1. Post-transplant diabetes mellitus and renal cell cancer after renal transplantation
- Author
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Esteban Porrini, Nuria Montero, Juan Manuel Díaz, Ricardo Lauzurrica, Juana Oramas Rodríguez, Irene Silva Torres, Francesc Moreso, Josep M Cruzado, Rocío Benítez Ruiz, Meritxel Ibernon Vilaró, Maria Xixiang Molina Lima, Simran Khemlani Ramchand, Juan Carlos Ruiz, Francisco Gainza de los Rios, Carla Rodríguez Alvarez, María del Carmen de Gracia Guindo, Manuel Macías, David Bonet Vela, Antonio Osuna, Beatriz Bayés-Genís, Cristina Aleman Sanchez, María del Carmen Ruiz, Ana Elena Rodríguez Rodríguez, Rosa Domínguez Rollán, Federico González Rinne, Alejandro Jiménez Sosa, Patricia Delgado Mallén, Ana González Rinne, Domingo Marrero Miranda, and Armando Torres
- Subjects
Transplantation ,Nephrology - Abstract
Background Diabetes is a risk factor for cancer in the general population. However, few data are available on the association between post-transplant diabetes mellitus (PTDM) and cancer after transplantation. Methods We analyzed this issue in a Spanish cohort of patients without diabetes before transplantation. PTDM was diagnosed with consensus criteria at 12 months after transplantation and 12 months before the diagnosis of cancer. The association between PTDM and cancer (overall and specific types) was evaluated with regression analysis. Results During a follow-up of 12 years (interquartile range 8–14), 85 cases of 603 developed cancer (829/100 000/year) and 164 (27%) PTDM. The most frequent cancers were renal cell cancer (RCC) n = 15, 146/cases/100 000/year), lung (n = 12, 117/cases/100 000/year), colon (n = 9, 88/cases/100 000/year) and prostate (n = 9, 88/cases/100 000/year). In logistic regression, PTDM was not associated with cancer. Eight of the 164 patients with PTDM (4.9%) vs 7 of the 439 without PTDM developed RCC (1.6%) (P = .027). In multivariate analysis, PTDM was independently associated with RCC [odds ratio (OR) 2.92, confidence interval (CI) 1.03–8.27], adjusting for smoking (OR 4.020, 95% CI 1.34–12.02) and other covariates. PTDM was not associated with other types of cancer. Conclusions Patients with PTDM must be considered a population at risk for RCC and accordingly, the subject of active surveillance.
- Published
- 2022