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5 results on '"Mercorella, S"'

2. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis

Author

Turola, E, Petta, S, Vanni, E, Milosa, F, Valenti, L, Critelli, R, Miele, Luca, Maccio, L, Calvaruso, V, Fracanzani, Al, Bianchini, M, Raos, N, Bugianesi, E, Mercorella, S, Di Giovanni, M, Craxì, A, Fargion, S, Grieco, Antonio, Cammà, C, Cotelli, F, Villa, E., Miele, L (ORCID:0000-0003-3464-0068), Grieco, Antonio (ORCID:0000-0002-0544-8993), Turola, E, Petta, S, Vanni, E, Milosa, F, Valenti, L, Critelli, R, Miele, Luca, Maccio, L, Calvaruso, V, Fracanzani, Al, Bianchini, M, Raos, N, Bugianesi, E, Mercorella, S, Di Giovanni, M, Craxì, A, Fargion, S, Grieco, Antonio, Cammà, C, Cotelli, F, Villa, E., Miele, L (ORCID:0000-0003-3464-0068), and Grieco, Antonio (ORCID:0000-0002-0544-8993)

Published
2015

4. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis

Author

Antonio Craxì, Antonio Grieco, Marisa Di Giovanni, Elena Turola, Luca Valenti, Luca Miele, Anna Ludovica Fracanzani, Calogero Cammà, Franco Cotelli, Fabiola Milosa, Nazarena Raos, Vincenza Calvaruso, Elisabetta Bugianesi, Livia Maccio, Silvia Fargion, Serena Mercorella, Rosina Maria Critelli, Marcello Bianchini, Erica Villa, Salvatore Petta, Ester Vanni, Turola, E., Petta, S., Vanni, E., Milosa, F., Valenti, L., Critelli, R., Miele, L., Maccio, L., Calvaruso, V., Fracanzani, A., Bianchini, M., Raos, N., Bugianesi, E., Mercorella, S., Di Giovanni, M., Craxì, A., Fargion, S., Grieco, A., Cammà, C., Cotelli, F., and Villa, E.

Subjects
Liver Cirrhosis, Male, Fibrosi, Biopsy, Physiology, lcsh:Medicine, Medicine (miscellaneous), Body Mass Index, Cohort Studies, Immunology and Microbiology (miscellaneous), Fibrosis, Non-alcoholic Fatty Liver Disease, Risk Factors, Odds Ratio, Zebrafish, Cellular Senescence, medicine.diagnostic_test, Anthropometry, Fatty liver, Middle Aged, Ovarian senescence, Menopause, Liver biopsy, Models, Animal, Disease Progression, Female, lcsh:RB1-214, Research Article, Senescence, Adult, medicine.medical_specialty, Fibrosis, Menopause, Non-alcoholic fatty liver disease, Ovarian senescence, Zebrafish, Neuroscience (miscellaneous), Non-alcoholic fatty liver disease, Biochemistry, Genetics and Molecular Biology (all), Biology, Real-Time Polymerase Chain Reaction, General Biochemistry, Genetics and Molecular Biology, Internal medicine, medicine, lcsh:Pathology, Animals, Humans, Aged, lcsh:R, Settore MED/09 - MEDICINA INTERNA, Ovary, Odds ratio, medicine.disease, Endocrinology, Steatosis, Body mass index
Abstract

Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to ‘The Pathology Committee of the NASH Clinical Research Network’. Young and old male and female zebrafish were fed for 24 weeks with a high-calorie diet. Weekly body mass index (BMI), histopathological examination and quantitative real-time PCR analysis on genes involved in lipid metabolism, inflammation and fibrosis were performed. In the entire cohort, at multivariate logistic regression, male gender [odds ratio (OR): 1.408, 95% confidence interval (95% CI): 0.779-2.542, P=0.25] vs women at reproductive age was not associated with F2-F4 fibrosis, whereas a trend was observed for menopause (OR: 1.752, 95% CI: 0.956-3.208, P=0.06). In women, menopause (OR: 2.717, 95% CI: 1.020-7.237, P=0.04) was independently associated with F2-F4 fibrosis. Similarly, in overfed zebrafish, old female fish with failing ovarian function [as demonstrated by extremely low circulating estradiol levels (1.4±0.1 pg/µl) and prevailing presence of atretic follicles in the ovaries] developed massive steatosis and substantial fibrosis (comparable with that occurring in males), whereas young female fish developed less steatosis and were totally protected from the development of fibrosis. Ovarian senescence significantly increases the risk of fibrosis severity both in humans with NAFLD and in zebrafish with experimental steatosis., Summary: This study provides clinical and experimental evidence for the different roles played by excess calorie intake in the development of NAFLD and fibrosis; these diseases are dependent on age and reproductive status.

Published
2015

5. Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis.

Author

Turola E, Petta S, Vanni E, Milosa F, Valenti L, Critelli R, Miele L, Maccio L, Calvaruso V, Fracanzani AL, Bianchini M, Raos N, Bugianesi E, Mercorella S, Di Giovanni M, Craxì A, Fargion S, Grieco A, Cammà C, Cotelli F, and Villa E

Subjects
Adult, Aged, Animals, Anthropometry, Biopsy, Body Mass Index, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Models, Animal, Odds Ratio, Real-Time Polymerase Chain Reaction, Risk Factors, Zebrafish, Cellular Senescence, Liver Cirrhosis pathology, Menopause, Non-alcoholic Fatty Liver Disease pathology, Ovary pathology
Abstract

Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non-alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. In 244 females and age-matched males with biopsy-proven NAFLD, we assessed anthropometric, biochemical and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to 'The Pathology Committee of the NASH Clinical Research Network'. Young and old male and female zebrafish were fed for 24 weeks with a high-calorie diet. Weekly body mass index (BMI), histopathological examination and quantitative real-time PCR analysis on genes involved in lipid metabolism, inflammation and fibrosis were performed. In the entire cohort, at multivariate logistic regression, male gender [odds ratio (OR): 1.408, 95% confidence interval (95% CI): 0.779-2.542, P=0.25] vs women at reproductive age was not associated with F2-F4 fibrosis, whereas a trend was observed for menopause (OR: 1.752, 95% CI: 0.956-3.208, P=0.06). In women, menopause (OR: 2.717, 95% CI: 1.020-7.237, P=0.04) was independently associated with F2-F4 fibrosis. Similarly, in overfed zebrafish, old female fish with failing ovarian function [as demonstrated by extremely low circulating estradiol levels (1.4±0.1 pg/µl) and prevailing presence of atretic follicles in the ovaries] developed massive steatosis and substantial fibrosis (comparable with that occurring in males), whereas young female fish developed less steatosis and were totally protected from the development of fibrosis. Ovarian senescence significantly increases the risk of fibrosis severity both in humans with NAFLD and in zebrafish with experimental steatosis., (© 2015. Published by The Company of Biologists Ltd.)

Published
2015
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