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89 results on '"Merkus, PJFM"'

1. Quality of life and psychosocial outcomes in children with severe acute asthma and their parents

Author

Boeschoten, Shelley, Dulfer, Karolijn, Boehmer, Annemie, Merkus, PJFM, van Rosmalen, Joost, Jongste, Johan, de Hoog, Matthijs, Buysse, Corinne, Heisterkamp, S, van Woensel, J, Haarman, E, Kapitein, Berber, Wösten-van Asperen, R, Kneyber, M, Lemson, J, Hartman, S, Van Waardenburg, D, Bunker, H, Brouwer, C, van Ewijk, B, Landstra, A, Verwaal, M, Vaessen-Verberne, A, Hammer, S, Pediatric Surgery, Epidemiology, Pediatrics, Sociology, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Paediatric Intensive Care, and AII - Inflammatory diseases

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, PICU, Psychological intervention, 03 medical and health sciences, Intrusion, 0302 clinical medicine, Quality of life, status asthmaticus, 030225 pediatrics, Intensive care, follow-up, Medicine, Response rate (survey), follow‐up, business.industry, parents, Original Articles, Asthma, Posttraumatic stress, 030228 respiratory system, Pediatrics, Perinatology and Child Health, Original Article, business, Psychosocial, Severe acute asthma
Abstract

To prospectively evaluate quality of life (QoL) and psychosocial outcomes in children with severe acute asthma (SAA) after pediatric intensive care (PICU) admission compared to children with SAA who were admitted to a general ward (GW). In addition, we assessed post-traumatic stress (PTS) and asthma-related QoL in the parents.A preplanned follow-up of 3-9 months of our nationwide prospective multicenter study, in which children with SAA admitted to a Dutch PICU (n=110) or GW (n=111) were enrolled between 2016-2018. Asthma-related QoL, PTS symptoms, emotional and behavioral problems, and social impact in children and/or parents were assessed with validated web-based questionnaires.We included 100 children after PICU and 103 after GW admission, with a response rate of 50% for the questionnaires. Median time to follow-up was 5 months (range 1-12 months). Time to reach full schooldays after admission was significantly longer in the PICU group (mean of 10 vs 4 days, p=0.001). Parents in the PICU group reported more PTS symptoms (intrusion p=0.01, avoidance p=0.01, arousal p=0.02) compared to the GW group.No significant differences were found between PICU and GW children on self-reported outcome domains, except for the time to reach full schooldays. PICU parents reported PTS symptoms more often than the GW group. Therefore, monitoring asthma symptoms and psychosocial screening of children and parents after PICU admission should both be part of standard care after SAA. This should identify those who are at risk for developing PTSD, in order to timely provide appropriate interventions. This article is protected by copyright. All rights reserved.

Published
2020

3. Hydrogen cyanide emission in the lung by Staphylococcus aureus

Author

Neerincx, AH, Linders, YAM, Vermeulen, L, Belderbos, Bob, Mandon, J, Mastrigt, Esther, Pijnenburg, Marielle, van Ingen, J, Mouton, Johan, Kluijtmans, LAJ, Wevers, RA, Harren, FJM, Cristescu, SM, Merkus, PJFM, Pediatrics, and Medical Microbiology & Infectious Diseases

Published
2016

5. Extended nitric oxide analysis may improve personalized anti-inflammatory treatment in asthmatic children with intermediate FENO50

Author

Thornadtsson, Alexandra, Neerincx, A, Högman, Marieann, Hugen, C, Sintnicolaas, C, Harren, FJM, Merkus, PJFM, Cristescu, SM, Thornadtsson, Alexandra, Neerincx, A, Högman, Marieann, Hugen, C, Sintnicolaas, C, Harren, FJM, Merkus, PJFM, and Cristescu, SM

Abstract

Exhaled nitric oxide (FENO) is elevated in asthma, and a clinical practice guideline has been published with recommendations for anti-inflammatory treatment. It summarizes that a FENO at an expiratory flow rate of 50 ml s−1 (FENO50) above 35 ppb in children indicates eosinophilic inflammation, and the most likely response is to use inhaled corticosteroids. Intermediate FENO50 between 20–35 ppb should be interpreted cautiously. The aim of the study was to investigate this guideline in a small group of asthmatic children. Thirty-seven asthmatic children; 23 boys and 14 girls, visited the outpatient clinic, and provided exhaled breath samples for offline NO measurement. These samples were analysed with chemiluminescence techniques. Three flow rates, namely 16, 90 and 230 ml s−1 were used for the extended NO analysis (Högman–Meriläinen algorithm, HMA) to estimate the alveolar concentration (CANO), diffusion rate of the airway wall (DawNO) and airway wall content (CawNO). For accuracy of the HMA, the estimated value of FENO at 50 ml s−1 (FENO50) was compared with measured FENO50. In nine children the difference was more than 5 ppb and the data were therefore excluded. Five children with FENO50 <20 ppb had no known allergy and their FENO50 geometrical mean (25th; 75th percentile) was 11 (10;14) and CawNO was 32 (20;43) ppb. Ten children with FENO50 > 35 ppb had an allergy and had FENO50 of 56 (47;60) ppb and CawNO of 140 (121;172) ppb. Thirteen children with allergies, with intermediate FENO50, had FENO50 of 27 (25;30) ppb with a wide range of CawNO. In five of these children, values were comparable to healthy children, 44 (43;50) ppb while eight children had elevated CawNO values of 108 (95;129) ppb. Our data indicate the clinical potential use of extended NO analysis to determine the personal target value of FENO50 for monitoring the treatment outcome. Furthermore, for children with intermediate FENO50 more than half of them could possibly benefit from an adjus

Published
2015
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7. Social cognition and executive functioning in newly diagnosed pediatric brain tumor patients

Author

Kok, Tessa, Kingma, Annette, Tucha, Oliver, Post, Wendy, Schieving, J, Gidding, C.E.M., Lemiere, J., van Gool, S., Oostrom, KJ, Van Vuurden, Dannis, Vrijlandt, E.J.L.E., Merkus, PJFM, de Bont, Eveline, Kamps, Willem, Clinical Neuropsychology, Developmental and behavioural disorders in education and care: assessment and intervention, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), and Groningen Research Institute for Asthma and COPD (GRIAC)

Published
2013

8. Neuropsychological functioning in children with cystic fibrosis: First results of a prospective comparative study

Author

Kok, Tessa, Kingma, Annette, Merkus, PJFM, Post, Wendy, Kamps, Willem, Tucha, Oliver, de Bont, Eveline, Vrijlandt, E.J.L.E., Clinical Neuropsychology, Developmental and behavioural disorders in education and care: assessment and intervention, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Stem Cell Aging Leukemia and Lymphoma (SALL), and Groningen Research Institute for Asthma and COPD (GRIAC)

Published
2013

9. Ernstige meervoudige beperkingen

Author

Merkus, PJFM, Kuethe, MC, Jongste, Johan, van Gent, R., Merkus, P., Pijnenburg, M, Rottier, B., and Pediatrics

Published
2012

13. Definition, assessment and treatment of wheezing disorders in preschool children

Author

Brand, Plp, Baraldi, E, Bisgaard, H, Boner, A, CASTRO RODRIGUEZ JA, Custovic, A, DE BLIC, J, DE JONGSTE JC, Eber, E, Everard, Ml, Frey, U, Gappa, M, GARCIA MARCOS, L, Grigg, J, Lenney, W, Lesouef, P, Mckenzie, S, Merkus, Pjfm, Midulla, Fabio, Paton, Jy, Piacentini, G, Pohunek, P, Rossi, G, Seddon, P, Silverman, M, Sly, Pd, Stick, S, Valiulis, A, VAN AALDEREN WMC, Wildhaber, Jh, Wennergren, G, Wilson, N, Zivkovic, Z, and Bush, A.

Published
2008

15. An official american thoracic society/ european respiratory society statement: pulmonary function testing in preschool children

Author

Beydon, N, Davis, SD, Lombardi, E, Allen, JL, Arets, HGM, Aurora, P, Bisgaard, H, Davis, GM, Ducharme, FM, Eigen, H, Gappa, M, Gaultier, C, Gustafsson, PM, Hall, GL, Hantos, Z, Healy, MJR, Jones, MH, Klug, B, Lodrup Carlsen, KC, McKenzie, SA, Marchal, F, Mayer, OH, Merkus, PJFM, Morris, MG, Oostveen, E, Pillow, JJ, Seddon, PC, Silverman, M, Sly, PD, Stocks, J, Tepper, RS, Vilozni, D, Wilson, NM, and Pediatrics

Published
2007

22. Luchtwegmalacie bij kinderen

Author

Boogaard, Ruben, Huijsmans, S, Pijnenburg, Marielle, Tiddens, H.A.W.M., Jongste, Johan, Merkus, PJFM, and Pediatrics

Published
2006

23. Lung diffusing capacity

Author

Jongste, Johan, Merkus, PJFM, Stam, H, Hammer, J, Eber, E, Pediatrics, and Pulmonary Medicine

Published
2005

50. Interpretatie gegevens spirometrisch onderzoek

Author

Quanjer, PhH, Stam, H (Hendrik), Aardweg, GJMJ, Bottema, BJAM, Demedts, M, Folgering, HThM, Merkus, PJFM, Roos, CM, Sterk, PJ, Pulmonary Medicine, and Radiation Oncology

Published
2000

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