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43 results on '"Meppelink, A. M."'

2. Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa

Author

Bradley, Paul M., Kolpin, Dana W., Thompson, Darrin A., Romanok, Kristin M., Smalling, Kelly L., Breitmeyer, Sara E., Cardon, Mary C., Cwiertny, David M., Evans, Nicola, Field, R. William, Focazio, Michael J., Beane Freeman, Laura E., Givens, Carrie E., Gray, James L., Hager, Gordon L., Hladik, Michelle L., Hofmann, Jonathan N., Jones, Rena R., Kanagy, Leslie K., Lane, Rachael F., McCleskey, R. Blaine, Medgyesi, Danielle, Medlock-Kakaley, Elizabeth K., Meppelink, Shannon M., Meyer, Michael T., Stavreva, Diana A., and Ward, Mary H.

Published
2023
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3. Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa

Author

Thompson, Darrin A., Kolpin, Dana W., Hladik, Michelle L., Lehmler, Hans-Joachim, Meppelink, Shannon M., Poch, Matthew C., Vargo, John D., Soupene, Victor A., Irfan, Nafis Md, Robinson, Morgan, Kannan, Kurunthachalam, Beane Freeman, Laura E., Hofmann, Jonathan N., Cwiertny, David M., and Field, R. William

Published
2023
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5. Mixed organic and inorganic tapwater exposures and potential effects in greater Chicago area, USA

Author

Bradley, Paul M., Argos, Maria, Kolpin, Dana W., Meppelink, Shannon M., Romanok, Kristin M., Smalling, Kelly L., Focazio, Michael J., Allen, Joshua M., Dietze, Julie E., Devito, Michael J., Donovan, Ariel R., Evans, Nicola, Givens, Carrie E., Gray, James L., Higgins, Christopher P., Hladik, Michelle L., Iwanowicz, Luke R., Journey, Celeste A., Lane, Rachael F., Laughrey, Zachary R., Loftin, Keith A., McCleskey, R. Blaine, McDonough, Carrie A., Medlock-Kakaley, Elizabeth, Meyer, Michael T., Putz, Andrea R., Richardson, Susan D., Stark, Alan E., Weis, Christopher P., Wilson, Vickie S., and Zehraoui, Abderrahman

Published
2020
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6. Photosensitivity and self-induction in patients aged 50 and older

Author

Genetica, van Asch, C. J.J., Spetgens, W. P.J., Bourez-Swart, M. D., Meppelink, A. M., Deckers, C. L.P., van Blooijs, D., Kasteleijn-Nolst Trenité, D. G.A., Genetica, van Asch, C. J.J., Spetgens, W. P.J., Bourez-Swart, M. D., Meppelink, A. M., Deckers, C. L.P., van Blooijs, D., and Kasteleijn-Nolst Trenité, D. G.A.

Published
2024

11. Photosensitivity and self‐induction in patients aged 50 and older

Author

Asch, C. J. J., Spetgens, W. P. J., Bourez‐Swart, M. D., Meppelink, A. M., Deckers, C. L. P., Blooijs, D., and Kasteleijn‐Nolst Trenité, D. G. A.

Abstract

Photosensitivity is known to occur predominantly in children and adolescents and with a clear female predominance. Little is known on the prevalence of photosensitivity in older patients (50+) and its phenotypical appearance. A retrospective observational study was performed investigating the prevalence of a photoparoxysmal EEG response (PPR) on at least one EEG during the period 2015–2021. Data were gathered from patients aged 50 years and older by retrieving clinical and EEG characteristics from existing medical records. Data on photosensitivity‐related symptoms in daily life were gathered with telephone interviewing. In 248 patients a PPR had been elicited, of whom 16 patients (6.5%) were 50 years or older. In older patients, photosensitivity was a persistent feature of childhood‐onset epilepsy (n= 8), of adult‐onset epilepsy (n= 7), or an incidental finding (n= 1). In the 50+ group, 56% of photosensitive patients was female, whereas 72% in the total PPR‐group. In six of 16 older patients, eye closure sensitivity was observed; two of these patients reported self‐induction. Symptoms of photosensitivity in daily life were present in eight out of nine patients who consented in a telephone interview. For seven of these patients, wearing sunglasses was helpful. Female preponderance for photosensitivity was not found in epilepsy patients of 50 years and older. In 44% of the older photosensitive patients in this series, the PPR was a feature of adult‐onset epilepsy. Symptoms of photosensitivity in daily life in older patients with epilepsy seem comparable to those in younger patients, and thus worthwhile to diagnose and treat them equally.

Published
2024
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13. Tapwater Exposures, Effects Potential, and Residential Risk Management in Northern Plains Nations

Author

Bradley, Paul M., primary, Romanok, Kristin M., additional, Smalling, Kelly L., additional, Focazio, Michael J., additional, Charboneau, Robert, additional, George, Christine Marie, additional, Navas-Acien, Ana, additional, O’Leary, Marcia, additional, Red Cloud, Reno, additional, Zacher, Tracy, additional, Breitmeyer, Sara E., additional, Cardon, Mary C., additional, Cuny, Christa K., additional, Ducheneaux, Guthrie, additional, Enright, Kendra, additional, Evans, Nicola, additional, Gray, James L., additional, Harvey, David E., additional, Hladik, Michelle L., additional, Kanagy, Leslie K., additional, Loftin, Keith A., additional, McCleskey, R. Blaine, additional, Medlock-Kakaley, Elizabeth K., additional, Meppelink, Shannon M., additional, Valder, Joshua F., additional, and Weis, Christopher P., additional

Published
2022
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14. Dystonia

Author

Sadnicka, A, Meppelink, A-M, Kalinowski, A, Oakeshott, P, and van den Dool, J

Published
2022

16. RNA-seq reveals potential gene biomarkers in fathead minnows (Pimephales promelas) for exposure to treated wastewater effluent

Author

Schumann, Peter G., primary, Meade, Emma B., additional, Zhi, Hui, additional, LeFevre, Gregory H., additional, Kolpin, Dana W., additional, Meppelink, Shannon M., additional, Iwanowicz, Luke R., additional, Lane, Rachael F., additional, Schmoldt, Angela, additional, Mueller, Olaf, additional, and Klaper, Rebecca D., additional

Published
2022
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17. Prevalence of Neonicotinoid Insecticides in Paired Private-Well Tap Water and Human Urine Samples in a Region of Intense Agriculture Overlying Vulnerable Aquifers in Eastern Iowa

Author

Thompson, Darrin A., primary, Kolpin, Dana W., additional, Hladik, Michelle L., additional, Lehmler, Hans-Joachim, additional, Meppelink, Shannon M., additional, Poch, Matthew C., additional, Vargo, John D., additional, Soupene, Victor A., additional, Irfan, Nafis Md., additional, Robinson, Morgan, additional, Kannan, Kurunthachalam, additional, Beane Freeman, Laura, additional, Hofmann, Jonathan N., additional, Cwiertny, David, additional, and Field, R. William, additional

Published
2022
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22. Reduced drift rate: a biomarker of impaired information processing in functional movement disorders

Author

Sadnicka, A, Daum, C, Meppelink, A-M, Manohar, S, and Edwards, M

Abstract

Functional neurological disorder is a common and phenomenologically diverse condition. Resultant disability is caused by both the dominant clinical presentation, e.g. paralysis or tremor and additional symptomatology such as cognitive symptoms. Recently the similarity of neuropsychiatric profiles across a range of functional syndromes has been highlighted. This is suggestive of a common underlying mechanism with a theoretical deficit of information processing proposed. Identification of an experimental biomarker for such deficits could offer novel assessment and therapeutic strategies. In this study, we took the temporal discrimination threshold as a paradigm that can be used to model sensory processing in functional movement disorders. Our hypothesis was that we would be able to delineate markers of slowed information processing in this paradigm removed from the phenomenological presentation with a movement disorder. We recorded both response accuracy and reaction time in a two-choice temporal resolution/discrimination task in 36 patients with functional movement disorders and 36 control subjects. A psychometric function was fitted to accuracy data for each individual revealing both abnormally high threshold values (P = 0.0053) and shallow psychometric slopes in patients (P = 0.0015). Patients with functional movement disorders also had significantly slower response times (P = 0.0065). We then used a well-established model for decision-making (the drift diffusion model) that uses both response accuracy and reaction time data to estimate mechanistic physiological dimensions of decision-making and sensory processing. This revealed pathologically reduced drift rate in the patient group, a parameter that quantifies the quality and rate of information accumulation within this sensory task (P = 0.002). We discuss how the deficits we observed in patients with functional movement disorders are likely to stem from abnormal allocation of attention that impairs the quality of sensory information available. Within a predictive coding framework sensory information could be down-weighted in favour of predictions encoded by the prior. Our results therefore offer a parsimonious account for a range of experimental and clinical findings. Reduced drift rate is a potential experimental marker for a generalized deficit in information processing across functional disorders that allows diverse symptomatology to be quantified under a common disease framework.

Published
2020

25. Concentrations of lead and other inorganic constituents in samples of raw intake and treated drinking water from the municipal water filtration plant and residential tapwater in Chicago, Illinois, and East Chicago, Indiana, July–December 2017

Author

Romanok, Kristin M., primary, Kolpin, Dana W., additional, Meppelink, Shannon M., additional, Focazio, Michael J., additional, Argos, Maria, additional, Hollingsworth, Mary E., additional, McCleskey, R. Blaine, additional, Putz, Andrea R., additional, Stark, Alan, additional, Weis, Christopher P., additional, Zehraoui, Abderrahman, additional, and Bradley, Paul M., additional

Published
2018
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26. Methods used for the collection and analysis of chemical and biological data for the Tapwater Exposure Study, United States, 2016–17

Author

Romanok, Kristin M., primary, Kolpin, Dana W., additional, Meppelink, Shannon M., additional, Argos, Maria, additional, Brown, Juliane B., additional, Devito, Michael J., additional, Dietze, Julie E., additional, Givens, Carrie E., additional, Gray, James L., additional, Higgins, Christopher P., additional, Hladik, Michelle L., additional, Iwanowicz, Luke R., additional, Loftin, Keith A., additional, McCleskey, R. Blaine, additional, McDonough, Carrie A., additional, Meyer, Michael T., additional, Strynar, Mark J., additional, Weis, Christopher P., additional, Wilson, Vickie S., additional, and Bradley, Paul M., additional

Published
2018
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31. Abstract P22

Author

Fairbairn, Neil, primary, Ng-Glazier, Joanna, additional, Meppelink, Amanda M., additional, Randolph, Mark A., additional, Valerio, Ian, additional, Fleming, Mark E., additional, Redmond, Robert W., additional, and Winograd, Jonathan M., additional

Published
2015
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35. Abstract P6

Author

Ng-Glazier, Joanna H, primary, Fairbairn, Neil G, additional, Meppelink, Amanda M, additional, Bodugoz-Senturk, Hatice, additional, Randolph, Mark A, additional, Muratoglu, Orhun K, additional, Winograd, Jonathan M, additional, and Redmond, Robert W, additional

Published
2014
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40. Differentiation of human bone marrow mesenchymal stem cells on decellularized extracellular matrix materials.

Author

Hoganson, D. M., Meppelink, A. M., Hinkel, C. J., Goldman, S. M., Liu, X.‐H., Nunley, R. M., Gaut, J. P., and Vacanti, J. P.

Abstract

Mesenchymal bone marrow stromal cells may be a source of cells to preseed decellularized biologic mesh materials for improved cellularization and promote a more physiologic tissue after remodeling. Spontaneous differentiation of mesenchymal stromal cells on the decellularized material would be undesirable. Conversely, induced differentiation of mesenchymal stem cells (MSC) on the material would suggest that these materials may have promise as scaffold materials for bone, cartilage, or adipocyte formation. Two sources of mesenchymal cells were evaluated for induced differentiation in control wells. These MSCs were also evaluated for spontaneous or induced differentiation on decellularized porcine dermis and mesothelium materials. Primarily harvested bone marrow MSCs and commercially obtained MSCs were induced into osteoblasts and adipocytes on decellularized dermis and mesothelium materials. The MSCs were able to be induced into chondrocytes in pellet form but not when grown as a monolayer on the materials. The MSCs did not undergo spontaneous differentiation when grown on the materials for up to four weeks. MSC grown on decellularized porcine dermis or mesothelium do not spontaneously differentiate and may serve as a source of autologous cells for preseeding these extracellular matrix materials prior to implantation. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2875-2883, 2014. [ABSTRACT FROM AUTHOR]

Published
2014
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41. Improving neurophysiological biomarkers for functional myoclonic movements.

Author

Beudel M, Zutt R, Meppelink AM, Little S, Elting JW, Stelten BML, Edwards M, and Tijssen MAJ

Subjects
Adolescent, Adult, Aged, Biomarkers, Child, Female, Humans, Male, Middle Aged, Young Adult, Beta Rhythm physiology, Contingent Negative Variation physiology, Electroencephalography standards, Electroencephalography Phase Synchronization physiology, Myoclonus diagnosis, Myoclonus physiopathology
Abstract

Introduction: Differentiating between functional jerks (FJ) and organic myoclonus can be challenging. At present, the only advanced diagnostic biomarker to support FJ is the Bereitschaftspotential (BP). However, its sensitivity is limited and its evaluation subjective. Recently, event related desynchronisation in the broad beta range (13-45 Hz) prior to functional generalised axial (propriospinal) myoclonus was reported as a possible complementary diagnostic marker for FJ. Here we study the value of ERD together with a quantified BP in clinical practice., Methods: Twenty-nine patients with FJ and 16 patients with cortical myoclonus (CM) were included. Jerk-locked back-averaging for determination of the 'classical' and quantified BP, and time-frequency decomposition for the event related desynchronisation (ERD) were performed. Diagnostic gain, sensitivity and specificity were obtained for individual and combined techniques., Results: We detected a classical BP in 14/29, a quantitative BP in 15/29 and an ERD in 18/29 patients. At group level we demonstrate that ERD in the broad beta band preceding a jerk has significantly higher amplitude in FJ compared to CM (respectively -0.14 ± 0.13 and +0.04 ± 0.09 (p < 0.001)). Adding ERD to the classical BP achieved an additional diagnostic gain of 53%. Furthermore, when combining ERD with quantified and classical BP, an additional diagnostic gain of 71% was achieved without loss of specificity., Conclusion: Based on the current findings we propose to the use of combined beta ERD assessment and quantitative BP analyses in patients with a clinical suspicion for all types of FJ with a negative classical BP., (Copyright © 2018. Published by Elsevier Ltd.)

Published
2018
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42. Event related desynchronisation predicts functional propriospinal myoclonus.

Author

Meppelink AM, Little S, Oswal A, Erro R, Kilner J, Tijssen MAJ, Brown P, Cordovari C, and Edwards M

Subjects
Adult, Aged, Electroencephalography, Electromyography, Female, Humans, Male, Middle Aged, Young Adult, Contingent Negative Variation physiology, Evoked Potentials physiology, Myoclonus physiopathology
Abstract

Objective: Recent diagnostic criteria for functional movement disorders have proposed a "laboratory supported" level of diagnostic certainty where the clinical diagnosis is supported by a positive test. For functional myoclonus the Bereitschaftspotential (BP) is generally accepted as a positive laboratory test. We hypothesised that a different EEG measure, event-related desynchronisation (ERD), might be more effective., Methods: We analysed 20 patients with functional propriospinal myoclonus (fPSM) and 9 controls with organic myoclonus and performed back-averaging for BPs plus time-frequency decomposition to assess ERD and calculated sensitivity and specificity for both techniques., Results: The BP was present in only 25% of patients with fPSM while the majority showed a significant ERD (mean 38 Hz; sensitivity 65%). ERD was significant at the group level (p < 0.001), but not the BP (p > 0.05). Both BP and ERD were absent in our control group., Conclusion: ERD in high-beta may be a useful new test for positive diagnosis of functional myoclonus., Competing Interests: Financial disclosure/conflict of interest None reported., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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43. Isolated task-specific lip tremor.

Author

Macerollo A, Meppelink AM, Teodoro T, Ricciardi L, Cordivari C, and Edwards MJ

Subjects
Drinking, Electromyography, Female, Humans, Middle Aged, Lip Diseases, Tremor
Published
2016
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