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At the dynamic nexus of artificial intelligence and quantum technology, quantum neural networks (QNNs) play an important role as an emerging technology in the rapidly developing field of quantum machine learning. This development is set to revolutionize the applications of quantum computing. This article reviews the concept of QNNs and their physical realizations, particularly implementations based on quantum optics . We first examine the integration of quantum principles with classical neural network architectures to create QNNs. Some specific examples, such as the quantum perceptron, quantum convolutional neural networks, and quantum Boltzmann machines are discussed. Subsequently, we analyze the feasibility of implementing QNNs through photonics. The key challenge here lies in achieving the required non-linear gates, and measurement-induced approaches, among others, seem promising. To unlock the computational potential of QNNs, addressing the challenge of scaling their complexity through quantum optics is crucial. Progress in controlling quantum states of light is continuously advancing the field. Additionally, we have discovered that different QNN architectures can be unified through non-Gaussian operations. This insight will aid in better understanding and developing more complex QNN circuits.

Gaussian Boson Sampling (GBS) exhibits a unique ability to solve graph problems, such as finding cliques in complex graphs. It is noteworthy that many drug discovery tasks can be viewed as the clique-finding process, making them potentially suitable for quantum computation. However, to perform these tasks in their quantum-enhanced form, a large-scale quantum hardware with universal programmability is essential, which is yet to be achieved even with the most advanced GBS devices. Here, we construct a time-bin encoded GBS photonic quantum processor that is universal, programmable, and software-scalable. Our processor features freely adjustable squeezing parameters and can implement arbitrary unitary operations with a programmable interferometer. Using our processor, we have demonstrated the clique-finding task in a 32-node graph, where we found the maximum weighted clique with approximately twice the probability of success compared to classical sampling. Furthermore, a multifunctional quantum pharmaceutical platform is developed. This GBS processor is successfully used to execute two different drug discovery methods, namely molecular docking and RNA folding prediction. Our work achieves the state-of-the-art in GBS circuitry with its distinctive universal and programmable architecture which advances GBS towards real-world applications., Comment: 11 pages, 3 figures