Search

Your search keyword '"Merks, Johannes H M"' showing total 427 results
Start Over Author "Merks, Johannes H M"
427 results on '"Merks, Johannes H M"'

3. Comparison of clinical selection-based genetic testing with phenotype-agnostic extensive germline sequencing to diagnose genetic predisposition in children with cancer: a prospective diagnostic study

Author

Bakhuizen, Jette J, van Dijk, Freerk, Koudijs, Marco J, Bladergroen, Reno S, Bon, Sebastian B B, Hopman, Saskia M J, Kester, Lennart A, Kranendonk, Mariëtte E G, Loeffen, Jan L C, Smetsers, Stephanie E, Sonneveld, Edwin, Tachdjian, Melissa, de Vos-Kerkhof, Evelien, Goudie, Catherine, Merks, Johannes H M, Kuiper, Roland P, and Jongmans, Marjolijn C J

Published
2024
Full Text
View/download PDF

4. Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee

Author

van Ewijk, Roelof, Chatziantoniou, Cyrano, Adams, Madeleine, Bertolini, Patrizia, Bisogno, Gianni, Bouhamama, Amine, Caro-Dominguez, Pablo, Charon, Valerie, Coma, Ana, Dandis, Rana, Devalck, Christine, De Donno, Giulia, Ferrari, Andrea, Fiocco, Marta, Gallego, Soledad, Giraudo, Chiara, Glosli, Heidi, ter Horst, Simone A. J., Jenney, Meriel, Klein, Willemijn M., Leemans, Alexander, Leseur, Julie, Mandeville, Henry C., McHugh, Kieran, Merks, Johannes H. M., Minard-Colin, Veronique, Moalla, Salma, Morosi, Carlo, Orbach, Daniel, Ording Muller, Lil-Sofie, Pace, Erika, Di Paolo, Pier Luigi, Perruccio, Katia, Quaglietta, Lucia, Renard, Marleen, van Rijn, Rick R., Ruggiero, Antonio, Sirvent, Sara I., De Luca, Alberto, and Schoot, Reineke A.

Published
2023
Full Text
View/download PDF

7. Imaging in rhabdomyosarcoma: a patient journey

Author

de Vries, Isabelle S. A., van Ewijk, Roelof, Adriaansen, Laura M. E., Bohte, Anneloes E., Braat, Arthur J. A. T., Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S., Hol, Marinka L. F., ter Horst, Simone A. J., de Keizer, Bart, Knops, Rutger R. G., Meister, Michael T., Schoot, Reineke A., Smeele, Ludi E., van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H. M., and van Rijn, Rick R.

Published
2023
Full Text
View/download PDF

8. Childhood Cancer Predisposition

Author

Merks, Johannes H. M., Diets, Illja, Brecht, Ines B., Jongmans, Marjolijn CJ, Reaman, Gregory H., Series Editor, Smith, Franklin O., Series Editor, Schneider, Dominik T., editor, Brecht, Ines B., editor, Olson, Thomas A., editor, and Ferrari, Andrea, editor

Published
2022
Full Text
View/download PDF

9. Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Author

Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, and Holstege, Frank C P

Published
2022
Full Text
View/download PDF

12. Clinical value of a screening tool for tumor predisposition syndromes in childhood cancer patients (TuPS): a prospective, observational, multi-center study

Author

Postema, Floor A. M., Hopman, Saskia M. J., de Borgie, Corianne A. J. M., Aalfs, Cora M., Anninga, Jakob K., Berger, Lieke P. V., Bleeker, Fonnet E., Dommering, Charlotte J., van Eijkelenburg, Natasha K. A., Hammond, Peter, van den Heuvel-Eibrink, Marry M., Hol, Janna A., Kors, Wijnanda A., Letteboer, Tom G. W., Loeffen, Jan L. C. M., Meijer, Lisethe, Olderode-Berends, Maran J. W., Wagner, Anja, Hennekam, Raoul C., and Merks, Johannes H. M.

Published
2021
Full Text
View/download PDF

13. Correction to: Imaging in rhabdomyosarcoma: a patient journey

Author

de Vries, Isabelle S. A., van Ewijk, Roelof, Adriaansen, Laura M. E., Bohte, Anneloes E., Braat, Arthur J. A. T., Fajardo, Raquel Dávila, Hiemcke‑Jiwa, Laura S., Hol, Marinka L. F., ter Horst, Simone A. J., de Keizer, Bart, Knops, Rutger R. G., Meister, Michael T., Schoot, Reineke A., Smeele, Ludi E., van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H. M., and van Rijn, Rick R.

Published
2023
Full Text
View/download PDF

15. Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial.

Author

Mandeville, Henry C., Bisogno, Gianni, Minard‐Colin, Veronique, Alaggio, Rita, Ben‐Arush, Myriam, Chargari, Cyrus, Coppadoro, Beatrice, Craigie, Ross, Devalck, Christine, Ferman, Sima, Ferrari, Andrea, Glosli, Heidi, Alvaro, Raquel Hladun, Hol, Marinka, Mudry, Peter, Orbach, Daniel, Albiac, Monica Ramos, Merks, Johannes H. M., and Jenney, Meriel E. M.

Subjects
SARCOMA, EYE-socket tumors, RHABDOMYOSARCOMA, OVERALL survival, SURGICAL excision
Abstract

Background: The authors report the prospective evaluation of reduced dose alkylator chemotherapy combined with radiotherapy for European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) standard risk nonalveolar rhabdomyosarcoma (NA‐RMS). Patients and Methods: Localized node negative Intergroup Rhabdomyosarcoma Study (IRS) II/III NA‐RMS at favorable sites (subgroup C), <25 years old, received five cycles of ifosfamide, vincristine, and dactinomycin (IVA) chemotherapy (30 g/m2 ifosfamide) and four cycles of vincristine and dactinomycin (if receiving radiotherapy), or nine cycles of IVA (54 g/m2 ifosfamide) ± radiotherapy. Delayed primary tumor excision was considered for IRS III tumors. The primary end points were event‐free survival (EFS) and overall survival (OS). Results: From October 2005 to December 2016, 359 evaluable patients were recruited: orbit, 164 (45.7%); head and neck nonparameningeal, 77 (21.4%); and genitourinary non–bladder/prostate, 118 (32.9%). EFS and OS were 77.4% (95% confidence interval [CI], 72.5–81.6) and 93.5% (95% CI, 90.1–95.8), respectively. Lower dose alkylator chemotherapy and radiotherapy achieved 5‐year OS of 93.7% but the difference with higher dose alkylator chemotherapy +/‐ radiotherapy was not significant (p = 0.8003). Adjuvant radiotherapy improved EFS with 5‐year estimates of 84.7% versus 65.2% for nonirradiated (p <.0001), but not OS (p =.9298). Omitting radiotherapy for orbital tumors reduced OS (5‐year was 87.1% vs. 97.3% for irradiated, p =.0257). Following R0 resection (n = 60), radiotherapy did not significantly improve EFS or OS. Conclusions: Radiotherapy for local tumor control allows for reduction of cumulative dose of alkylators in EpSSG standard risk subgroup C RMS patients. The omission of radiotherapy did not affect OS in all patients except those with orbital RMS and was associated with inferior EFS. Radiotherapy allowed effective reduction in cumulative dose of alkylators for localized Intergroup Rhabdomyosarcoma Study II/III nonalveolar rhabdomyosarcoma (RMS) at favorable sites in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 trial. The omission of radiotherapy is associated with inferior event‐free survival but not overall survival (OS), although inferior OS was observed for orbital RMS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Onderzoek Beeld, Dávila Fajardo, Raquel, Scarzello, Giovanni, Gaze, Mark N, Boterberg, Tom, Cameron, Alison, Fuchs, Joerg, Guérin, Florent, Hoskin, Peter, Krasin, Matthew J, Kroon, Petra, Magelssen, Henriette, Mercke, Claes, Merks, Johannes H M, Paulsen, Frank, Pommier, Pascal, Ramos, Monica, Rees, Helen, Rogers, Tim, Schmid, Maximilian, Seitz, Guido, Slater, Olga, Smeulders, Naima, Stenman, Jakob, Terwisscha, Sheila, Chargari, Cyrus, Mandeville, Henry C, MS Radiotherapie, Cancer, Klinische Fysica RT, Onderzoek Beeld, Dávila Fajardo, Raquel, Scarzello, Giovanni, Gaze, Mark N, Boterberg, Tom, Cameron, Alison, Fuchs, Joerg, Guérin, Florent, Hoskin, Peter, Krasin, Matthew J, Kroon, Petra, Magelssen, Henriette, Mercke, Claes, Merks, Johannes H M, Paulsen, Frank, Pommier, Pascal, Ramos, Monica, Rees, Helen, Rogers, Tim, Schmid, Maximilian, Seitz, Guido, Slater, Olga, Smeulders, Naima, Stenman, Jakob, Terwisscha, Sheila, Chargari, Cyrus, and Mandeville, Henry C

Published
2024

17. Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram.

Author

De Salvo, Gian Luca, Del Bianco, Paola, Minard‐Colin, Veronique, Chisholm, Julia, Jenney, Meriel, Guillen, Gabriela, Devalck, Christine, Van Rijn, Rick, Shipley, Janet, Orbach, Daniel, Kelsey, Anna, Rogers, Timothy, Guerin, Florent, Scarzello, Giovanni, Ferrari, Andrea, Cesen Mazic, Maja, Merks, Johannes H. M., and Bisogno, Gianni

Subjects
SARCOMA, RHABDOMYOSARCOMA, PROGNOSIS, PROPORTIONAL hazards models, NOMOGRAPHY (Mathematics)
Abstract

Background: The objective of this study was to investigate the role of clinical factors together with FOXO1 fusion status in patients with nonmetastatic rhabdomyosarcoma (RMS) to develop a predictive model for event‐free survival and provide a rationale for risk stratification in future trials. Methods: The authors used data from patients enrolled in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 study (EpSSG RMS 2005; EudraCT number 2005‐000217‐35). The following baseline variables were considered for the multivariable model: age at diagnosis, sex, histology, primary tumor site, Intergroup Rhabdomyosarcoma Studies group, tumor size, nodal status, and FOXO1 fusion status. Main effects and significant second‐order interactions of candidate predictors were included in a multiple Cox proportional hazards regression model. A nomogram was generated for predicting 5‐year event‐free survival (EFS) probabilities. Results: The EFS and overall survival rates at 5 years were 70.9% (95% confidence interval, 68.6%–73.1%) and 81.0% (95% confidence interval, 78.9%–82.8%), respectively. The multivariable model retained five prognostic factors, including age at diagnosis interacting with tumor size, tumor primary site, Intergroup Rhabdomyosarcoma Studies clinical group, and FOXO1 fusion status. Based on each patient's total score in the nomogram, patients were stratified into four groups. The 5‐year EFS rates were 94.1%, 78.4%, 65.2%, and 52.1% in the low‐risk, intermediate‐risk, high‐risk, and very‐high‐risk groups, respectively, and the corresponding 5‐year overall survival rates were 97.2%, 91.5%, 74.3%, and 60.8%, respectively. Conclusions: The results presented here provide the rationale to modify the EpSSG stratification, with the most significant change represented by the replacement of histology with fusion status. This classification was adopted in the new international trial launched by the EpSSG. Traditional clinical factors, together with FOXO1 fusion status, in nonmetastatic rhabdomyosarcoma were investigated to develop a predictive model for event‐free survival and provide a rationale for risk stratification in future trials. The most important result was the replacement of histology with fusion status, and this model was used for patient stratification in the new European Pediatric Soft Tissue Sarcoma Study Group Frontline and Relapse Rhabdomyosarcoma trial (ClinicalTrials.gov identifier NCT04625907). [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)

Author

Chisholm, Julia, primary, Mandeville, Henry, additional, Adams, Madeleine, additional, Minard-Collin, Veronique, additional, Rogers, Timothy, additional, Kelsey, Anna, additional, Shipley, Janet, additional, van Rijn, Rick R., additional, de Vries, Isabelle, additional, van Ewijk, Roelof, additional, de Keizer, Bart, additional, Gatz, Susanne A., additional, Casanova, Michela, additional, Hjalgrim, Lisa Lyngsie, additional, Firth, Charlotte, additional, Wheatley, Keith, additional, Kearns, Pamela, additional, Liu, Wenyu, additional, Kirkham, Amanda, additional, Rees, Helen, additional, Bisogno, Gianni, additional, Wasti, Ajla, additional, Wakeling, Sara, additional, Heenen, Delphine, additional, Tweddle, Deborah A., additional, Merks, Johannes H. M., additional, and Jenney, Meriel, additional

Published
2024
Full Text
View/download PDF

20. Novel Circulating Hypermethylated RASSF1A ddPCR for Liquid Biopsies in Patients With Pediatric Solid Tumors

Author

van Zogchel, Lieke M. J., Lak, Nathalie S. M., Verhagen, Onno J. H. M., Tissoudali, Ahmed, Gussmalla Nuru, Mohammed, Gelineau, Nina U., Zappeij-Kannengieter, Lily, Javadi, Ahmad, Zijtregtop, Eline A. M., Merks, Johannes H. M., van den Heuvel-Eibrink, Marry, Schouten-van Meeteren, Antoinette Y. N., Stutterheim, Janine, van der Schoot, C. Ellen, and Tytgat, Godelieve A. M.

Published
2021
Full Text
View/download PDF

21. Facial deformation following treatment for pediatric head and neck rhabdomyosarcoma; the difference between treatment modalities. Results of a trans‐Atlantic, multicenter cross‐sectional cohort study

Author

Hol, Marinka L. F., primary, Indelicato, Daniel J., additional, Slater, Olga, additional, Kolb, Frederic, additional, Hewitt, Richard J, additional, Ong, Juling, additional, Becking, Alfred G., additional, Gains, Jenny, additional, Bradley, Julie, additional, Sandler, Eric, additional, Gaze, Mark N., additional, Pieters, Bradley, additional, Mandeville, Henry, additional, Fajardo, Raquel Dávila, additional, Schoot, Reineke, additional, Merks, Johannes H. M., additional, Hammond, Peter, additional, Smeele, Ludwig E., additional, and Suttie, Michael, additional

Published
2023
Full Text
View/download PDF

22. Intra‐abdominal desmoplastic small round cell tumor: The European pediatric Soft tissue sarcoma Study Group (E p SSG) experience

Author

Berlanga, Pablo, primary, Orbach, Daniel, additional, Schoot, Reineke A., additional, Casanova, Michela, additional, Alaggio, Rita, additional, Corradini, Nadege, additional, Brennan, Bernadette, additional, Ramirez‐Villar, Gema L., additional, Hjalgrim, Lisa Lyngsie, additional, Chisholm, Julia C., additional, Bisogno, Gianni, additional, Coppadoro, Beatrice, additional, Safwat, Akmal, additional, Merks, Johannes H. M., additional, Burrieza, Gabriela Guillen, additional, van Noesel, Max M., additional, and Ferrari, Andrea, additional

Published
2023
Full Text
View/download PDF

23. Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols

Author

Guérin, Florent, primary, Martelli, Hélène, additional, Rogers, Timothy, additional, Zanetti, Ilaria, additional, van Scheltinga, Sheila Terwisscha, additional, De Corti, Federica, additional, Burrieza, Gabriella Guillen, additional, Minard‐Colin, Véronique, additional, Orbach, Daniel, additional, van Noesel, Max M., additional, Karanian, Marie, additional, Fajardo, Raquel Dávila, additional, Merks, Johannes H. M., additional, Ferrari, Andrea, additional, and Bisogno, Gianni, additional

Published
2023
Full Text
View/download PDF

24. Metastatic adult‐type non‐rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group

Author

Ferrari, Andrea, primary, Orbach, Daniel, additional, Casanova, Michela, additional, van Noesel, Max M., additional, Berlanga, Pablo, additional, Brennan, Bernadette, additional, Corradini, Nadege, additional, Schoot, Reineke A., additional, Ramirez‐Villar, Gema L., additional, Hjalgrim, Lisa Lyngsie, additional, Alaggio, Rita, additional, Guillen Burrieza, Gabriela, additional, Safwat, Akmal, additional, Cameron, Alison L., additional, van Rijn, Rick R., additional, Minard‐Colin, Veronique, additional, Zanetti, Ilaria, additional, Bisogno, Gianni, additional, Chisholm, Julia C., additional, and Merks, Johannes H. M., additional

Published
2023
Full Text
View/download PDF

27. Intra-abdominal desmoplastic small round cell tumor: The European pediatric Soft tissue sarcoma Study Group (EpSSG) experience

Author

Onderzoek Beeld, Cancer, Berlanga, Pablo, Orbach, Daniel, Schoot, Reineke A, Casanova, Michela, Alaggio, Rita, Corradini, Nadege, Brennan, Bernadette, Ramirez-Villar, Gema L, Hjalgrim, Lisa Lyngsie, Chisholm, Julia C, Bisogno, Gianni, Coppadoro, Beatrice, Safwat, Akmal, Merks, Johannes H M, Burrieza, Gabriela Guillen, van Noesel, Max M, Ferrari, Andrea, Onderzoek Beeld, Cancer, Berlanga, Pablo, Orbach, Daniel, Schoot, Reineke A, Casanova, Michela, Alaggio, Rita, Corradini, Nadege, Brennan, Bernadette, Ramirez-Villar, Gema L, Hjalgrim, Lisa Lyngsie, Chisholm, Julia C, Bisogno, Gianni, Coppadoro, Beatrice, Safwat, Akmal, Merks, Johannes H M, Burrieza, Gabriela Guillen, van Noesel, Max M, and Ferrari, Andrea

Published
2023

28. Metastatic adult-type non-rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group

Author

Onderzoek Beeld, Cancer, PMC Medisch specialisten, Ferrari, Andrea, Orbach, Daniel, Casanova, Michela, van Noesel, Max M, Berlanga, Pablo, Brennan, Bernadette, Corradini, Nadege, Schoot, Reineke A, Ramirez-Villar, Gema L, Hjalgrim, Lisa Lyngsie, Alaggio, Rita, Guillen Burrieza, Gabriela, Safwat, Akmal, Cameron, Alison L, van Rijn, Rick R, Minard-Colin, Veronique, Zanetti, Ilaria, Bisogno, Gianni, Chisholm, Julia C, Merks, Johannes H M, Onderzoek Beeld, Cancer, PMC Medisch specialisten, Ferrari, Andrea, Orbach, Daniel, Casanova, Michela, van Noesel, Max M, Berlanga, Pablo, Brennan, Bernadette, Corradini, Nadege, Schoot, Reineke A, Ramirez-Villar, Gema L, Hjalgrim, Lisa Lyngsie, Alaggio, Rita, Guillen Burrieza, Gabriela, Safwat, Akmal, Cameron, Alison L, van Rijn, Rick R, Minard-Colin, Veronique, Zanetti, Ilaria, Bisogno, Gianni, Chisholm, Julia C, and Merks, Johannes H M

Published
2023

29. Correction to: Imaging in rhabdomyosarcoma: a patient journey

Author

Onderzoek Beeld, Cancer, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, PMC Medisch specialisten, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, van Rijn, Rick R, Onderzoek Beeld, Cancer, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, PMC Medisch specialisten, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, and van Rijn, Rick R

Published
2023

30. Cell-Free DNA as a Diagnostic and Prognostic Biomarker in Pediatric Rhabdomyosarcoma

Author

Onderzoek Beeld, Cancer, Lak, Nathalie S M, van Zogchel, Lieke M J, Zappeij-Kannegieter, Lily, Javadi, Ahmad, van Paemel, Ruben, Vandeputte, Charlotte, De Preter, Katleen, De Wilde, Bram, Chicard, Mathieu, Iddir, Yasmine, Schleiermacher, Gudrun, Ruhen, Olivia, Shipley, Janet, Fiocco, Marta, Merks, Johannes H M, van Noesel, Max M, van der Schoot, C Ellen, Tytgat, Godelieve A M, Stutterheim, Janine, Onderzoek Beeld, Cancer, Lak, Nathalie S M, van Zogchel, Lieke M J, Zappeij-Kannegieter, Lily, Javadi, Ahmad, van Paemel, Ruben, Vandeputte, Charlotte, De Preter, Katleen, De Wilde, Bram, Chicard, Mathieu, Iddir, Yasmine, Schleiermacher, Gudrun, Ruhen, Olivia, Shipley, Janet, Fiocco, Marta, Merks, Johannes H M, van Noesel, Max M, van der Schoot, C Ellen, Tytgat, Godelieve A M, and Stutterheim, Janine

Published
2023

31. Imaging in rhabdomyosarcoma: a patient journey

Author

Cancer, Arts-assistenten Radiologie, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, van Rijn, Rick R, Cancer, Arts-assistenten Radiologie, MS Radiologie, MS Radiotherapie, Pathologie Groep Van Diest, MS KNO, de Vries, Isabelle S A, van Ewijk, Roelof, Adriaansen, Laura M E, Bohte, Anneloes E, Braat, Arthur J A T, Fajardo, Raquel Dávila, Hiemcke-Jiwa, Laura S, Hol, Marinka L F, Ter Horst, Simone A J, de Keizer, Bart, Knops, Rutger R G, Meister, Michael T, Schoot, Reineke A, Smeele, Ludi E, van Scheltinga, Sheila Terwisscha, Vaarwerk, Bas, Merks, Johannes H M, and van Rijn, Rick R

Published
2023

32. Intra‐abdominal desmoplastic small round cell tumor: The European pediatric Soft tissue sarcoma Study Group (EpSSG) experience.

Author

Berlanga, Pablo, Orbach, Daniel, Schoot, Reineke A., Casanova, Michela, Alaggio, Rita, Corradini, Nadege, Brennan, Bernadette, Ramirez‐Villar, Gema L., Hjalgrim, Lisa Lyngsie, Chisholm, Julia C., Bisogno, Gianni, Coppadoro, Beatrice, Safwat, Akmal, Merks, Johannes H. M., Burrieza, Gabriela Guillen, van Noesel, Max M., and Ferrari, Andrea

Published
2023
Full Text
View/download PDF

33. Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm

Author

Bakhuizen, Jette J., primary, Hopman, Saskia M. J., additional, Bosscha, Machteld I., additional, Dommering, Charlotte J., additional, van den Heuvel-Eibrink, Marry M., additional, Hol, Janna A., additional, Kester, Lennart A., additional, Koudijs, Marco J., additional, Langenberg, Karin P. S., additional, Loeffen, Jan L. C., additional, van der Lugt, Jasper, additional, Moll, Annette C., additional, van Noesel, Max M., additional, Smetsers, Stephanie E., additional, de Vos-Kerkhof, Evelien, additional, Merks, Johannes H. M., additional, Kuiper, Roland P., additional, and Jongmans, Marjolijn C. J., additional

Published
2023
Full Text
View/download PDF

36. Metastatic rhabdomyosarcoma with exclusive distant lymph node involvement: A European Pediatric Soft tissue sarcoma Study Group (EpSSG) report

Author

Mercolini, Federico, primary, Merks, Johannes H. M., additional, Minard‐Colin, Veronique, additional, Cameron, Alison, additional, van Scheltinga, Scheila E. J. Terwisscha, additional, Sher, Osnat, additional, Fichera, Giulia, additional, Orbach, Daniel, additional, Glosli, Heidi, additional, Coppadoro, Beatrice, additional, Gallego, Soledad, additional, Chisholm, Julia C., additional, and Bisogno, Gianni, additional

Published
2022
Full Text
View/download PDF

37. Shedding a Light on the Challenges of Adolescents and Young Adults with Rhabdomyosarcoma

Author

Ferrari, Andrea, primary, Gatz, Susanne Andrea, additional, Minard-Colin, Veronique, additional, Alaggio, Rita, additional, Hovsepyan, Shushan, additional, Orbach, Daniel, additional, Gasparini, Patrizia, additional, Defachelles, Anne-Sophie, additional, Casanova, Michela, additional, Milano, Giuseppe Maria, additional, Chisholm, Julia C., additional, Jenney, Meriel, additional, Bisogno, Gianni, additional, Rogers, Timothy, additional, Mandeville, Henry C., additional, Shipley, Janet, additional, Miah, Aisha B., additional, Merks, Johannes H. M., additional, and van der Graaf, Winette T. A., additional

Published
2022
Full Text
View/download PDF

40. Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma

Author

Diepstraten, Franciscus A., primary, Wiersma, Jan, additional, Schoot, Reineke A., additional, Knops, Rutger R. G., additional, Zuur, Charlotte L., additional, Meijer, Annelot J. M., additional, Dávila Fajardo, Raquel, additional, Pieters, Bradley R., additional, Balgobind, Brian V., additional, Westerveld, Henrike, additional, Freling, Nicole, additional, van Tinteren, Harm, additional, Smeele, Ludwig E., additional, Bel, Arjan, additional, van den Heuvel-Eibrink, Marry M., additional, Stokroos, Robert J., additional, Merks, Johannes H. M., additional, Hoetink, Alexander E., additional, and Hol, Marinka L. F., additional

Published
2022
Full Text
View/download PDF

41. Patients with completely resected nongenitourinary low‐risk embryonal rhabdomyosarcoma are candidates for reduced duration low‐intensity chemotherapy

Author

Bisogno, Gianni, primary, Fuchs, Joerg, additional, Dasgupta, Roshni, additional, Ferrari, Andrea, additional, Haduong, Josephine H., additional, Rogers, Timothy, additional, Walterhouse, David O., additional, Coppadoro, Beatrice, additional, Xue, Wei, additional, Vokuhl, Christian, additional, Hawkins, Douglas S., additional, Seitz, Guido, additional, Merks, Johannes H. M., additional, Sparber‐Sauer, Monika, additional, and Venkatramani, Rajkumar, additional

Published
2022
Full Text
View/download PDF

42. Patient‐reported outcomes in childhood head and neck rhabdomyosarcoma survivors and their relation to physician‐graded adverse events—A multicenter study using the FACE‐Q Craniofacial module

Author

Morfouace, Michèle, primary, Hol, Marinka L. F., additional, Schoot, Reineke A., additional, Slater, Olga, additional, Indelicato, Daniel J., additional, Kolb, Frédéric, additional, Smeele, Ludwig E., additional, Merks, Johannes H. M., additional, Rae, Charlene, additional, Maurice‐Stam, Heleen, additional, Klassen, Anne F., additional, and Grootenhuis, Martha A., additional

Published
2022
Full Text
View/download PDF

44. Paratesticular rhabdomyosarcoma in children and adolescents—Outcome and patterns of relapse when utilizing a nonsurgical strategy for lymph node staging: Report from the International Society of Paediatric Oncology (SIOP) Malignant Mesenchymal Tumour 89 and 95 studies

Author

Rogers, Timothy, Minard‐Colin, Veronique, Cozic, Nathalie, Jenney, Meriel, Merks, Johannes H. M., Gallego, Soledad, Devalck, Christine, Gaze, Mark N., Kelsey, Anna, Oberlin, Odile, Stevens, Mike, Spicer, Richard D., Bergeron, Christophe, and Martelli, Helene

Published
2017
Full Text
View/download PDF

45. Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study

Author

Vaarwerk, Bas, van der Lee, Johanna H., Breunis, Willemijn B., Orbach, Daniel, Chisholm, Julia C., Cozic, Nathalie, Jenney, Meriel, van Rijn, Rick R., McHugh, Kieran, Gallego, Soledad, Glosli, Heidi, Devalck, Christine, Gaze, Mark N., Kelsey, Anna, Bergeron, Christophe, Stevens, Michael C. G., Oberlin, Odile, Minard‐Colin, Veronique, and Merks, Johannes H. M.

Published
2018
Full Text
View/download PDF

46. Interactive Education on Sleep Hygiene with a Social Robot at a Pediatric Oncology Outpatient Clinic: Feasibility, Experiences, and Preliminary Effectiveness

Author

van Bindsbergen, Kelly L. A., primary, van der Hoek, Hinke, additional, van Gorp, Marloes, additional, Ligthart, Mike E. U., additional, Hindriks, Koen V., additional, Neerincx, Mark A., additional, Alderliesten, Tanja, additional, Bosman, Peter A. N., additional, Merks, Johannes H. M., additional, Grootenhuis, Martha A., additional, and van Litsenburg, Raphaële R. L., additional

Published
2022
Full Text
View/download PDF

47. Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study

Author

Ferrari, Andrea, primary, Chisholm, Julia C, additional, Jenney, Meriel, additional, Minard-Colin, Veronique, additional, Orbach, Daniel, additional, Casanova, Michela, additional, Guillen, Gabriela, additional, Glosli, Heidi, additional, van Rijn, Rick R, additional, Schoot, Reineke A, additional, Cameron, Alison L, additional, Rogers, Timothy, additional, Alaggio, Rita, additional, Ben-Arush, Myriam, additional, Mandeville, Henry C, additional, Devalck, Christine, additional, Defachelles, Anne-Sophie, additional, Coppadoro, Beatrice, additional, Bisogno, Gianni, additional, and Merks, Johannes H M, additional

Published
2022
Full Text
View/download PDF

48. Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Author

DeMartino, Jeff, primary, Meister, Michael T., additional, Visser, Lindy, additional, Brok, Mariël, additional, Groot Koerkamp, Marian J. A., additional, Hiemcke-Jiwa, Laura S., additional, de Souza, Terezinha, additional, Merks, Johannes H. M., additional, Holstege, Frank C. P., additional, Margaritis, Thanasis, additional, and Drost, Jarno, additional

Published
2022
Full Text
View/download PDF

49. Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study

Author

Ferrari, Andrea, Chisholm, Julia, Jenney, Meriel, Minard-Colin, Véronique, Orbach, Daniel, Casanova, Michela, Guillen, Gabriela, Glosli, Heidi, Van Rijn, Rick Robert, Schoot, Reineke R.A., Cameron, Alison, Rogers, Timothy, Alaggio, Rita, Ben-Arush, Myriam, Mandeville, Henry H.C., Devalck, Christine, Defachelles, Anne Sophie, Coppadoro, Beatrice, Bisogno, Gianni, Merks, Johannes H M, Ferrari, Andrea, Chisholm, Julia, Jenney, Meriel, Minard-Colin, Véronique, Orbach, Daniel, Casanova, Michela, Guillen, Gabriela, Glosli, Heidi, Van Rijn, Rick Robert, Schoot, Reineke R.A., Cameron, Alison, Rogers, Timothy, Alaggio, Rita, Ben-Arush, Myriam, Mandeville, Henry H.C., Devalck, Christine, Defachelles, Anne Sophie, Coppadoro, Beatrice, Bisogno, Gianni, and Merks, Johannes H M

Abstract

Background: Adolescent and young adult patients with rhabdomyosarcoma often have poorer outcomes than do children. We aimed to compare the findings of adolescent and young adult patients with children enrolled in two prospective clinical protocols. Methods: This retrospective observational analysis was based on data from the European paediatric Soft tissue sarcoma Study Group (EpSSG) rhabdomyosarcoma 2005 trial (phase 3 randomised trial for localised rhabdomyosarcoma, open from April, 2006, to December, 2016) and the EpSSG MTS 2008 protocol (prospective, observational, single-arm study for metastatic rhabdomyosarcoma, open from June, 2010, to December, 2016), which involved 108 centres from 14 different countries in total. For this analysis, patients were categorised according to their age into children (age 0–14 years) and adolescents and young adults (age 15–21 years). For the analysis of adherence to treatment and toxicity, only patients with high-risk localised rhabdomyosarcoma included in the randomised part of the rhabdomyosarcoma 2005 study were considered. The primary outcome of event-free survival (assessed in all participants) was defined as the time from diagnosis to the first event (eg, tumour progression, relapse) or to the latest follow-up. Secondary outcomes were overall survival, response to chemotherapy, and toxicity. Findings: Our analysis included 1977 patients, 1720 children (median age 4·7 years; IQR 2·6–8·4) and 257 adolescents and young adults (16·6 years; 15·8–18·0). 1719 patients were from the EpSSG rhabdomyosarcoma 2005 study (1523 aged <15 years and 196 aged 15–21 years) and 258 patients were from the EPSSG MTS 2008 study (197 aged <15 years and 61 aged 15–21 years). Adolescent and young adult patients were more likely than were children to have metastatic tumours (61 [23·7%] of 257 vs 197 [11·5%] of 1720; p<0·0001), unfavourable histological subtypes (119 [46·3%] vs 451 [26·2%]; p<0·0001), tumours larger than 5 cm (177 [68·9%] vs 891 [51·, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

50. Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma

Author

MS Radiotherapie, Cancer, Zorgeenheid KNO Medisch, Brain, Audiologen, MS KNO, Diepstraten, Franciscus A, Wiersma, Jan, Schoot, Reineke A, Knops, Rutger R G, Zuur, Charlotte L, Meijer, Annelot J M, Dávila Fajardo, Raquel, Pieters, Bradley R, Balgobind, Brian V, Westerveld, Henrike, Freling, Nicole, van Tinteren, Harm, Smeele, Ludwig E, Bel, Arjan, van den Heuvel-Eibrink, Marry M, Stokroos, Robert J, Merks, Johannes H M, Hoetink, Alexander E, Hol, Marinka L F, MS Radiotherapie, Cancer, Zorgeenheid KNO Medisch, Brain, Audiologen, MS KNO, Diepstraten, Franciscus A, Wiersma, Jan, Schoot, Reineke A, Knops, Rutger R G, Zuur, Charlotte L, Meijer, Annelot J M, Dávila Fajardo, Raquel, Pieters, Bradley R, Balgobind, Brian V, Westerveld, Henrike, Freling, Nicole, van Tinteren, Harm, Smeele, Ludwig E, Bel, Arjan, van den Heuvel-Eibrink, Marry M, Stokroos, Robert J, Merks, Johannes H M, Hoetink, Alexander E, and Hol, Marinka L F

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results