1. Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.
- Author
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Merhar SL, Yolton K, DeMauro SB, Beiersdorfer T, Newman JE, Lorch SA, Wilson-Costello D, Ambalavanan N, Bangdiwala A, Peralta-Carcelen M, Poindexter BB, Davis JM, Limperopoulos C, and Bann CM
- Abstract
Objective: To describe distinctive profiles of neurobehavior in opioid-exposed and unexposed neonates., Study Design: The Outcomes of Babies with Opioid Exposure (OBOE) study is a multisite, prospective, observational study in neonates born at term with opioid exposure and unexposed controls. As part of the OBOE study protocol, certified examiners administered the NeoNatal Neurobehavioral Scales, 2
nd edition (NNNS-II) before 6 weeks postnatal age. We used latent profile analysis to determine distinctive classes of neurobehavior and linear mixed effect models to compare NNNS-II scores by exposure status., Results: The study included 291 neonates with NNNS-II, 194 exposed and 97 unexposed. Latent profile analysis resulted in 4 unique classes. Class 4 showed the most signs of stress and included almost exclusively exposed neonates. Scores for exposed neonates were significantly different than unexposed neonates on most NNNS-II subscales. In addition to opioids, associations were found between profile membership and prenatal exposure to benzodiazepines, e-cigarettes/tobacco, and selective serotonin reuptake inhibitors., Conclusions: Neonates with prenatal exposure to opioids and other psychotropic substances have distinctive patterns of neurobehavior. Additional follow-up is needed to determine if these neurobehavioral differences serve as a marker for future problems with attention and behavior., (Copyright © 2025 Elsevier Inc. All rights reserved.)- Published
- 2025
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