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3. Life Course of Physical Activity and Risk and Prognosis of Amyotrophic Lateral Sclerosis in a German ALS Registry

Author

Rosenbohm, Angela, Peter, Raphael, Baier, Hartmut, Vasic, Nenad, Baezner, Hansjoerg, Beattie, James, Behne, Friedrich, Bengel, Dietmar, Boertlein, Axel, Vera, Bracknies, Alber, Burkhard, Buttmann, Mathias, Dempewolf, Silke, Dorst, Johannes, Dettmers, Christian, Freund, Wolfgang, Gasser, Thomas, Gold, Hans-Juergen, Hamann, Gerhard, Hecht, Martin, Heimbach, Bernhard, Herting, Birgit, Huber, Roman, Huelser, Paul-Juergen, Kassubek, Jan, HuberHartmann, Karlheinz, Jüttler, Eric, Kaspar, Attila, Kern, Rolf, Kimmig, Hubert, Christof, Klötzsch, Chatzikonstantinou, Anastasios, Klopstock, Thomas, Kohler, Andreas, Lichy, Christoph, Rothenbacher, Dietrich, Lindner, Alfred, Lingor, Paul, Lulé, Dorothee, Metrikat, Jens, Meudt, Oliver, Meyer, Andreas, Naegele, Andrea, Naumann, Markus, Neher, Klaus-Dieter, Neuhaus, Oliver, Nagel, Gabriele, Neusch, Clemens, Niehaus, Ludwig, Raape, Jan, Ratzka, Peter, Reinhard, Matthias, Rothmeier, Johann, Sabolek, Michael, Schabet, Martin, SchaeffVogelsang, MDMario, Schell, Caroline, Ludolph, Albert, Schweigert, Barbara, Sommer, Norbert, Stroick, Mark, Synofzik, Mathis, Tumani, Hayrettin, Volkmann, Jens, Weiler, Markus, Wick, Wolfgang, Opherk, Christian, Group, ALS Registry Swabia Study, Weiller, Cornelius, Zeller, Daniel, Baumgärtner, Jessica, Born, Christoph, Bürgy, Martin, Connemann, Bernhard, Etzersdorfer, Elmar, Friederich, Hubertus, Gahr, Maximilian, Gogolkiewicz, Alex, Andres, Frank, Greber, Ralf, Gebhardt, Jochen, Grunze, Heinz, Henkel, Karsten, Hewer, Walter, Raether, Andreas, Joos, Andreas, Köhler, Matthias, Kozian, Ralf, Laske, Christoph, Arnold, Guy, Michaelides, Alexandros, Munk, Matthias, Niestroj, Andreas, Schmauss, Max, SchoenebergerStroick, Katrin, Schoerner, Kai-Uwe, Spannhorst, Stefan, Steber, Raimund, and Thomas, Christine

Subjects
medicine.medical_specialty, Population, diagnosis [Amyotrophic Lateral Sclerosis], Metabolic equivalent, Life Change Events, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, ddc:610, Registries, Amyotrophic lateral sclerosis, Risk factor, education, Exercise, education.field_of_study, business.industry, Amyotrophic Lateral Sclerosis, Odds ratio, medicine.disease, Prognosis, Confidence interval, Case-Control Studies, Neurology (clinical), business, Body mass index
Abstract

Background and ObjectivesWhether physical activity (PA) is a risk factor for amyotrophic lateral sclerosis (ALS) is controversial because data on lifelong PA are rare. The main objective of this study is to provide insight into PA as a potential risk factor for ALS, reporting data on cumulative PA, leisure-time PA, and occupational PA. This study also aims to gather evidence on the role of PA as a prognostic factor in disease course.MethodsLifetime PA values collected by questionnaires addressing work and leisure time were quantified into metabolic equivalents (METs). A population-based case-control study embedded in the ALS Registry Swabia served to calculate the odds ratio (OR) of ALS by PA in different time intervals and prognosis.ResultsIn ALS cases (393 cases, 791 age- and sex-matched controls), we observed reduced total PA at interview and up to 5 years before interview compared to controls. Total PA was not associated with ALS risk 5 to 55 years before interview. Heavy occupational work intensity was associated with increased ALS risk (OR 1.97, 95% confidence interval 1.34, 2.89). Total PA levels were associated with survival in a nonlinear manner: inactive patients and highest activity levels (25 MET-h/wk) revealed the worst survival time of 15.4 and 19.3 months, respectively. Best median survival with 29.8 months was seen at 10.5 MET-h/wk after adjustment for other prognostic factors.DiscussionLifetime combined PA decreased sharply several years before disease onset compared to controls. The risk of developing ALS was not associated with former total PA levels 5 to 55 years before interview in contrast to occupational PA, probably reflecting work-associated exposures. We found a strong nonlinear association of current and prediagnostic PA level and survival in ALS cases with the best survival with moderate PA. PA intensity may be a disease-modifying factor with an unfavorable outcome in sedentary and hyperactive behavior.Classification of EvidenceThis study provides Class III evidence that PA was not associated with the development of ALS.

Published
2021
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4. Konzept der akademischen Ausbildung am Bundeswehrkrankenhaus Ulm

Author

Kulla, Martin, Mauer, Uwe Max, Ahrens, Jörg, Aspacher, Konstantin, Claußnitzer, Christian, Friemert, Benedikt, Häfner, Simon, Kremmeter, Susanne, Kupferschmid, Sebastian, Metrikat, Jens, Tisch, Matthias, and Wilde, Frank

Subjects
Praktisches Jahr, Medizinstudium, Lehre, PJ, Humanmedizin, ddc:610, Education, Medical, Graduate, Germany, Curriculum, DDC 610 / Medicine & health
Abstract

In unserem Krankenhaus stehen neben der Patientenversorgung die Lehre und Forschung im Mittelpunkt. Als Akademisches Krankenhaus der Universitätsklinik Ulm stehen wir für medizinische Versorgung auf höchsten Niveau - in der Region und weltweit. Modernste computergestützte Diagnostik und Operationsverfahren gehören bei uns zum Standard. Dennoch ist für uns der menschliche Umgang mit den Patienten und Mitarbeitern die Grundlage allen Handelns.

Published
2020
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5. Konzept der akademischen Ausbildung am Bundeswehrkrankenhaus Ulm

Author

Becker, Heike, Claußsnitzer, Christian, Friemert, Benedikt, Grobecker, Susanne, Gümbel, Hermann, Häfner, Simon, Hoffmann, Ralf, Kremmeter, Susanne, Kulla, Martin, Lampl, Lorenz, Lorenz, Kai, Martinschek, Andreas, Mauer, Uwe, Metrikat, Jens, Tisch, Matthias, Wilde, Frank, and Sparwasser, Christoph

Subjects
Education, medical, graduate, Germany, Studium, Praktisches Jahr, Medizinstudium, PJ, Medizin, Humanmedizin, Lehre, ddc:610, Education, Medical, Graduate, Curriculum, DDC 610 / Medicine & health, Kurrikulum
Abstract

Das Manuskript "Konzept der akademischen Ausbildung am Bundeswehrkrankenhaus Ulm" dient der Information der Studierenden im Praktischen Jahr. Es enth��lt eine ��bersicht der klinischen Abteilungen des Bundeswehrkrankenhauses Ulm sowie deren Ausbildungskonzepte und Ansprechpartner. Es wird im j��hrlichen Rhythmus ��berarbeitet und im A5 Format gedruckt. (Auflage ca, 150 Exemplare/ Jahr)

Published
2019

6. Effects of Low-Dose Alcohol Consumption on Postural Control with a Particular Focus on the Role of the Visual System.

Author

Palm, Hans-Georg, Waitz, Oliver, Strobel, Johannes, Metrikat, Jens, Hay, Birgit, and Friemert, Benedikt

Subjects
POSTURE, SITTING position, ALCOHOL drinking, ALCOHOL, POSTURAL balance, PROPRIOCEPTION, HUMAN attitude & movement
Abstract

There is clear evidence that vision contributes to stabilizing posture and that large quantities of alcohol affect balance. It has, however, not yet been investigated whether and how the consumption of low doses of ethanol affects postural control and the visual system. The purpose of this study was therefore to assess the influence of low-dose alcohol intake on balance. After having performed stability tests in a sober condition, 26 healthy males were instructed to consume 0.32 g of ethanol/kg body weight. At predefined time points, blood samples were collected and stability index scores were calculated using computerized dynamic posturography. Thirty minutes after ethanol intake, blood alcohol levels reached a mean peak of 0.037%. Whereas the ability to maintain balance significantly deteriorated during eyes-open testing, it surprisingly did not decrease during eyes-closed testing. Apparently, the visual system is particularly affected by ethanol and plays a major role in maintaining postural stability. [ABSTRACT FROM AUTHOR]

Published
2010
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9. Relationship between physical fitness and lifestyle behaviour in healthy young men

Author

Ortlepp, Jan R., Metrikat, Jens, Albrecht, Marlies, and Maya-Pelzer, Peter

Abstract

Background There is substantial knowledge about the inverse association of physical fitness and CVD risk factors and CVD mortality. However, physical fitness per se might be influenced by lifestyle conditions such as physical training, smoking and drinking habits.Hypothesis We evaluated the relationship between physical fitness, physical activity, endurance training, smoking and drinking habits and blood pressure, lipids and leukocytes as surrogate cardiovascular risk markers in a large-scale cross-sectional study of healthy young men.Study design and methods A total of 6748 healthy young men were selected during their primary flight medical examination for military flying duties. Physical fitness was assessed by achieved physical working capacity at a heart rate of 170 beats per min (PWC170) during cycle ergometry. Parameters such as physical activity, endurance sports, smoking of cigarettes and drinking of alcoholic beverages were assessed by means of standardized questionnaires. Systolic and diastolic blood pressures were measured manually. Fasting cholesterol and triglycerides as well as white blood counts were obtained.Results Physical activity itself was not related to significant differences in the tested variables, whereas good physical fitness showed a significant association with improved blood pressure and blood lipids (P< 0.001) with no detectable threshold. This effect was independent of endurance training, smoking and drinking. Whereas drinking was associated with elevated systolic blood pressure, smoking was associated with markedly increased triglycerides as well as with elevated leukocytes.Conclusion Physical fitness is associated with improved blood pressure and blood lipids. This effect is independent of participating mainly in endurance or nonendurance sports, of physical activity per se, and it does not depend on smoking and drinking habits. Smoking itself revealed relevant higher inflammation independent of fitness.

Published
2004
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