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18 results on '"Merbah, Melanie"'

1. Priming with Japanese encephalitis virus or yellow fever virus vaccination led to the recognition of multiple flaviviruses without boosting antibody responses induced by an inactivated Zika virus vaccine

Author

Li, Yifan, Merbah, Mélanie, Wollen-Roberts, Suzanne, Beckman, Bradley, Mdluli, Thembi, Curtis, Daniel J., Currier, Jeffrey R., Mendez-Rivera, Letzibeth, Dussupt, Vincent, Krebs, Shelly J., De La Barrera, Rafael, Michael, Nelson L., Paquin-Proulx, Dominic, Eller, Michael A., Koren, Michael A., Modjarrad, Kayvon, and Rolland, Morgane

Published
2023
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2. Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Author

Li, Yifan, Merbah, Melanie, Wollen-Roberts, Suzanne, Beckman, Bradley, Mdluli, Thembi, Swafford, Isabella, Mayer, Sandra V., King, Jocelyn, Corbitt, Courtney, Currier, Jeffrey R., Liu, Heather, Esber, Allahna, Pinyakorn, Suteeraporn, Parikh, Ajay, Francisco, Leilani V., Phanuphak, Nittaya, Maswai, Jonah, Owuoth, John, Kibuuka, Hannah, Iroezindu, Michael, Bahemana, Emmanuel, Vasan, Sandhya, Ake, Julie A., Modjarrad, Kayvon, Gromowski, Gregory, Paquin-Proulx, Dominic, and Rolland, Morgane

Subjects
Immune response -- Analysis, Antigens -- Testing, Monoclonal antibodies -- Testing, Health
Abstract

COVID-19 clinical manifestations range from asymptomatic infection to death. Whether prior immune responses to human coronaviruses affect responses to SARS-CoV-2 remains unclear. At the population level, disparities in COVID-19 outcomes [...]

Published
2022
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5. Neutralization Sensitivity of a Novel HIV-1 CRF01_AE Panel of Infectious Molecular Clones

Author

Chenine, Agnes-Laurence, primary, Merbah, Melanie, additional, Wieczorek, Lindsay, additional, Molnar, Sebastian, additional, Mann, Brendan, additional, Lee, Jenica, additional, O'Sullivan, Anne-Marie, additional, Bose, Meera, additional, Sanders-Buell, Eric, additional, Kijak, Gustavo H., additional, Herrera, Carolina, additional, McLinden, Robert, additional, O'Connell, Robert J., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Kim, Jerome H., additional, Polonis, Victoria R., additional, and Tovanabutra, Sodsai, additional

Published
2018
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6. HIV-1 sequences with more predicted glycans in acute infection were associated with the development of higher neutralization breadth

Author

Merbah, Melanie, primary, Sanders-Buell, Eric, additional, Donofrio, Gina, additional, Li, Yifan, additional, Bose, Meera, additional, O’Sullivan, Anne-Marie, additional, Townsley, Samantha, additional, Slike, Bonnie, additional, Kibuuka, Hannah, additional, Maganga, Lucas, additional, Nitayaphan, Sorachai, additional, Eller, Leigh-Ann, additional, Krebs, Shelly, additional, Tovanabutra, Sodsai, additional, Michael, Nelson, additional, Robb, Merlin, additional, and Rolland, Morgane, additional

Published
2018
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7. Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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8. Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

Kijak, Gustavo H., primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurence, additional, Eller, Michael A., additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth A., additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O’Sullivan, Anne Marie, additional, Billings, Erik, additional, Merbah, Melanie, additional, Costanzo, Margaret C., additional, Warren, Joanna A., additional, Slike, Bonnie, additional, Li, Hui, additional, Peachman, Kristina K., additional, Fischer, Will, additional, Gao, Feng, additional, Cicala, Claudia, additional, Arthos, James, additional, Eller, Leigh A., additional, O’Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rao, Mangala, additional, Marovich, Mary A., additional, Krebs, Shelly J., additional, Rolland, Morgane, additional, Korber, Bette T., additional, Shaw, George M., additional, Michael, Nelson L., additional, Robb, Merlin L., additional, Tovanabutra, Sodsai, additional, and Kim, Jerome H., additional

Published
2017
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9. TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

Author

Allam, Atef, primary, Majji, Sai, additional, Peachman, Kristina, additional, Jagodzinski, Linda, additional, Kim, Jiae, additional, Ratto-Kim, Silvia, additional, Wijayalath, Wathsala, additional, Merbah, Melanie, additional, Kim, Jerome H., additional, Michael, Nelson L., additional, Alving, Carl R., additional, Casares, Sofia, additional, and Rao, Mangala, additional

Published
2015
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10. Real Time Fitness Assay of Two CRF01_A/E HIV-1 Transmitted Founder Variants

Author

Merbah, Melanie, primary, Kijak, Gustavo, additional, Eller, Leigh Anne, additional, Sanders-Buell, Eric, additional, Mann, Brendan T., additional, Pillis, Devin M., additional, O'Sullivan, Anne Marie, additional, Bose, Meera, additional, Lee, Jenica L., additional, Poltavee, Kultida, additional, Michael, Nelson, additional, Kim, Jerome, additional, Robb, Merlin, additional, Tovanabutra, Sodsai, additional, and Chenine, Agnes-Laurence, additional

Published
2014
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11. Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection

Author

Kijak, Gustavo Hernan, primary, Sanders-Buell, Eric, additional, Chenine, Agnes-Laurance, additional, Eller, Michael, additional, Goonetilleke, Nilu, additional, Thomas, Rasmi, additional, Leviyang, Sivan, additional, Harbolick, Elizabeth, additional, Bose, Meera, additional, Pham, Phuc, additional, Oropeza, Celina, additional, Poltavee, Kultida, additional, O'Sullivan, Anne Marie, additional, Merbah, Melanie, additional, Costanzo, Margaret, additional, Li, Hui, additional, Fischer, Will, additional, Gao, Feng, additional, Eller, Leigh Anne, additional, O'Connell, Robert J., additional, Sinei, Samuel, additional, Maganga, Lucas, additional, Kibuuka, Hannah, additional, Nitayaphan, Sorachai, additional, Rolland, Morgane, additional, Korber, Bette, additional, McCutchan, Francine, additional, Shaw, George, additional, Michael, Nelson, additional, Robb, Merlin, additional, Tovanabutra, Sodsai, additional, and Kim, Jerome, additional

Published
2014
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13. Exploiting the Anti-HIV-1 Activity of Acyclovir: Suppression of Primary and Drug-Resistant HIV Isolates and Potentiation of the Activity by Ribavirin

Author

Vanpouille, Christophe, primary, Lisco, Andrea, additional, Introini, Andrea, additional, Grivel, Jean-Charles, additional, Munawwar, Arshi, additional, Merbah, Melanie, additional, Schinazi, Raymond F., additional, Derudas, Marco, additional, McGuigan, Christopher, additional, Balzarini, Jan, additional, and Margolis, Leonid, additional

Published
2012
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14. Contrasting Roles for TLR Ligands in HIV-1 Pathogenesis

Author

Brichacek, Beda, primary, Vanpouille, Christophe, additional, Kiselyeva, Yana, additional, Biancotto, Angelique, additional, Merbah, Melanie, additional, Hirsch, Ivan, additional, Lisco, Andrea, additional, Grivel, Jean Charles, additional, and Margolis, Leonid, additional

Published
2010
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15. Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Author

O’Connell, Robert J., Michael, Nelson L., Oropeza, Celina, Arthos, James, Bose, Meera, Nitayaphan, Sorachai, Slike, Bonnie, Thomas, Rasmi, Chenine, Agnes-Laurence, Tovanabutra, Sodsai, Marovich, Mary A., O’Sullivan, Anne Marie, Rolland, Morgane, Maganga, Lucas, Merbah, Melanie, Warren, Joanna A., Shaw, George M., Billings, Erik, Goonetilleke, Nilu, Cicala, Claudia, Eller, Michael A., Poltavee, Kultida, Kibuuka, Hannah, Pham, Phuc, Kim, Jerome H., Sanders-Buell, Eric, Korber, Bette T., Fischer, Will, Li, Hui, Peachman, Kristina K., Leviyang, Sivan, Sinei, Samuel, Harbolick, Elizabeth A., Eller, Leigh A., Krebs, Shelly J., Gao, Feng, Costanzo, Margaret C., Rao, Mangala, Robb, Merlin L., and Kijak, Gustavo H.

Subjects
3. Good health
Abstract

In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events occurring during acute HIV-1 infection (AHI). Using viral deep sequencing on six participants from the early capture acute infection RV217 cohort, we have studied HIV-1 evolution in plasma collected twice weekly during the first weeks following the advent of viremia. The analysis of infections established by multiple transmitted/founder (T/F) viruses revealed novel viral profiles that included: a) the low-level persistence of minor T/F variants, b) the rapid replacement of the major T/F by a minor T/F, and c) an initial expansion of the minor T/F followed by a quick collapse of the same minor T/F to low frequency. In most participants, cytotoxic T-lymphocyte (CTL) escape was first detected at the end of peak viremia downslope, proceeded at higher rates than previously measured in HIV-1 infection, and usually occurred through the exploration of multiple mutational pathways within an epitope. The rapid emergence of CTL escape variants suggests a strong and early CTL response. Minor T/F viral strains can contribute to rapid and varied profiles of HIV-1 quasispecies evolution during AHI. Overall, our results demonstrate that early, deep, and frequent sampling is needed to investigate viral/host interaction during AHI, which could help identify prerequisites for prevention and cure of HIV-1 infection.

16. TFH cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1.

Author

Allam, Atef, Majji, Sai, Peachman, Kristina, Jagodzinski, Linda, Kim, Jiae, Ratto-Kim, Silvia, Wijayalath, Wathsala, Merbah, Melanie, Kim, Jerome H., Michael, Nelson L., Alving, Carl R., Casares, Sofia, and Rao, Mangala

Subjects
LABORATORY mice, B cells, LYMPH node diseases, PROTEIN precursors, AIDS vaccines, FEMALE reproductive organs
Abstract

CD4+ T follicular helper cells (TFH) in germinal centers are required for maturation of B-cells. While the role of TFH-cells has been studied in blood and lymph nodes of HIV-1 infected individuals, its role in the mucosal tissues has not been investigated. We show that the gut and female reproductive tract (FRT) of humanized DRAG mice have a high level of human lymphocytes and a high frequency of TFH (CXCR5+PD-1++) and precursor-TFH (CXCR5+PD-1+) cells. The majority of TFH-cells expressed CCR5 and CXCR3 and are the most permissive to HIV-1 infection. A single low-dose intravaginal HIV-1 challenge of humanized DRAG mice results in 100% infectivity with accumulation of TFH-cells mainly in the Peyer's patches and FRT. The novel finding of TFH-cells in the FRT may contribute to the high susceptibility of DRAG mice to HIV-1 infection. This mouse model thus provides new opportunities to study TFH-cells and to evaluate HIV-1 vaccines. [ABSTRACT FROM AUTHOR]

Published
2015
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17. Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection.

Author

Sanders-Buell, Eric, Chenine, Agnes-Laurance, Eller, Michael, Goonetilleke, Nilu, Thomas, Rasmi, Leviyang, Sivan, Harbolick, Elizabeth, Bose, Meera, Pham, Phuc, Oropeza, Celina, Poltavee, Kultida, O'Sullivan, Anne Marie, Merbah, Melanie, Costanzo, Margaret, Li, Hui, Fischer, Will, Gao, Feng, Eller, Leigh Anne, O'Connell, Robert J., and Sinei, Samuel

Abstract

An abstract of the article "Cryptic Multiple HIV-1 Infection Revealed by Early, Frequent, and Deep Sampling during Acute Infection" by Gustavo Hernan Kijak, Eric Sanders-Buell, Agnes-Laurance Chenine and colleagues is presented.

Published
2014
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18. Neutralization Sensitivity of a Novel HIV-1 CRF01_AE Panel of Infectious Molecular Clones.

Author

Chenine AL, Merbah M, Wieczorek L, Molnar S, Mann B, Lee J, OʼSullivan AM, Bose M, Sanders-Buell E, Kijak GH, Herrera C, McLinden R, OʼConnell RJ, Michael NL, Robb ML, Kim JH, Polonis VR, and Tovanabutra S

Subjects
Cell Line, HIV-1 immunology, HIV-1 pathogenicity, Humans, Antibodies, Neutralizing immunology, HIV Infections virology, HIV-1 genetics
Abstract

Background: HIV-1 CRF01&#95;AE is dominant in Thailand where RV144 vaccine trial was conducted. To study immune correlates of protection in ongoing trials, CRF01&#95;AE-derived reagents are essential. Here, we present a panel of 14 HIV-1 infectious molecular clones (IMCs) identified from different stages of infection and characterization of their neutralization sensitivity using 2 standard assays., Methods: One full-length IMC was constructed using a transmitted-founder virus to express Renilla luciferase (LucR) reporter gene and full-length envelopes (envs) of exogenous HIV-1. A panel of IMCs was generated, expressing envs of viruses from acute (Fiebig stages I/II and I-IV) and chronic (>Fiebig VI) infection. Neutralization assays were performed using TZM-bl or A3R5 cell lines, and sera or monoclonal antibodies (mAbs). Wilcoxon matched-paired test was used to assess neutralization differences between assays and reagents; correlation coefficients were evaluated by linear regression., Results: Neutralization potency observed was significantly higher in the A3R5 assay when testing mAbs and serum pools (P < 0.0001); the stage of infection from which env was derived did not associate with IMC neutralization sensitivity. Neutralization values from A3R5 and TZM-bl assays were strongly correlated when mAbs were tested (R = 0.7, P < 0.0001), but a weaker association was seen with serum pools (R = 0.17, P = 0.03)., Conclusions: This novel panel of CRF01&#95;AE reporter IMC is useful for assessing vaccine-induced neutralizing antibodies in multiple assays, including those using primary cell targets. The significant differences in TZM-bl and A3R5 neutralization sensitivity, as well as the poor association when using polyclonal sera indicates the need for caution in choosing one specific platform.

Published
2018
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