8 results on '"Messerschmidt, Liesl"'
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2. Impact of Gender on Long-Term Treatment Outcomes of Highly Active Antiretroviral Therapy (HAART) in the TREAT Asia HIV Observational Database
- Author
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Po Lee, Man, Zhou, Jialun, Messerschmidt, Liesl, Honda, Miwako, Ditangco, Rossana, Sirisanthana, Thira, Kumarasamy, Nagalingeswaran, Phanuphak, Praphan, Arthur Chen, Yi-Ming, Zhang, Fujie, Saphonn, Vonthanak, Kiertiburanakul, Sasisopin, KC Lee, Christopher, Pujari, Sanjay, Yong Choi, Jun, Kamarulzaman, Adeeba, Yunihastuti, Evy, Parwati Merati, Tuti, Lim, Poh-Lian, and CK Li, Patrick
- Published
- 2015
- Full Text
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3. Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database
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Lim, Poh?Lian, Zhou, Jialun, Ditangco, Rossana A., Law, Matthew G., Sirisanthana, Thira, Kumarasamy, Nagalingeswaran, Chen, Yi?Ming A., Phanuphak, Praphan, Lee, Christopher Kc, Saphonn, Vonthanak, Oka, Shinichi, Zhang, Fujie, Choi, Jun Y., Pujari, Sanjay, Kamarulzaman, Adeeba, Li, Patrick Ck, Merati, Tuti P., Yunihastuti, Evy, Messerschmidt, Liesl, and Sungkanuparph, Somnuek
- Subjects
Antiviral agents -- Dosage and administration ,Pneumocystis carinii pneumonia -- Prevention -- Risk factors ,HIV infection -- Complications and side effects -- Care and treatment ,Health - Abstract
Background: Pneumocystis jiroveci pneumonia (PCP) prophylaxis is recommended for patients with CD4 counts of less than 200 cells/mm[sup.3]. This study examines the proportion of patients in the TREAT Asia HIV Observational Database (TAHOD) receiving PCP prophylaxis, and its effect on PCP and mortality. Methods: TAHOD patients with prospective follow up had data extracted for prophylaxis using co‐trimoxazole, dapsone or pentamidine. The proportion of patients on prophylaxis was calculated for each calendar year since 2003 among patients with CD4 counts of less than 200 cells/mm[sup.3]. The effect of prophylaxis on PCP and survival were assessed using random‐effect Poisson regression models. Results: There were a total of 4050 patients on prospective follow up, and 90% of them were receiving combination antiretroviral therapy. Of those with CD4 counts of less than 200 cells/mm[sup.3], 58% to 72% in any given year received PCP prophylaxis, predominantly co‐trimoxazole. During follow up, 62 patients developed PCP (0.5 per 100 person‐years) and 169 died from all causes (1.36/100 person‐years). After stratifying by site and adjusting for age, CD4 count, CDC stage and antiretroviral treatment, those without prophylaxis had no higher risk of PCP, but had a significantly higher risk of death (incident rate ratio 10.8, p < 0.001). PCP prophylaxis had greatest absolute benefit in patients with CD4 counts of less than 50 cells/mm[sup.3], lowering mortality rates from 33.5 to 6.3 per 100 person‐years. Conclusions: Approximately two‐thirds of TAHOD patients with CD4 counts of less than 200 cells/mm[sup.3] received PCP prophylaxis. Patients without prophylaxis had significantly higher mortality, even in the era of combination ART. Although PCP may be under‐diagnosed, these data suggest that prophylaxis is associated with important survival benefits., Background Pneumocystis jiroveci pneumonia (PCP) remains a major cause of morbidity and mortality among HIV‐infected persons presenting with advanced infection [1]. Although PCP rates have dropped in the combination antiretroviral [...]
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- 2012
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4. Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices
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Ballif, Marie, Renner, Lorna, Claude Dusingize, Jean, Leroy, Valeriane, Ayaya, Samuel, Wools-Kaloustian, Kara, Cortes, Claudia P., McGowan, Catherine C., Graber, Claire, Mandalakas, Anna M., Mofenson, Lynne M., Egger, Matthias, Kumara Wati, Ketut Dewi, Nallusamy, Revathy, Reubenson, Gary, Davies, Mary-Ann, Fenner, Lukas, Ajayi, Samuel, Anastos, Kathryn, Bashi, Jules, Bishai, William, Boulle, Andrew, Braitstein, Paula, Carriquiry, Gabriela, Carter, Jane E., Cegielski, Peter, Chimbetete, Cleophas, Conrad, Joseph, Cortes, Claudia, Diero, Lameck, Duda, Stephany, Durier, Nicolas, Dusingize, Jean Claude, Eboua, Tanoh F., Gasser, Adrian, Geng, Elvin, Gnokori, Joachim Charles, Hardwicke, Laura, Hoffmann, Chris, Huebner, Robin, Kancheya, Nzali, Kiertiburanakul, Sasisopin, Kim, Peter, Lameck, Diero, Leroy, Valériane, Lewden, Charlotte, Lindegren, Mary Lou, Mandalakas, Anna, Maskew, Mhairi, McKaig, Rosemary, Mofenson, Lynne, Mpoudi-Etame, Mireille, Okwara, Benson, Phiri, Sam, Prasitsuebsai, Wasana, Petit, April, Prozesky, Hans, Reid, Stewart E., Sohn, Annette, Sterling, Timothy, Vo, Quynh, Walker, Dana, Wehbe, Firas, Wejse, Christian, Wester, William, Williams, Carlie, Wood, Robin, Yao, Zhang, Yunihastuti, Evy, Abrams, Elaine, Ananworanich, Jintanat, Azondekon, Alain, Frieda Behets, Melanie Bacon, Cahn, Pedro, Cesar, Carina, Ciaranello, Andrea, Dabis, François, Edmonds, Andrew, Feinstein, Lydia, Hazra, Rohan, Hoover, Don, Keiser, Olivia, Magneres, Maria Cecilia, McGowan, Catherine, Messerschmidt, Liesl, Biribonwoha, Harriet Nuwagaba, Sharp, Gerald, Vreeman, Rachel, Worrell, Carol, Yiannoutsos, Constantine, and Zwickl, Beth
- Abstract
Background The global burden of childhood tuberculosis (TB) is estimated to be 0.5 million new cases per year. Human immunodeficiency virus (HIV)-infected children are at high risk for TB. Diagnosis of TB in HIV-infected children remains a major challenge. Methods We describe TB diagnosis and screening practices of pediatric antiretroviral treatment (ART) programs in Africa, Asia, the Caribbean, and Central and South America. We used web-based questionnaires to collect data on ART programs and patients seen from March to July 2012. Forty-three ART programs treating children in 23 countries participated in the study. Results Sputum microscopy and chest Radiograph were available at all programs, mycobacterial culture in 40 (93%) sites, gastric aspiration in 27 (63%), induced sputum in 23 (54%), and Xpert MTB/RIF in 16 (37%) sites. Screening practices to exclude active TB before starting ART included contact history in 41 sites (84%), symptom screening in 38 (88%), and chest Radiograph in 34 sites (79%). The use of diagnostic tools was examined among 146 children diagnosed with TB during the study period. Chest Radiograph was used in 125 (86%) children, sputum microscopy in 76 (52%), induced sputum microscopy in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children. Conclusions Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood TB, and screening was largely based on symptom identification. There is an urgent need to improve the capacity of ART programs in low- and middle-income countries to exclude and diagnose TB in HIV-infected children
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- 2017
5. Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices
- Author
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Ballif, Marie, Renner, Lorna, Claude Dusingize, Jean, Leroy, Valeriane, Ayaya, Samuel, Wools-Kaloustian, Kara, Cortes, Claudia P., McGowan, Catherine C., Graber, Claire, Mandalakas, Anna M., Mofenson, Lynne M., Egger, Matthias, Kumara Wati, Ketut Dewi, Nallusamy, Revathy, Reubenson, Gary, Davies, Mary-Ann, Fenner, Lukas, Ajayi, Samuel, Anastos, Kathryn, Bashi, Jules, Bishai, William, Boulle, Andrew, Braitstein, Paula, Carriquiry, Gabriela, Carter, Jane E., Cegielski, Peter, Chimbetete, Cleophas, Conrad, Joseph, Cortes, Claudia, Diero, Lameck, Duda, Stephany, Durier, Nicolas, Dusingize, Jean Claude, Eboua, Tanoh F., Gasser, Adrian, Geng, Elvin, Gnokori, Joachim Charles, Hardwicke, Laura, Hoffmann, Chris, Huebner, Robin, Kancheya, Nzali, Kiertiburanakul, Sasisopin, Kim, Peter, Lameck, Diero, Leroy, Valériane, Lewden, Charlotte, Lindegren, Mary Lou, Mandalakas, Anna, Maskew, Mhairi, McKaig, Rosemary, Mofenson, Lynne, Mpoudi-Etame, Mireille, Okwara, Benson, Phiri, Sam, Prasitsuebsai, Wasana, Petit, April, Prozesky, Hans, Reid, Stewart E., Sohn, Annette, Sterling, Timothy, Vo, Quynh, Walker, Dana, Wehbe, Firas, Wejse, Christian, Wester, William, Williams, Carlie, Wood, Robin, Yao, Zhang, Yunihastuti, Evy, Abrams, Elaine, Ananworanich, Jintanat, Azondekon, Alain, Frieda Behets, Melanie Bacon, Cahn, Pedro, Cesar, Carina, Ciaranello, Andrea, Dabis, François, Edmonds, Andrew, Feinstein, Lydia, Hazra, Rohan, Hoover, Don, Keiser, Olivia, Magneres, Maria Cecilia, McGowan, Catherine, Messerschmidt, Liesl, Biribonwoha, Harriet Nuwagaba, Sharp, Gerald, Vreeman, Rachel, Worrell, Carol, Yiannoutsos, Constantine, Zwickl, Beth, and Wejse, Christian
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Pediatrics ,medicine.medical_specialty ,Tuberculosis ,Asia ,Anti-HIV Agents ,Human immunodeficiency virus (HIV) ,HIV Infections ,Diagnostic tools ,medicine.disease_cause ,Active tb ,medicine ,Humans ,Child ,610 Medicine & health ,Developing Countries ,Poverty ,Africa South of the Sahara ,Microscopy ,medicine.diagnostic_test ,business.industry ,Sputum ,Infant ,General Medicine ,Mycobacterium tuberculosis ,medicine.disease ,Antiretroviral therapy ,Infectious Diseases ,Low and middle income countries ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Radiography, Thoracic ,medicine.symptom ,Americas ,Chest radiograph ,business ,Original Articles and Commentaries ,360 Social problems & social services - Abstract
BACKGROUND: The global burden of childhood tuberculosis (TB) is estimated to be 0.5 million new cases per year. Human immunodeficiency virus (HIV)-infected children are at high risk for TB. Diagnosis of TB in HIV-infected children remains a major challenge.METHODS: We describe TB diagnosis and screening practices of pediatric antiretroviral treatment (ART) programs in Africa, Asia, the Caribbean, and Central and South America. We used web-based questionnaires to collect data on ART programs and patients seen from March to July 2012. Forty-three ART programs treating children in 23 countries participated in the study.RESULTS: Sputum microscopy and chest Radiograph were available at all programs, mycobacterial culture in 40 (93%) sites, gastric aspiration in 27 (63%), induced sputum in 23 (54%), and Xpert MTB/RIF in 16 (37%) sites. Screening practices to exclude active TB before starting ART included contact history in 41 sites (84%), symptom screening in 38 (88%), and chest Radiograph in 34 sites (79%). The use of diagnostic tools was examined among 146 children diagnosed with TB during the study period. Chest Radiograph was used in 125 (86%) children, sputum microscopy in 76 (52%), induced sputum microscopy in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children.CONCLUSIONS: Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood TB, and screening was largely based on symptom identification. There is an urgent need to improve the capacity of ART programs in low- and middle-income countries to exclude and diagnose TB in HIV-infected children.
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- 2015
- Full Text
- View/download PDF
6. HIV-1 Drug Resistance Mutations Among Antiretroviral-Naïve HIV-1–Infected Patients in Asia: Results From the TREAT Asia Studies to Evaluate Resistance-Monitoring Study.
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Sungkanuparph, Somnuek, Oyomopito, Rebecca, Sirivichayakul, Sunee, Sirisanthana, Thira, Li, Patrick C. K., Kantipong, Pacharee, Lee, Christopher K. C., Kamarulzaman, Adeeba, Messerschmidt, Liesl, Law, Matthew G., and Phanuphak, Praphan
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DRUG resistance ,HIV-positive persons ,ANTIRETROVIRAL agents ,BIOLOGICAL monitoring ,DISEASE prevalence - Abstract
Of 682 antiretroviral-na_ve patients initiating antiretroviral therapy in a prospective, multicenter HIV-1 drug resistance monitoring study involving eight sites in Hong Kong, Malaysia, and Thailand, the prevalence of patients with ≥1 drug resistance mutation(s) was 13.8%. Primary HIV drug resistance is emerging after rapid scaling-up of antiretroviral therapy in Asia.(See editorial commentary by Jordan on pages 1058–1060.)Of 682 antiretroviral-naïve patients initiating antiretroviral therapy in a prospective, multicenter human immunodeficiency virus type 1 (HIV-1) drug resistance monitoring study involving 8 sites in Hong Kong, Malaysia, and Thailand, the prevalence of patients with ≥1 drug resistance mutation was 13.8%. Primary HIV drug resistance is emerging after rapid scaling-up of antiretroviral therapy use in Asia. [ABSTRACT FROM AUTHOR]
- Published
- 2011
7. Impact of Gender on Long-Term Treatment Outcomes of Highly Active Antiretroviral Therapy (HAART) in the TREAT Asia HIV Observational Database.
- Author
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Lee, Man Po, Zhou, Jialun, Messerschmidt, Liesl, Honda, Miwako, Ditangco, Rossana, Sirisanthana, Thira, Kumarasamy, Nagalingeswaran, Phanuphak, Praphan, Chen, Yi-Ming Arthur, Zhang, Fujie, Saphonn, Vonthanak, Kiertiburanakul, Sasisopin, Lee, Christopher KC, Pujari, Sanjay, Choi, Jun Yong, Kamarulzaman, Adeeba, Yunihastuti, Evy, Merati, Tuti Parwati, Lim, Poh-Lian, and Li, Patrick CK
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AIDS ,DRUG toxicity ,LONGITUDINAL method ,MULTIVARIATE analysis ,SCIENTIFIC observation ,PROBABILITY theory ,REGRESSION analysis ,RESEARCH funding ,SEX distribution ,STATISTICAL hypothesis testing ,LOGISTIC regression analysis ,VIRAL load ,HIGHLY active antiretroviral therapy ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DATA analysis software ,CD4 lymphocyte count - Abstract
A letter to the editor is presented on a study to examine impact of sex on viro-immunological responses to highly active antiretroviral therapy.
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- 2015
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8. Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices
- Author
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Ballif, Marie, Renner, Lorna, Claude Dusingize, Jean, Leroy, Valeriane, Ayaya, Samuel, Wools-Kaloustian, Kara, Cortes, Claudia P., McGowan, Catherine C., Graber, Claire, Mandalakas, Anna M., Mofenson, Lynne M., Egger, Matthias, Kumara Wati, Ketut Dewi, Nallusamy, Revathy, Reubenson, Gary, Davies, Mary-Ann, Fenner, Lukas, Ajayi, Samuel, Anastos, Kathryn, Bashi, Jules, Bishai, William, Boulle, Andrew, Braitstein, Paula, Carriquiry, Gabriela, Carter, Jane E., Cegielski, Peter, Chimbetete, Cleophas, Conrad, Joseph, Cortes, Claudia, Diero, Lameck, Duda, Stephany, Durier, Nicolas, Dusingize, Jean Claude, Eboua, Tanoh F., Gasser, Adrian, Geng, Elvin, Gnokori, Joachim Charles, Hardwicke, Laura, Hoffmann, Chris, Huebner, Robin, Kancheya, Nzali, Kiertiburanakul, Sasisopin, Kim, Peter, Lameck, Diero, Leroy, Valériane, Lewden, Charlotte, Lindegren, Mary Lou, Mandalakas, Anna, Maskew, Mhairi, McKaig, Rosemary, Mofenson, Lynne, Mpoudi-Etame, Mireille, Okwara, Benson, Phiri, Sam, Prasitsuebsai, Wasana, Petit, April, Prozesky, Hans, Reid, Stewart E., Sohn, Annette, Sterling, Timothy, Vo, Quynh, Walker, Dana, Wehbe, Firas, Wejse, Christian, Wester, William, Williams, Carlie, Wood, Robin, Yao, Zhang, Yunihastuti, Evy, Abrams, Elaine, Ananworanich, Jintanat, Azondekon, Alain, Frieda Behets, Melanie Bacon, Cahn, Pedro, Cesar, Carina, Ciaranello, Andrea, Dabis, François, Edmonds, Andrew, Feinstein, Lydia, Hazra, Rohan, Hoover, Don, Keiser, Olivia, Magneres, Maria Cecilia, McGowan, Catherine, Messerschmidt, Liesl, Biribonwoha, Harriet Nuwagaba, Sharp, Gerald, Vreeman, Rachel, Worrell, Carol, Yiannoutsos, Constantine, Zwickl, Beth, Ballif, Marie, Renner, Lorna, Claude Dusingize, Jean, Leroy, Valeriane, Ayaya, Samuel, Wools-Kaloustian, Kara, Cortes, Claudia P., McGowan, Catherine C., Graber, Claire, Mandalakas, Anna M., Mofenson, Lynne M., Egger, Matthias, Kumara Wati, Ketut Dewi, Nallusamy, Revathy, Reubenson, Gary, Davies, Mary-Ann, Fenner, Lukas, Ajayi, Samuel, Anastos, Kathryn, Bashi, Jules, Bishai, William, Boulle, Andrew, Braitstein, Paula, Carriquiry, Gabriela, Carter, Jane E., Cegielski, Peter, Chimbetete, Cleophas, Conrad, Joseph, Cortes, Claudia, Diero, Lameck, Duda, Stephany, Durier, Nicolas, Dusingize, Jean Claude, Eboua, Tanoh F., Gasser, Adrian, Geng, Elvin, Gnokori, Joachim Charles, Hardwicke, Laura, Hoffmann, Chris, Huebner, Robin, Kancheya, Nzali, Kiertiburanakul, Sasisopin, Kim, Peter, Lameck, Diero, Leroy, Valériane, Lewden, Charlotte, Lindegren, Mary Lou, Mandalakas, Anna, Maskew, Mhairi, McKaig, Rosemary, Mofenson, Lynne, Mpoudi-Etame, Mireille, Okwara, Benson, Phiri, Sam, Prasitsuebsai, Wasana, Petit, April, Prozesky, Hans, Reid, Stewart E., Sohn, Annette, Sterling, Timothy, Vo, Quynh, Walker, Dana, Wehbe, Firas, Wejse, Christian, Wester, William, Williams, Carlie, Wood, Robin, Yao, Zhang, Yunihastuti, Evy, Abrams, Elaine, Ananworanich, Jintanat, Azondekon, Alain, Frieda Behets, Melanie Bacon, Cahn, Pedro, Cesar, Carina, Ciaranello, Andrea, Dabis, François, Edmonds, Andrew, Feinstein, Lydia, Hazra, Rohan, Hoover, Don, Keiser, Olivia, Magneres, Maria Cecilia, McGowan, Catherine, Messerschmidt, Liesl, Biribonwoha, Harriet Nuwagaba, Sharp, Gerald, Vreeman, Rachel, Worrell, Carol, Yiannoutsos, Constantine, and Zwickl, Beth
- Abstract
Background The global burden of childhood tuberculosis (TB) is estimated to be 0.5 million new cases per year. Human immunodeficiency virus (HIV)-infected children are at high risk for TB. Diagnosis of TB in HIV-infected children remains a major challenge. Methods We describe TB diagnosis and screening practices of pediatric antiretroviral treatment (ART) programs in Africa, Asia, the Caribbean, and Central and South America. We used web-based questionnaires to collect data on ART programs and patients seen from March to July 2012. Forty-three ART programs treating children in 23 countries participated in the study. Results Sputum microscopy and chest Radiograph were available at all programs, mycobacterial culture in 40 (93%) sites, gastric aspiration in 27 (63%), induced sputum in 23 (54%), and Xpert MTB/RIF in 16 (37%) sites. Screening practices to exclude active TB before starting ART included contact history in 41 sites (84%), symptom screening in 38 (88%), and chest Radiograph in 34 sites (79%). The use of diagnostic tools was examined among 146 children diagnosed with TB during the study period. Chest Radiograph was used in 125 (86%) children, sputum microscopy in 76 (52%), induced sputum microscopy in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children. Conclusions Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood TB, and screening was largely based on symptom identification. There is an urgent need to improve the capacity of ART programs in low- and middle-income countries to exclude and diagnose TB in HIV-infected children
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