R, Nedelcheva-Datsova, M, Rahal, R, Ribeiro, R, Radtke, T, Searston, R, Jai-ai, R, Habte, R, Zdybek, P, Chen, S, Wajanatinapart, P, Maturan, P, Perillo, J, Isager, P, Kacmar, P, Macapagal, P, Maniaci, M, Szwed, P, Hanel, P, Forbes, P, Arriaga, P, Paris, B, Parashar, N, Papachristopoulos, K, Correa, P, Kacha, O, Bernardo, M, Campos, O, Bravo, O, Galindo-Caballero, O, Ogbonnaya, C, Bialobrzeska, O, Kiselnikova, N, Simonovic, N, Cohen, N, Nock, N, Hernandez, A, Thogersen-Ntouma, C, Ntoumanis, N, Johannes, N, Albayrak-Aydemir, N, Say, N, Neubauer, A, Martin, N, Torunsky, N, van Antwerpen, N, Van Doren, N, Sunami, N, Rachev, N, Majeed, N, Schmidt, N, Nadif, K, Corral-Frias, N, Ouherrou, N, Abbas, N, Pantazi, M, Lucas, M, Vasilev, M, Ortiz, M, Butt, M, Kurfali, M, Kabir, M, Muda, R, Rivera, M, Sirota, M, Seehuus, M, Parzuchowski, M, Toro, M, Hricova, M, Maldonado, M, Rentzelas, P, Vansteenkiste, M, Metz, M, Marszalek, M, Karekla, M, Mioni, G, Bosma, M, Westerlund, M, Vdovic, M, Bialek, M, Silan, M, Anne, M, Misiak, M, Gugliandolo, M, Grinberg, M, Capizzi, M, Barria, M, Mensink, M, Harutyunyan, M, Khosla, M, Dunn, M, Korbmacher, M, Adamkovic, M, Ribeiro, M, Terskova, M, Hruska, M, Martoncik, M, Voracek, M, Cadek, M, Frias-Armenta, M, Kowal, M, Topor, M, Roczniewska, M, Oosterlinck, M, Kohlova, M, Paruzel-Czachura, M, Sabristov, M, Romanova, M, Papadatou-Pastou, M, Lund, M, Antoniadi, M, Magrin, M, Jones, M, Li, M, Manavalan, M, Muminov, A, Kossowska, M, Friedemann, M, Wielgus, M, van Hooff, M, Varella, M, Standage, M, Nicolotti, M, Colloff, M, Bradford, M, Vaughn, L, Eudave, L, Vieira, L, Lu, J, Pineda, L, Matos, L, Perez, L, Lazarevic, L, Jaremka, L, Smit, E, Kushnir, E, Ferguson, L, Anton-Boicuk, L, Coelho, G, Ahlgren, L, Liga, F, Levitan, C, Micheli, L, Gunton, L, Volz, L, Stojanovska, M, Boucher, L, Samojlenko, L, Delgado, L, Kaliska, L, Beatrix, L, Warmelink, L, Rojas-Berscia, L, Yu, K, Wylie, K, Wachowicz, J, Desai, K, Barzykowski, K, Kozma, L, Evans, K, Kirgizova, K, Agesin, B, Koehn, M, Wolfe, K, Korobova, T, Morris, K, Klevjer, K, van Schie, K, Vezirian, K, Damnjanovic, K, Thommesen, K, Schmidt, K, Filip, K, Staniaszek, K, Grzech, K, Hoyer, K, Moon, K, Khaobunmasiri, S, Rana, K, Janjic, K, Suchow, J, Kielinska, J, Vasquez, J, Chanal, J, Beitner, J, Vargas-Nieto, J, Roxas, J, Taber, J, Urriago-Rayo, J, Pavlacic, J, Benka, J, Bavolar, J, Soto, J, Olofsson, J, Vilsmeier, J, Messerschmidt, J, Czamanski-Cohen, J, Waterschoot, J, Moss, J, Boudesseul, J, Lee, J, Kamburidis, J, Joy-Gaba, J, Zickfeld, J, Miranda, J, Verharen, J, Hristova, E, Beshears, J, Djordjevic, J, Bosch, J, Valentova, J, Antfolk, J, Berkessel, J, Schrotter, J, Urban, J, Roer, J, Norton, J, Silva, J, Pickering, J, Vintr, J, Uttley, J, Kunst, J, Ndukaihe, I, Iyer, A, Vilares, I, Ivanov, A, Ropovik, I, Sula, I, Sarieva, I, Metin-Orta, I, Prusova, I, Pinto, I, Bozdoc, A, Almeida, I, Pit, I, Dalgar, I, Zakharov, I, Arinze, A, Ihaya, K, Stephen, I, Gjoneska, B, Brohmer, H, Flowe, H, Godbersen, H, Kocalar, H, Hedgebeth, M, Chuan-Peng, H, Sharifian, M, Manley, H, Akkas, H, Hajdu, N, Azab, H, Kaminski, G, Nilsonne, G, Anjum, G, Travaglino, G, Feldman, G, Pfuhl, G, Czarnek, G, Marcu, G, Hofer, G, Banik, G, Adetula, G, Bijlstra, G, Verbruggen, F, Kung, F, Martela, F, Foroni, F, Forest, J, Singer, G, Muchembled, F, Azevedo, F, Mosannenzadeh, F, Marinova, E, Strukelj, E, Etebari, Z, Bradshaw, E, Baskin, E, Garcia, E, Musser, E, van Steenkiste, I, Ahn, E, Quested, E, Pronizius, E, Jackson, E, Manunta, E, Agadullina, E, Sakan, D, Dursun, P, Dujols, O, Dubrov, D, Willis, M, Tumer, M, Beaudry, J, Popovic, D, Dunleavy, D, Djamai, I, Krupic, D, Herrera, D, Vega, D, Du, H, Mola, D, Chakarova, D, Davis, W, Holford, D, Lewis, D, Vaidis, D, Ozery, D, Ricaurte, D, Storage, D, Sousa, D, Alvarez, D, Boller, D, Dalla Rosa, A, Dimova, D, Marko, D, Moreau, D, Reeck, C, Correia, R, Whitt, C, Lamm, C, Solorzano, C, von Bastian, C, Sutherland, C, Overkott, C, Aberson, C, Wang, C, Niemiec, C, Karashiali, C, Noone, C, Chiu, F, Picciocchi, C, Brownlow, C, Karaarslan, C, Cellini, N, Esteban-Serna, C, Reyna, C, Ferreyra, C, Batres, C, Li, R, Grano, C, Carpentier, J, Tamnes, C, Fu, C, Ishkhanyan, B, Bylinina, L, Jaeger, B, Bundt, C, Allred, T, Vermote, B, Bokkour, A, Bogatyreva, N, Shi, J, Chopik, W, Antazo, B, Behzadnia, B, Becker, M, Bayyat, M, Cocco, B, Chou, W, Barkoukis, V, Hubena, B, Zuro, B, Aczel, B, Baklanova, E, Bai, H, Balci, B, Babincak, P, Soenens, B, Dixson, B, Mokady, A, Kappes, H, Atari, M, Szala, A, Szabelska, A, Aruta, J, Domurat, A, Arinze, N, Modena, A, Adiguzel, A, Monajem, A, El Arabi, K, Ozdogru, A, Rothbaum, A, Torres, A, Theodoropoulou, A, Skowronek, A, Jurkovic, A, Singh, A, Kassianos, A, Findor, A, Hartanto, A, Landry, A, Ferreira, A, Santos, A, De la Rosa-Gomez, A, Gourdon-Kanhukamwe, A, Luxon, A, Todsen, A, Karababa, A, Janak, A, Pilato, A, Bran, A, Tullett, A, Kuzminska, A, Krafnick, A, Urooj, A, Khaoudi, A, Ahmed, A, Groyecka-Bernard, A, Askelund, A, Adetula, A, Belaus, A, Charyate, A, Wichman, A, Stoyanova, A, Greenburgh, A, Thomas, A, Arvanitis, A, Forscher, P, Mallik, P, Coles, N, Miller, J, Moshontz, H, Urry, H, Ijzerman, H, Basnight-Brown, D, Ebersole, C, Chartier, C, Buchanan, E, Primbs, M, Nguyen, TV, Zsido, AN, Ceary, CD, Jang, YN, Lin, YJ, Xiao, QY, Jiang, XM, Du, XK, Ryan, WS, Wilson, JP, Collins, WM, Richard, KL, Kadreva, VH, Adoric, VC, Tran, US, Yeung, SK, Machin, MA, Lima, TJS, Sverdrup, TE, Hostler, TJ, von Bormann, SM, Janssen, SMJ, Schulenberg, SE, Drexler, SM, Levine, SL, Geniole, SN, Izquierdo, SM, Tshonda, SS, Alves, SG, Solas, SA, Ocovaj, SB, Geiger, SJ, Modares, SF, Walczak, RB, Carcamo, RA, Ross, RM, McCarthy, R, Westgate, EC, Ryan, RM, Ren, DN, Monteiro, RP, Reips, UD, Calin-Jagema, RJ, Rahal, RM, Ribeiro, RR, Chen, SC, Maturan, PLG, Perillo, JT, Isager, PM, Macapagal, PM, Maniaci, MR, Hanel, PHP, Forbes, PAG, Correa, PS, Bravo, ON, Galindo-Caballero, OJ, Ogbonnaya, CE, Nock, NL, Neubauer, AB, Martin, NI, Rachev, NR, Majeed, NM, Schmidt, ND, Corral-Frias, NS, Lucas, MY, Vasilev, MR, Ortiz, MV, Butt, MM, Rivera, MDT, Maldonado, MA, Metz, MA, Bosma, MJ, Silan, MA, Gugliandolo, MC, Barria, MFE, Kurfali, MA, Mensink, MC, Dunn, MR, Ribeiro, MFF, Kohlova, MB, Lund, ML, Magrin, ME, Jones, MV, Li, MY, Ortiz, MS, van Hooff, MLM, Varella, MAC, Colloff, MF, Vaughn, LA, Lu, JG, Pineda, LMS, Perez, LC, Lazarevic, LB, Jaremka, LM, Smit, ES, Ferguson, LJ, Coelho, GLD, Levitan, CA, Gunton, LA, Delgado, LGJ, Rojas-Berscia, LM, Agesin, BBE, Koehn, MA, Thommesen, KK, Suchow, JW, Vasquez, JEC, Vargas-Nieto, JC, Roxas, JCT, Pavlacic, JM, Soto, JA, Olofsson, JK, Vilsmeier, JK, Moss, JD, Lee, JM, Joy-Gaba, JA, Miranda, JF, Verharen, JPH, Beshears, JE, Djordjevic, JM, Valentova, JV, Berkessel, JB, Roer, JP, Norton, JO, Silva, JR, Pickering, JS, Kunst, JR, Ndukaihe, ILG, Bozdoc, AI, Almeida, IAT, Pit, IL, Arinze, AI, Stephen, ID, Kocalar, HE, Hedgebeth, MV, Travaglino, GA, Marcu, GM, Adetula, GA, Kung, FYH, Bradshaw, EL, Garcia, EOL, van Steenkiste, IMM, Ahn, ER, Jackson, EA, Beaudry, JL, Du, HF, Davis, WE, Holford, DL, Lewis, DMG, Vaidis, DC, Ozery, DH, Ricaurte, DZ, Alvarez, DS, Correia, RC, Whitt, CM, Solorzano, CS, von Bastian, CC, Sutherland, CAM, Aberson, CL, Wang, CH, Niemiec, CP, Li, RR, Tamnes, CK, Fu, CHY, Allred, TB, Vermote, BJ, Shi, JX, Chopik, WJ, Bayyat, MM, Chou, WL, Balci, BB, Dixson, BJW, Kappes, HB, Aruta, JJB, Arinze, NC, El Arabi, KA, Ozdogru, AA, Rothbaum, AO, Torres, AO, Jurkovic, AP, Kassianos, AP, Landry, AT, Santos, AC, Luxon, AM, Todsen, AL, Tullett, AM, Kuzminska, AO, Krafnick, AJ, Askelund, AD, Charyate, AC, Wichman, AL, Thomas, AG, Forscher, PS, Mallik, PR, Coles, NA, Miller, JK, Urry, HL, IJzerman, H, Basnight-Brown, DM, Ebersole, CR, Chartier, CR, Buchanan, EM, Primbs, MA, Legate, N, Nguyen, T, Weinstein, N, Moller, A, Legault, L, Vally, Z, Tajchman, Z, Zsido, A, Zrimsek, M, Chen, Z, Ziano, I, Gialitaki, Z, Ceary, C, Jang, Y, Lin, Y, Kunisato, Y, Yamada, Y, Xiao, Q, Jiang, X, Du, X, Yao, E, Ryan, W, Wilson, J, Cyrus-Lai, W, Jimenez-Leal, W, Law, W, Unanue, W, Collins, W, Richard, K, Vranka, M, Ankushev, V, Schei, V, Lerche, V, Kovic, V, Krizanic, V, Kadreva, V, Adoric, V, Tran, U, Yeung, S, Hassan, W, Houston, R, Machin, M, Lima, T, Ostermann, T, Frizzo, T, Sverdrup, T, House, T, Gill, T, Fedotov, M, Paltrow, T, Jernsather, T, Rahman, T, Machin, T, Koptjevskaja-Tamm, M, Hostler, T, Ishii, T, Szaszi, B, Adamus, S, Suter, L, von Bormann, S, Habib, S, Studzinska, A, Stojanovska, D, Janssen, S, Stieger, S, Schulenberg, S, Tatachari, S, Azouaghe, S, Sorokowski, P, Sorokowska, A, Song, X, Morbee, S, Lewis, S, Sinkolova, S, Grigoryev, D, Drexler, S, Daches, S, Levine, S, Geniole, S, Akter, S, Vracar, S, Massoni, S, Costa, S, Zorjan, S, Sarioguz, E, Izquierdo, S, Tshonda, S, Alves, S, Pontinen, S, Solas, S, Ordonez-Riano, S, Ocovaj, S, Onie, S, Lins, S, Biberauer, T, Coksan, S, Khumkom, S, Sacakli, A, Ruiz-Fernandez, S, Geiger, S, Modares, S, Walczak, R, Betlehem, R, Vilar, R, Carcamo, R, Ross, R, Mccarthy, R, Ballantyne, T, Westgate, E, Ryan, R, Gargurevich, R, Afhami, R, Ren, D, Monteiro, R, Reips, U, Reggev, N, Calin-Jagema, R, Pourafshari, R, Oliveira, R, Nedelcheva-Datsova, M, Rahal, R, Ribeiro, R, Radtke, T, Searston, R, Jai-ai, R, Habte, R, Zdybek, P, Chen, S, Wajanatinapart, P, Maturan, P, Perillo, J, Isager, P, Kacmar, P, Macapagal, P, Maniaci, M, Szwed, P, Hanel, P, Forbes, P, Arriaga, P, Paris, B, Parashar, N, Papachristopoulos, K, Correa, P, Kacha, O, Bernardo, M, Campos, O, Bravo, O, Galindo-Caballero, O, Ogbonnaya, C, Bialobrzeska, O, Kiselnikova, N, Simonovic, N, Cohen, N, Nock, N, Hernandez, A, Thogersen-Ntouma, C, Ntoumanis, N, Johannes, N, Albayrak-Aydemir, N, Say, N, Neubauer, A, Martin, N, Torunsky, N, van Antwerpen, N, Van Doren, N, Sunami, N, Rachev, N, Majeed, N, Schmidt, N, Nadif, K, Corral-Frias, N, Ouherrou, N, Abbas, N, Pantazi, M, Lucas, M, Vasilev, M, Ortiz, M, Butt, M, Kurfali, M, Kabir, M, Muda, R, Rivera, M, Sirota, M, Seehuus, M, Parzuchowski, M, Toro, M, Hricova, M, Maldonado, M, Rentzelas, P, Vansteenkiste, M, Metz, M, Marszalek, M, Karekla, M, Mioni, G, Bosma, M, Westerlund, M, Vdovic, M, Bialek, M, Silan, M, Anne, M, Misiak, M, Gugliandolo, M, Grinberg, M, Capizzi, M, Barria, M, Mensink, M, Harutyunyan, M, Khosla, M, Dunn, M, Korbmacher, M, Adamkovic, M, Ribeiro, M, Terskova, M, Hruska, M, Martoncik, M, Voracek, M, Cadek, M, Frias-Armenta, M, Kowal, M, Topor, M, Roczniewska, M, Oosterlinck, M, Kohlova, M, Paruzel-Czachura, M, Sabristov, M, Romanova, M, Papadatou-Pastou, M, Lund, M, Antoniadi, M, Magrin, M, Jones, M, Li, M, Manavalan, M, Muminov, A, Kossowska, M, Friedemann, M, Wielgus, M, van Hooff, M, Varella, M, Standage, M, Nicolotti, M, Colloff, M, Bradford, M, Vaughn, L, Eudave, L, Vieira, L, Lu, J, Pineda, L, Matos, L, Perez, L, Lazarevic, L, Jaremka, L, Smit, E, Kushnir, E, Ferguson, L, Anton-Boicuk, L, Coelho, G, Ahlgren, L, Liga, F, Levitan, C, Micheli, L, Gunton, L, Volz, L, Stojanovska, M, Boucher, L, Samojlenko, L, Delgado, L, Kaliska, L, Beatrix, L, Warmelink, L, Rojas-Berscia, L, Yu, K, Wylie, K, Wachowicz, J, Desai, K, Barzykowski, K, Kozma, L, Evans, K, Kirgizova, K, Agesin, B, Koehn, M, Wolfe, K, Korobova, T, Morris, K, Klevjer, K, van Schie, K, Vezirian, K, Damnjanovic, K, Thommesen, K, Schmidt, K, Filip, K, Staniaszek, K, Grzech, K, Hoyer, K, Moon, K, Khaobunmasiri, S, Rana, K, Janjic, K, Suchow, J, Kielinska, J, Vasquez, J, Chanal, J, Beitner, J, Vargas-Nieto, J, Roxas, J, Taber, J, Urriago-Rayo, J, Pavlacic, J, Benka, J, Bavolar, J, Soto, J, Olofsson, J, Vilsmeier, J, Messerschmidt, J, Czamanski-Cohen, J, Waterschoot, J, Moss, J, Boudesseul, J, Lee, J, Kamburidis, J, Joy-Gaba, J, Zickfeld, J, Miranda, J, Verharen, J, Hristova, E, Beshears, J, Djordjevic, J, Bosch, J, Valentova, J, Antfolk, J, Berkessel, J, Schrotter, J, Urban, J, Roer, J, Norton, J, Silva, J, Pickering, J, Vintr, J, Uttley, J, Kunst, J, Ndukaihe, I, Iyer, A, Vilares, I, Ivanov, A, Ropovik, I, Sula, I, Sarieva, I, Metin-Orta, I, Prusova, I, Pinto, I, Bozdoc, A, Almeida, I, Pit, I, Dalgar, I, Zakharov, I, Arinze, A, Ihaya, K, Stephen, I, Gjoneska, B, Brohmer, H, Flowe, H, Godbersen, H, Kocalar, H, Hedgebeth, M, Chuan-Peng, H, Sharifian, M, Manley, H, Akkas, H, Hajdu, N, Azab, H, Kaminski, G, Nilsonne, G, Anjum, G, Travaglino, G, Feldman, G, Pfuhl, G, Czarnek, G, Marcu, G, Hofer, G, Banik, G, Adetula, G, Bijlstra, G, Verbruggen, F, Kung, F, Martela, F, Foroni, F, Forest, J, Singer, G, Muchembled, F, Azevedo, F, Mosannenzadeh, F, Marinova, E, Strukelj, E, Etebari, Z, Bradshaw, E, Baskin, E, Garcia, E, Musser, E, van Steenkiste, I, Ahn, E, Quested, E, Pronizius, E, Jackson, E, Manunta, E, Agadullina, E, Sakan, D, Dursun, P, Dujols, O, Dubrov, D, Willis, M, Tumer, M, Beaudry, J, Popovic, D, Dunleavy, D, Djamai, I, Krupic, D, Herrera, D, Vega, D, Du, H, Mola, D, Chakarova, D, Davis, W, Holford, D, Lewis, D, Vaidis, D, Ozery, D, Ricaurte, D, Storage, D, Sousa, D, Alvarez, D, Boller, D, Dalla Rosa, A, Dimova, D, Marko, D, Moreau, D, Reeck, C, Correia, R, Whitt, C, Lamm, C, Solorzano, C, von Bastian, C, Sutherland, C, Overkott, C, Aberson, C, Wang, C, Niemiec, C, Karashiali, C, Noone, C, Chiu, F, Picciocchi, C, Brownlow, C, Karaarslan, C, Cellini, N, Esteban-Serna, C, Reyna, C, Ferreyra, C, Batres, C, Li, R, Grano, C, Carpentier, J, Tamnes, C, Fu, C, Ishkhanyan, B, Bylinina, L, Jaeger, B, Bundt, C, Allred, T, Vermote, B, Bokkour, A, Bogatyreva, N, Shi, J, Chopik, W, Antazo, B, Behzadnia, B, Becker, M, Bayyat, M, Cocco, B, Chou, W, Barkoukis, V, Hubena, B, Zuro, B, Aczel, B, Baklanova, E, Bai, H, Balci, B, Babincak, P, Soenens, B, Dixson, B, Mokady, A, Kappes, H, Atari, M, Szala, A, Szabelska, A, Aruta, J, Domurat, A, Arinze, N, Modena, A, Adiguzel, A, Monajem, A, El Arabi, K, Ozdogru, A, Rothbaum, A, Torres, A, Theodoropoulou, A, Skowronek, A, Jurkovic, A, Singh, A, Kassianos, A, Findor, A, Hartanto, A, Landry, A, Ferreira, A, Santos, A, De la Rosa-Gomez, A, Gourdon-Kanhukamwe, A, Luxon, A, Todsen, A, Karababa, A, Janak, A, Pilato, A, Bran, A, Tullett, A, Kuzminska, A, Krafnick, A, Urooj, A, Khaoudi, A, Ahmed, A, Groyecka-Bernard, A, Askelund, A, Adetula, A, Belaus, A, Charyate, A, Wichman, A, Stoyanova, A, Greenburgh, A, Thomas, A, Arvanitis, A, Forscher, P, Mallik, P, Coles, N, Miller, J, Moshontz, H, Urry, H, Ijzerman, H, Basnight-Brown, D, Ebersole, C, Chartier, C, Buchanan, E, Primbs, M, Nguyen, TV, Zsido, AN, Ceary, CD, Jang, YN, Lin, YJ, Xiao, QY, Jiang, XM, Du, XK, Ryan, WS, Wilson, JP, Collins, WM, Richard, KL, Kadreva, VH, Adoric, VC, Tran, US, Yeung, SK, Machin, MA, Lima, TJS, Sverdrup, TE, Hostler, TJ, von Bormann, SM, Janssen, SMJ, Schulenberg, SE, Drexler, SM, Levine, SL, Geniole, SN, Izquierdo, SM, Tshonda, SS, Alves, SG, Solas, SA, Ocovaj, SB, Geiger, SJ, Modares, SF, Walczak, RB, Carcamo, RA, Ross, RM, McCarthy, R, Westgate, EC, Ryan, RM, Ren, DN, Monteiro, RP, Reips, UD, Calin-Jagema, RJ, Rahal, RM, Ribeiro, RR, Chen, SC, Maturan, PLG, Perillo, JT, Isager, PM, Macapagal, PM, Maniaci, MR, Hanel, PHP, Forbes, PAG, Correa, PS, Bravo, ON, Galindo-Caballero, OJ, Ogbonnaya, CE, Nock, NL, Neubauer, AB, Martin, NI, Rachev, NR, Majeed, NM, Schmidt, ND, Corral-Frias, NS, Lucas, MY, Vasilev, MR, Ortiz, MV, Butt, MM, Rivera, MDT, Maldonado, MA, Metz, MA, Bosma, MJ, Silan, MA, Gugliandolo, MC, Barria, MFE, Kurfali, MA, Mensink, MC, Dunn, MR, Ribeiro, MFF, Kohlova, MB, Lund, ML, Magrin, ME, Jones, MV, Li, MY, Ortiz, MS, van Hooff, MLM, Varella, MAC, Colloff, MF, Vaughn, LA, Lu, JG, Pineda, LMS, Perez, LC, Lazarevic, LB, Jaremka, LM, Smit, ES, Ferguson, LJ, Coelho, GLD, Levitan, CA, Gunton, LA, Delgado, LGJ, Rojas-Berscia, LM, Agesin, BBE, Koehn, MA, Thommesen, KK, Suchow, JW, Vasquez, JEC, Vargas-Nieto, JC, Roxas, JCT, Pavlacic, JM, Soto, JA, Olofsson, JK, Vilsmeier, JK, Moss, JD, Lee, JM, Joy-Gaba, JA, Miranda, JF, Verharen, JPH, Beshears, JE, Djordjevic, JM, Valentova, JV, Berkessel, JB, Roer, JP, Norton, JO, Silva, JR, Pickering, JS, Kunst, JR, Ndukaihe, ILG, Bozdoc, AI, Almeida, IAT, Pit, IL, Arinze, AI, Stephen, ID, Kocalar, HE, Hedgebeth, MV, Travaglino, GA, Marcu, GM, Adetula, GA, Kung, FYH, Bradshaw, EL, Garcia, EOL, van Steenkiste, IMM, Ahn, ER, Jackson, EA, Beaudry, JL, Du, HF, Davis, WE, Holford, DL, Lewis, DMG, Vaidis, DC, Ozery, DH, Ricaurte, DZ, Alvarez, DS, Correia, RC, Whitt, CM, Solorzano, CS, von Bastian, CC, Sutherland, CAM, Aberson, CL, Wang, CH, Niemiec, CP, Li, RR, Tamnes, CK, Fu, CHY, Allred, TB, Vermote, BJ, Shi, JX, Chopik, WJ, Bayyat, MM, Chou, WL, Balci, BB, Dixson, BJW, Kappes, HB, Aruta, JJB, Arinze, NC, El Arabi, KA, Ozdogru, AA, Rothbaum, AO, Torres, AO, Jurkovic, AP, Kassianos, AP, Landry, AT, Santos, AC, Luxon, AM, Todsen, AL, Tullett, AM, Kuzminska, AO, Krafnick, AJ, Askelund, AD, Charyate, AC, Wichman, AL, Thomas, AG, Forscher, PS, Mallik, PR, Coles, NA, Miller, JK, Urry, HL, IJzerman, H, Basnight-Brown, DM, Ebersole, CR, Chartier, CR, Buchanan, EM, and Primbs, MA

Abstract

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This crosscountry, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one's core values) or behavioral intentions. Results supported hypothesized associations between people's existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges.

Published
2022

11. In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries

Author

Dorison, C. A., Lerner, J. S., Heller, B. H., Rothman, A. J., Kawachi, I. I., Wang, K., Rees, V. W., Gill, B. P., Gibbs, N., Ebersole, C. R., Vally, Z., Tajchman, Z., Zsido, A. N., Zrimsek, M., Chen, Z., Ziano, I., Gialitaki, Z., Ceary, C. D., Jang, Y., Lin, Y., Kunisato, Y., Yamada, Y., Xiao, Q., Jiang, X., Du, X., Yao, E., Ryan, W., Wilson, J. P., Cyrus-Lai, W., Jimenez-Leal, W., Law, W., Unanue, W., Collins, W. M., Richard, K. L., Vranka, M., Ankushev, V., Schei, V., DePaola, C., Lerche, V., Kovic, V., Križanić, V., Kadreva, V. H., Adoric, V. C., Tran, U. S., Yeung, S. K., Hassan, W., Houston, R., Machin, M. A., Lima, T. J. S., Ostermann, T., Frizzo, T., Sverdrup, T. E., House, T., Gill, T., Fedotov, M., Paltrow, T., Jernsäther, T., Rahman, T., Machin, T., Koptjevskaja-Tamm, M., Hostler, T. J., Ishii, T., Szaszi, B., Adamus, S., Suter, L., von Bormann, S. M., Habib, S., Studzinska, A., Stojanovska, D., Janssen, S. M. J., Stieger, S., Schulenberg, S. E., Tatachari, S., Azouaghe, S., Sorokowski, P., Sorokowska, A., Song, X., Morbée, S., Lewis, S. C., Sinkolova, S., Grigoryev, D., Drexler, S. M., Daches, S., Levine, S. L., Geniole, S. N., Akter, S., Vračar, S., Massoni, S., Costa, S., Zorjan, S., Sarıoğuz, E., Morales Izquierdo, S., Tshonda, S. S., Alves, S. G., Pöntinen, S., Álvarez Solas, S., Ordoñez-Riaño, S., Batić Očovaj, S., Onie, S., Lins, S., Biberauer, T., Çoksan, S., Khumkom, S., Sacakli, A., Ruiz-Fernández, S., Geiger, S. J., FatahModares, S., Walczak, R. B., Betlehem, R., Vilar, R., Doekemeijer, R., Cárcamo, R., Ross, R. M., McCarthy, R., Ballantyne, T., Westgate, E. C., Gargurevich, R., Afhami, R., Ren, D., Monteiro, R. P., Reips, U-D., Reggev, N., Calin-Jageman, R. J., Pourafshari, R., London, R., Oliveira, R., Nedelcheva-Datsova, M., Rahal, R-M., Ribeiro, R. R., Radtke, T., Searston, R., Jai-ai, R., Habte, R., Zdybek, P., Chen, S-C., Wajanatinapart, P., Maturan, P. L. G., Perillo, J. T., Isager, P. M., Kačmár, P., Macapagal, P. M., Maniaci, M. R., Szwed, P., Hanel, P. H. P., Forbes, P. A. G., Arriaga, P., Paris, B., Parashar, N., Papachristopoulos, K., Sebastián-Correa, P., Kácha, O., Bernardo, M., Campos, O., Niño Bravo, O., Galindo-Caballero, O. J., Ogbonnaya, C. E., Bialobrzeska, O., Kiselnikova, N., Simonovic, N., Cohen, N., Nock, N. L., Hernandez, A., Thogersen-Ntoumani, C., Ntoumanis, N., Johannes, N., Albayrak-Aydemir, N., Say, N., Neubauer, A. B., Martin, N. I., Torunsky, N., van Antwerpen, N., Van Doren, N., Sunami, N., Rachev, N. R., Majeed, N. M., Schmidt, N-D., Nadif, K., Corral-Frías, N. S., Ouherrou, N., Abbas, N., Pantazi, M., Lucas, M. Y., Vasilev, Martin R., Ortiz, M. V., Butt, M. M., Kurfali, M., Kabir, M., Muda, R., Tejada Rivera, M. C., Sirota, M., Seehuus, M., Parzuchowski, M., Toro, M., Hricova, M., Alarcón Maldonado, M., Rentzelas, P., Vansteenkiste, M., Metz, M. A., Marszalek, M., Karekla, M., Mioni, G., Bosma, M. J., Westerlund, M., Vdovic, M., Bialek, M., Silan, M. A., Anne, M., Misiak, M., Gugliandolo, M. C., Grinberg, M., Capizzi, M., Espinoza Barría, M. F., Kurfali, M. A., Mensink, M. C., Harutyunyan, M., Khosla, M., Dunn, M. R., Korbmacher, M., Adamkovič, M., Ribeiro, M. F. F., Terskova, M., Hruška, M., Martončik, M., Jansen, M., Voracek, M., Čadek, M., Frias-Armenta, M., Kowal, M., Topor, M., Roczniewska, M., Oosterlinck, M., Braun Kohlová, M., Paruzel-Czachura, M., Sabristov, M., Romanova, M., Papadatou-Pastou, M., Lund, M. L., Antoniadi, M., Magrin, M. E., Jones, M. V., Ortiz, M. S., Manavalan, M., Muminov, A., Kossowska, M., Friedemann, M., Wielgus, M., van Hooff, M. L. M., Varella, M. A. C., Standage, M., Nicolotti, M., Colloff, M. F., Bradford, M., Vaughn, L. A., Eudave, L., Vieira, L., Sanabria Pineda, L. M., Matos, L., Calderón Pérez, L., Lazarevic, L. B., Jaremka, L. M., Smit, E. S., Kushnir, E., Ferguson, L. J., Anton-Boicuk, L., Lins de Holanda Coelho, G., Ahlgren, L., Liga, F., Levitan, C. A., Micheli, L., Gunton, L-A., Volz, L., Stojanovska, M., Boucher, L., Samojlenko, L., Javela Delgado, L. G., Kaliska, L., Labadi, B., Warmelink, L., Rojas-Berscia, L. M., Yu, K., Wylie, K., Wachowicz, J., Desai, K., Barzykowski, K., Kozma, L., Evans, K., Kirgizova, K., Agesin, B. E., Koehn, M. A., Wolfe, K., Korobova, T., Morris, K., Klevjer, K., van Schie, K., Vezirian, K., Damnjanović, K., Krabbe Thommesen, K., Schmidt, K., Filip, K., Staniaszek, K., Grzech, K., Hoyer, K., Moon, K., Khaobunmasiri, S., Rana, K., Janjić, K., Suchow, J. W., Kielińska, J., Cruz Vásquez, J. E., Chanal, J., Beitner, J., Vargas-Nieto, J. C., Roxas, J. C. T., Taber, J., Urriago-Rayo, J., Pavlacic, J. M., Benka, J., Bavolar, J., Soto, J. A., Olofsson, J. K., Vilsmeier, J. K., Messerschmidt, J., Czamanski-Cohen, J., Waterschoot, J., Moss, J. D., Boudesseul, J., Lee, J. M., Kamburidis, J., Joy-Gaba, J. A., Zickfeld, J., Miranda, J. F., Verharen, J. P. H., Hristova, E., Beshears, J. E., Đorđević, J. M., Bosch, J., Valentova, J. V., Antfolk, J., Berkessel, J. B., Schrötter, J., Urban, J., Röer, J. P., Norton, J. O., Silva, J. R., Pickering, J. S., Vintr, J., Uttley, J., Kunst, J. R., Ndukaihe, I. L. G., Iyer, A., Vilares, I., Ivanov, A., Ropovik, I., Sula, I., Sarieva, I., Metin-Orta, I., Prusova, I., Pinto, I., Bozdoc, A. I., Almeida, I. A. T., Pit, I. L., Dalgar, I., Zakharov, I., Arinze, A. I., Ihaya, K., Stephen, I. D., Gjoneska, B., Brohmer, H., Flowe, H., Godbersen, H., Kocalar, H. E., Hedgebeth, M. V., Chuan-Peng, H., Sharifian, M. H., Manley, H., Akkas, H., Hajdu, N., Azab, H., Kaminski, G., Nilsonne, G., Anjum, G., Travaglino, G. A., Feldman, G., Pfuhl, G., Czarnek, G., Marcu, G. M., Hofer, G., Banik, G., Adetula, G. A., Bijlstra, G., Verbruggen, F., Kung, F. Y. H., Martela, F., Foroni, F., Forest, J., Singer, G., Muchembled, F., Azevedo, F., Mosannenzadeh, F., Marinova, E., Štrukelj, E., Etebari, Z., Baskin, E., Garcia, E. O. L., Musser, E., van Steenkiste, I. M. M., Bradshaw, E. L., Ahn, E. R., Quested, E., Pronizius, E., Jackson, E. A., Manunta, E., Agadullina, E., Šakan, D., Dursun, P., Dujols, O., Dubrov, D., Willis, M., Tümer, M., Beaudry, J. L., Popović, D., Dunleavy, D., Djamai, I., Krupić, D., Herrera, D., Vega, D., Du, H., Mola, D., Chakarova, D., Davis, W. E., Holford, D. L., Lewis, D. M. G., Vaidis, D. C., Hausman Ozery, D., Zambrano Ricaurte, D., Storage, D., Sousa, D., Serrato Alvarez, D., Boller, D., Dalla Rosa, A., Dimova, D., Marko, D., Moreau, D., Reeck, C., Correia, R. C., Whitt, C. M., Lamm, C., Singh Solorzano, C., von Bastian, C.C., Sutherland, C. A. M., Overkott, C., Aberson, C. L., Wang, C., Niemiec, C. P., Reimer, C., Karashiali, C., Noone, C., Chiu, F., Picciocchi, C., Eben, C., Brownlow, C., Karaarslan, C., Cellini, N., Esteban-Serna, C., Reyna, C., Ferreyra, C., Batres, C., Li, R., Grano, C., Carpentier, J., Tamnes, C. K., Fu, C. H. Y., Ishkhanyan, B., Bylinina, L., Jaeger, B., Bundt, C., Bulut Allred, T., Vermote, B. J., Bokkour, A., Bogatyreva, N., Shi, J., Chopik, W. J., Antazo, B., Becker, M., Bayyat, M. M., Cocco, B., Chou, W-L., Barkoukis, V., Aczel, B., Baklanova, E., Bai, H., Balci, B. B., Babinčák, P., Soenens, B., Dixson, B. J. W., Mokady, A., Kappes, H. B., Atari, M., Szala, A., Szabelska, A., Aruta, J. J. B., Domurat, A., Arinze, N. C., Modena, A., Adiguzel, A., Monajem, A., El Arabi, K. A., Özdoğru, A. A., Rothbaum, A. O., Torres, A. J. O., Theodoropoulou, A., Skowronek, A., Jurković, A. P., Singh, A., Kassianos, A. P., Findor, A., Hartanto, A., Thibault Landry, A., Ferreira, A., Caetano Santos, A., De la Rosa-Gomez, A., Gourdon-Kanhukamwe, A., Luxon, A. M., Todsen, A. L., Karababa, A., Janak, A., Pilato, A., Bran, A., Tullett, A. M., Kuzminska, A. O., Krafnick, A. J., Urooj, A., Khaoudi, A., Ahmed, A., Groyecka-Bernard, A., Askelund, A. D., Adetula, A., Belaus, A., Charyate, A. C., Wichman, A. L., Stoyanova, A., Greenburgh, A., Thomas, A. G., Arvanitis, A., Forscher, P. S., Mallik, P. R., Primbs, M. A., Miller, J. K., Moshontz, H., Urry, H. L., IJzerman, H., Basnight-Brown, D. M., Chartier, C. R., Buchanan, E. M., Coles, N. A., MÜ, Eğitim Fakültesi, Eğitim Bilimleri Bölümü, Kocalar, Halil Emre, Faculdade de Psicologia e de Ciências da Educação, Organizational Psychology, Jernsäther, Teodor [0000-0002-7030-3299], Tatachari, Srinivasan [0000-0003-1838-2361], Geiger, Sandra J [0000-0002-3262-5609], Butt, Muhammad Mussaffa [0000-0001-5271-111X], Varella, Marco A C [0000-0002-7274-7360], Stephen, Ian D [0000-0001-9714-8295], Kaminski, Gwenael [0000-0001-5300-5655], Bai, Hui [0000-0003-2671-5955], Coles, Nicholas A [0000-0001-8583-5610], Apollo - University of Cambridge Repository, Center Ph. D. Students, Department of Social Psychology, Tilburg University, and Medical and Clinical Psychology

Subjects
Nudges, Behaviour Change and Well-being, ddc:150, 230 Affective Neuroscience, SDG 3 - Good Health and Well-being, message framing, anxiety, nudges, COVID-19, Message framing, General Medicine, Anxiety
Abstract

Contains fulltext : 284232.pdf (Publisher’s version ) (Closed access) The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., "If you do not practice these steps, you can endanger yourself and others") or potential gains (e.g., "If you practice these steps, you can protect yourself and others")? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message framing on COVID-19-related judgments, intentions, and feelings. Loss- (vs. gain-) framed messages increased self-reported anxiety among participants cross-nationally with little-to-no impact on policy attitudes, behavioral intentions, or information seeking relevant to pandemic risks. These results were consistent across 84 countries, three variations of the message framing wording, and 560 data processing and analytic choices. Thus, results provide an empirical answer to a global communication question and highlight the emotional toll of loss-framed messages. Critically, this work demonstrates the importance of considering unintended affective consequences when evaluating nudge-style interventions. 26 p.

Published
2022
Full Text
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12. Erratum: Author Correction: A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic (Nature human behaviour (2021) 5 8 (1089-1110))

Author

Wang, K., Goldenberg, A., Dorison, C. A., Miller, J. K., Uusberg, A., Lerner, J. S., Gross, J. J., Agesin, B. B., Bernardo, M., Campos, O., Eudave, L., Grzech, K., Ozery, D. H., Jackson, E. A., Garcia, E. O. L., Drexler, S. M., Jurkovic, A. P., Rana, K., Wilson, J. P., Antoniadi, M., Desai, K., Gialitaki, Z., Kushnir, E., Nadif, K., Bravo, O. N., Nauman, R., Oosterlinck, M., Pantazi, M., Pilecka, N., Szabelska, A., van Steenkiste, I. M. M., Filip, K., Bozdoc, A. I., Marcu, G. M., Agadullina, E., Adamkovic, M., Roczniewska, M., Reyna, C., Kassianos, A. P., Westerlund, M., Ahlgren, L., Pontinen, S., Adetula, G. A., Dursun, P., Arinze, A. I., Arinze, N. C., Ogbonnaya, C. E., Ndukaihe, I. L. G., Dalgar, I., Akkas, H., Macapagal, P. M., Lewis, S., Metin-Orta, I., Foroni, F., Willis, M., Santos, A. C., Mokady, A., Reggev, N., Kurfali, M. A., Vasilev, M. R., Nock, N. L., Parzuchowski, M., Espinoza Barria, M. F., Vranka, M., Kohlova, M. B., Ropovik, I., Harutyunyan, M., Wang, C., Yao, E., Becker, M., Manunta, E., Kaminski, G., Boudesseul, J., Marko, D., Evans, K., Lewis, D. M. G., Findor, A., Landry, A. T., Aruta, J. J. B., Ortiz, M. S., Vally, Z., Pronizius, E., Voracek, M., Lamm, C., Grinberg, M., Li, R., Valentova, J. V., Mioni, G., Cellini, N., Chen, S. -C., Zickfeld, J., Moon, K., Azab, H., Levy, N., Karababa, A., Beaudry, J. L., Boucher, L., Collins, W. M., Todsen, A. L., van Schie, K., Vintr, J., Bavolar, J., Kaliska, L., Krizanic, V., Samojlenko, L., Pourafshari, R., Geiger, S. J., Beitner, J., Warmelink, L., Ross, R. M., Stephen, I. D., Hostler, T. J., Azouaghe, S., Mccarthy, R., Szala, A., Grano, C., Solorzano, C. S., Anjum, G., Jimenez-Leal, W., Bradford, M., Perez, L. C., Cruz Vasquez, J. E., Galindo-Caballero, O. J., Vargas-Nieto, J. C., Kacha, O., Arvanitis, A., Xiao, Q., Carcamo, R., Zorjan, S., Tajchman, Z., Vilares, I., Pavlacic, J. M., Kunst, J. R., Tamnes, C. K., von Bastian, C. C., Atari, M., Sharifian, M., Hricova, M., Kacmar, P., Schrotter, J., Rahal, R. -M., Cohen, N., Fatahmodares, S., Zrimsek, M., Zakharov, I., Koehn, M. A., Esteban-Serna, C., Calin-Jageman, R. J., Krafnick, A. J., Strukelj, E., Isager, P. M., Urban, J., Silva, J. R., Martoncik, M., Ocovaj, S. B., Sakan, D., Kuzminska, A. O., Djordjevic, J. M., Almeida, I. A. T., Ferreira, A., Lazarevic, L. B., Manley, H., Ricaurte, D. Z., Monteiro, R. P., Etabari, Z., Musser, E., Dunleavy, D., Chou, W., Godbersen, H., Ruiz-Fernandez, S., Reeck, C., Batres, C., Kirgizova, K., Muminov, A., Azevedo, F., Alvarez, D. S., Butt, M. M., Lee, J. M., Chen, Z., Verbruggen, F., Ziano, I., Tumer, M., Charyate, A. C. A., Dubrov, D., Tejada Rivera, M. D. C. M. C., Aberson, C., Palfi, B., Maldonado, M. A., Hubena, B., Sacakli, A., Ceary, C. D., Richard, K. L., Singer, G., Perillo, J. T., Ballantyne, T., Cyrus-Lai, W., Fedotov, M., Du, H., Wielgus, M., Pit, I. L., Hruska, M., Sousa, D., Aczel, B., Hajdu, N., Szaszi, B., Adamus, S., Barzykowski, K., Micheli, L., Schmidt, N. -D., Zsido, A. N., Paruzel-Czachura, M., Muda, R., Bialek, M., Kowal, M., Sorokowska, A., Misiak, M., Mola, D., Ortiz, M. V., Correa, P. S., Belaus, A., Muchembled, F., Ribeiro, R. R., Arriaga, P., Oliveira, R., Vaughn, L. A., Szwed, P., Kossowska, M., Czarnek, G., Kielinska, J., Antazo, B., Betlehem, R., Stieger, S., Nilsonne, G., Simonovic, N., Taber, J., Gourdon-Kanhukamwe, A., Domurat, A., Ihaya, K., Yamada, Y., Urooj, A., Gill, T., Cadek, M., Bylinina, L., Messerschmidt, J., Kurfali, M., Adetula, A., Baklanova, E., Albayrak-Aydemir, N., Kappes, H. B., Gjoneska, B., House, T., Jones, M. V., Berkessel, J. B., Chopik, W. J., Coksan, S., Seehuus, M., Khaoudi, A., Bokkour, A., El Arabi, K. A., Djamai, I., Iyer, A., Parashar, N., Adiguzel, A., Kocalar, H. E., Bundt, C., Norton, J. O., Papadatou-Pastou, M., De la Rosa-Gomez, A., Ankushev, V., Bogatyreva, N., Grigoryev, D., Ivanov, A., Prusova, I., Romanova, M., Sarieva, I., Terskova, M., Hristova, E., Kadreva, V. H., Janak, A., Schei, V., Sverdrup, T. E., Askelund, A. D., Pineda, L. M. S., Krupic, D., Levitan, C. A., Johannes, N., Ouherrou, N., Say, N., Sinkolova, S., Janjic, K., Stojanovska, M., Stojanovska, D., Khosla, M., Thomas, A. G., Kung, F. Y. H., Bijlstra, G., Mosannenzadeh, F., Balci, B. B., Reips, U. -D., Baskin, E., Ishkhanyan, B., Czamanski-Cohen, J., Dixson, B. J. W., Moreau, D., Sutherland, C. A. M., Chuan-Peng, H., Noone, C., Flowe, H., Anne, M., Janssen, S. M. J., Topor, M., Majeed, N. M., Kunisato, Y., Yu, K., Daches, S., Hartanto, A., Vdovic, M., Anton-Boicuk, L., Forbes, P. A. G., Kamburidis, J., Marinova, E., Nedelcheva-Datsova, M., Rachev, N. R., Stoyanova, A., Schmidt, K., Suchow, J. W., Koptjevskaja-Tamm, M., Jernsather, T., Olofsson, J. K., Bialobrzeska, O., Marszalek, M., Tatachari, S., Afhami, R., Law, W., Antfolk, J., Zuro, B., Van Doren, N., Soto, J. A., Searston, R., Miranda, J., Damnjanovic, K., Yeung, S. K., Hoyer, K., Jaeger, B., Ren, D., Pfuhl, G., Klevjer, K., Corral-Frias, N. S., Frias-Armenta, M., Lucas, M. Y., Torres, A. O., Toro, M., Delgado, L. G. J., Vega, D., Solas, S. A., Vilar, R., Massoni, S., Frizzo, T., Bran, A., Vaidis, D. C., Vieira, L., Paris, B., Capizzi, M., Coelho, G. L. H., Greenburgh, A., Whitt, C. M., Tullett, A. M., Du, X., Volz, L., Bosma, M. J., Karaarslan, C., Sarioguz, E., Allred, T. B., Korbmacher, M., Colloff, M. F., Lima, T. J. S., Ribeiro, M. F. F., Verharen, J. P. H., Karekla, M., Karashiali, C., Sunami, N., Jaremka, L. M., Storage, D., Habib, S., Studzinska, A., Hanel, P. H. P., Holford, D. L., Sirota, M., Wolfe, K., Chiu, F., Theodoropoulou, A., Ahn, E. R., Lin, Y., Westgate, E. C., Brohmer, H., Hofer, G., Dujols, O., Vezirian, K., Feldman, G., Travaglino, G. A., Ahmed, A., Li, M., Bosch, J., Torunsky, N., Bai, H., Manavalan, M., Song, X., Walczak, R. B., Zdybek, P., Friedemann, M., Rosa, A. D., Kozma, L., Alves, S. G., Lins, S., Pinto, I. R., Correia, R. C., Babincak, P., Banik, G., Rojas-Berscia, L. M., Varella, M. A. C., Uttley, J., Beshears, J. E., Thommesen, K. K., Behzadnia, B., Geniole, S. N., Silan, M. A., Maturan, P. L. G., Vilsmeier, J. K., Tran, U. S., Izquierdo, S. M., Mensink, M. C., Sorokowski, P., Groyecka-Bernard, A., Radtke, T., Adoric, V. C., Carpentier, J., Ozdogru, A. A., Joy-Gaba, J. A., Hedgebeth, M. V., Ishii, T., Wichman, A. L., Roer, J. P., Ostermann, T., Davis, W. E., Suter, L., Papachristopoulos, K., Zabel, C., Onie, S., Ebersole, C. R., Chartier, C. R., Mallik, P. R., Urry, H. L., Buchanan, E. M., Coles, N. A., Primbs, M. A., Basnight-Brown, D. M., Ijzerman, H., Forscher, P. S., and Moshontz, H.

Published
2022

13. Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment

Author

van der Velpen, V., Hollman, P.C., van Nielen, M., Schouten, E.G., Mensink, M., Veer, P van't, and Geelen, A.

Subjects
Postmenopausal women -- Health aspects, Isoflavones -- Health aspects, Blood plasma -- Health aspects, Health risk assessment -- Methods, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: Isoflavones are present in soy foods and soy-based supplements. Despite low plasma isoflavone concentrations in the general Western population, concentrations in supplement users exceed those suggested to be beneficial for health in Asian populations, raising concerns for adverse effects. To aid risk assessment, quantification of the relation between isoflavone intake and plasma concentrations is essential. SUBJECTS/METHODS: Plasma samples were collected from postmenopausal women in three placebo-controlled crossover studies with 8-week periods for supplements (two studies, ~ 100 mg isoflavones/day, n = 88) or 4-week periods for soy foods (one study, ~48 mg isoflavones/day, n = 15). Plasma isoflavone concentrations (daidzein, equol, genistein and glycitein) were quantified using high-performance liquid chromatography and electrochemical detection. The association between plasma concentrations and isoflavone intake, equol producer status, intake-producer interaction and background dietary intake was assessed based on the assumption of a log-linear relation. RESULTS: Median plasma total isoflavone concentrations after the soy food and supplement interventions were respectively 2.16 and 3.47 µmol/l for equol producers and 1.30 and 2.39 µmol/l for non-producers. Regression analysis showed that doubling isoflavone intake increased plasma concentrations by 55-62% (± s.e. 1-2%, [R.sup.2] > 0.87) for daidzein, genistein, equol (only for producers) and total isoflavones; for glycitein the association was weaker (15 ± 1%, [R.sup.2] = 0.48). Adjustments for energy, carbohydrate and fat intake did not affect these estimates. Inter-individual variation, estimated based on repeated measures in one of the studies, was 30-96%. CONCLUSIONS: Although the relation between isoflavone intake and plasma concentrations was adequately quantified, the use of isoflavone intake data for risk assessment needs caution due to large inter-individual variation in plasma concentrations. European Journal of Clinical Nutrition (2014) 68, 1141-1147; doi: 10.1038/ejcn.2014.108; published online 18 June 2014, INTRODUCTION Isoflavones, present in soy products, are suggested to relieve menopausal complaints (1,2) and to have a number of other beneficial health effects, such as prevention of osteoporosis and cardiovascular [...]

Published
2014
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14. High dietary protein intake, reducing or eliciting insulin resistance?

Author

Rietman, A., Schwarz, J., Tome, D., Koke, F.J., and Mensink, M.

Subjects
Proteins in human nutrition -- Health aspects, Insulin resistance -- Observations, Type 2 diabetes -- Risk factors, Food/cooking/nutrition, Health
Abstract

Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway. European Journal of Clinical Nutrition (2014) 68, 973-979; doi: 10.1038/ejcn.2014.123; published online 2 July 2014, INTRODUCTION Insulin resistance is defined as tissues no longer being sensitive to the physiological actions of insulin, in particular glucose uptake. The insulin-mediated uptake of glucose can decrease when tissues [...]

Published
2014
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15. A 2 Week Cross-over Intervention with a Low Carbohydrate, High Fat Diet Compared to a High Carbohydrate Diet Attenuates Exercise-Induced Cortisol Response, but Not the Reduction of Exercise Capacity, in Recreational Athletes

Author

Terink, Rieneke, Witkamp, R.F., Hopman, M.T.E., Siebelink, E., Savelkoul, H.F.J., Mensink, M., Terink, Rieneke, Witkamp, R.F., Hopman, M.T.E., Siebelink, E., Savelkoul, H.F.J., and Mensink, M.

Abstract

Contains fulltext : 230359.pdf (publisher's version ) (Open Access)

Published
2021

20. A 4-week exercise and protein program improves muscle mass and physical functioning in older adults - A pilot study.

Author

Grootswagers, P., Regt, M. de, Domić, J., Dronkers, J., Visser, Marlieke, Witteman, B., Hopman, M.T., Mensink, M., Grootswagers, P., Regt, M. de, Domić, J., Dronkers, J., Visser, Marlieke, Witteman, B., Hopman, M.T., and Mensink, M.

Abstract

01 november 2020, Contains fulltext : 229788.pdf (Publisher’s version ) (Open Access), BACKGROUND: Prehabilitation might attenuate common surgery-induced losses in muscle mass and physical performance. Beneficial effects of physical exercise with protein supplementation have been reported in older adults, but typically after an intervention of at least 12 weeks. The time-window for pre-surgery training is often limited to around 30 days, and it is not known if it is possible to achieve comparable results in such a short time window. OBJECTIVES: The aim of this study was to pilot-test the effectiveness of a controlled four-week combined exercise and protein supplementation program on skeletal muscle-related outcomes in a Dutch older adult population. DESIGN: This study was a one-armed pilot trial. PARTICIPANTS: Seventeen older men and women, aged 55-75y, not scheduled for surgery. INTERVENTION: A 4-week intervention program consisting of a twice-weekly supervised resistance and high-intensity aerobic exercise training of 75 min, combined with daily protein supplementation (2 doses of 15.5 g/day at breakfast and lunch). MEASUREMENT: After two and four weeks, isometric quadriceps maximal voluntary contraction (MVC) was assessed via Biodex and quadriceps cross-sectional area (CSA) via magnetic resonance imaging. Other outcome measures were handgrip strength, chair rise time and maximal aerobic capacity (VO(2)-max), as assessed from a submaximal exercise test. RESULTS: Compliance to the supervised training sessions (99.3%) and the protein supplementation (97%) was very high. The 4-week exercise and protein program led to an increase in quadriceps CSA of 2.3 ± 0.7 cm(2) (P = 0.008) in the dominant leg and 3.2 ± 0.7 cm(2) (P < 0.001) in the non-dominant leg. Isometric quadriceps MVC increased in the dominant leg (Δ14 ± 4 Nm, P = 0.001) and in the non-dominant leg (Δ17 ± 5 Nm, P = 0.003). Chair rise test time improved with -3.8 ± 0.5 s (P < 0.0001), and VO(2)-max improved with 3.3 ± 1.1 ml/min/kg (P = 0.014). We observed no changes in body weight and handgrip

Published
2020

22. Nutritional strategies to improve muscle quality during ageing

Author

de Groot, L., Mensink, M., Grootswagers, Pol, de Groot, L., Mensink, M., and Grootswagers, Pol

Abstract

Increased lifespan is a great achievement of humankind, and opens new opportunities for the life of ageing human beings, in part conditional on health and independence. Health and independence are related to physical performance which is often compromised in older adults, to some extent due to age-related decreases in muscle mass and muscle strength decrease. During ageing, muscle strength decreases at a faster rate than muscle mass, indicating a loss in muscle quality. Muscle quality is defined as muscle strength per unit of muscle mass and is determined by factors such as specific muscle fibre atrophy, mitochondrial functioning, neuromuscular functioning and degree of fat infiltration. Targeting the quality of muscle tissue is a promising strategy to improve muscle quality during ageing.An active lifestyle seems to prevent losses in muscle quality to some extent, whereby exercise programs can improve markers of muscle quality. Not many intervention trials have aimed to improve muscle quality via nutrition. However, metabolic aspects play a role in muscle quality, and many nutrients act on pathways that are related to physiological determinants of muscle quality. Together, this gives reasons to pursue the identification of nutritional strategies to target muscle quality. Therefore, in this thesis, we aimed to identify novel nutritional strategies to improve muscle quality and physical performance in older adults.In Chapter 2, we investigated the reliability and validity of handheld dynamometry (HHD) for the assessment of leg strength. Leg strength assessment is proposed to be a better alternative to the often used handgrip strength measurement. However, the current advised equipment to measure leg strength is static and costly, while handgrip strength can be measured with an inexpensive and small device. The results of Chapter 2 show that the HHD is a valid and reliable tool to assess changes in leg strength in older adults or to rank older adults on strength level

Published
2020

33. Cytokine responses to repeated, prolonged walking in lean versus overweight/obese individuals.

Author

Verheggen, R.J.H.M., Eijsvogels, T.M.H., Catoire, M., Terink, R., Ramakers, R.E.F.S., Bongers, C.C.W.G., Mensink, M., Hermus, A.R.M.M., Thijssen, D.H.J., Hopman, M.T.E., Verheggen, R.J.H.M., Eijsvogels, T.M.H., Catoire, M., Terink, R., Ramakers, R.E.F.S., Bongers, C.C.W.G., Mensink, M., Hermus, A.R.M.M., Thijssen, D.H.J., and Hopman, M.T.E.

Abstract

01 februari 2019, Item does not contain fulltext, OBJECTIVES: Obesity is characterized by a pro-inflammatory state, which plays a role in the pathogenesis of metabolic and cardiovascular disease. An exercise bout causes a transient increase in pro-inflammatory cytokines, whilst training has anti-inflammatory effects. No previous study examined whether the exercise-induced increase in pro-inflammatory cytokines is altered with repeated prolonged exercise bouts and whether this response differs between lean and overweight/obese individuals. DESIGN: Lean (n=25, BMI 22.9+/-1.5kg/m(2)) and age-/sex-matched overweight/obese (n=25; BMI 27.9+/-2.4kg/m(2)) individuals performed walking exercise for 30, 40 or 50km per day on four consecutive days (distances similar between groups). METHODS: Circulating cytokines (IL-6, IL-10, TNF-alpha, IL-1beta and IL-8) were examined at baseline and <30min after the finish of each exercise day. RESULTS: At baseline, no differences in circulating cytokines were present between groups. In response to prolonged exercise, all cytokines increased on day 1 (IL-1beta: P=0.02; other cytokines: P<0.001). IL-6 remained significantly elevated during the 4 exercise days, when compared to baseline. IL-10, TNF-alpha, IL-1beta and IL-8 returned to baseline values from exercise day 2 (IL-10, IL-1beta, IL-8) or exercise day 3 (TNF-alpha) onward. No significant differences were found between groups for all cytokines, except IL-8 (Time*Group Interaction P=0.02). CONCLUSIONS: These data suggest the presence of early adaptive mechanisms in response to repeated prolonged walking, demonstrated by attenuated exercise-induced elevations in cytokines on consecutive days that occur similar in lean and overweight/obese individuals.

Published
2019

34. Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

Author

Loeffen, EAH, Kremer, L.C.M. (Leontien), Wetering, M.D, Mulder, R.L. (Renée), Font-Gonzalez, A., Dupuis, L.L., Campbell, F., Tissing, W.J.E. (Wim), Anghelescu, D.L., Birnie, K., Bont, J.M. (Judith Maria) de, Bredlau, A.L., Cullen, P., Daniels, S., Dick, B., Dijk, M. (Monique) van, Dingeman, R.S., Evan, E., Gegg, J., Gibson, F., Grotel, M. (Martine) van, Jibb, L., Kao, R., Knops, R., Kulkarni, K., Leroy, P., Liossi, C., Ljungman, G., McLean, J., Mensink, M., Michiels, E, Muckaden, M.A., Newman, B. (Beth), Positano, K., Rijsdijk, M., Rowe, E., Sangha, G., Stinson, J., Taddio, A. (Anna), Taylor, H. (Hugh), Tutelman, P., Twycross, A., Wijnen, M., Zeltzer, L., Loeffen, EAH, Kremer, L.C.M. (Leontien), Wetering, M.D, Mulder, R.L. (Renée), Font-Gonzalez, A., Dupuis, L.L., Campbell, F., Tissing, W.J.E. (Wim), Anghelescu, D.L., Birnie, K., Bont, J.M. (Judith Maria) de, Bredlau, A.L., Cullen, P., Daniels, S., Dick, B., Dijk, M. (Monique) van, Dingeman, R.S., Evan, E., Gegg, J., Gibson, F., Grotel, M. (Martine) van, Jibb, L., Kao, R., Knops, R., Kulkarni, K., Leroy, P., Liossi, C., Ljungman, G., McLean, J., Mensink, M., Michiels, E, Muckaden, M.A., Newman, B. (Beth), Positano, K., Rijsdijk, M., Rowe, E., Sangha, G., Stinson, J., Taddio, A. (Anna), Taylor, H. (Hugh), Tutelman, P., Twycross, A., Wijnen, M., and Zeltzer, L.

Abstract

Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and physical management of tumor-, treatment-, and procedure-related pain in children with cancer. In this paper, we present our thorough methodology for this development, including the challenges we faced and how we approached these. This lays the foundation for our clinical practice guideline, for which there is a high clinical demand.

Published
2019
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39. Changes in cytokine levels after prolonged and repeated moderate intensity exercise in middle-aged men and women

Author

Terink, R., Bongers, C.C.W.G., Witkamp, R.F., Mensink, M., Eijsvogels, T.M., Klein Gunnewiek, J.M.T., Hopman, M.T.E., Terink, R., Bongers, C.C.W.G., Witkamp, R.F., Mensink, M., Eijsvogels, T.M., Klein Gunnewiek, J.M.T., and Hopman, M.T.E.

Abstract

Previous studies have shown that exercise-induced changes in cytokine profiles depend on exercise duration and intensity. Studies are generally limited to a single day, and insight into the time course during multiple days of exercise is lacking. Therefore, this study assessed cytokine responses during multiple days of moderate intensity exercise in men and women. Fifty males (58.9 ± 9.9 years) and fifty females (50.9 ± 11.2 years) were monitored on 4 consecutive days at which they walked on average ~9 h/d at a self-determined pace. Blood samples were collected 1 or 2 days prior to the start of the exercise (baseline) and every walking day immediately post-exercise. Blood samples were analyzed for IL-6, IL-8, IL-10, IL-1β, and TNF-α concentrations. All cytokine concentrations increased from baseline to post-exercise at day 1 (P < .001). Thereafter, concentrations decreased from day 1 to day 2 (P < .01), remaining rather stable during the next days. IL-1β and TNF-α were higher in men at baseline and during all days. In conclusion, exercise-induced cytokine increases attenuated on subsequent days, although daily workload remained constant. Men and women showed different baseline levels but similar exercise responses. These results suggest that individuals adapt rapidly to this type of repeated exercise.

Published
2018

40. Changes in iron metabolism during prolonged repeated walking exercise in middle-aged men and women.

Author

Terink, R., Haaf, D.S. ten, Bongers, C.C.W.G., Balvers, M.G.J., Witkamp, R.F., Mensink, M., Eijsvogels, T.M.H., Gunnewiek, J.M., Hopman, M.T.E., Terink, R., Haaf, D.S. ten, Bongers, C.C.W.G., Balvers, M.G.J., Witkamp, R.F., Mensink, M., Eijsvogels, T.M.H., Gunnewiek, J.M., and Hopman, M.T.E.

Abstract

Contains fulltext : 196745.pdf (Publisher’s version ) (Open Access), PURPOSE: The aim of the present study was to assess the effect of prolonged and repeated exercise on iron metabolism in middle-aged adults and to compare differences between sexes. METHODS: 50 male (58.9 +/- 9.9 year) and 48 female (50.9 +/- 11.2 year) individuals were monitored on 4 consecutive days at which they walked on average 8 h and 44 min per day at a self-determined pace. Blood samples were collected 1 or 2 days prior to the start of the exercise (baseline) and every day immediately post-exercise. Samples were analysed for iron, ferritin, haemoglobin, and haptoglobin concentrations. RESULTS: Plasma iron decreased across days, while ferritin increased across days (both p < 0.001). Haptoglobin showed a decrease (p < 0.001) after the first day and increased over subsequent days (p < 0.001). Haemoglobin did not change after the first day, but increased during subsequent days (p < 0.05). At baseline, 8% of the participants had iron concentrations below minimum reference value (10 micromol/L), this increased to 43% at day 4. There was an interaction between sex and exercise days on iron (p = 0.028), ferritin (p < 0.001) and haemoglobin levels (p = 0.004), but not on haptoglobin levels. CONCLUSION: This study showed decreases in iron, increases in ferritin, a decrease followed by increases in haptoglobin and no change followed by increases in haemoglobin. This is most likely explained by (foot strike) haemolysis, inflammation, and sweat and urine losses. These processes resulted in iron levels below minimum reference value in a large number of our participants.

Published
2018

41. Functional Heterogeneity of CD4(+) Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

Author

Oja, A.E., Piet, B., Zwan, D. van der, Blaauwgeers, H., Mensink, M., Kivit, S. de, Borst, J., Nolte, M.A., Lier, R.A.W. van, Stark, R., Hombrink, P., Oja, A.E., Piet, B., Zwan, D. van der, Blaauwgeers, H., Mensink, M., Kivit, S. de, Borst, J., Nolte, M.A., Lier, R.A.W. van, Stark, R., and Hombrink, P.

Abstract

Contains fulltext : 200117.pdf (publisher's version ) (Open Access), Resident memory T cells (TRM) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that CD103(+) TRM are not only important in combating secondary infections, but also for the elimination of tumor cells. In several solid cancers, intratumoral CD103(+)CD8(+) tumor infiltrating lymphocytes (TILs), with TRM properties, are a positive prognostic marker. To better understand the role of TRM in tumors, we performed a detailed characterization of CD8(+) and CD4(+) TIL phenotype and functional properties in non-small cell lung cancer (NSCLC). Frequencies of CD8(+) and CD4(+) T cell infiltrates in tumors were comparable, but we observed a sharp contrast in TRM ratios compared to surrounding lung tissue. The majority of both CD4(+) and CD8(+) TILs expressed CD69 and a subset also expressed CD103, both hallmarks of TRM. While CD103(+)CD8(+) T cells were enriched in tumors, CD103(+)CD4(+) T cell frequencies were decreased compared to surrounding lung tissue. Furthermore, CD103(+)CD4(+) and CD103(+)CD8(+) TILs showed multiple characteristics of TRM, such as elevated expression of CXCR6 and CD49a, and decreased expression of T-bet and Eomes. In line with the immunomodulatory role of the tumor microenvironment, CD8(+) and CD4(+) TILs expressed high levels of inhibitory receptors 2B4, CTLA-4, and PD-1, with the highest levels found on CD103(+) TILs. Strikingly, CD103(+)CD4(+) TILs were the most potent producers of TNF-alpha and IFN-gamma, while other TIL subsets lacked such cytokine production. Whereas, CD103(+)CD4(+)PD-1(low) TILs produced the most effector cytokines, CD103(+)CD4(+)PD-1(++) and CD69(+)CD4(+)PD-1(++) TILs produced CXCL13. Furthermore, a large proportion of TILs expressed co-stimulatory receptors CD27 and CD28, unlike lung TRM, suggesting a less differentiated phenotype. Agonistic triggering of these receptors improved cytokine production of CD103(+)CD4(+) and CD69(+)CD8(+) TILs. Our findings thus p

Published
2018

45. Anti-apoptotic A1 is not essential for lymphoma development in E mu-Myc mice but helps sustain transplanted E mu-Myc tumour cells

Author

Mensink, M, Anstee, NS, Robati, M, Schenk, RL, Herold, MJ, Cory, S, Vandenberg, CJ, Mensink, M, Anstee, NS, Robati, M, Schenk, RL, Herold, MJ, Cory, S, and Vandenberg, CJ

Abstract

The transcription factor c-MYC regulates a multiplicity of genes involved in cellular growth, proliferation, metabolism and DNA damage response and its overexpression is a hallmark of many tumours. Since MYC promotes apoptosis under conditions of stress, such as limited availability of nutrients or cytokines, MYC-driven cells are very much dependent on signals that inhibit cell death. Stress signals trigger apoptosis via the pathway regulated by opposing fractions of the BCL-2 protein family and previous genetic studies have shown that the development of B lymphoid tumours in Eµ-Myc mice is critically dependent on expression of pro-survival BCL-2 relatives MCL-1, BCL-W and, to a lesser extent, BCL-XL, but not BCL-2 itself, and that sustained growth of these lymphomas is dependent on MCL-1. Using recently developed mice that lack expression of all three functional pro-survival A1 genes, we show here that the kinetics of lymphoma development in Eµ-Myc mice and the competitive repopulation capacity of Eµ-Myc haemopoietic stem and progenitor cells is unaffected by the absence of A1. However, conditional loss of a single remaining functional A1 gene from transplanted A1-a-/-A1-b fl/fl A1-c-/- Eµ-Myc lymphomas slowed their expansion, significantly extending the life of the transplant recipients. Thus, A1 contributes to the survival of malignant Eµ-Myc-driven B lymphoid cells. These results strengthen the case for BFL-1, the human homologue of A1, being a valid target for drug development for MYC-driven tumours.

Published
2018

46. Nutrition and Disease: Nutrition, Heart disease and Diabetes : MOOC

Author

Geleijnse, M., Küpers, L., Mensink, M., Geleijnse, M., Küpers, L., and Mensink, M.

Abstract

Learn about the role of nutrition in relation to diseases of the circulatory system and diabetes, which are major causes of death worldwide. You’ll learn about the etiology of heart attacks, type 2 diabetes, stroke, other forms of cardiovascular diseases and how often these occur worldwide. You will learn about biological modifiable risk factors, such as blood pressure, blood cholesterol and obesity, and how they impact these diseases in a different way. After completing this course you will also have gained a deeper insight in underlying pathophysiological mechanisms, such as insulin resistance, and the role of (epi)genetic factors. Dieticians and doctors often get questions from their patients on what they can do to improve their health. In this course, part of the Professional Certificate Program Nutrition and Disease, you will learn about the interaction between nutrients, diets and cardiometabolic disease (heart disease and diabetes). You'll learn about the current progress in nutrition and cardiometabolic disease research. You will learn how cardiometabolic diseases can be prevented on the population level through lifestyle and dietary modifications. This course is especially valuable for professionals (in training) from various disciplines related to nutrition and health, e.g. nutritionists, epidemiologists, public health workers, physicians, health care professionals, health policy makers, nutrition educators, biologists, and food scientists.

Published
2018

48. Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation.

Author

Terink, R., Balvers, M.G.J., Hopman, M.T.E., Witkamp, R.F., Mensink, M., Gunnewiek, J.M., Terink, R., Balvers, M.G.J., Hopman, M.T.E., Witkamp, R.F., Mensink, M., and Gunnewiek, J.M.

Abstract

1 juni 2017, Item does not contain fulltext, Magnesium is essential for optimal sport performance, generating an interest to monitor its status in athletes. However, before measuring magnesium status in blood could become routine, more insight into its diurnal fluctuations and effects of exercise itself is necessary. Therefore, we measured the effect of an acute bout of exercise on ionized (iMg) and total plasma magnesium (tMg) in blood obtained from 18 healthy well-trained endurance athletes (age, 31.1 +/- 8.1 yr.; VO2max, 50.9 +/- 7.5 ml/kg/min) at multiple time points, and compared this with a resting situation. At both days, 7 blood samples were taken at set time points (8:30 fasted, 11:00, 12:30, 13:30, 15:00, 16:00, 18:30). The control day was included to correct for a putative diurnal fluctuation of magnesium. During the exercise day, athletes performed a 90 min bicycle ergometer test (70% VO2max) between 11:00 and 12:30. Whole blood samples were analyzed for iMg and plasma for tMg concentrations. Both concentrations decreased significantly after exercise (0.52 +/- 0.04-0.45 +/- 0.03 mmol/L and 0.81 +/- 0.07-0.73 +/- 0.06 mmol/L, respectively, p < .001) while no significant decline was observed during that time-interval on control days. Both, iMg and tMg, returned to baseline, on average, 2.5 hr after exercise. These findings suggest that timing of blood sampling to analyze Mg status is important. Additional research is needed to establish the recovery time after different types of exercise to come to a general advice regarding the timing of magnesium status assessment in practice.

Published
2017

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