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9 results on '"Mercey-Ressejac, Marion"'

2. PD1 and TIM3 Expression is Associated with Very Early Hepatocellular Carcinoma Recurrence After Percutaneous Thermal Ablation

Author

Ghelfi, Julien, primary, Macek Jilkova, Zuzana, additional, Sengel, Christian, additional, Brusset, Bleuenn, additional, Teyssier, Yann, additional, Costentin, Charlotte, additional, Mercey-Ressejac, Marion, additional, Dumolard, Lucile, additional, Manceau, Marc, additional, Mathieu, Eliott, additional, Bricault, Ivan, additional, and Decaens, Thomas, additional

Published
2024
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3. Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model

Author

Kurma, Keerthi, primary, Zeybek Kuyucu, Ayca, additional, Roth, Gaël S., additional, Sturm, Nathalie, additional, Mercey-Ressejac, Marion, additional, Abbadessa, Giovanni, additional, Yu, Yi, additional, Lerat, Herve, additional, Marche, Patrice N., additional, Decaens, Thomas, additional, and Macek Jilkova, Zuzana, additional

Published
2022
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4. Chronic Intermittent Hypoxia Increases Cell Proliferation in Hepatocellular Carcinoma

Author

Carreres, Lydie, primary, Mercey-Ressejac, Marion, additional, Kurma, Keerthi, additional, Ghelfi, Julien, additional, Fournier, Carole, additional, Manches, Olivier, additional, Chuffart, Florent, additional, Rousseaux, Sophie, additional, Minoves, Mélanie, additional, Decaens, Thomas, additional, Lerat, Herve, additional, and Macek Jilkova, Zuzana, additional

Published
2022
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5. Increased Intrahepatic Expression of Immune Checkpoint Molecules in Autoimmune Liver Disease

Author

Jilkova, Zuzana Macek, Hilleret, Marie Noelle, Gerster, Theophile, Sturm, Nathalie, Mercey-Ressejac, Marion, Zarski, Jean-Pierre, Leroy, Vincent, Marche, Patrice N., Costentin, Charlotte, and Decaens, Thomas

Subjects
Male, autoimmune hepatitis, QH301-705.5, Liver Diseases, autoimmune liver disease, CD8-Positive T-Lymphocytes, Middle Aged, Immune Checkpoint Proteins, Models, Biological, Article, Autoimmune Diseases, 4-1BB, Liver, immune checkpoint molecules, embryonic structures, PD-1, Humans, Female, Lymphocytes, Biology (General), Biomarkers
Abstract

Immune checkpoint molecules (ICM) are critical in maintaining immunologic homeostasis and participate in preventing or promoting autoimmune disease development. Exploring a large panel of intrahepatic inhibitory and stimulatory ICM is necessary for drawing a general picture of the immune alterations in autoimmune hepatitis (AIH). Here, we performed a multiparametric analysis of ICM, including PD-1, TIM3, LAG3, CTLA-4, OX40 and 4-1BB, and we determined their expression on intrahepatic lymphocyte subsets in untreated and in treated patients with AIH in comparison to normal liver tissue. AIH patient-derived liver tissue revealed the overexpression of ICM, mainly PD-1 and 4-1BB, as well as the strong correlation between PD-1+ CD8+ T-cell abundance and severity of AIH (alanine transaminase and aspartate transaminase levels). Our results show that the ICM play an important role in the loss of immune homeostasis in the liver, providing an attractive approach to investigate their role as targets for effective therapeutic interventions.

Published
2021

7. DEN-Induced Rat Model Reproduces Key Features of Human Hepatocellular Carcinoma

Author

Kurma, Keerthi, primary, Manches, Olivier, additional, Chuffart, Florent, additional, Sturm, Nathalie, additional, Gharzeddine, Khaldoun, additional, Zhang, Jianhui, additional, Mercey-Ressejac, Marion, additional, Rousseaux, Sophie, additional, Millet, Arnaud, additional, Lerat, Herve, additional, Marche, Patrice N., additional, Macek Jilkova, Zuzana, additional, and Decaens, Thomas, additional

Published
2021
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8. Hybrid multimodal contrast agent for multiscalein vivoinvestigation of neuroinflammation

Author

Karpati, Szilvia, primary, Hubert, Violaine, additional, Hristovska, Inès, additional, Lerouge, Frédéric, additional, Chaput, Frédéric, additional, Bretonnière, Yann, additional, Andraud, Chantal, additional, Banyasz, Akos, additional, Micouin, Guillaume, additional, Monteil, Maëlle, additional, Lecouvey, Marc, additional, Mercey-Ressejac, Marion, additional, Dey, Arindam K., additional, Marche, Patrice N., additional, Lindgren, Mikael, additional, Pascual, Olivier, additional, Wiart, Marlène, additional, and Parola, Stephane, additional

Published
2021
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