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265 results on '"Mentaverri, Romuald"'

2. The Metabolism of Epoxyeicosatrienoic Acids by Soluble Epoxide Hydrolase Is Protective against the Development of Vascular Calcification

Author

Varennes, Olivier, Mentaverri, Romuald, Duflot, Thomas, Kauffenstein, Gilles, Objois, Thibaut, Lenglet, Gaëlle, Avondo, Carine, Morisseau, Christophe, Brazier, Michel, Kamel, Saïd, Six, Isabelle, and Bellien, Jeremy

Subjects
Biochemistry and Cell Biology, Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Microbiology, Cardiovascular, Heart Disease - Coronary Heart Disease, Heart Disease, 2.1 Biological and endogenous factors, Animals, Carotid Arteries, Cell Differentiation, Disease Susceptibility, Endothelium, Epoxide Hydrolases, Fatty Acids, Monounsaturated, Humans, Lipid Metabolism, Phosphoric Monoester Hydrolases, RNA, Messenger, Rats, Vascular Calcification, vascular calcification, soluble epoxide hydrolase, phosphatase, epoxyeicosatrienoic acids, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

This study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes endothelium-derived epoxyeicosatrienoic acids, plays a role in vascular calcification. The sEH inhibitor trans-4-(4-(3-adamantan-1-yl-ureido)-cyclohexyloxy)-benzoic acid (t-AUCB) potentiated the increase in calcium deposition of rat aortic rings cultured in high-phosphate conditions. This was associated with increased tissue-nonspecific alkaline phosphatase activity and mRNA expression level of the osteochondrogenic marker Runx2. The procalcifying effect of t-AUCB was prevented by mechanical aortic deendothelialization or inhibition of the production and action of epoxyeicosatrienoic acids using the cytochrome P450 inhibitor fluconazole and the antagonist 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE), respectively. Similarly, exogenous epoxyeicosatrienoic acids potentiated the calcification of rat aortic rings through a protein kinase A (PKA)-dependent mechanism and of human aortic vascular smooth muscle cells when sEH was inhibited by t-AUCB. Finally, a global gene expression profiling analysis revealed that the mRNA expression level of sEH was decreased in human carotid calcified plaques compared to adjacent lesion-free sites and was inversely correlated with Runx2 expression. These results show that sEH hydrolase plays a protective role against vascular calcification by reducing the bioavailability of epoxyeicosatrienoic acids.

Published
2020

4. Severe hypophosphatemia induced by excessive production of FGF23 in acute hepatitis: from bedside to bench.

Author

Hamroun, Aghiles, Boukrout, Nihad, Cauffiez, Christelle, Fellah, Sandy, Hauwaert, Cynthia Van der, Pottier, Nicolas, Mentaverri, Romuald, Zaworski, Jeremy, Gnemmi, Viviane, Gibier, Jean-Baptiste, Letavernier, Emmanuel, Louvet, Alexandre, Provôt, François, Lenain, Rémi, Maanaoui, Mehdi, Glowacki, François, and Lionet, Arnaud

Subjects
HEPATIC fibrosis, FIBROBLAST growth factors, GENE expression, CIRRHOSIS of the liver, IN situ hybridization
Abstract

Background Although hepatic production of FGF23 has been suggested in chronic settings, there are no data indicating hypophosphatemia resulting from acute hepatic FGF23 production. Based on two clinical observations of profound hypophosphatemia in the setting of acute hepatitis, our study investigates the hypothesis of acute FGF23 liver expression. Methods Retrospective analyses were conducted to estimate FGF23 liver expression both qualitatively (in situ hybridization) and quantitatively (relative FGF23 gene expression and protein production) on histological specimens of human and murine acute hepatitis livers, compared with controls of hepatic fibrosis or healthy liver. Results The index clinical case involves acute alcoholic hepatitis complicated by profound hypophosphatemia due to phosphate diabetes, revealing a major production of both FGF23 C-terminal fraction (cFGF23) and bio-intact form (iFGF23, 39 751 RU/mL, N: 21–91; and 228.6 pg/mL, N: 22.7–93.1, respectively). A second case of acute hepatitis related to erythrocytic protoporphyria also exhibited comparable abnormalities. In both cases, no other cause of renal phosphate wasting was identified, and the hydroelectrolytic disorders disappeared in parallel with normalization of the liver balance and FGF23 levels. Histological data of acute hepatitis compared with cirrhosis and healthy liver confirmed our hypothesis of hepatic FGF23 overproduction. Furthermore, mouse models showed a significant increase in FGF23 mRNA relative liver expression in acute hepatitis and a moderate increase in cirrhosis, compared with healthy liver (respectively 60.55 ± 16.75 and 3.70 ± 0.87 vs 1.00 ± 0.65, both P  < .05). These findings were also confirmed at the protein level. Conclusion This translational study raises the hypothesis of renal phosphate wasting induced by excessive hepatic production of FGF23 in case of acute hepatitis. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study

Author

Bourron, Olivier, Phan, Franck, Diallo, Mamadou Hassimiou, Hajage, David, Aubert, Carole-Elodie, Carlier, Aurélie, Salem, Joe-Elie, Funck-Brentano, Christian, Kemel, Salim, Cluzel, Philippe, Redheuil, Alban, Davaine, Jean-Michel, Massy, Ziad, Mentaverri, Romuald, Bonnefont-Rousselot, Dominique, Gillery, Philippe, Jaisson, Stéphane, Vermeer, Cees, Lacorte, Jean-Marc, Bouziri, Nesrine, Laroche, Suzanne, Amouyal, Chloé, and Hartemann, Agnes

Published
2020
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12. Chronic kidney disease is a key risk factor for aortic stenosis progression.

Author

Candellier, Alexandre, Bohbot, Yohann, Pasquet, Agnes, Diouf, Momar, Vermes, Emmanuelle, Goffin, Eric, Gun, Mesut, Peugnet, Fanny, Hénaut, Lucie, Rusinaru, Dan, Mentaverri, Romuald, Kamel, Saïd, Choukroun, Gabriel, Vanoverschelde, Jean-Louis, and Tribouilloy, Christophe

Subjects
CHRONIC kidney failure, AORTIC stenosis, AORTIC valve transplantation, VENTRICULAR ejection fraction, GLOMERULAR filtration rate, AORTIC valve insufficiency
Abstract

Background Rapid progression of aortic stenosis (AS) has been observed in patients undergoing dialysis, but existing cross-sectional evidence is contradictory in non-dialysis-dependent chronic kidney disease (CKD). The present study sought to evaluate whether CKD is associated with the progression of AS over time in a large cohort of patients with AS. Methods We retrospectively studied all consecutive patients diagnosed with AS [peak aortic jet velocity (Vmax) ≥2.5 m/s] and left ventricular ejection fraction ≥50% in the echocardiography laboratories of two tertiary centers between 2000 and 2018. The estimated glomerular filtration rate (eGFR) (mL/min/1.73 m2) was calculated from serum creatinine values. Patients were divided into five CKD stages according to the baseline eGFR. Annual rates of change in the aortic valve area (AVA) were determined by a linear mixed-effects model. Results Among the 647 patients included, 261 (40%) had CKD. After a median follow-up of 2.9 (interquartile range 1.8–4.8) years, the mean overall rate of change in AVA was –0.077 (95% confidence interval –0.082; –0.073) cm2/year. There was an inverse relationship between the progression rate and kidney function. The more severe the CKD stage, the greater the AVA narrowing (P  < .001). By multivariable linear regression analysis, the eGFR was also negatively associated (P  < .001) with AS progression. An eGFR strata below 45 mL/min/1.73 m2 was associated with higher odds of rapid progression of AS than normal kidney function. During the clinical follow-up, event-free survival (patients free of aortic valve replacement or death) decreased as CKD progressed. Rapid progression of AS in patients with kidney dysfunction was associated with worse outcomes. Conclusions Patients with CKD exhibit more rapid progression of AS over time and require close monitoring. The link between kidney dysfunction and rapid progression of AS is still unknown and requires further research. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Vasorin plays a critical role in vascular smooth muscle cells and arterial functions

Author

Louvet, Loïc, primary, Lenglet, Gaëlle, additional, Krautzberger, A. Michaela, additional, Mentaverri, Romuald, additional, Hague, Frédéric, additional, Kowalewski, Clara, additional, Mahtal, Nassim, additional, Lesieur, Julie, additional, Bonnet, Anne‐Laure, additional, Andrique, Caroline, additional, Gaucher, Céline, additional, Gomila, Cathy, additional, Schrewe, Heinrich, additional, Tharaux, Pierre‐Louis, additional, Kamel, Said, additional, Chaussain, Catherine, additional, and Six, Isabelle, additional

Published
2022
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29. Inhibiting the phosphatase activity of soluble epoxide hydrolase reduces arterial calcification and prevents the cardiovascular complications of chronic kidney disease

Author

Hind Messaoudi, Varennes Olivie, Nicolas Perzo, null Berg, Thomas Levesque, Duflot Thomas, null Chegrani, null Brunel, Six Isabelle, Mentaverri Romuald, Richard Vincent, null Anegon, Morisseau Christophe, Kamel Saïd, Proschak Eugen, and Jérémy Bellien

Subjects
Cardiology and Cardiovascular Medicine
Published
2022
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36. Circulating Receptor Activator of Nuclear factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in Type 2 Diabetes: a prospective, observational cohort study.

Author

Bourron, Olivier, primary, Phan, Franck, additional, Diallo, Mamadou Hassimiou, additional, Hajage, David, additional, Aubert, Carole-Elodie, additional, Carlier, Aurélie, additional, Salem, Joe-Elie, additional, Funck-Brentano, Christian, additional, Kemel, Salim, additional, Cluzel, Philippe, additional, Redheuil, Alban, additional, Davaine, Jean-Michel, additional, Massy, Ziad, additional, Mentaverri, romuald, additional, Bonnefont-Rousselot, Dominique, additional, Gillery, Philippe, additional, Jaisson, Stéphane, additional, Vermeer, Cees, additional, Lacorte, Jean-Marc, additional, Bouziri, Nesrine, additional, Laroche, Suzanne, additional, Amouyal, Chloé, additional, and Hartemann, Agnès, additional

Published
2020
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40. Supplementary_information – Supplemental material for Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting

Author

Batteux, Benjamin, Gras-Champel, Valérie, Lando, Mathilde, Brazier, François, Mentaverri, Romuald, Desailly-Henry, Isabelle, Amayelle Rey, Bennis, Youssef, Masmoudi, Kamel, Choukroun, Gabriel, and Liabeuf, Sophie

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, Supplementary_information for Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting by Benjamin Batteux, Valérie Gras-Champel, Mathilde Lando, François Brazier, Romuald Mentaverri, Isabelle Desailly-Henry, Amayelle Rey, Youssef Bennis, Kamel Masmoudi, Gabriel Choukroun and Sophie Liabeuf in Therapeutic Advances in Musculoskeletal Disease

Published
2020
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42. Bone Complications of Mastocytosis: A Link between Clinical and Biological Characteristics

Author

Guillaume, Nicolas, Desoutter, Judith, Chandesris, Olivia, Merlusca, Lavinia, Henry, Isabelle, Georgin-Lavialle, Sophie, Barete, Stéphane, Hirsch, Isabelle, Bouredji, Daoud, Royer, Bruno, Gruson, Bérengère, Lok, Catherine, Sevestre, Henri, Mentaverri, Romuald, Brazier, Michel, Meynier, Jonathan, Hermine, Olivier, Marolleau, Jean-Pierre, Kamel, Said, and Damaj, Gandhi

Published
2013
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45. Early steroid withdrawal has a positive effect on bone in kidney transplant recipients: a propensity score study with inverse probability-of-treatment weighting

Author

Batteux, Benjamin, primary, Gras-Champel, Valérie, additional, Lando, Mathilde, additional, Brazier, François, additional, Mentaverri, Romuald, additional, Desailly-Henry, Isabelle, additional, Rey, Amayelle, additional, Bennis, Youssef, additional, Masmoudi, Kamel, additional, Choukroun, Gabriel, additional, and Liabeuf, Sophie, additional

Published
2020
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