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16. Intracellular Mechanisms in GH Control

Author

Schettini, G., Florio, T., Meucci, O., Landolfi, E., Grimaldi, M., Magri, G., Merola, B., Lombardi, G., Müller, Eugenio E., editor, MacLeod, Robert M., editor, Wass, John A. H., editor, and Scanlon, Maurice F., editor

Published
1989
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19. Abnormal vascular reactivity in growth hormone deficiency

Author

CAPALDO, BRUNELLA, GUARDASOLE V. PARDO F, MATARAZZO M, DI RELLA F. NUMIS F, MEROLA B, LONGOBARDI S, SACC L., Capaldo, Brunella, GUARDASOLE V., PARDO F, Matarazzo, M, DI RELLA F., NUMIS F, Merola, B, Longobardi, S, and Sacc, L.

Published
2001

23. Growth hormone and heart performance. A novel mechanism ofcardiac wall stress regulation in humans

Author

Fazio S, Cittadini A, Sabatini D, Merola B, Colao A, BIONDI, BERNADETTE, Longobardi S, Lombardi G, Saccà L., Fazio, S, Cittadini, A, Sabatini, D, Merola, B, Colao, A, Biondi, Bernadette, Longobardi, S, Lombardi, G, and Saccà, L.

Abstract

OBJECTIVES: This study was designed to assess systolic wall stress and ventricular function in patients with deranged growth hormone secretion, in an attempt to elucidate the mechanisms of growth hormone interaction with heart performance. DESIGN: A case-control study. SUBJECTS: Thirty patients with active acromegaly, free of diabetes mellitus and coronary artery disease, and 25 subjects with congenital growth hormone deficiency were studied. Twelve growth hormone-deficient subjects were reevaluated after 12 months of recombinant human growth hormone therapy. Two groups of 30 normal subjects each were used as controls for the acromegalic and growth hormone-deficient patients, respectively. RESULTS: In the acromegalics, end-systolic wall stress was reduced (-20%; P < 0.01) due to ventricular wall thickening (+ 26%; P < 0.001), whereas cardiac output was significantly increased (+ 20%; P < 0.01). The velocity of fibre shortening was unchanged. In growth hormone-deficient subjects, end-systolic wall stress was markedly increased (+ 38%; P < 0.001) due to a significant reduction of ventricular wall thickness (- 28%; P < 0.001), whereas cardiac output was significantly decreased (-44%; P < 0.001). Replacement therapy with recombinant human growth hormone produced a partial correction of wall thickness and stress. Consequently, systolic performance and cardiac output improved significantly. CONCLUSION: This study demonstrates that growth hormone plays a role in the control of cardiac wall stress and performance through a mechanism mediated by the effect of growth hormone on myocardial tissue growth. The data may have therapeutic implications in cardiac diseases that lead to heart failure.

Published
1997

26. Cardiovascular aspects in acromegaly: effects of treatment

Author

Lombardi, G, Colao, A, Ferone, Diego, Marzullo, P, Landi, Ml, Longobardi, S, Iervolino, E, Cuocolo, A, Fazio, S, Merola, B., Lombardi, G., Colao, A., Ferone, D., Marzullo, P., Landi, M. L., Longobardi, S., Cuocolo, A., Fazio, Serafino, Merola, B., and Sacca', Luigi

Published
1996

29. Impaired cardiac performance is a distinct feature ofuncomplicated acromegaly

Author

Fazio S, Cittadini A, Cuocolo A, Merola B, Sabatini D, Colao A, Lombardi G, Saccà L., BIONDI, BERNADETTE, Fazio, S, Cittadini, A, Cuocolo, A, Merola, B, Sabatini, D, Colao, A, Biondi, Bernadette, Lombardi, G, and Saccã, L.

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, acromegaly, Biochemistry
Abstract

This study was designed to assess right and left ventricular function in patients with active acromegaly. To this end, 26 acromegalic patients (9 of whom had arterial hypertension) and 15 normal subjects of comparable age and sex distribution were studied by radionuclide angiography at rest and during supine bicycle-ergometer exercise and echocardiography. At rest, the filling rates of left (-19%; P < 0.005) and right ventricle (-32%; P < 0.001) were significantly reduced in acromegalic patients, whereas right and left ventricle ejection fractions (EFs) were normal. During physical exercise, EF was considerably lower in the acromegalic patients than in controls. This was true for both left, (61 +/- 11% us. 75 +/- 8%; P < 0.001) and right ventricle (45 +/- 13 vs. 58 +/- 11%; < 0.002). In as many as 73% of patients, EF increased less than 5%, thus fulfilling the criteria for impaired cardiac performance. Left ventricular mass index was 60% greater in acromegalics than in controls (P < 0.001). A significant difference in left ventricular mass index was also present when normotensive acromegalic patients were compared with controls (P < 0.001). No significant difference in the indices of systolic and diastolic function was observed between the subgroups of normotensive and hypertensive acromegalics, either at rest or during exercise. The data demonstrate that in uncomplicated acromegaly, besides cardiac hypertrophy, there are also important alterations of systolic and diastolic function of both ventricles, leading to a significant impairment of cardiac performance.

Published
1994

30. Ormone della crescita e cuore

Author

FAZIO S, SABATINI D, BIONDI B, MEROLA B, COLAO A, LOMBARDI G, SACCÁ L., CITTADINI, ANTONIO, Fazio, S, Sabatini, D, Cittadini, Antonio, Biondi, B, Merola, B, Colao, A, Lombardi, G, and Saccá, L.

Published
1994

32. Impairment of cardiac performance in adult growth-hormone deficiency

Author

CITTADINI, ANTONIO, CUOCOLO A, MEROLA B, FAZIO S, SABATINI D, NICOLAI E, COLAO A, LONGOBARDI S, LOMBARDI G, SACCÁ L., Cittadini, Antonio, Cuocolo, A, Merola, B, Fazio, S, Sabatini, D, Nicolai, E, Colao, A, Longobardi, S, Lombardi, G, and Saccá, L.

Published
1994

37. Effetti cardiaci del GH

Author

FAZIO S, SABATINI D, SANTOMAURO M, MEROLA B, BIONDI, BERNADETTE, COLAO A, LOMBARDI G, S.A.C.C.A.'.L., CITTADINI, ANTONIO, Fazio, S, Sabatini, D, Cittadini, Antonio, Santomauro, M, Merola, B, Biondi, Bernadette, Colao, A, Lombardi, G, and S. A. C. C. A. '., L.

Published
1993

38. Valutazione della funzione ventricolare sinistra in pazienti con acromegalia: studio radionuclidico

Author

IMBRIACO, MASSIMO, MAUREA, SIMONE, Cuocolo A, Nicolai E, Nappi A, Sullo P, Cardei S, Klain M, Cittadini A, Sabatini D, Colao A, Ferone D, BIONDI, BERNADETTE, Merola B, Fazio S, Squame G, Salvatore M., Imbriaco, Massimo, Cuocolo, A, Nicolai, E, Maurea, Simone, Nappi, A, Sullo, P, Cardei, S, Klain, M, Cittadini, A, Sabatini, D, Colao, A, Ferone, D, Biondi, Bernadette, Merola, B, Fazio, S, Squame, G, and Salvatore, M.

Published
1993

39. Valutazione ecocardiografica nel paziente adulto con deficit di GH

Author

LOMBARDI G, MEROLA B, COLAO A, LONGOBARDI S, ROSSI E, BIONDI, BERNADETTE, SABATINI D, FAZIO S., CITTADINI, ANTONIO, Lombardi, G, Merola, B, Colao, A, Longobardi, S, Rossi, E, Biondi, Bernadette, Cittadini, Antonio, Sabatini, D, and Fazio, S.

Published
1993

41. Ormone della crescita e cuore

Author

FAZIO, SERAFINO, SABATINI D., CITTADINI A., LOMBARDI G., MEROLA B., BIONDI, BERNADETTE, COLAO A., LONGOBARDI S., SACCÀ L., Fazio, Serafino, Sabatini, D., Cittadini, A., Lombardi, G., Merola, B., Biondi, Bernadette, Colao, A., Longobardi, S., and Saccà, L.

Published
1993

45. Cardiac muscle in adult patients affected with GH deficiency (AGHD)

Author

MEROLA B, ROSSI E, LONGOBARDI S, FERONE D, ESPOSITO V, COLAO A, FAZIO S, ORIO F, LOMBARDI G., CITTADINI, ANTONIO, Merola, B, Rossi, E, Longobardi, S, Ferone, D, Esposito, V, Colao, A, Cittadini, Antonio, Fazio, S, Orio, F, and Lombardi, G.

Published
1992

47. Heart and acromegaly

Author

MEROLA B, COLAO A, BIONDI B, CATALDI, MAURO, ROSSI E, FAZIO S, PICARDI G, SABATINI D, SACC L., CITTADINI, ANTONIO, Merola, B, Colao, A, Biondi, B, Cataldi, Mauro, Rossi, E, Fazio, S, Cittadini, Antonio, Picardi, G, Sabatini, D, and Sacc, L.

Published
1991

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