250 results on '"Metaxa, V."'
Search Results
2. Advance Directives in the United Kingdom: Ethical, Legal, and Practical Considerations
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Metaxa, V. and Vincent, Jean-Louis, Series Editor
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- 2020
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3. Dairy products, surrogate markers, and cardiovascular disease; a sex-specific analysis from the ATTICA prospective study
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Skoumas, Y., Katinioti, N., Papadimitriou, L., Masoura, C., Vellas, S., Lentzas, Y., Kambaxis, M., Paliou, K., Metaxa, V., Skourlis, N., Papanikolaou, C., Kalogeropoulou, A., Pitaraki, E., Laskaris, A., Hatzigeorgiou, M., Grekas, A., Kokkou, E., Vassiliadou, C., Dedousis, G., Toutouza-Giotsa, M., Tselika, C., Poulopouloou, S., Toutouza, M., Kouvari, Matina, Panagiotakos, Demosthenes B., Chrysohoou, Christina, Georgousopoulou, Ekavi N., Yannakoulia, Mary, Tousoulis, Dimitrios, and Pitsavos, Christos
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- 2020
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4. Mastering the brain in critical conditions: an update
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Robba, C, Zanier, E, Lopez Soto, C, Park, S, Sonneville, R, Helbolk, R, Sarwal, A, Newcombe, V, van der Jagt, M, Gunst, J, Gauss, T, Figueiredo, S, Duranteau, J, Skrifvars, M, Iaquaniello, C, Muehlschlegel, S, Metaxa, V, Sandroni, C, Citerio, G, Meyfroidt, G, Robba, Chiara, Zanier, Elisa R, Lopez Soto, Carmen, Park, Soojin, Sonneville, Romain, Helbolk, Raimund, Sarwal, Aarti, Newcombe, Virginia F J, van der Jagt, Mathieu, Gunst, Jan, Gauss, Tobias, Figueiredo, Samy, Duranteau, Jacques, Skrifvars, Markus B, Iaquaniello, Carolina, Muehlschlegel, Susanne, Metaxa, Victoria, Sandroni, Claudio, Citerio, Giuseppe, Meyfroidt, Geert, Robba, C, Zanier, E, Lopez Soto, C, Park, S, Sonneville, R, Helbolk, R, Sarwal, A, Newcombe, V, van der Jagt, M, Gunst, J, Gauss, T, Figueiredo, S, Duranteau, J, Skrifvars, M, Iaquaniello, C, Muehlschlegel, S, Metaxa, V, Sandroni, C, Citerio, G, Meyfroidt, G, Robba, Chiara, Zanier, Elisa R, Lopez Soto, Carmen, Park, Soojin, Sonneville, Romain, Helbolk, Raimund, Sarwal, Aarti, Newcombe, Virginia F J, van der Jagt, Mathieu, Gunst, Jan, Gauss, Tobias, Figueiredo, Samy, Duranteau, Jacques, Skrifvars, Markus B, Iaquaniello, Carolina, Muehlschlegel, Susanne, Metaxa, Victoria, Sandroni, Claudio, Citerio, Giuseppe, and Meyfroidt, Geert
- Abstract
Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events—vascular damage in strokes and biomechanical damage in traumatic brain injuries—they share common secondary injury mechanisms influencing long-term outcomes. Growing evidence suggests that a more personalized approach to optimize energy substrate delivery to the injured brain and prognosticate towards families could be beneficial. In this context, continuous invasive and/or non-invasive neuromonitoring, together with clinical evaluation and neuroimaging to support strategies that optimize cerebral blood flow and metabolic delivery, as well as approaches to neuroprognostication are gaining interest. Recently, the European Society of Intensive Care Medicine organized a 2-day course focused on a practical case-based clinical approach of acute brain-injured patients in different scenarios and on future perspectives to advance the management of this population. The aim of this manuscript is to update clinicians dealing with acute brain injured patients in the intensive care unit, describing current knowledge and clinical practice based on the insights presented during this course.
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- 2024
5. Mastering the brain in critical conditions: an update
- Author
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Robba, C., Zanier, E. R., Lopez Soto, C., Park, S., Sonneville, R., Helbolk, R., Sarwal, A., Newcombe, V. F. J., van der Jagt, M., Gunst, J., Gauss, T., Figueiredo, S., Duranteau, J., Skrifvars, M. B., Iaquaniello, C., Muehlschlegel, S., Metaxa, V., Sandroni, Claudio, Citerio, G., Meyfroidt, G., Sandroni C. (ORCID:0000-0002-8878-2611), Robba, C., Zanier, E. R., Lopez Soto, C., Park, S., Sonneville, R., Helbolk, R., Sarwal, A., Newcombe, V. F. J., van der Jagt, M., Gunst, J., Gauss, T., Figueiredo, S., Duranteau, J., Skrifvars, M. B., Iaquaniello, C., Muehlschlegel, S., Metaxa, V., Sandroni, Claudio, Citerio, G., Meyfroidt, G., and Sandroni C. (ORCID:0000-0002-8878-2611)
- Abstract
Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events—vascular damage in strokes and biomechanical damage in traumatic brain injuries—they share common secondary injury mechanisms influencing long-term outcomes. Growing evidence suggests that a more personalized approach to optimize energy substrate delivery to the injured brain and prognosticate towards families could be beneficial. In this context, continuous invasive and/or non-invasive neuromonitoring, together with clinical evaluation and neuroimaging to support strategies that optimize cerebral blood flow and metabolic delivery, as well as approaches to neuroprognostication are gaining interest. Recently, the European Society of Intensive Care Medicine organized a 2-day course focused on a practical case-based clinical approach of acute brain-injured patients in different scenarios and on future perspectives to advance the management of this population. The aim of this manuscript is to update clinicians dealing with acute brain injured patients in the intensive care unit, describing current knowledge and clinical practice based on the insights presented during this course.
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- 2024
6. Correction to: ICU-outcomes in CAR-T patients—A single centre experience
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Materski, T., John, M., Pirani, T., Benjamin, R., Kuhnl, A., Potter, V., Sanderson, R., and Metaxa, V.
- Published
- 2021
- Full Text
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7. Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA
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Benoit, D. D., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., and Rusinova, K.
- Subjects
Care and treatment ,Ethical aspects ,Comparative analysis ,Patient outcomes ,Decision making -- Comparative analysis ,Decision-making -- Comparative analysis - Abstract
Author(s): D. D. Benoit [sup.1], H. I. Jensen [sup.2] [sup.3], J. Malmgren [sup.4], V. Metaxa [sup.5], A. K. Reyners [sup.6], M. Darmon [sup.7], K. Rusinova [sup.8], D. Talmor [sup.9], A. [...], Purpose Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown. Methods In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis. Results Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0-1.00) and 85.9% (75.4-92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20-2.92) or receiving a written TLD (HR 2.32, CI 1.11-4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former. Conclusion Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life.
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- 2018
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8. Effects of alcohol consumption and the metabolic syndrome on 10-year incidence of diabetes: The ATTICA study
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Koloverou, E., Panagiotakos, D.B., Pitsavos, C., Chrysohoou, C., Georgousopoulou, E.N., Metaxa, V., and Stefanadis, C.
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- 2015
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9. End‐of‐life care in the intensive care unit
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Tanaka Gutiez, M., primary, Efstathiou, N., additional, Innes, R., additional, and Metaxa, V., additional
- Published
- 2023
- Full Text
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10. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016
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Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. P., Divatia, J. V., Murbach, L. D., Leite, M. A., Osaku, E. F., Costa, C. R. L. M., Pelenz, M., Neitzke, N. M., Moraes, M. M., Jaskowiak, J. L., Silva, M. M. M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Moore, J., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Randall, D., Adwaney, A., Blunden, M., Prowle, J.R., Kirwan, C. J., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., Girbes, A. R. J., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. J., Boerma, E. C., Rulisek, J., Balik, M., Zacharov, S., Kim, H. S., Jeon, S. J., Namgung, H., Lee, E., Lee, E., Cho, Y. J., Lee, Y. J., Huang, A., Cioccari, L., Luethi, N., Mårtensson, J., Bellomo, R., Forsberg, M., Edman, G., Höjer, J., Forsberg, S., Freile, M. T. Chiquito, Hidalgo, F. N., Molina, J. A. Martinez, Lecumberri, R., Rosselló, A. Figuerola, Travieso, P. Medrano, Leon, G. Tuero, Sanchez, J. Gonzalez, Frias, L. Sahuquillo, Rosello, D. Balsells, Verdejo, J. A. Garcia, Serrano, J. A. Noria, Winterwerp, D., van Galen, T., Vazin, A., Karimzade, I., Zand, A., Ozen, E., Ekemen, S., Akcan, A., Sen, E., Yelken, B. Buyukkidan, Kureshi, N., Fenerty, L., Thibault-Halman, G., Erdogan, M., Walling, S., Green, R. S., Clarke, D. B., Briassoulis, P., Kalimeris, K., Ntzouvani, A., Nomikos, T., Papaparaskeva, K., Politi, E., Kostopanagiotou, G., Crewdson, K., Rehn, M., Weaver, A., Brohi, K., Lockey, D., Wright, S., Thomas, K., Baker, C., Mansfield, L., Stafford, V., Wade, C., Watson, G., Bryant, A., Chadwick, T., Shen, J., Wilkinson, J., Furneval, J., Henderson, A., Hugill, K., Howard, P., Roy, A., Bonner, S., Baudouin, S., Ramírez, C. Sánchez, Escalada, S. Hípola, Viera, M. A. Hernández, Santana, M. Cabrera, Balcázar, L. Caipe, Monroy, N. Sangil, Campelo, F. Artiles, Vázquez, C. F. Lübbe, Santana, P. Saavedra, Santana, S. Ruiz, Carteron, L., Patet, C., Quintard, H., Solari, D., Bouzat, P., Oddo, M., Wollersheim, T., Malleike, J., Haas, K., Carbon, N., Schneider, J., Birchmeier, C., Fielitz, J., Spuler, S., Weber-Carstens, S., Enseñat, L., Pérez-Madrigal, A., Saludes, P., Proença, L., Gruartmoner, G., Espinal, C., Mesquida, J., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Lahmer, T., Mayr, U., Herner, A., Schellnegger, R., Schneider, J., Schmid, R. M., Ayoub, W., Samy, W., Esmat, A., Battah, A., Mukhtar, S., Mongkolpun, W., Cortés, D. Orbegozo, Cordeiro, C. P. R., Vincent, J. L., Creteur, J., Funcke, S., Groesdonk, H., Saugel, B., Wagenpfeil, G., Wagenpfeil, S., Reuter, D. A., Fernandez, M. M., Fernandez, R., Magret, M., González-Castro, A., Bouza, M. T., Ibañez, M., García, C., Balerdi, B., Mas, A., Arauzo, V., Añón, J. M., Ruiz, F., Ferreres, J., Tomás, R., Alabert, M., Tizón, A. I., Altaba, S., Llamas, N., Goligher, E C., Fan, E., Herridge, M., Vorona, S., Sklar, M., Dres, M., Rittayamai, N., Lanys, A., Urrea, C., Tomlinson, G., Reid, W. D., Rubenfeld, G. D., Kavanagh, B. P., Brochard, L. J., Ferguson, N. D., Neto, A. Serpa, de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Guérin, C., Papazian, L., Reignier, J., Ayzac, L., Loundou, A., Forel, J. M., Rolland-Debord, C., Bureau, C., Poitou, T., Clavel, M., Perbet, S., Terzi, N., Kouatchet, A., Similowski, T., Demoule, A., Hunfeld, N., Trogrlic, Z., Ladage, S., Osse, R. J., Koch, B., Rietdijk, W., Devlin, J., van der Jagt, M., Picetti, E., Ceccarelli, P., Mensi, F., Malchiodi, L., Risolo, S., Rossi, I., Antonini, M. V., Servadei, F., Caspani, M. L., Roquilly, A., Lasocki, S., Seguin, P., Geeraerts, T., Perrigault, P. F., Dahyot-Fizelier, C., Paugam-Burtz, C., Cook, F., Cinotti, R., dit Latte, D. Demeure, Mahe, P. J., Fortuit, C., Feuillet, F., Asehnoune, K., Marzorati, C., Spina, S., Scaravilli, V., Vargiolu, A., Riva, M., Giussani, C., Sganzerla, E., Citerio, G., Barbadillo, S., de Molina, F. J. González, Álvarez-Lerma, F., Rodríguez, A., Zakharkina, T., Martin-Loeches, I., Matamoros, S., Povoa, P., Torres, A., Kastelijn, J., Hofstra, J. J., de Jong, M., Schultz, M., Sterk, P., Artigas, A., Bos, L. J., Moreau, A. S., Martin-Loeches, I., Povoa, P., Salluh, J., Rodriguez, A., Nseir, S., de Jong, E., van Oers, J. A., Beishuizen, A., Girbes, A. R. J., Nijsten, M. W. N., de Lange, D. W., Bonvicini, D., Labate, D., Benacchio, L., Olivieri, A., Pizzirani, E., Lopez-Delgado, J. C., Gonzalez-Romero, M., Fuentes-Mila, V., Berbel-Franco, D., Romera-Peregrina, I., Martinez-Pascual, A., Perez-Sanchez, J., Abellan-Lencina, R., Ávila-Espinoza, R. E., Moreno-Gonzalez, G., Sbraga, F., Griffiths, S., Grocott, M. P. W., Creagh-Brown, B., Doyle, J., Wilkerson, P., Soon, Y., Huddart, S., Dickinson, M., Riga, A., Zuleika, A., Miyamoto, K., Kawazoe, Y., Morimoto, T., Yamamoto, T., Fuke, A., Hashimoto, A., Koami, H., Beppu, S., Katayama, Y., Ito, M., Ohta, Y., Yamamura, H., Rygård, S. L., Holst, L B., Wetterslev, J., Johansson, P. I., Perner, A., Soliman, I. W., de Lange, D. W., van Dijk, D., van Delden, J. J. M., Cremer, O. L., Slooter, A. J. C., Peelen, L. M., McWilliams, D., Snelson, C., Neves, A. Das, Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Veronesi, M., Lischinsky, A., López, F. J. L., Mori, L. Benito, Plotnikow, G., Díaz, A., Giannasi, S., Hernandez, R., Krzisnik, L., Cecotti, C., Viola, L., Lopez, R., Sottile, J. P., Benavent, G., Estenssoro, E., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Chan, K. S., Roeker, L. E., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., Robinson, M. K., Christopher, K. 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I., Doherty, P., Black, E., Stenhouse, P., Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Yatabe, T., Inoue, S., Sakaguchi, M., Egi, M., Abdelhamid, Y. Ali, Plummer, M. P., Finnis, M. E., Phillips, L. K., Kar, P., Bihari, S., Biradar, V., Moodie, S., Horowitz, M., Shaw, J. E., Deane, A. M., Hokka, M., Egi, M., Mizobuchi, S., Kar, P., Plummer, M., Abdelhamid, Y. Ali, Giersch, E., Summers, M., Hatzinikolas, S., Heller, S., Chapman, M., Jones, K., Horowitz, M., Deane, A., Schweizer, R., Jacquet-Lagreze, M., Portran, P., Junot, S., Allaouchiche, B., Fellahi, J. L., Guerci, P., Ergin, B., Kapucu, A., Ince, C., Cioccari, L., Luethi, N., Crisman, M., Bellomo, R., Mårtensson, J., Shinotsuka, C. Righy, Fagnoul, D., Brasseur, A., Orbegozo, D., Vincent, J. L., Preiser, J. C., Preiser, J. C., Lheureux, O., Thooft, A., Brimioulle, S., Vincent, J. 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F., Garcia, I. Palacios, Martin, A. Diaz, Marqués, M. Gil, Moreno, A. Puppo, Pizarraya, A. Gutierrez, Diaz, J. Pachón, Ibañez, M. Pachón, Smani, Y., Connell, M. Mc, Zhang, L. A., Parker, R. S., Banerjee, I., Clermont, G., Norberg, E., Oras, J., Cuisinier, A., Maufrais, C., Payen, J. F., Nottin, S., Walther, G., Bouzat, P., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Crippa, I. A., Monfort, B., Stazi, E., Roig, A. Lozano, Creteur, J., Taccone, F. S., Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Kalaiselvan, M. S., Renuka, M. K., Arunkumar, A. 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C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA
- Published
- 2016
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11. Arterial aging mediates the effect of TNF-α and ACE polymorphisms on mental health in elderly individuals: insights from IKARIA study
- Author
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Georgiopoulos, G., Chrysohoou, C., Errigo, A., Pes, G., Metaxa, V., Zaromytidou, M., Skoumas, J., Kariori, M., Lazaros, G., Vogiatzi, G., Poulain, M., Tousoulis, D., Pitsavos, C., and Stefanadis, C.
- Published
- 2017
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12. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016
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Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
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- 2016
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13. End of life decisions in immunocompromised patients with acute respiratory failure
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Burghi, G., Metaxa, V., Pickkers, P., Soares, M., Rello, J., Bauer, P.R., Azoulay, E., Jong, A. de, Burghi, G., Metaxa, V., Pickkers, P., Soares, M., Rello, J., Bauer, P.R., Azoulay, E., and Jong, A. de
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Item does not contain fulltext
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- 2022
14. Improving the intensive care experience from the perspectives of different stakeholders
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Latour, Jos, Kentish-Barnes, N., Jacques, T., Wysocki, M., Azoulay, E., Metaxa, V., Latour, Jos, Kentish-Barnes, N., Jacques, T., Wysocki, M., Azoulay, E., and Metaxa, V.
- Abstract
The intensive care unit (ICU) is a complex environment where patients, family members and healthcare professionals have their own personal experiences. Improving ICU experiences necessitates the involvement of all stakeholders. This holistic approach will invariably improve the care of ICU survivors, increase family satisfaction and staff wellbeing, and contribute to dignified end-of-life care. Inclusive and transparent participation of the industry can be a significant addition to develop tools and strategies for delivering this holistic care. We present a report, which follows a round table on ICU experience at the annual congress of the European Society of Intensive Care Medicine. The aim is to discuss the current evidence on patient, family and healthcare professional experience in ICU is provided, together with the panel’s suggestions on potential improvements. Combined with industry, the perspectives of all stakeholders suggest that ongoing improvement of ICU experience is warranted.
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- 2022
15. ICU-acquired pneumonia in immunosuppressed patients with acute hypoxemic respiratory failure: A post-hoc analysis of a prospective international cohort study
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Martin-Loeches, I, Darmon, M, Demoule, A, Grp, Nine-I Study, Investigators, Efraim, Antonelli, M, Schellongowski, P, Pickkers, P, Soares, M, Rello, J, Bauer, P, van de Louw, A, Lemiale, V, Grimaldi, D, Balik, M, Mehta, S, Kouatchet, A, Barratt-Due, A, Valkonen, M, Reignier, J, Metaxa, V, Moreau, AS, Burghi, G, Mokart, D, Azoulay, E, HUS Perioperative, Intensive Care and Pain Medicine, Clinicum, Anestesiologian yksikkö, and Department of Diagnostics and Therapeutics
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medicine.medical_specialty ,health care facilities, manpower, and services ,VA-LRTI ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Critical Care and Intensive Care Medicine ,Cohort Studies ,Sepsis ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Risk Factors ,Intensive care ,Settore MED/41 - ANESTESIOLOGIA ,Post-hoc analysis ,Humans ,Medicine ,Hospital Mortality ,Prospective Studies ,Risk factor ,Prospective cohort study ,Immunosuppression ,Infection ,Pneumonia ,business.industry ,030208 emergency & critical care medicine ,3126 Surgery, anesthesiology, intensive care, radiology ,medicine.disease ,3. Good health ,Intensive Care Units ,030228 respiratory system ,Cohort ,Emergency medicine ,Female ,Respiratory Insufficiency ,business ,Cohort study - Abstract
Objective: Intensive Care Units (ICU) acquired Pneumonia (ICU-AP) is one of the most frequent nosocomial infections in critically ill patients. Our aim was to determine the effects of having an ICU-AP in immunosuppressed patients with acute hypoxemic respiratory failure. Design: Post-hoc analysis of a multinational, prospective cohort study in 16 countries. Settings: ICU. Patients: Immunosuppressed patients with acute hypoxemic respiratory failure. Intervention: None. Measurements and main results: The original cohort had 1611 and in this post-hoc analysis a total of 1512 patients with available data on hospital mortality and occurrence of ICU-AP were included. ICU-AP occurred in 158 patients (10.4%). Hospital mortality was higher in patients with ICU-AP (14.8% vs. 7.1% p < 0.001). After adjustment for confounders and centre effect, use of vasopressors (Odds Ratio (OR) 2.22; 95%CI 1.46-.39) and invasive me-chanical ventilation at day 1 (OR 2.12 vs. high flow oxygen; 95%CI 1.07-4.20) were associated with increased risk of ICU-AP while female gender (OR 0.63; 95%CI 0.43-94) and chronic kidney disease (OR 0.43; 95%CI 0.22-0.88) were associated with decreased risk of ICU-AP. After adjustment for confounders and centre effect, ICU-AP was independently associated with mortality (Hazard Ratio 1.48; 95%CI 14.-1.91; P = 0.003). Conclusions: The attributable mortality of ICU-AP has been repetitively questioned in immunosuppressed pa-tients with acute respiratory failure. This manuscript found that ICU-AP represents an independent risk factor for hospital mortality.(c) 2020 Elsevier Inc. All rights reserved.
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- 2021
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16. Statement paper on diversity for the European Society of Intensive Care Medicine (ESICM)
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Weiss, Bjoern, Weiss, B., Prisco, L., Boulanger, C., Einav, S., Gruber, P., Laake, J. H., Mehta, S., Ostermann, M., Antonelli, M., Ben Nun, M., Bollen Pinto, B., Borkowska, M., Borthwick, M., Cecconi, M., Costa-Pinto, R., Derde, L. P. G., Forni, L. G., Galazzi, A., Girbes, A., Herridge, M., Hofsø, K., Juffermans, N. P., Kesecioglu, J., Lobo-Valbuena, B., Machado, F. R., Mekontso Dessap, A., Metaxa, V., Myatra, S. N., Olusanya, O., Rosenthal, M., Rygård, S. L., Schaller, S. J., Underman, K., Wade, D. M., Intensive Care Medicine, Intensive care medicine, and ACS - Diabetes & metabolism
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Male ,medicine.medical_specialty ,Critical Care ,media_common.quotation_subject ,Culture ,Ethnic group ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,Politics ,0302 clinical medicine ,Sex Factors ,NOMINATE ,medicine ,Humans ,Intensive care medicine ,Society ,Minority Groups ,Societies, Medical ,media_common ,Diversity ,business.industry ,030208 emergency & critical care medicine ,Cultural Diversity ,Identification (information) ,030228 respiratory system ,Socioeconomic Factors ,Sexual orientation ,What's New in Intensive Care ,Female ,Element (criminal law) ,Working group ,business ,Diversity (politics) - Abstract
Introduction Diversity has become a key-strategic element of success in various political and economic fields. The European Society of Intensive Care Medicine (ESICM) decided to make diversity a key strategic priority for the future and appointed a Task-Force on this topic. Methods In a consensus process, three Working-Groups, nominated by Task-Force members, developed statements on strategic future topics. In addition, diversity-related data available from the membership database have been analyzed and reported in aggregated form. Results The Task-Force decided to nominate working groups on (1) “sex, gender identity and sexual orientation”, (2) “ethnicity, culture and socio-economic status”, and (3) “multiprofessionalism”. These are the first prioritized topics for the near future. The first diversity-report shows targetable items in all three domains. Conclusion The diversity Task-Force defined actionable items for a one- and three-year plan that are especially aiming at the identification of potential gaps and an implementation of concrete projects for members of the ESICM. Electronic supplementary material The online version of this article (10.1007/s00134-019-05606-0) contains supplementary material, which is available to authorized users.
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- 2019
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17. Bereavement care in UK ICUs: a national survey
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Berry, M, Brink, E, and Metaxa, V
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- 2015
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18. Prevalence of psychiatric disorders in trauma patients: results from a major trauma unit
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Adlam, M, Feehan, A, and Metaxa, V
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- 2015
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19. Outcomes in patients treated with chimeric antigen receptor T-cell therapy who were admitted to intensive care (CARTTAS): an international, multicentre, observational cohort study
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Azoulay, É., Castro, P., Maamar, A., Metaxa, V., Moraes, A.G. de, Voigt, L., Wallet, F., Klouche, K., Picard, M., Moreau, A.S., Louw, A. van de, Seguin, A., Mokart, D., Chawla, S., Leroy, J., Böll, B., Issa, N., Levy, B., Hemelaar, P., Fernandez, S., Munshi, L., Bauer, P., Schellongowski, P., Joannidis, M., Moreno-Gonzalez, G., Galstian, G., Darmon, M., Valade, S., Azoulay, É., Castro, P., Maamar, A., Metaxa, V., Moraes, A.G. de, Voigt, L., Wallet, F., Klouche, K., Picard, M., Moreau, A.S., Louw, A. van de, Seguin, A., Mokart, D., Chawla, S., Leroy, J., Böll, B., Issa, N., Levy, B., Hemelaar, P., Fernandez, S., Munshi, L., Bauer, P., Schellongowski, P., Joannidis, M., Moreno-Gonzalez, G., Galstian, G., Darmon, M., and Valade, S.
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Item does not contain fulltext, BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy can induce side-effects such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (ICANS), which often require intensive care unit admission. The aim of this study was to describe management of critically ill CAR T-cell recipients in intensive care. METHODS: This international, multicentre, observational cohort study was done in 21 intensive care units in France, Spain, the USA, the UK, Russia, Canada, Germany, and Austria. Eligible patients were aged 18 years or older; had received CAR T-cell therapy in the past 30 days; and had been admitted to intensive care for any reason. Investigators retrospectively included patients admitted between Feb 1, 2018, and Feb 1, 2019, and prospectively included patients admitted between March 1, 2019, and Feb 1, 2020. Demographic, clinical, laboratory, treatment, and outcome data were extracted from medical records. The primary endpoint was 90-day mortality. Factors associated with mortality were identified using a Cox proportional hazard model. FINDINGS: 942 patients received CAR T-cell therapy, of whom 258 (27%) required admission to intensive care and 241 (26%) were included in the analysis. Admission to intensive care was needed within median 4·5 days (IQR 2·0-7·0) of CAR T-cell infusion. 90-day mortality was 22·4% (95% CI 17·1-27·7; 54 deaths). At initial evaluation on admission, isolated cytokine release syndrome was identified in 101 patients (42%), cytokine release syndrome and ICANS in 93 (39%), and isolated ICANS in seven (3%) patients. Grade 3-4 cytokine release syndrome within 1 day of admission to intensive care was found in 50 (25%) of 200 patients and grade 3-4 ICANS in 38 (35%) of 108 patients. Bacterial infection developed in 30 (12%) patients. Life-saving treatments were used in 75 (31%) patients within 24 h of admission to intensive care, primarily vasoactive drugs in 65 (27%) patients. Factors independently associated
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- 2021
20. Acute Respiratory Failure Outcomes in Patients with Hematologic Malignancies and Hematopoietic Cell Transplant: A Secondary Analysis of the EFRAIM Study
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Munshi, L., Darmon, M., Soares, M., Pickkers, P., Bauer, P., Meert, A.P., Martin-Loeches, I., Staudinger, T., Pene, F., Antonelli, M., Barratt-Due, A., Demoule, A., Metaxa, V., Lemiale, V., Taccone, F., Mokart, D., Azoulay, E., Mehta, S., Munshi, L., Darmon, M., Soares, M., Pickkers, P., Bauer, P., Meert, A.P., Martin-Loeches, I., Staudinger, T., Pene, F., Antonelli, M., Barratt-Due, A., Demoule, A., Metaxa, V., Lemiale, V., Taccone, F., Mokart, D., Azoulay, E., and Mehta, S.
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Item does not contain fulltext, Patients with allogeneic hematopoietic cell transplantation (HCT) who develop acute respiratory failure (ARF) are perceived to have worse outcomes than autologous HCT recipients and non-transplant patients with hematologic malignancy (HM). Within a large international prospective cohort, we evaluated clinical outcomes in these 3 populations. We conducted a secondary analysis of the EFRAIM study, a multicenter observational study of immunocompromised adults with ARF admitted to 62 intensive care units (ICUs) in 16 countries. We described characteristics and compared outcomes of patients with HM who did not undergo transplantation and patients who underwent autologous or allogeneic HCT using multivariable logistic regression and propensity score-matched analyses. A total of 801 patients were included: 570 who did not undergo transplantation, 86 autologous HCT recipients and 145 allogeneic HCT recipients. Acute myelogenous leukemia (171 of 570; 30%) was the most common HM and most common indication for allogeneic HCT (76 of 145; 52%). Compared with the patients who did not undergo HCT and autologous HCT recipients, allogeneic HCT recipients were younger, had fewer comorbid conditions, and were more likely to undergo diagnostic bronchoscopy in the ICU. Unadjusted ICU and hospital mortality were 35% and 45%, respectively, across the entire cohort. In multivariable regression analysis, autologous HCT (odds ratio [OR], 1.07; 95% confidence interval [CI], .57 to 2.03; P = .82) and allogeneic HCT (OR, .99; 95% CI, .60 to 1.66; P = .98) were not associated with higher hospital mortality compared with the no-HCT cohort, adjusting for demographic, functional, clinical, malignancy, and ARF characteristics. The results were similar when analyzed using propensity score-matching techniques. Our findings indicate that autologous and allogeneic HCT recipients who develop ARF and require ICU admission have similar hospital mortality as patients with HM not treated with HCT.
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- 2021
21. Bacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort
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Louw, A. van de, Rello, J., Martin-Loeches, I., Mokart, D., Metaxa, V., Benoit, D., Barratt-Due, A., Soares, M., Pickkers, P., Antonelli, M., Demoule, A., Schellongowski, P., Kouatchet, A., Mehta, S., Balik, M., Bauer, P.R., Lemiale, V., Walter, V., Azoulay, E., Louw, A. van de, Rello, J., Martin-Loeches, I., Mokart, D., Metaxa, V., Benoit, D., Barratt-Due, A., Soares, M., Pickkers, P., Antonelli, M., Demoule, A., Schellongowski, P., Kouatchet, A., Mehta, S., Balik, M., Bauer, P.R., Lemiale, V., Walter, V., and Azoulay, E.
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Contains fulltext : 245016.pdf (Publisher’s version ) (Closed access), PURPOSE: The characteristics and impact of bacteremia have not been widely investigated in immunocompromised patients with acute respiratory failure (ARF). METHODS: We performed a secondary analysis of a prospective cohort of immunocompromised patients with ARF (EFRAIM study). After exclusion of blood cultures positive for coagulase negative Staphylococci, we compared patients with (n = 236) and without (n = 1127) bacteremia. RESULTS: The incidence of bacteremia was 17%. Bacterial pneumonia and extra-pulmonary ARDS were the main causes of ARF in bacteremic patients. Bacteremia involved gram negative rods (48%), gram positive cocci (40%) or were polymicrobial (10%). Bacteremic patients had more hematological malignancy, higher SOFA scores and increased organ support within 7 days. Bacteremia was associated with higher crude ICU mortality (40% versus 32%, p = 0.02), but neither hospital (49% versus 44%, p = 0.17) nor 90-day mortality (60% versus 56%, p = 0.25) were different from non-bacteremic patients. After propensity score matching based on baseline characteristics, the difference in ICU mortality lost statistical significance (p = 0.06), including in a sensitivity analysis restricted to patients with pneumonia. CONCLUSIONS: We analyzed a large population of immunocompromised patients with ARF and an incidence of bacteremia of 17%. We could not demonstrate an impact of bacteremia on mortality after adjusting for baseline characteristics.
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- 2021
22. Dairy products, surrogate markers, and cardiovascular disease; a sex-specific analysis from the ATTICA prospective study
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Kouvari, Matina, primary, Panagiotakos, Demosthenes B., additional, Chrysohoou, Christina, additional, Georgousopoulou, Ekavi N., additional, Yannakoulia, Mary, additional, Tousoulis, Dimitrios, additional, Pitsavos, Christos, additional, Skoumas, Y., additional, Katinioti, N., additional, Papadimitriou, L., additional, Masoura, C., additional, Vellas, S., additional, Lentzas, Y., additional, Kambaxis, M., additional, Paliou, K., additional, Metaxa, V., additional, Skourlis, N., additional, Papanikolaou, C., additional, Kalogeropoulou, A., additional, Pitaraki, E., additional, Laskaris, A., additional, Hatzigeorgiou, M., additional, Grekas, A., additional, Kokkou, E., additional, Vassiliadou, C., additional, Dedousis, G., additional, Toutouza-Giotsa, M., additional, Tselika, C., additional, Poulopouloou, S., additional, and Toutouza, M., additional
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- 2020
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23. Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA
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Benoit, D.D. (Dominique), Jensen, H.I. (H. I.), Malmgren, J. (J.), Metaxa, V. (V.), Reyners, A.K.L. (Anna), Darmon, M. (M.), Rusinova, K. (K.), Talmor, D. (Daniel), Meert, A.P. (A. P.), Cancelliere, L. (L.), Zubek, L. (L.), Maia, P. (P.), Michalsen, A. (A.), Vanheule, S. (S.), Kompanje, E.J.O. (E. J.O.), Decruyenaere, J. (J.), Vandenberghe, S. (S.), Vansteelandt, S. (Stijn), Gadeyne, B. (B.), van Den Bulcke, B. (B.), Azoulay, E. (Elie), Piers, R.D. (Ruth), Spapen, H., van Malderen, M.-C. (Marie-Claire), Opdenacker, G. (Godelieve), Meyfroidt, G. (Geert), Mesotten, D., Wauters, J. (Joost), van Laer, M. (Marie), Wilmer, A. (Alexander), Ceunen, H. (H.), De Laet, I. (Inneke), Jans, A. (Anita), Benoit, D. (Dominique), Oeyen, S. (Sandra), Herck, I. (Ingrid), Bracke, S. (Stephanie), Clauwaert, C. (Charlotte), Meert, A.-P. (Anne-Pascale), Leclercq, N. (Nathalie), Jacques, D. (Devriendt), Philippe, D. (Dechamps), Zykova, I. (Ivana), Malaska, J. (Jan), Schmidt, M. (Matous), Satinsky, I. (Igor), Kieslichova, E. (Eva), Krizova, J. (Jarmila), Janda, R. (Robert), Fortova, M. (Magdalena), Matyas, J. (Jiri), Rusinova, K. (Katerina), Kopecky, O. (Ondrej), Pedersen, C.A.K. (Christian Alves Køhler), Hebsgaard, S. (Stine), Johnsen, R.F.A. (Rikke Frank Aagaard), Hansen, T.C.B. (Tina Charlotte Bitsch), Darmon, M. (Michael), Reuter, D. (Danielle), Mokart, D. (Djamel), Vincent, F. (François), Hartog, C.S. (Christiane), Gretenkort, P. (Peter), Michalsen, A. (Andrej), Kounougeri, A. (Aikaterini), Nanas, S. (Serafim), Papachristou, D. (Despina), Soultati, I. (Ioanna), Lathyris, D. (Dimitrios), Pasakiotou, M. (Marili), Oikonomou, M. (Marina), Elö, G. (Gabor), Szücs, O. (Orsolya), Fogas, J. (János), Bobek, I. (Ilona), Corte, F.D. (Francesco Della), Olivieri, C. (Carlo), Vaschetto, R. (Rosanna), Cancelliere, L. (Laura), Marinangeli, F. (Franco), Pozone, T. (Tullio), Ciccozzi, A. (Alessandra), Schouten, A. (A.), Bruns, M. (Monique), Gerritsen, R.T. (Rik T.), Koopmans, M. (Matty), Kompanje, E.J.O. (Erwin), van Duijn, M.A.J. (Marijtje A. J.), Zijlstra, J.G. (Jan G.), Reyners, A.K. (Anne KL.), Lutisan, J.G. (Johan), Monte, R. (Raquel), Pinho, J.A. (José António), Pimenta, P. (Pedro), Fernandes, P. (Paula), Paixão, A.I. (Ana Isabel), Faria, R. (Rui), Malmgren, J.A. (Johan A.), Andersson, B. (Bertil), Akerman, E. (Eva), Hvarfner, A. (Andreas), Svensson, R. (Robert), Metaxa, V. (Victoria), Mueller, A. (Ariel), Banner-Goodspeed, V. (Valerie), Rickett, D. (Dee), Wilson, M.E. (Michael E.), Hinds, R. (Richard), Benoit, D.D. (Dominique), Jensen, H.I. (H. I.), Malmgren, J. (J.), Metaxa, V. (V.), Reyners, A.K.L. (Anna), Darmon, M. (M.), Rusinova, K. (K.), Talmor, D. (Daniel), Meert, A.P. (A. P.), Cancelliere, L. (L.), Zubek, L. (L.), Maia, P. (P.), Michalsen, A. (A.), Vanheule, S. (S.), Kompanje, E.J.O. (E. J.O.), Decruyenaere, J. (J.), Vandenberghe, S. (S.), Vansteelandt, S. (Stijn), Gadeyne, B. (B.), van Den Bulcke, B. (B.), Azoulay, E. (Elie), Piers, R.D. (Ruth), Spapen, H., van Malderen, M.-C. (Marie-Claire), Opdenacker, G. (Godelieve), Meyfroidt, G. (Geert), Mesotten, D., Wauters, J. (Joost), van Laer, M. (Marie), Wilmer, A. (Alexander), Ceunen, H. (H.), De Laet, I. (Inneke), Jans, A. (Anita), Benoit, D. (Dominique), Oeyen, S. (Sandra), Herck, I. (Ingrid), Bracke, S. (Stephanie), Clauwaert, C. (Charlotte), Meert, A.-P. (Anne-Pascale), Leclercq, N. (Nathalie), Jacques, D. (Devriendt), Philippe, D. (Dechamps), Zykova, I. (Ivana), Malaska, J. (Jan), Schmidt, M. (Matous), Satinsky, I. (Igor), Kieslichova, E. (Eva), Krizova, J. (Jarmila), Janda, R. (Robert), Fortova, M. (Magdalena), Matyas, J. (Jiri), Rusinova, K. (Katerina), Kopecky, O. (Ondrej), Pedersen, C.A.K. (Christian Alves Køhler), Hebsgaard, S. (Stine), Johnsen, R.F.A. (Rikke Frank Aagaard), Hansen, T.C.B. (Tina Charlotte Bitsch), Darmon, M. (Michael), Reuter, D. (Danielle), Mokart, D. (Djamel), Vincent, F. (François), Hartog, C.S. (Christiane), Gretenkort, P. (Peter), Michalsen, A. (Andrej), Kounougeri, A. (Aikaterini), Nanas, S. (Serafim), Papachristou, D. (Despina), Soultati, I. (Ioanna), Lathyris, D. (Dimitrios), Pasakiotou, M. (Marili), Oikonomou, M. (Marina), Elö, G. (Gabor), Szücs, O. (Orsolya), Fogas, J. (János), Bobek, I. (Ilona), Corte, F.D. (Francesco Della), Olivieri, C. (Carlo), Vaschetto, R. (Rosanna), Cancelliere, L. (Laura), Marinangeli, F. (Franco), Pozone, T. (Tullio), Ciccozzi, A. (Alessandra), Schouten, A. (A.), Bruns, M. (Monique), Gerritsen, R.T. (Rik T.), Koopmans, M. (Matty), Kompanje, E.J.O. (Erwin), van Duijn, M.A.J. (Marijtje A. J.), Zijlstra, J.G. (Jan G.), Reyners, A.K. (Anne KL.), Lutisan, J.G. (Johan), Monte, R. (Raquel), Pinho, J.A. (José António), Pimenta, P. (Pedro), Fernandes, P. (Paula), Paixão, A.I. (Ana Isabel), Faria, R. (Rui), Malmgren, J.A. (Johan A.), Andersson, B. (Bertil), Akerman, E. (Eva), Hvarfner, A. (Andreas), Svensson, R. (Robert), Metaxa, V. (Victoria), Mueller, A. (Ariel), Banner-Goodspeed, V. (Valerie), Rickett, D. (Dee), Wilson, M.E. (Michael E.), and Hinds, R. (Richard)
- Abstract
Purpose: Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown. Methods: In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis. Results: Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0–1.00) and 85.9% (75.4–92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20–2.92) or receiving a written TLD (HR 2.32, CI 1.11–4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former. Conclusion: Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life.
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- 2018
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24. BLACK AND GREENTEA CONSUMPTION HAS BENEFICIAL EFFECT ON GLUCOSE LEVELS IN NON-DIABETIC ELDERLY MEN AND WOMEN FROM THE IKARIA STUDY
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Galiatsatos, N., Chrysohoou, C., Metaxa, V., Strigou, M., Mamatas, S., Zaromitidou, M., Katte, A., Mylonakis, C., Pitsavos, C., Alexandropoulos, N., and Stefanadis, Ch.
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- 2010
25. HIGH PHYSICAL ACTIVITY MINIMIZES THE RISK FOR CARDIOVASCULAR DISEASE IN ELDERLY INHABITANS OF IKARIA ISLAND, IRRESPECTIVELY OF OBESITY STATUS
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Galiatsatos, N., Chrysohoou, C., Metaxa, V., Skoumas, I., Economou, E., Andreou, I., Siassos, G., Lagoudakou, S., Zaromitidou, M., Christoforatou, E., Alexopoulos, N., Pitsavos, C., Alexandropoulos, N., and Stefanadis, Ch.
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- 2010
26. CLOSE ADHERENCE TO THE MEDITERRANEAN DIET IN COMBINATION WITH STATIN TREATMENT CAN SUBSTANTIALLY DECREASE LIPIDS LEVELS IN ELDERLY INDIVIDUALS. IKARIA STUDY
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Galiatsatos, N., Chrysohoou, C., Skoumas, I., Giakoumi, E., Triantafyllou, G., Siassos, G., Psaltopoulou, T., Plytaria, S., Metaxa, V., Vogiatzoglou, S., Pitsavos, C., Alexandropoulos, N., and Stefanadis, Ch.
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- 2010
27. BENEFICIAL EFFECT OF BLACK AND GREEN TEA CONSUMPTION ON LIPID PROFILE IN ELDERLY DIABETIC MEN AND WOMEN FROM THE IKARIA STUDY
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Galiatsatos, N., Chrysohoou, C., Metaxa, V., Vogiatzi, G., Vogiatzoglou, S., Tsiachris, D., Economou, E., Dimitriadis, K., Marinos, G., Athanasopoulou, S., Valatsou, A., Pitsavos, C., Alexandropoulos, N., and Stefanadis, Ch.
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- 2010
28. Dairy products, surrogate markers, and cardiovascular disease; a sex-specific analysis from the ATTICA prospective study
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Kouvari, M. Panagiotakos, D.B. Chrysohoou, C. Georgousopoulou, E.N. Yannakoulia, M. Tousoulis, D. Pitsavos, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Paliou, K. Metaxa, V. Skourlis, N. Papanikolaou, C. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Kokkou, E. Vassiliadou, C. Dedousis, G. Toutouza-Giotsa, M. Tselika, C. Poulopouloou, S. Toutouza, M. The ATTICA study Investigators
- Abstract
Background and aims: Dairy products are a very diverse food group with multiple effects on the cardiac health of men and women. The aim of this work was to evaluate the sex-specific association between dairy products (total and subtypes) and 10-year first fatal/nonfatal cardiovascular disease (CVD) incidence. Methods and results: In 2001–2002, n = 1514 men and n = 1528 women (>18 years old) from greater Athens area, Greece, were enrolled. Dietary assessment was based on a validated semi-quantitative food frequency questionnaire. Dairy product consumption was examined in relation to 10-year CVD incidence. Follow-up (2011–2012) was achieved in n = 2020 participants (n = 317 CVD cases). Ranking from lowest (2 servings/day) total dairy intake, CVD incidence in men was 17.8%, 15.0%, and 10.9% (p = 0.41), while in women it was 14%, 6.0%, and 5.7% (p = 0.02). Multiadjusted analysis revealed that total dairy intake protected against CVD only in women [Hazard Ratio (HR) = 0.48 and 95% Confidence Interval (95% CI) (0.23, 0.90)], irrespective of the fat content. Further analysis revealed that only fermented products (yogurt and cheese), protected against CVD. For per 200 g/day yogurt consumption, CVD risk was 20%–30% lower with this claim being more evident in women, while for per 30 g/day cheese intake, about 5% lower risk was observed particularly in men. As for butter, nonsignificant associations were highlighted. These associations were mainly retained in the case of hepatic steatosis, insulin resistance, and systemic inflammation. Conclusions: This work provides incentives for researchers to elucidate the diversity of ingredients and mechanisms through which dairy products exert their effect on cardiac health separately for men and women. © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
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- 2020
29. Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS: A Secondary Analysis of the EFRAIM Study
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Demoule, A., Antonelli, M., Schellongowski, P., Pickkers, P., Soares, M., Meyhoff, T., Rello, J., Bauer, P.R., Louw, A. van de, Lemiale, V., Grimaldi, D., Martin-Loeches, I., Balik, M., Mehta, S., Kouatchet, A., Barratt-Due, A., Valkonen, M., Reignier, J., Metaxa, V., Moreau, A.S., Burghi, G., Mokart, D., Mayaux, J., Darmon, M., and Azoulay, E.
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lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] - Abstract
Contains fulltext : 229309.pdf (Publisher’s version ) (Closed access) BACKGROUND: In view of the high mortality rate of immunocompromised patients with ARDS, it is important to identify targets for improvement. RESEARCH QUESTION: This study investigated factors associated with mortality in this specific ARDS population, including factors related to respiratory mechanics (plateau pressure [Pplat,rs], compliance [Crs], and driving pressure [ΔPrs]). STUDY DESIGN AND METHODS: This study consisted of a predefined secondary analysis of the EFRAIM data. Overall, 789 of 1,611 patients met the Berlin criteria for ARDS, and Pplat,rs, ΔPrs, and Crs were available for 494 patients. A hierarchical model was used to assess factors at ARDS onset independently associated with hospital mortality. RESULTS: Hospital mortality was 56.3%. After adjustment, variables independently associated with hospital mortality included ARDS of undetermined etiology (OR, 1.66; 95% CI, 1.01-2.72), need for vasopressors (OR, 1.91; 95% CI, 1.27-2.88), and need for renal replacement therapy (OR, 2.02; 95% CI, 1.37-2.97). ARDS severity according to the Berlin definition, neutropenia on admission, and the type of underlying disease were not significantly associated with mortality. Before adjustment, higher Pplat,rs, higher ΔPrs, and lower Crs were associated with higher mortality. Addition of each of these individual variables to the final hierarchical model revealed a significant association with mortality: ΔPrs (OR, 1.08; 95% CI, 1.05-1.12), Pplat,rs (OR, 1.07; 95% CI, 1.04-1.11), and Crs (OR, 0.97; 95% CI, 0.95-0.98). Tidal volume was not associated with mortality. INTERPRETATION: In immunocompromised patients with ARDS, respiratory mechanics provide additional prognostic information to predictors of hospital mortality. Studies designed to define lung-protective ventilation guided by these physiological variables may be warranted in this specific population.
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- 2020
30. Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy
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Bauer, Pr, Chevret, S, Yadav, H, Mehta, S, Pickkers, P, Bukan, Rb, Rello, J, van de Louw, A, Klouche, K, Meert, Ap, Martin-Loeches, I, Marsh, B, Crespi, Ls, Moreno-Gonzalez, G, Buchtele, N, Amrein, K, Balik, M, Antonelli, Massimo, Nyunga, M, Barratt-Due, A, Bergmans, Dcjj, Spoelstra-de Man, Ame, Kuitunen, A, Wallet, F, Seguin, A, Metaxa, V, Lemiale, V, Burghi, G, Demoule, A, Karvunidis, T, Cotoia, A, Klepstad, P, Moller, Am, Mokart, D, Azoulay, E, Rabbat, A, Darmon, M, Platon, L, Mayaux, J, Chermak, A, Lemaitre, C, Artaud-Macari, E, Nelsen, J, Kaufmann, T, Viana, W, Lishoa, T, Correa, Td, Encina, B, Socias, A, Manez, R, Rodriguez-Ruis, E, Benoit, D, Staudinger, T, Heinz, G, Sengolge, G, Zauner, C, Jaksch, P, Mcmahon, A, Martin, B, Cinnella, G, Shah, S, Hemelaar, P, Taccone, Fs, Salluh, J, Schellongowski, P, Rusinova, K, Terzi, N, Kouatchet, A, Valkonen, M, Bruneel, F, Pene, F, Moreau, As, Girault, C, Silva, Uva, Montini, Luca, Barbier, F, Gaborit, B, Viana, Wn, de Moraes, App, Moralez, Gm, Vinatier, I, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biostatistiques et information médicale [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPC), University of Toronto, Radboud University Medical Center [Nijmegen], Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III [Madrid] (ISC), Vall d'Hebron University Hospital [Barcelona], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Université libre de Bruxelles (ULB), St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Universitat de Barcelona (UB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service de réanimation médicale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurophysiologie Respiratoire Expérimentale et Clinique, Intensive Care, MUMC+: MA Medische Staf IC (9), MUMC+: MA Arts Assistenten IC (9), RS: NUTRIM - R2 - Liver and digestive health, Intensive care medicine, ACS - Atherosclerosis & ischemic syndromes, and ACS - Diabetes & metabolism
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,BRONCHOALVEOLAR LAVAGE ,HEMATOLOGIC MALIGNANCIES ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,All institutes and research themes of the Radboud University Medical Center ,Bronchoscopy ,law ,Settore MED/41 - ANESTESIOLOGIA ,Severity of illness ,FLEXIBLE BRONCHOSCOPY ,medicine ,030212 general & internal medicine ,Prospective cohort study ,UTILITY ,medicine.diagnostic_test ,business.industry ,GROUPE ,Diagnosis outcome acute respiratory failure immunocompromised patients ,Intensive care unit ,3. Good health ,ONCOLOGY PATIENTS ,Bronchoalveolar lavage ,YIELD ,030228 respiratory system ,Respiratory failure ,INFECTIONS ,SAFETY ,Propensity score matching ,Emergency medicine ,Observational study ,Pneumologie ,business - Abstract
OBJECTIVE: We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added to noninvasive testing in immunocompromised patients. In this setting, an inability to identify the cause of acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made to obtain a diagnosis, either with noninvasive testing alone or combined with bronchoscopy. However, our understanding of the risks and benefits of bronchoscopy remains uncertain. PATIENTS AND METHODS: This was a pre-planned secondary analysis of Efraim, a prospective, multinational, observational study of 1611 immunocompromised patients with acute respiratory failure admitted to the intensive care unit (ICU). We compared patients with noninvasive testing only to those who had also received bronchoscopy by bivariate analysis and after propensity score matching. RESULTS: Bronchoscopy was performed in 618 (39%) patients who were more likely to have haematological malignancy and a higher severity of illness score. Bronchoscopy alone achieved a diagnosis in 165 patients (27% adjusted diagnostic yield). Bronchoscopy resulted in a management change in 236 patients (38% therapeutic yield). Bronchoscopy was associated with worsening of respiratory status in 69 (11%) patients. Bronchoscopy was associated with higher ICU (40% versus 28%; p, SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2019
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31. Advance care planning in critically ill haematology patients
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Metaxa, V, Lambert, J, Barrow, A, and De Vos, J
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- 2014
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32. PATIENT CONTROLLED ANALGESIA VERSUS CONTINUOUS EPIDURAL ANALGESIA AND INTRAMUSCULAR INJECTIONS: COMPARISON OF PATIENT PAIN EXPERIENCE AND SATISFACTION AFTER ABDOMINAL SURGERY: 756
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Trikoupi, A. P., Vassilakos, D., Soultati, I., Andreopoulos, K., Matsi, K., Metaxa, V., Kesisoglou, I. I., and Giala, M.
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- 2006
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33. Ethical climate and intention to leave among critical care clinicians: an observational study in 68 intensive care units across Europe and the United States
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Van den Bulcke, B, Metaxa, V, Reyners, AK, Rusinova, K, Jensen, HI, Malmgren, J, Darmon, M, Talmor, D, Meert, AP, Cancelliere, L, Zubek, L, Maia, P, Michalsen, A, Kompanje, Erwin, Vlerick, P, Roels, J, Vansteelandt, S, Decruyenaere, J, Azoulay, E, Vanheule, S, Piers, R, Benoit, D, Van den Bulcke, B, Metaxa, V, Reyners, AK, Rusinova, K, Jensen, HI, Malmgren, J, Darmon, M, Talmor, D, Meert, AP, Cancelliere, L, Zubek, L, Maia, P, Michalsen, A, Kompanje, Erwin, Vlerick, P, Roels, J, Vansteelandt, S, Decruyenaere, J, Azoulay, E, Vanheule, S, Piers, R, and Benoit, D
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- 2020
34. Delayed post-ischaemic administration of xenon reduces brain damage in a rat model of global ischaemia
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Metaxa, V, Lagoudaki, R, Meditskou, S, Thomareis, O, and Sakadamis, A
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- 2012
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35. Impact of increased numbers of intensive care consultants on outcome in a central London teaching hospital
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Metaxa, V, Bell, C, Feehan, A, Peters, K, Chang, T, Hopkins, P, and Ervine, M
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- 2011
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36. P187 Acute NIV: Factors associated with clinical outcomes at a central London teaching hospital
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Mackay, E, primary, Cho, P, additional, Papamanoli, A, additional, Burney, A, additional, Lyall, R, additional, Patel, A, additional, Metaxa, V, additional, and Lee, KK, additional
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- 2019
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37. Influenza and associated co-infections in critically ill immunosuppressed patients
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Martin-Loeches, I., Lemiale, V., Geoghegan, P., McMahon, M.A., Pickkers, P., Soares, M., Perner, A., Meyhoff, T.S., Bukan, R.B., Rello, J., Bauer, P.R., Louw, A. van de, Taccone, F.S., Salluh, J., Hemelaar, P., Schellongowski, P., Rusinova, K., Terzi, N., Mehta, S., Antonelli, M., Kouatchet, A., Klepstad, P., Valkonen, M., Landburg, P.P., Barratt-Due, A., Bruneel, F., Pene, F., Metaxa, V., Moreau, A.S., Souppart, V., Burghi, G., Girault, C., Silva, U.V.A., Montini, L., Barbier, F., Nielsen, L.B., Gaborit, B., Mokart, D., Chevret, S., Azoulay, E., Martin-Loeches, I., Lemiale, V., Geoghegan, P., McMahon, M.A., Pickkers, P., Soares, M., Perner, A., Meyhoff, T.S., Bukan, R.B., Rello, J., Bauer, P.R., Louw, A. van de, Taccone, F.S., Salluh, J., Hemelaar, P., Schellongowski, P., Rusinova, K., Terzi, N., Mehta, S., Antonelli, M., Kouatchet, A., Klepstad, P., Valkonen, M., Landburg, P.P., Barratt-Due, A., Bruneel, F., Pene, F., Metaxa, V., Moreau, A.S., Souppart, V., Burghi, G., Girault, C., Silva, U.V.A., Montini, L., Barbier, F., Nielsen, L.B., Gaborit, B., Mokart, D., Chevret, S., and Azoulay, E.
- Abstract
Contains fulltext : 206594.pdf (publisher's version ) (Open Access), BACKGROUND: It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure. METHODS: Preplanned secondary analysis of EFRAIM, a prospective cohort study of 68 hospitals in 16 countries. We included 1611 patients aged 18 years or older with non-AIDS-related immunocompromise, who were admitted to the ICU with acute hypoxemic respiratory failure. The main exposure of interest was influenza infection status. The primary outcome of interest was all-cause hospital mortality, and secondary outcomes ICU length of stay (LOS) and 90-day mortality. RESULTS: Influenza infection status was categorized into four groups: patients with influenza alone (n = 95, 5.8%), patients with influenza plus pulmonary co-infection (n = 58, 3.6%), patients with non-influenza pulmonary infection (n = 820, 50.9%), and patients without pulmonary infection (n = 638, 39.6%). Influenza infection status was associated with a requirement for intubation and with LOS in ICU (P < 0.001). Patients with influenza plus co-infection had the highest rates of intubation and longest ICU LOS. On crude analysis, influenza infection status was associated with ICU mortality (P < 0.001) but not hospital mortality (P = 0.09). Patients with influenza plus co-infection and patients with non-influenza infection alone had similar ICU mortality (41% and 37% respectively) that was higher than patients with influenza alone or those without infection (33% and 26% respectively). A propensity score-matched analysis did not show a difference in hospital mortality attributable to influenza infection (OR = 1.01, 95%CI 0.90-1.13, P = 0.85). Age, severity scores, ARDS, and performance status were all associated with ICU, hospital, and 90-day mortality. CONCLUSIONS: Category of infectious etiology of respiratory failure (influenza, non-influenza, influenza plus co-infection, and non-infectious) was associat
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- 2019
38. Ethical climate and intention to leave among critical care clinicians: an observational study in 68 intensive care units across Europe and the United States
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Van den Bulcke, B. (Bo), Metaxa, V. (Victoria), Reyners, A.K.L. (Anna), Rusinova, K. (Katerina), Jensen, H.I. (Hanne I.), Malmgren, J. (J.), Darmon, M. (Michael), Talmor, D. (Daniel), Meert, A.-P. (Anne-Pascale), Cancelliere, L. (Laura), Zubek, L. (László), Maia, P. (Paulo), Michalsen, A. (Andrej), Kompanje, E.J.O. (Erwin), Vlerick, P. (Peter), Roels, J. (Jolien), Vansteelandt, S. (Stijn), Decruyenaere, J. (Johan), Azoulay, E. (Elie), Vanheule, S. (Stijn), Piers, R.D. (Ruth), Benoit, D.D. (Dominique), Van den Bulcke, B. (Bo), Metaxa, V. (Victoria), Reyners, A.K.L. (Anna), Rusinova, K. (Katerina), Jensen, H.I. (Hanne I.), Malmgren, J. (J.), Darmon, M. (Michael), Talmor, D. (Daniel), Meert, A.-P. (Anne-Pascale), Cancelliere, L. (Laura), Zubek, L. (László), Maia, P. (Paulo), Michalsen, A. (Andrej), Kompanje, E.J.O. (Erwin), Vlerick, P. (Peter), Roels, J. (Jolien), Vansteelandt, S. (Stijn), Decruyenaere, J. (Johan), Azoulay, E. (Elie), Vanheule, S. (Stijn), Piers, R.D. (Ruth), and Benoit, D.D. (Dominique)
- Abstract
Purpose: Apart from organizational issues, quality of inter-professional collaboration during ethical decision-making may affect the intention to leave one’s job. To determine whether ethical climate is associated with the intention to leave after adjustment for country, ICU and clinicians characteristics. Methods: Perceptions of the ethical climate among clinicians working in 68 adult ICUs in 12 European countries and the US were measured using a self-assessment questionnaire, together with job characteristics and intent to leave as a sub-analysis of the Dispropricus study. The validated ethical decision-making climate questionnaire included seven factors: not avoiding decision-making at end-of-life (EOL), mutual respect within the interdisciplinary team, open interdisciplinary reflection, ethical awareness, self-reflective physician leadership, active decision-making at end-of-life by physicians, and involvement of nurses in EOL. Hierarchical mixed effect models were used to assess associations between these factors, and the intent to leave in clinicians within IC
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- 2019
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39. Diagnosis and outcome of acute respiratory failure in immunocompromised patients after bronchoscopy
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Bauer, P. R., Chevret, S., Yadav, H., Mehta, S., Pickkers, P., Bukan, R. B., Rello, J., van de Louw, A., Klouche, K., Meert, A. -P., Martin-Loeches, I., Marsh, B., Crespi, L. S., Moreno-Gonzalez, G., Buchtele, N., Amrein, K., Balik, M., Antonelli, Massimo, Nyunga, M., Barratt-Due, A., Bergmans, D. C. J. J., Spoelstra-De Man, A. M. E., Kuitunen, A., Wallet, F., Seguin, A., Metaxa, V., Lemiale, V., Burghi, G., Demoule, A., Karvunidis, T., Cotoia, A., Klepstad, P., Moller, A. M., Mokart, D., Azoulay, E., Antonelli M. (ORCID:0000-0003-3007-1670), Bauer, P. R., Chevret, S., Yadav, H., Mehta, S., Pickkers, P., Bukan, R. B., Rello, J., van de Louw, A., Klouche, K., Meert, A. -P., Martin-Loeches, I., Marsh, B., Crespi, L. S., Moreno-Gonzalez, G., Buchtele, N., Amrein, K., Balik, M., Antonelli, Massimo, Nyunga, M., Barratt-Due, A., Bergmans, D. C. J. J., Spoelstra-De Man, A. M. E., Kuitunen, A., Wallet, F., Seguin, A., Metaxa, V., Lemiale, V., Burghi, G., Demoule, A., Karvunidis, T., Cotoia, A., Klepstad, P., Moller, A. M., Mokart, D., Azoulay, E., and Antonelli M. (ORCID:0000-0003-3007-1670)
- Abstract
Objective: We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added to noninvasive testing in immunocompromised patients. In this setting, an inability to identify the cause of acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made to obtain a diagnosis, either with noninvasive testing alone or combined with bronchoscopy. However, our understanding of the risks and benefits of bronchoscopy remains uncertain. Patients and methods: This was a pre-planned secondary analysis of Efraim, a prospective, multinational, observational study of 1611 immunocompromised patients with acute respiratory failure admitted to the intensive care unit (ICU). We compared patients with noninvasive testing only to those who had also received bronchoscopy by bivariate analysis and after propensity score matching. Results: Bronchoscopy was performed in 618 (39%) patients who were more likely to have haematological malignancy and a higher severity of illness score. Bronchoscopy alone achieved a diagnosis in 165 patients (27% adjusted diagnostic yield). Bronchoscopy resulted in a management change in 236 patients (38% therapeutic yield). Bronchoscopy was associated with worsening of respiratory status in 69 (11%) patients. Bronchoscopy was associated with higher ICU (40% versus 28%; p<0.0001) and hospital mortality (49% versus 41%; p=0.003). The overall rate of undiagnosed causes was 13%. After propensity score matching, bronchoscopy remained associated with increased risk of hospital mortality (OR 1.41, 95% CI 1.08–1.81). Conclusions: Bronchoscopy was associated with improved diagnosis and changes in management, but also increased hospital mortality. Balancing risk and benefit in individualised cases should be investigated further.
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- 2019
40. Intracerebral hemorrhage in ICU: is it worth treating?
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Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, Kingma, W, Navis, G, Boerma, E, Rulisek, J, Balik, M, Zacharov, S, Kim, H, Jeon, S, Namgung, H, Lee, E, Cho, Y, Lee, Y, Huang, A, Cioccari, L, Luethi, N, Mårtensson, J, Bellomo, R, Forsberg, M, Edman, G, Höjer, J, Forsberg, S, Freile, M, Hidalgo, F, Molina, J, Lecumberri, R, Rosselló, A, Travieso, P, Leon, G, Sanchez, J, Frias, L, Rosello, D, Verdejo, J, Serrano, J, Winterwerp, D, van Galen, T, Vazin, A, Karimzade, I, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, B, Kureshi, N, Fenerty, L, Thibault Halman, G, Erdogan, M, Walling, S, Green, R, Clarke, D, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Politi, E, Kostopanagiotou, G, Crewdson, K, Rehn, M, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Baker, C, Mansfield, L, Stafford, V, Wade, C, Watson, G, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Furneval, J, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Baudouin, S, Ramírez, C, Escalada, S, Viera, M, Santana, M, Balcázar, L, Monroy, N, Campelo, F, Vázquez, C, Santana, P, Santana, S, Quintard, H, Bouzat, P, Wollersheim, T, Malleike, J, Haas, K, Carbon, N, Schneider, J, Birchmeier, C, Fielitz, J, Spuler, S, Weber Carstens, S, Enseñat, L, Pérez Madrigal, A, Saludes, P, Proença, L, Gruartmoner, G, Espinal, C, Mesquida, J, Huber, W, Eckmann, M, Elkmann, F, Gruber, A, Lahmer, T, Mayr, U, Herner, A, Schellnegger, R, Schmid, R, Ayoub, W, Samy, W, Esmat, A, Battah, A, Mukhtar, S, Mongkolpun, W, Cortés, D, Cordeiro, C, Funcke, S, Groesdonk, H, Saugel, B, Wagenpfeil, G, Wagenpfeil, S, Reuter, D, Fernandez, M, Fernandez, R, Magret, M, González Castro, A, Bouza, M, García, C, Balerdi, B, Mas, A, Arauzo, V, Añón, J, Ruiz, F, Ferreres, J, Tomás, R, Alabert, M, Tizón, A, Altaba, S, Llamas, N, Goligher, E, Fan, E, Herridge, M, Vorona, S, Sklar, M, Dres, M, Rittayamai, N, Lanys, A, Urrea, C, Tomlinson, G, Reid, W, Rubenfeld, G, Kavanagh, B, Brochard, L, Ferguson, N, Neto, A, de Abreu, M, Pelosi, P, Schultz, M, Guérin, C, Papazian, L, Reignier, J, Ayzac, L, Loundou, A, Forel, J, Rolland Debord, C, Bureau, C, Poitou, T, Clavel, M, Perbet, S, Terzi, N, Kouatchet, A, Similowski, T, Demoule, A, Hunfeld, N, Trogrlic, Z, Ladage, S, Osse, R, Koch, B, Rietdijk, W, Devlin, J, van der Jagt, M, Picetti, E, Ceccarelli, P, Mensi, F, Malchiodi, L, Risolo, S, Rossi, I, Antonini, M, Servadei, F, Caspani, M, Roquilly, A, Lasocki, S, Seguin, P, Geeraerts, T, Perrigault, P, Dahyot Fizelier, C, Paugam Burtz, C, Cook, F, Cinotti, R, Dit Latte, D, Mahe, P, Fortuit, C, Feuillet, F, Asehnoune, K, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Barbadillo, S, de Molina, F, Álvarez Lerma, F, Rodríguez, A, Zakharkina, T, Martin Loeches, I, Matamoros, S, Povoa, P, Torres, A, Kastelijn, J, Hofstra, J, de Jong, M, Sterk, P, Artigas, A, Bos, L, Moreau, A, Salluh, J, Rodriguez, A, Nseir, S, de Jong, E, van Oers, J, Nijsten, M, de Lange, D, Bonvicini, D, Labate, D, Benacchio, L, Olivieri, A, Pizzirani, E, Lopez Delgado, J, Gonzalez Romero, M, Fuentes Mila, V, Berbel Franco, D, Romera Peregrina, I, Martinez Pascual, A, Perez Sanchez, J, Abellan Lencina, R, Ávila Espinoza, R, Moreno Gonzalez, G, Sbraga, F, Griffiths, S, Grocott, M, Doyle, J, Wilkerson, P, Soon, Y, Huddart, S, Dickinson, M, Riga, A, Zuleika, A, Miyamoto, K, Kawazoe, Y, Morimoto, T, Yamamoto, T, Fuke, A, Hashimoto, A, Koami, H, Beppu, S, Katayama, Y, Ito, M, Ohta, Y, Yamamura, H, Rygård, S, Holst, L, Wetterslev, J, Johansson, P, Perner, A, Soliman, I, van Dijk, D, van Delden, J, Cremer, O, Mcwilliams, D, Snelson, C, Neves, A, Loudet, C, Busico, M, Vazquez, D, Villalba, D, Veronesi, M, Lischinsky, A, López, F, Mori, L, Plotnikow, G, Díaz, A, Giannasi, S, Hernandez, R, Krzisnik, L, Cecotti, C, Viola, L, Lopez, R, Sottile, J, Benavent, G, Estenssoro, E, Chen, C, Lai, C, Cheng, K, Chou, W, Chan, K, Roeker, L, Horkan, C, Gibbons, F, Christopher, K, Weijs, P, Mogensen, K, Rawn, J, Robinson, M, Tang, Z, Qiu, C, Ouyang, B, Cai, C, Guan, X, Regueira, T, Cea, L, Carlos, S, Elisa, B, Puebla, C, Vargas, A, Poulsen, M, Thomsen, L, Kjærgaard, S, Rees, S, Karbing, D, Frank, S, Müller, M, Skrypnikov, V, Pickerodt, P, Falk, R, Mahlau, A, Lee, A, Inglis, R, Morgan, R, Barker, G, Kamata, K, Abe, T, Saitoh, D, Tokuda, Y, Butler, M, Hwa, H, Gil, L, Vaquero, R, Rodriguez Ruiz, E, Lago, A, Allut, J, Gestal, A, Thomas Rüddel, D, Schwarzkopf, D, Fleischmann, C, Reinhart, K, Suwanpasu, S, Sattayasomboon, Y, Filho, N, Oliveira, J, Ballalai, C, De Lucia, C, Araponga, G, Veiga, L, Silva, C, Garrido, M, Ramos, B, Ricaldi, E, Gomes, S, Wright, C, Docking, R, Doherty, P, Black, E, Stenhouse, P, Plummer, M, Finnis, M, Phillips, L, Kar, P, Bihari, S, Biradar, V, Moodie, S, Horowitz, M, Shaw, J, Yatabe, T, Inoue, S, Sakaguchi, M, Egi, M, Abdelhamid, Y, Hokka, M, Mizobuchi, S, Giersch, E, Summers, M, Hatzinikolas, S, Heller, S, Jones, K, Schweizer, R, Jacquet Lagreze, M, Portran, P, Junot, S, Allaouchiche, B, Fellahi, J, Guerci, P, Ergin, B, Kapucu, A, Ince, C, Crisman, M, Shinotsuka, C, Fagnoul, D, Orbegozo, D, Preiser, J, Thooft, A, Brimioulle, S, Iwasaka, H, Tahara, S, Nagamine, M, Ichigatani, A, Cabrera, A, Zepeda, E, Granillo, J, Sánchez, J, Montoya, A, Montenegro, A, Blanco, G, Robles, C, Drolz, A, Horvatits, T, Roedl, K, Rutter, K, Funk, G, Schneeweiss, B, Fuhrmann, V, Sabetian, G, Pooresmaeel, F, Ghaffaripour, S, Farbod, A, Tabei, H, Taheri, L, Anandanadesan, R, Metaxa, V, Teixeira, C, Pereira, S, Hernández Marrero, P, Carvalho, A, Beckmann, M, Hartog, C, Raadts, A, Robertsen, A, Førde, R, Skaga, N, Helseth, E, Honeybul, S, Ho, K, Lopez, P, Ortega, P, Sola, E, Spasova, T, Kopecky, O, Rusinova, K, Waldauf, P, Cepeplikova, Z, Domínguez, J, Almudevar, P, Carmona, S, Muñoz, J, Castañeda, D, Abellán, A, Villamizar, P, Ramos, J, Pérez, L, Lucendo, A, Ejarque, M, Estella, A, Camps, V, Martín, M, Masnou, N, Barbosa, S, Varela, A, Palma, I, Cristina, L, Nunes, E, Pereira, I, Campello, G, Granja, C, Pande, R, Pandey, M, Varghese, S, Chanu, M, Van Dam, M, Ter Braak, E, Gracia, M, Viciana, R, Recuerda, M, Fontaiña, L, Tharmalingam, B, Kovari, F, Rose, L, Mcginlay, M, Amin, R, Burns, K, Connolly, B, Hart, N, Jouvet, P, Katz, S, Leasa, D, Mawdsley, C, Mcauley, D, Blackwood, B, Denham, S, Worrall, R, Arshad, M, Isherwood, P, Khadjibaev, A, Sabirov, D, Rosstalnaya, A, Parpibaev, F, Sharipova, V, Guzman, C, Cha, Y, Lee, S, Tyagi, N, Rajput, R, Taneja, S, Singh, V, Sharma, S, Mittal, S, Rao, B, Ayachi, J, Fraj, N, Romdhani, S, Khedher, A, Meddeb, K, Sma, N, Azouzi, A, Bouneb, R, Chouchene, I, El Ghardallou, M, Boussarsar, M, Jennings, R, Walter, E, Ribeiro, J, Moniz, I, Marçal, R, Santos, A, Candeias, C, E. Silva, Z, Gomez, S, Nieto, O, Gonzalez, J, Cuellar, A, Mildh, H, Pettilä, V, Korhonen, A, Karlsson, S, Ala Kokko, T, Reinikainen, M, Vaara, S, Zaleska Kociecka, M, Grabowski, M, Dąbrowski, M, Wozniak, S, Piotrowska, K, Banaszewski, M, Imiela, J, Stepinska, J, Pérez, A, Ordoñez, P, Giribet, A, Cuervo, M, Cuervo, R, Esteban, M, Fraile, L, Mittelbrum, C, Albaiceta, G, Koeze, J, Keus, F, Dieperink, W, van der Horst, I, van Meurs, M, Zijlstra, J, Roberts, S, Caballero, C, Isgro, G, Hall, D, Beitland, S, Trøseid, A, Brusletto, B, Waldum Grevbo, B, Berg, J, Sunde, K, Huertas, D, Manzano, F, Quintana, M, Osuna, A, Santiago Ruiz, F, Rodríguez Mejías, C, Wangensteen, R, Jamaati, H, Hashemian, S, Abbasi, G, Khaloo, V, Tabei, S, Kafilzadeh, A, Bakhodaei, H, Diaz, J, Silva, R, Garcia, D, Luis, E, Gomez, M, Soriano, R, Gonzalez, P, Ibrahim, I, Rafik, M, Al Ansary, A, Algendi, M, Ali, A, Benten, D, Kluwe, J, Siedler, S, Adedugbe, I, Bird, G, Kennedy, R, Yugi, G, Haroon, B, Witter, T, Khaliq, W, Singer, M, Havaldar, A, Krishna, B, Sriram, S, Espinoza, E, Pozo, M, Edul, V, Furche, M, Motta, M, Vazquez, A, Birri, P, Dubin, A, Dogliotti, A, Ramos, A, Lovesio, C, Delile, E, Nevière, R, Thiébaut, P, Maupoint, J, Mulder, P, Coquerel, D, Renet, S, do Rego, J, Rieusset, J, Richard, V, Tamion, F, Andreis, D, Smit, B, Smulders, Y, van Straaten, H, Eringa, E, Man, A, Alegría, L, Soto, D, Luengo, C, Gomez, J, Jarufe, N, Bruhn, A, Castro, R, Kattan, E, Tapia, P, Rebolledo, R, Achurra, P, Ospina Tascón, G, Bakker, J, Hernández, G, Bertini, P, Guarracino, F, Baldassarri, R, Pinsky, M, Vera, M, Dreyse, J, Carpio, D, Henriquez, C, Gajardo, D, Bravo, S, Lee, M, Park, S, So, S, Kačar, M, Kačar, S, Uddin, I, Belhaj, A, Aydın, M, Avsec, D, Kapuağası, A, Kaymak, Ç, Kovach, L, Şencan, I, Meço, B, Özçelik, M, Ünal, N, Jenni Moser, B, Jeitziner, M, Galassi, M, Sales, F, de Moraes, K, Batista, C, Júnior, J, Marcari, T, Lobato, R, Castro, C, de Souza, L, Rodrigues, F, Correa, N, Pelegrini, A, Eid, R, Timenetsky, K, Cazati, D, Lobato, M, Diniz, P, Rocha, L, Cavalheiro, A, Lucinio, N, Santos, E, Norrenberg, M, Gleize, A, Simón, I, Valhonrat, I, Almudévar, P, Dávila, F, Rubio, J, Reina, Á, López, N, Pérez, M, Apolo, D, Villén, L, García, I, Izurieta, J, Guerrero, J, Calvert, S, Quint, M, Adeniji, K, Young, R, Shevill, D, Robertson, E, Garside, P, Isotti, P, De Vecchi, M, Perduca, A, Negro, A, Villa, G, Manara, D, Cabrini, L, Zangrillo, A, Frencken, J, van Baal, L, Donker, D, Horn, J, van der Poll, T, van Klei, W, Bonten, M, Menard, C, Kumar, A, Rimmer, E, Doucette, S, Turgeon, A, Houston, B, Houston, D, Zarychanski, R, Pinto, B, Carrara, M, Ferrario, M, Bendjelid, K, Nunes, J, Diaz, P, Silva, G, Escórcio, S, Chaves, S, Jardim, M, Fernandes, N, Câmara, M, Duarte, R, Pereira, C, Vieira, J, Nóbrega, J, de Oca Sandoval, M, Sánchez Rodríguez, A, Joya Galeana, J, Correa Morales, A, Camarena Alejo, G, Aguirre Sánchez, J, Franco Granillo, J, Soliman, M, Al Azab, A, El Hossainy, R, Nagy, H, Nirmalan, M, Crippa, I, Cavicchi, F, Chaari, A, Hakim, K, Hassanein, H, Etman, M, El Bahr, M, Bousselmi, K, Khalil, E, Kauts, V, Casey, W, Imahase, H, Sakamoto, Y, Yamada, K, Miike, T, Nagashima, F, Iwamura, T, Boscolo, A, Lucchetta, V, Piasentini, E, Bertini, D, Manesso, L, Spiezia, L, Simioni, P, Ori, C, Souza, R, Martins, A, Liberatore, A, Kang, Y, Nakamae, M, Koh, I, Hanslin, K, Wilske, F, Skorup, P, Sjölin, J, Lipcsey, M, Long, W, Zhen, C, Vakalos, A, Avramidis, V, Wu, S, Shyu, L, Li, C, Yu, C, Chen, H, Wang, C, Lin, K, Aray, Z, Gómez, C, Tejero, A, Monge, D, Losada, V, Tarancón, C, Cortés, S, Gutiérrez, A, Álvarez, T, Rouze, A, Jaffal, K, Six, S, Stolz, K, Cattoen, V, Arnal, J, Saoli, M, Novotni, D, Garnero, A, Becher, T, Buchholz, V, Schädler, D, Frerichs, I, Weiler, N, Eronia, N, Mauri, T, Gatti, S, Maffezzini, E, Bronco, A, Alban, L, Sasso, T, Marenghi, C, Grasselli, G, Pesenti, A, Bellani, G, Al Fares, A, Del Sorbo, L, Anwar, S, Facchin, F, Azad, S, Zamel, R, Cypel, M, 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Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, and Azevedo, L
- Subjects
intracerebral haemorrhage in intensive care - Published
- 2016
41. Effects of alcohol consumption and the metabolic syndrome on 10-year incidence of diabetes: The ATTICA study
- Author
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Koloverou, E. Panagiotakos, D.B. Pitsavos, C. Chrysohoou, C. Georgousopoulou, E.N. Metaxa, V. Stefanadis, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, S. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Vassiliadou, C. Dedoussis, G. Toutouza-Giotsa, M. Tselika, C. Poulopoulou, S. Toutouza, M. the ATTICA study group and Koloverou, E. Panagiotakos, D.B. Pitsavos, C. Chrysohoou, C. Georgousopoulou, E.N. Metaxa, V. Stefanadis, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, S. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Vassiliadou, C. Dedoussis, G. Toutouza-Giotsa, M. Tselika, C. Poulopoulou, S. Toutouza, M. the ATTICA study group
- Abstract
Aim: The purpose of this prospective study was to investigate the effect of alcohol consumption on the 10-year diabetes incidence. Methods: In 2001-2002, a random sample of 1514 men (18-89 years old) and 1528 women (18-87 years old) was selected to participate in the ATTICA study (Athens metropolitan area, Greece). Among various other characteristics, average daily alcohol intakes (abstention, low, moderate, high) and type of alcoholic drink were evaluated. Diabetes was defined according to American Diabetes Association criteria. During 2011-2012, the 10-year follow-up was performed. Results: The 10-year incidence of diabetes was 13.4% in men and 12.4% in women. After making various adjustments, those who consumed up to 1 glass/day of alcohol had a 53% lower diabetes risk (RR = 0.47; 95% CI: 0.26, 0.83) compared with abstainers, while trend analysis revealed a significant U-shaped relationship between quantity of alcohol drunk and diabetes incidence (P< 0.001 for trend). Specific types of drinks were not associated with diabetes incidence; however, a one-unit increase in ratio of wine/beer/vodka vs. other spirits was associated with an 89% lower risk of diabetes (RR = 0.11; 95% CI: 0.02, 0.67). The protective effect of low alcohol consumption on diabetes incidence was more prominent among individuals with stricter adherence to the Mediterranean diet (RR = 0.08; 95% CI: 0.011, 0.70) and without the metabolic syndrome (RR = 0.34; 95% CI: 0.16, 0.70). Conclusion: This work revealed the protective effect of modest alcohol consumption of particularly wine and beer against the long-term incidence of diabetes, possibly due to their pleiotropic health effects. © 2014 Elsevier Masson SAS.
- Published
- 2015
42. Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA
- Author
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Benoit, DD, Jensen, HI, Malmgren, J, Metaxa, V, Reyners, AK, Darmon, M, Rusinova, K, Talmor, D, Meert, AP, Cancelliere, L, Zubek, L, Maia, P, Michalsen, A, Vanheule, S, Kompanje, Erwin, Decruyenaere, J, Vandenberghe, S, Vansteelandt, S, Gadeyne, B, Van den Bulcke, B, Azoulay, E, Piers, RD, Benoit, DD, Jensen, HI, Malmgren, J, Metaxa, V, Reyners, AK, Darmon, M, Rusinova, K, Talmor, D, Meert, AP, Cancelliere, L, Zubek, L, Maia, P, Michalsen, A, Vanheule, S, Kompanje, Erwin, Decruyenaere, J, Vandenberghe, S, Vansteelandt, S, Gadeyne, B, Van den Bulcke, B, Azoulay, E, and Piers, RD
- Published
- 2018
43. Arterial aging mediates the effect of TNF-α and ACE polymorphisms on mental health in elderly individuals: Insights from IKARIA study
- Author
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Georgiopoulos, G. Chrysohoou, C. Errigo, A. Pes, G. Metaxa, V. Zaromytidou, M. Skoumas, J. Kariori, M. Lazaros, G. Vogiatzi, G. Poulain, M. Tousoulis, D. Pitsavos, C. Stefanadis, C.
- Abstract
Background: Aging is characterized by an insidious decline in cognitive function. Several genetic and lifestyle factors have been implicated in the increased risk or early onset of dementia Aim: We sought to assess the role of tumor necrosis factor (TNF) and angiotensin-converting enzyme (ACE) polymorphisms on the development of impaired mental health in respect to indices of arterial aging in nonagenarian individuals. Design: 178 consecutive subjects above 75 years that permanently inhabit in the island of IKARIA, Greece were recruited. Methods: Aortic distensibility (AoD) was calculated and genetic evaluation was performed on the ACE Insertion/Deletion gene polymorphism (intron 16) and the G/A transition (position -308) of the TNF gene. Cognitive function was evaluated using the Mini-mental State Examination (MMSE). Results: The DD genotype for ACE was independently associated (b=-0.44, P = 0.007) with AD while AoD remained an independent determinant of mental status (OR=1.82, P = 0.036). Interestingly though, when a combined genetic index (GI) was calculated for both genes (ACE and TNF), subjects being double homozygous (DD for ACE and GG for TNF) for these loci presented significantly decreased MMSE (adjusted OR=0.259, P = 0.033). This GI independently associated with AD (beta coefficient =-0.785, P = 0.002). When AoD was included, GI lost its predictive role (OR=0.784, P = 0.783) towards MMSE. AoD has marginal indirect mediating effect in the association of the GI with MMSE (P = 0.07). Conclusion: Vascular aging may modulates the genetic substrate of elderly subjects on the risk for developing dementia. © The Author 2017.
- Published
- 2017
44. ESICM LIVES 2016: part two
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Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. 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M., Zaponi, R. S., Abentroth, L. R. L., Ogasawara, S. M., Jorge, A. C., Duarte, P. A. D., Hernández-Sánchez, N., Sánchez-Hurtado, L. A., García-Guillen, F. J., Ñamendys-Silva, S. A., Maghsoudi, B., Emami, M., Khosravi, M. B., Zand, F., Tabatabaie, H. R., Masjedi, M., Sabetiyan, G., Mokri, A., Troubleyn, J., Diltoer, M., Jacobs, R., Nguyen, D. N., De Waele, E., De Regt, J., Honoré, P. M., Van Gorp, V., Spapen, H. D., Contreras, R. S., Toapanta, N. D., Moreno, G., Sabater, J., Torrado, H., Gonzalez, M., Marin, M., Farigola, E., Gonzalez, A., Fernandez, J., Vera, A., Gisbert, X., Juliá, C., Uya, J., Corral, L., Elias-Jones, I., Gemmell, L., MacKay, A., Randall, D., Adwaney, A., Blunden, M., Prowle, J. R., Kirwan, C. J., Thomas, N., Martin, A., Owen, H., Darwin, L., Conway, D., Atkinson, D., Sharman, M., Barbanti, C., Amour, J., Gaudard, P., Rozec, B., Mauriat, P., M’rini, M., Leger, P. L., Cambonie, G., Liet, J. M., Girard, C., Laroche, S., Damas, P., Assaf, Z., Loron, G., Lecourt, L., Pouard, P., Prowle, J.R., Kim, S. H., Na, S., Kim, J., Oh, S. Y., Jung, C. W., Yoo, S. H., Min, S. H., Chung, E. J., Lee, H., Lee, N. J., Lee, K. W., Suh, K. S., Ryu, H. G., Marshall, D. C., Goodson, R. J., Salciccioli, J. D., Shalhoub, J., Potter, E. K., Kirk-Bayley, J., Karanjia, N. D., Forni, L. G., Creagh-Brown, B. C., Bossy, M., Nyman, M., Tailor, A., Creagh-Brown, B., D’Antini, D., Spadaro, S., Valentino, F., Sollitto, F., Cinnella, G., Mirabella, L., Calvo, F. J. Redondo, Bejarano, N., Padilla, D., Baladron, V., Villajero, P., Villazala, R., Redondo, J., Yuste, A. S., Liu, J., Shen, F., Teboul, J. L., Anguel, N., Beurton, A., Bezaz, N., Richard, C., Monnet, X., Fossali, T., Colombo, R., Ottolina, D., Rossetti, M., Mazzucco, C., Marchi, A., Porta, A., Catena, E., Tollisen, K. H., Andersen, G. Ø., Heyerdahl, F., Jacobsen, D., de Waard, M. C., van IJzendoorn, M. C. O., Buter, H., Kingma, W. P., Navis, G. 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T., Russ, M., Braun, W., Walter, M., Francis, R., Lachmann, B., Leonhardt, S., Landaverde-López, A., Canedo-Castillo, N. A., Esquivel-Chávez, A., Arvizu-Tachiquín, P. C., Baltazar-Torres, J. A., Cardoso, V., Krystopchuk, A., Castro, S., Melão, L., Firmino, S., Marreiros, A., Almaziad, S., Kubbara, A., Barnett, W., Nakity, R., Alamoudi, W., Altook, R., Tarazi, T., Fida, M., Safi, F., Assaly, R., Santini, A., Milesi, M., Maraffi, T., Pugni, P., Cavenago, M., Gattinoni, L., Protti, A., Perchiazzi, G., Borges, J. B., Bayat, S., Porra, L., Broche, L., Hedenstierna, G., Larsson, A., Roneus, A., Segelsjö, M., Vestito, M. C., Gremo, E., Nyberg, A., Castegren, M., Pikwer, A., Yoshida, T., Engelberts, D., Otulakowski, G., Katira, B., Post, M., Brochard, L., Amato, M. B. P., Koch, N., Hoellthaler, J., Mair, S., Phillip, V., Beitz, A., Baladrón, V., Villarejo, P., Steenstra, R. J., Banierink, H., Hof, J., van der Horst, I. C., Nijsten, M. W., Hoekstra, M., Sterz, F., Horvatits, K., Herkner, H., Kott, M., Zitta, K., Brandt, B., Schildhauer, C., Elke, G., Hummitzsch, L., Albrecht, M., González, L. Rey, Alonso, D. Cabestrero, Sánchez, R. de Pablo, Lucas, J. Higuera, Ferlitsch, A., Fauler, G., Trauner, M., Pischke, S., Fischer, L., Thaiss, F., Koch, M., Bangert, K., Lohse, A. W., Nashan, B., Sterneck, M., Faenza, S., Siniscalchi, A., Pierucci, E., Mancini, E., Ricci, D., Gemelli, C., Cuoghi, A., Magnani, S., Atti, M., Sotos, F., Cánovas, J., López, A., Burruezo, A., Torres, D., Herrera-Gutierrez, M. E., Barrueco-Francioni, J., Arias-Verdú, D., Lozano-Saez, R., Quesada-Garcia, G., Seller-Pérez, G., Figueiredo, A., Anzola, Y., Pereira, R., Bento, L., Lai, M., Deiana, M., Seller-Perez, G., Vardas, K., Ilia, S., Sertedaki, A., Charmadari, E., Stratakis, C. A., Briassouli, E., Goukos, D., Psarra, K., Botoula, E., Tsagarakis, S., Mageira, E., Routsi, C., Nanas, S., Campello, E., Radu, C. M., Su, H., Lam, Y. M., Willis, K., Pullar, V., Hubner, R. P., Tsang, J. L., de Guadiana-Romualdo, L. García, Rebollo-Acebes, S., Esteban-Torrella, P., Jiménez-Sánchez, R., Jiménez-Santos, E., Ortín-Freire, A., Hernando-Holgado, A., Albaladejo-Otón, M. D., Coelho, L., Rabello, L., Póvoa, P., Varis, E., Poukkanen, M., Jacob, S., Takala, J., Wilkman, E., Lundberg, O. H. M., Bergenzaun, L., Rydén, J., Rosenqvist, M., Melander, O., Chew, M. S., Kishihara, Y., Yasuda, H., Jimenez, R., Torrella, P. Esteban, Fernandez, A., Sanchez, S., Ortin, A., Prats, R. Guillamat, Aguilera, E., Marti, D., Fernandez, L., Ferrer, M., Lanziotti, V. S., Pulcheri, L., Ribeiro, M. O., Barbosa, A. P., e Silva, J. R. Lapa, Soares, M., Salluh, J. I. F., Marqués, M. Gil, Moreno, A. Puppo, Pizarraya, A. Gutierrez, Diaz, J. Pachón, Smani, Y., Connell, M. Mc, Zhang, L. A., Parker, R. S., Banerjee, I., Clermont, G., Norberg, E., Oras, J., Cuisinier, A., Maufrais, C., Payen, J. F., Nottin, S., Walther, G., Arib, S., Bilotta, F., Badenes, R., Rubulotta, F., Mirek, S., Monfort, B., Stazi, E., Roig, A. Lozano, Magnoni, S., Marando, M., Pifferi, S., Conte, V., Ortolano, F., Carbonara, M., Bertani, G., Scola, E., Cadioli, M., Triulzi, F., Colombo, A., Stocchetti, N., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Guimillo, M. Rodriguez, Piqueras, C. Sanchís, Guia, J. Romero, Simon, M. García, Arizmendi, A. Mesejo, Carratalá, A., El Maraghi, S., Yehia, A., Bakry, M., Shoman, A., Backes, F. N., Bianchin, M. M., Vieira, S. R. R., de Souza, A., Backes, A. N., Klein, C., Arunkumar, A. S., Lozano, A., Gallaher, C., Cattlin, S., Gordon, S., Picard, J., Fontana, V., Bond, O., Nobile, L., Mrozek, S., Delamarre, L., Capilla, F., Al-Saati, T., Fourcade, O., Dominguez-Berrot, A. M., Gonzalez-Vaquero, M., Vallejo-Pascual, M. E., Gupta, D., Ivory, B. D., Chopra, M., McCarthy, J., Felderhof, C. L., MacNeil, C., Maggiorini, M., Duska, F., Fumis, R. R. L., Junior, J. M. Vieira, Amarante, G., Skorko, A., Sanders, S., Aron, J., Kroll, R. J., Redfearn, C., Krishnan, P., Khalil, J. E., Kongpolprom, N., Gulia, V., Lourenço, E., Duro, C., Baptista, G., Alves, A., Arminda, B., Rodrigues, M., Hayward, J., Baldwin, F., Gray, R., Katinakis, P. A., Stijf, M., Ten Kleij, M., Jansen-Frederiks, M., Broek, R., de Bruijne, M., Spronk, P. E., Sinha, K., Luney, M., Palmer, K., Keating, L., Abu-Habsa, M., Bahl, R., Baskaralingam, N., Ahmad, A., Kanapeckaite, L., Bhatti, P., Glace, S., Jeyabraba, S., Lewis, H. F., Kostopoulos, A., Raja, M., West, A., Ely, A., Turkoglu, L. M., Zolfaghari, P., Baptista, J. P., Marques, M. P., Martins, P., Pimentel, J., Su, Y. C., Villacres, S., Stone, M. E., Parsikia, A., Medar, S., O’Dea, K. P., Porter, J., Tirlapur, N., Jonathan, J. M., Singh, S., Takata, M., McWhirter, E., Lyon, R., Hariz, M. L., Azmi, E., Alkhan, J., Movsisyan, V., Petrikov, S., Marutyan, Z., Aliev, I., Evdokimov, A., Antonucci, E., Merz, T., Hartmann, C., Calzia, E., Radermacher, P., Nußbaum, B., Huber-Lang, M., Gröger, M., Svoren-Jabalera, E., Davenport, E. E., Humburg, P., Knight, J., Hinds, C. J., Jun, I. J., Kim, W. J., Lee, E. H., Besch, G., Perrotti, A., Puyraveau, M., Baltres, M., Samain, E., Chocron, S., Pili-Floury, S., Plata-Menchaca, E. P., Sabater-Riera, J., Estruch, M., Boza, E., Toscana-Fernández, J., Bruguera-Pellicer, E., Ordoñez-Llanos, J., Pérez-Fernández, X. L., Cavaleiro, P., Tralhão, A., Arrigo, M., Lopes, J.-P., Lebrun, M., Cholley, B., PerezVela, J. L., MarinMateos, H., Rivera, J. J. Jimenez, Llorente, M. A. Alcala, De Marcos, B. Gonzalez, Fernandez, F. J. Gonzalez, Laborda, C. Garcia, Zamora, D. Fernandez, Delgado, J. C. Lopez, Imperiali, C., Dastis, M., Górka, J., Górka, K., Iwaniec, T., Frołow, M., Polok, K., Fronczek, J., Kózka, M., Musiał, J., Szczeklik, W., Sileli, M., Moursia, C., Maleoglou, H., Leleki, K., Uz, Z., Ince, Y., Papatella, R., Bulent, E., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Tamura, T., Miyajima, I., Yamashita, K., Yokoyama, M., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Hathorn, K. E., Purtle, S. W., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Lorente, M., Włudarczyk, A., Hałek, A., Bargouth, M., Bennasr, M., Abdelghani, K. Ben, Abdallah, T. Ben, Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Welsh, S. P., Guerra, E., Zerpa, M. C. l., Zechner, F., Berdaguer, F., Risso-Vazquez, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Morales, M. A. Lopez, Pires, T., and Azevedo, L. C. P.
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Meeting Abstracts - Abstract
Introduction In addition to systemic hemodynamics, the management\ud of neurocritically ill patients is often informed by neuromonitoring. In\ud the absence of high-level evidence clinicians are often guided by personal\ud and local expertise. Little is known about practices as they pertain\ud to the use of such monitoring in patients with acute brain injury (ABI).\ud Objectives To investigate practices in bedside monitoring for ABI patients.\ud Particularly interested in differences among “neurointensivists”\ud (NIs; defined here as intensivists whose clinical practice is comprised\ud > 1/3 by neurocritical care) and other intensivists (OIs). Also, to\ud explore patterns specific to traumatic brain injury (TBI) and subarachnoid\ud hemorrhage (SAH), as well as preferences and availability of\ud particular technologies/devices.\ud Methods Electronic survey of 22 items including two case-based scenarios;\ud endorsed by SCCM (9,000 recipients) and ESICM (on-line\ud newsletter) in 2013. A sample size of 370 was calculated based on a\ud population of 10,000 physician members, a 5 % margin error, and\ud 95 % confidence interval. We summarized results using descriptive\ud statistics (proportions with 95 % confidence intervals). A chi-square\ud test was used to compare proportions of responses between NIs and\ud OIs with a significance p < 0.05.\ud Results There were 655 responders (66 % completion rate); 422(65 %)\ud were classified as OIs and 226(35 %) as NIs. More NIs follow\ud hemodynamic protocols for neurocritically-ill patients (56 % vs. 43 %, p\ud 0.001), in TBI (44.5 % vs. 33.3 %, p 0.007), and in SAH (38.1 % vs. 21.3 %,\ud p < 000.1). For delayed cerebral ischemia (DCI), more NIs target cardiac\ud index (CI) (35 % vs. 21 %, p 0.0001), and fluid responsiveness (62 % vs.\ud 53 %, p 0.03), use more bedside ultrasound (BUS) (42 % vs. 29 %, p\ud 0.005) and arterial waveform analysis (40 % vs. 29 %, p 0.02). For DCI\ud neuromonitoring, NIs use more angiography (57 % vs. 43 %, p 0.004),\ud TCD (46 % vs. 38 %, p 0.0001), and CTP (32 % vs.16 %, p 0.0001). For\ud CPP optimization in TBI, NIs use more arterial waveform analysis (45 %\ud vs. 35 %, p 0.019), and BUS (37 % vs. 27.7 %, p 0.023), while more OIs\ud monitor mixed venous oxygen saturation (54.1 % vs. 45 %, p 0.045). For\ud TBI neuromonitoring, NIs use more PbtO2 (28 % vs. 10 %, p 0.0001). In\ud the case scenario of raised ICP/low PbtO2, most employ analgosedation\ud (47 %) and osmotherapy (38 %). Fewer make use of preserved pressure\ud reactivity, particularly OIs (vasopressor use 23 % vs. 34 %, p 0.014).\ud Conclusions There is large heterogeneity in the use of monitoring protocols,\ud variables, and technologies/devices. “Neurointensivists” not only\ud employ more neuromonitoring but also more hemodynamic monitoring\ud in patients with acute brain injury. ICP/CPP remain the most commonly\ud followed neuro-variables in TBI patients, with low use of other\ud brain-physiology parameters, sugg
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- 2016
45. Adherence to Mediterranean diet and 10-year incidence (2002-2012) of diabetes: Correlations with inflammatory and oxidative stress biomarkers in the ATTICA cohort study
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Koloverou, E. Panagiotakos, D.B. Pitsavos, C. Chrysohoou, C. Georgousopoulou, E.N. Grekas, A. Christou, A. Chatzigeorgiou, M. Skoumas, I. Tousoulis, D. Stefanadis, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. The ATTICA Study Group
- Abstract
Background: The purpose of this work was to investigate the links between oxidative stress, inflammation and coagulation and their effect on Mediterranean diet-diabetes relationship. Methods: In 2001-2002, a random sample of 1514 men (18-87 years old) and 1528 women (18-89 years old) was selected to participate in the ATTICA study, where Athens is the major metropolis. A validated questionnaire was used to assess lifestyle and dietary factors. Adherence to Mediterranean diet was recorded using MedDietScore. Among others, oxidative stress and inflammatory biomarkers were recorded. During 2011-2012, the 10-year follow-up was performed. Diabetes incidence was defined according to the American Diabetes Association criteria. Results: A total of 191 incident cases of diabetes were documented, yielding an incidence of 12.9% (13.4% in men and 12.4% in women). Medium and high adherence was found to decrease diabetes risk by 49% (95% CI: 0.30, 0.88) and 62% (95% CI: 0.16, 0.88), respectively, compared with low adherence. A logarithmic trend between Mediterranean diet and diabetes incidence was also revealed (p for trend=0.042). Individuals with abnormal waist circumference (>94 for men, >80 for women) were benefited the most. Wholegrain cereals, fruits and legumes had the greatest predictive ability. The anti-diabetic effect of Mediterranean diet correlated with measurements of tumour necrosis factor-α, homocysteine and total antioxidant capacity. Conclusions: The reported results support the role of Mediterranean diet as a promising dietary tool for the primary prevention of diabetes, by attenuating inflammation and fostering total antioxidant capacity. This dietary pattern may have therapeutic potential for many cardiometabolic disorders associated with inflammation and/or oxidative stress. © 2016 John Wiley & Sons, Ltd.
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- 2016
46. Education status determines 10-year (2002-2012) survival from cardiovascular disease in Athens metropolitan area: The ATTICA study, Greece
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Panagiotakos, D.B. Georgousopoulou, E. Notara, V. Pitaraki, E. Kokkou, E. Chrysohoou, C. Skoumas, Y. Metaxa, V. Pitsavos, C. Stefanadis, C. ATTICA study group
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Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, and educational level seems to be an important determinant of the disease occurrence. The aim of this work was to investigate the association between education status and 10-year incidence of CVD, controlling for various socio-demographic lifestyle and clinical factors. From May 2001 to December 2002, 1514 men and 1528 women (>18 years) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. Education status was measured in years of schooling. The 10-year incidence of CVD was 15.7% [95% confidence intervals (CI) 14.1%-17.4%], 19.7% in men and 11.7% in women (Pgender < 0.001). Age-and gender-adjusted analyses revealed that those with low education (12 years of schooling). People in the low education group had higher prevalence of hypertension, diabetes and dyslipidaemias, were more likely to be smokers and sedentary, had less healthy dietary habits, as compared with those in the high education group. When controlling for participants' medical history, smoking, dietary and lifestyle habits, low education was no longer significantly associated with CVD, illustrating the mediating effect of clinical and behavioural factors in the link between education and disease. It was of interest that low education status interacted with alcohol drinking, enhancing the adverse effect of low education on CVD risk (relative risk 1.44, 95% CI 0.94%-2.20%), after various adjustments made. In this study, it was concluded that low educational level was associated with increased CVD risk. This was mainly explained by the intermediate association of low education with unhealthy choices that consequently worsen clinical status. © 2016 John Wiley & Sons Ltd.
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- 2016
47. Mediterranean diet and 10-year (2002-2012) incidence of diabetes and cardiovascular disease in participants with prediabetes: The ATTICA study
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Filippatos, T.D. Panagiotakos, D.B. Georgousopoulou, E.N. Pitaraki, E. Kouli, G.-M. Chrysohoou, C. Tousoulis, D. Stefanadis, C. Pitsavos, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Vassiliadou, C. Dedoussis, G. Toutouza-Giotsa, M. Tselika, C. Poulopoulou, S. Toutouza, M. The ATTICA Study Group
- Abstract
BACKGROUND: Prediabetes has been related to an increased risk of developing diabetes and cardiovascular disease (CVD). AIM: The aim of the present study was to examine the effect of the Mediterranean diet on diabetes and CVD risk in subjects with impaired fasting glucose (IFG, i.e. fasting plasma glucose 100-125 mg/dl). METHODS: During 2001-2002, 3042 men and women (>18y) were enrolled for the study. The participants showed no clinical evidence of CVD or any other chronic disease, and were living in the greater Athens (Greece) area. In 2011 and 2012, the 10-year follow-up examinations were performed, including a working sample of n = 1875 participants without diabetes at baseline. Adherence to the Mediterranean diet at baseline evaluation was assessed using the MedDietScore (range 0-55). RESULTS: The prediabetic subjects (n = 343) had a significantly higher incidence of diabetes (25% vs. 10%, p < 0.001) and CVD (17.8% vs. 12.3%, p = 0.007) compared with subjects with normal glucose values. A significant trend towards lower diabetes and CVD incidence was observed with medium and high adherence to the Mediterranean diet compared with low adherence (p < 0.001). High adherence to the Mediterranean diet (>35/55 score) was associated with lower 10-year incidence of diabetes and CVD. In multiple logistic regression models, participants with high levels of adherence to the Mediterranean diet were significantly less affected by diabetes and CVD than those with low adherence levels. CONCLUSION: High adherence to the Mediterranean diet is associated with a low risk of developing diabetes and CVD in prediabetic subjects. © by Lab & Life Press/SBDR.
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- 2016
48. Metabolic syndrome and 10-year cardiovascular disease incidence: The ATTICA study
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Kastorini, C.-M. Panagiotakos, D.B. Georgousopoulou, E.N. Laskaris, A. Skourlis, N. Zana, A. Chatzinikolaou, C. Chrysohoou, C. Puddu, P.E. Tousoulis, D. Stefanadis, C. Pitsavos, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Mihail Hatzigeorgiou Athanasios Grekas Kokkou, E. ATTICA Study Group
- Abstract
Aims: To evaluate the influence of metabolic syndrome (MetS) as well as inflammatory and renal markers on cardiovascular disease (CVD) incidence. Methods and results: During 2001-2002, 1514 men and 1528 women (>18y) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. MetS was defined using three definitions, provided by the National Cholesterol Education Program Adult Treatment panel III (revised NCEP ATP III), the International Diabetes Federation (IDF) or the Harmonized definition. Furthermore, the contributory predictive role of C-reactive protein (CRP), inteleukin-6, uric acid and estimated glomerular filtration rate in the aforementioned models was evaluated. History of MetS-NCEP was positively associated with CVD, adjusting for potential confounding factors (OR:1.83, 95%CI:1.24-2.72). Not statistically significant associations with CVD incidence were observed when using the IDF or the Harmonized definition. Additionally, none of the added inflammatory and renal function markers mediated the influence of MetS on CVD incidence (all p's from Sobel test >0.40). C-statistic values for the MetS definitions used exceeded 0.789 (CI:0.751-0.827), indicating fair-to-good predictive probability of the models. Conclusion: Results of the present work revealed the negative impact of MetS-NCEP, but not of the other MetS definitions, on CVD incidence, a key-point that may help in better understanding the role of IDF and Harmonized MetS definitions on CVD. © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
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- 2016
49. Metabolic syndrome, adherence to the Mediterranean diet and 10-year cardiovascular disease incidence: The ATTICA study
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Kastorini, C.-M. Panagiotakos, D.B. Chrysohoou, C. Georgousopoulou, E. Pitaraki, E. Puddu, P.E. Tousoulis, D. Stefanadis, C. Pitsavos, C. Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Kokkou, E. Tsetsekou, E. Vassiliadou, C. Dedoussis, G. Toutouza-Giotsa, M. Tselika, C. Poulopoulou, S. Toutouza, M. The ATTICA Study Group
- Abstract
Background and aims: To better understand the metabolic syndrome (MS) spectrum through principal components analysis and further evaluate the role of the Mediterranean diet on MS presence. Methods: During 2001-2002, 1514 men and 1528 women (>18y) without any clinical evidence of CVD or any other chronic disease, at baseline, living in greater Athens area, Greece, were enrolled. In 2011-2012, the 10-year follow-up was performed in 2583 participants (15% of the participants were lost to follow-up). Incidence of fatal or non-fatal CVD was defined according to WHO-ICD-10 criteria. MS was defined by the National Cholesterol Education Program Adult Treatment panel III (revised NCEP ATP III) definition. Adherence to the Mediterranean diet was assessed using the MedDietScore (range 0-55). Results: Five principal components were derived, explaining 73.8% of the total variation, characterized by the: a) body weight and lipid profile, b) blood pressure, c) lipid profile, d) glucose profile, e) inflammatory factors. All components were associated with higher likelihood of CVD incidence. After adjusting for various potential confounding factors, adherence to the Mediterranean dietary pattern for each 10% increase in the MedDietScore, was associated with 15% lower odds of CVD incidence (95%CI: 0.71-1.06). For the participants with low adherence to the Mediterranean diet all five components were significantly associated with increased likelihood of CVD incidence. However, for the ones following closely the Mediterranean pattern positive, yet not significant associations were observed. Conclusion: Results of the present work propose a wider MS definition, while highlighting the beneficial role of the Mediterranean dietary pattern. © 2015 Elsevier Ireland Ltd.
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- 2016
50. Dietary patterns and 10-year (2002-2012) incidence of type 2 diabetes: Results from the ATTICA cohort study
- Author
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Koloverou, E. Panagiotakos, D.B. Georgousopoulou, E.N. Grekas, A. Christou, A. Chatzigeorgiou, M. Chrysohoou, C. Tousoulis, D. Stefanadis, C. Pitsavos, C. ATTICA Study Group Skoumas, Y. Katinioti, N. Papadimitriou, L. Masoura, C. Vellas, S. Lentzas, Y. Kambaxis, M. Palliou, K. Metaxa, V. Ntzouvani, A. Mpougatsas, D. Skourlis, N. Papanikolaou, C. Kouli, G.-M. Christou, A. Zana, A. Ntertimani, M. Kalogeropoulou, A. Pitaraki, E. Laskaris, A. Hatzigeorgiou, M. Grekas, A. Vassiliadou, C. Dedoussis, G. Toutouza-Giotsa, M. Tselika, C. Poulopoulou, S. Toutouza, M.
- Abstract
AIM: To identify dietary patterns among apparently healthy individuals and to determine their long-term effect on diabetes incidence. METHODS: During 2001-2002, a random sample of 3,042 men and women (18-89 years old), living in greater Athens, was randomly selected to participate in the study. During 2011-2012, the 10-year follow-up was performed in 2,583 participants (15% drop-out rate). After excluding participants with diabetes at baseline and those for whom no information on diabetes status was available at follow- up, the working sample consisted of 1,485 participants. Dietary habits were assessed by means of a validated semiquantitative, food frequency questionnaire. Factor analysis was performed to extract dietary patterns from 18 food groups. RESULTS: Diabetes diagnosis at follow-up was made in 191 participants, yielding an incidence rate of 12.9%. Six factors (i.e. dietary patterns) were identified that explained 54% of the variation in consumption. After adjusting for major confounders, and stratification by age-group, logistic regression revealed that the most healthful pattern consisted of the consumption of fruits, vegetables, legumes, bread, rusk, and pasta which reduced the 10-year diabetes risk by 40%, among participants aged 45-55 years. The association reached marginal statistical significance (95% CI: 0.34, 1.07), while no significant association was observed for the other age-groups. When the analysis was additionally adjusted for carbohydrate percentage, statistical significance was lost completely, suggesting a possibly mediating effect of this macronutrient. CONCLUSIONS: The results confirm the potentially protective effect of a plant-based dietary pattern in the primary prevention of diabetes, in particular among middle-aged people. Carbohydrate content may be a specific factor in this relationship; other micronutrients found in plant-based food groups may also play a role. © by Lab & Life Press/SBDR.
- Published
- 2016
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