230 results on '"Mettang T"'
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2. Einschätzungen zur Situation der Peritonealdialyse in Deutschland aus Nephrologensicht: Ergebnisse aus der bundesweiten Befragung im MAU-PD-Projekt
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Ohnhäuser, T., Schellartz, I., Mettang, T., and Scholten, N.
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- 2019
- Full Text
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3. Pruritus bei systemischen Erkrankungen: Häufiges und Seltenes
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Kremer, A. E. and Mettang, T.
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- 2019
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4. Extremer Juckreiz bei einem Dialysepatienten
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Strutz, F. and Mettang, T.
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- 2019
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5. Peritonitisbehandlung bei der Peritonealdialyse: Was bringen die aktuellen Leitlinien?
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Mettang, T.
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- 2018
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6. Pruritus im Alter – eine interdisziplinäre Herausforderung
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Weisshaar, E. and Mettang, T.
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- 2018
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7. Pruritus bei systemischen Erkrankungen: Häufiges und Seltenes
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Kremer, A. E. and Mettang, T.
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- 2016
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8. Urämischer Pruritus
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Mettang, T.
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- 2016
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9. Therapie des Pruritus bei inneren Erkrankungen: Was ist gesichert?
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Mettang, T., Ständer, S., and Kremer, A.E.
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- 2015
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10. Klinische Charakteristika und Prurigo nodularis bei nephrogenem Pruritus
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Böhme, T., Heitkemper, T., Mettang, T., Phan, N.Q., and Ständer, S.
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- 2014
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11. Einschätzungen zur Situation der Peritonealdialyse in Deutschland aus Nephrologensicht
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Ohnhäuser, T., Schellartz, I., Mettang, T., and Scholten, N.
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- 2024
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12. Extremer Juckreiz bei einem Dialysepatienten
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Strutz, F. and Mettang, T.
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- 2024
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13. Pruritus bei inneren Erkrankungen
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Mettang, T., Streit, M., and Weisshaar, E.
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- 2006
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14. Klinische Klassifikation von chronischem Pruritus: Interdisziplinärer Konsensusvorschlag für einen diagnostischen Algorithmus
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Ständer, S., Weisshaar, E., Mettang, T., Streit, M., Darsow, U., Schneider, G., Metze, D., and Schmelz, M.
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- 2006
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15. Neues zum paraneoplastischen Pruritus: AKS07/05
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Wei, M., Zylicz, Z., Mettang, T., and Weisshaar, E.
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- 2013
16. Somnolenter Patient mit zunehmender metabolischer Azidose, erhöhter osmotischer Lücke und akutem Nierenversagen
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Braun, N., Alscher, D. M., Mettang, T., and Kuhlmann, U.
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- 2002
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17. Prurigo nodularis bei Dermatosen und systemischen Erkrankungen
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Mettang, T., Vonend, A., and Raap, U.
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- 2014
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18. Nephrogener Pruritus: ab wann ist eine Niereninsuffizienz pruritogen?: WS04/04
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Mettang, T
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- 2011
19. Autotaxin ist spezifisch für den cholestatischen Juckreiz und korreliert mit dem Therapieansprechen: AKS06/02
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Kremer, A E, Kuiper, E M, Leckie, P, Schaap, F G, Mettang, T, Reiners, K S, Raap, U, van Buuren, H R, van Erpecum, K J, Davies, N A, Engert, A, Jansen, P L, Jalan, R, Oude Elferink, R P, and Beuers, U
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- 2011
20. Pruritus bei Inneren Erkrankungen - Was gibt es Neues?: AKS06/04
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Mettang, T
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- 2009
21. Inflammation bei Pruritus innerer Erkrankungen: AKS14/03
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Mettang, T
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- 2007
22. Prurigo nodularis: Ein Rätsel seit mehr als 100 Jahren
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Ständer, S. and Mettang, T.
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- 2014
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23. Non-dermatological Challenges of Chronic Itch
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Kremer, A, primary, Mettang, T, additional, and Weisshaar, E, additional
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- 2020
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24. The course of chronic itch in hemodialysis patients: results of a 4‐year follow‐up study of GEHIS (German Epidemiological Hemodialysis Itch Study)
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Plewig, N., primary, Ofenloch, R., additional, Mettang, T., additional, and Weisshaar, E., additional
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- 2019
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25. Assessments of the Situation of Peritoneal Dialysis in Germany from a Nephrologist Perspective Results from the nationwide Survey in the MAU-PD Project
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Ohnhaeuser, T., Schellartz, I., Mettang, T., Scholten, N., Ohnhaeuser, T., Schellartz, I., Mettang, T., and Scholten, N.
- Published
- 2019
26. European S2k Guideline on Chronic Pruritus
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Weisshaar, E., Szepietowski, J. C., Dalgard, F. J., Garcovich, S., Gieler, U., Gimenez-Arnau, A. M., Lambert, J., Leslie, T., Mettang, T., Misery, L., Savk, E., Streit, M., Tschachler, E., Wallengren, J., Stander, S., Garcovich S. (ORCID:0000-0001-8967-6688), Weisshaar, E., Szepietowski, J. C., Dalgard, F. J., Garcovich, S., Gieler, U., Gimenez-Arnau, A. M., Lambert, J., Leslie, T., Mettang, T., Misery, L., Savk, E., Streit, M., Tschachler, E., Wallengren, J., Stander, S., and Garcovich S. (ORCID:0000-0001-8967-6688)
- Abstract
Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Pruritus may be the result of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases chronic pruritus may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of chronic pruritus comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet phototherapy and systemic treatment. Treating chronic pruritus needs to be targeted, multimodal and performed in a step-wise procedure requiring an interdisciplinary approach. We present the updated and consensus based (S2k) European guideline on chronic pruritus by a team of European pruritus experts from different disciplines. This version is an updated version of the guideline that was published in 2012 and updated in 2014 (www.euroderm.org).
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- 2019
27. Multidimensionale Analyse der Ursachen für die niedrige Prävalenz der ambulanten Peritonealdialyse in Deutschland – MAU-PD
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Scholten, N, Hellmich, M, Karbach, U, Mettang, T, Pfaff, H, Stock, S, and von Gersdorff, G
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Hintergrund: Die symptomatische Therapie bei Nierenversagen ist die Dialyse. Zu den Nierenersatzverfahren zählen die Hämodialyse (HD), ein extrakorporales Verfahren, welches fast ausschließlich in Dialysezentren durchgeführt wird, und die Peritonealdialyse (PD), ein Verfahren, welches[zum vollständigen Text gelangen Sie über die oben angegebene URL], 16. Deutscher Kongress für Versorgungsforschung (DKVF)
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- 2017
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28. Mortality of Haemodialysis Patients With and Without Chronic Itch: A Follow-up Study of the German Epidemiological Hemodialysis Itch Study (GEHIS)
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Grochulska, K, primary, Ofenloch, R, additional, Mettang, T, additional, and Weisshaar, E, additional
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- 2019
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29. Strong Associations Between Inflammation, Pruritus and Mental Health in Dialysis Patients
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Schricker, S, primary, Heider, T, additional, Schanz, M, additional, Dippon, J, additional, Alscher, M, additional, Weiss, H, additional, Mettang, T, additional, and Kimmel, M, additional
- Published
- 2019
- Full Text
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30. European S2k Guideline on Chronic Pruritus
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Weisshaar, E, primary, Szepietowski, J, additional, Dalgard, F, additional, Garcovich, S, additional, Gieler, U, additional, Giménez-Arnau, A, additional, Lambert, J, additional, Leslie, T, additional, Mettang, T, additional, Misery, L, additional, Şavk, E, additional, Streit, M, additional, Tschachler, E, additional, Wallengren, J, additional, and Ständer, S, additional
- Published
- 2019
- Full Text
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31. Implantation von PD-Kathetern – Auswahl und Implantationstechniken
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Mettang, T., primary
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- 2018
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32. Rationale Diagnostik bei Pruritus
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Weisshaar, E., additional and Mettang, T., additional
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- 2017
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33. Lower prevalence of chronic itch in haemodialysis patients on loop diuretics: results from GEHIS (German Epidemiological Hemodialysis Itch Study)
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Hayani, K., primary, Kunzmann, K., additional, Mettang, T., additional, Weiss, M., additional, Tschulena, U., additional, and Weisshaar, E., additional
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- 2017
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34. Fibroblast Growth-factor 23 and Calcium-binding Proteins are not Associated with Chronic Itch in Patients on Haemodialysis
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Mettang, T, primary, Kunzmann, K, additional, Roth, H, additional, and Weisshaar, E, additional
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- 2017
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35. Paraneoplastic Itch: An Expert Position Statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI)
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Weisshaar, E, primary, Weiss, M, additional, Mettang, T, additional, Yosipovitch, G, additional, and Zylicz, Z, additional
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- 2015
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36. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein
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Pauli-Magnus C, Oliver von Richter, Burk O, Ziegler A, Mettang T, Eichelbaum M, and Mf, Fromm
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Digoxin ,Cardiotonic Agents ,Swine ,Biological Transport, Active ,Epithelial Cells ,Calcium Channel Blockers ,Cell Line ,Kinetics ,Verapamil ,Nitriles ,Animals ,Humans ,LLC-PK1 Cells ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Caco-2 Cells - Abstract
Verapamil is subject to extensive oxidative metabolism mediated by cytochrome P450 enzymes with less than 5% of an oral dose being excreted unchanged in urine. Furthermore, verapamil is known to be a potent inhibitor of P-glycoprotein function. There is evidence from in vivo investigations that some verapamil metabolites might be actively transported. The aim of the present study was to investigate P-glycoprotein-mediated transport and inhibition properties of verapamil and its metabolites norverapamil, D-620, D-617, and D-703. Polarized transport of these compounds was assessed in P-glycoprotein-expressing Caco-2 and L-MDR1 cells (LLC-PK1 cells stably transfected with human MDR1-P-glycoprotein). Inhibition of P-glycoprotein-mediated transport by these compounds was determined using digoxin as P-glycoprotein substrate. At concentrations of 5 microM, significant differences between basal-to-apical and apical-to-basal apparent permeability coefficients were observed for D-617 and D-620 in all P-glycoprotein-expressing cell monolayers, indicating that both are P-glycoprotein substrates. In contrast, no P-glycoprotein-dependent transport was found for verapamil, norverapamil, and D-703 in Caco-2 cells and for D-703 in L-MDR1 cells. Moreover, verapamil, norverapamil, and D-703 inhibited P-glycoprotein-mediated digoxin transport with IC(50) values of 1.1, 0.3, and 1.6 microM, respectively, whereas D-617 and D-620 did not (at concentrations up to 100 microM). We conclude that verapamil phase I metabolites exhibit different P-glycoprotein substrate and inhibition characteristics, with the N-dealkylated metabolites D-617 and D-620 being P-glycoprotein substrates and norverapamil and D-703 being inhibitors of P-glycoprotein function, which may influence P-glycoprotein-dependent drug disposition and elimination.
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- 2000
37. Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease.
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Reaich R., Schouten D., Rashid H., Birtcher K., Cantu J., Tait C., Taun W., Fadem S., Das D., Khosla U., Brown C., Brown T., Buquing J., Cromwell H., Dickson N., Najimipour B., Robeson J., Tabibi W., Mulloy L., Bailey K., Burton B., Fall P., Jagadeesan M., Paulson W., Szerlip H., White J., Faulkner M., Adeleye O., Boatright D., Mensah D., Nwankwo U., Crutcher L., Cummings C., Floyd M., Putatunda B., Ross J., Sanford V., Thadani U., Haragsim L., Parker B., Rogan L., Thresher M., Turner J., Dworkin L., Mignano D., O'Mara A., Shemin D., Bakris G., Basta E., Chua D., Neri G., Ahmed I., Elliott W., Fondren L., Hasabou N., Khosla N., Mazin A., Riehle J., Kovesdy C., Mendoza J., Ahmadzadeh S., Iranmanesh A., Lewis M., Lu J., Benabe J., Gonzalez-Melendez E., Padilla B., Serrano J., Russ T., Athmann L., Funke L., Larson P., Roach D., Salveson B., Nogueira J., Hanes D., Hise M., Light P., Copland E., Fink J., Hakim M., Hough K., McMinn S., Weir M., Young C., Kershaw G., Hill I., White B., Plumb T., Florescu M., Groggel G., Martin M., Rao V., Denu-Ciocca C., Candiani C., Cooper J., Gordon B., Joy M., Kiser M., Lambeth C., Rosas S., Cochetti P., Robinson J., Schankel K., Teng H., Weise W., Geneidy A., Murray P., Solomon R., De Waal D., LaPointe S., Schoenknecht A., Campese V., Habashy M., Ananthakrisna R., Bedwani D., Fazli U., Fetrat M., Frampton Q., Kaldas B., Kazarian V., Pitts L., Sadeghi A., Yeasmin N., Young E., Fissell R., Belanger K., Ricci N., Farwell W., Bowman T., Dhingra R., Pesenson A., Ambrosino J., Chittamooru S., Kaufman J., Ramos M., Yap C., Nakhle S., Aligaen L., Duren D., Laine B., Moore S., Tuazon H., Coyne D., Audrain J., Bryant B., Dombek S., Freeman S., Klein P., Germain M., Berkowitz A., Bokhari A., Braden G., Diaz A., Greco B., Mulhern J., O'Shea M., Poindexter A., Poppel D., Ryan M., Sweet S., Ye J., Osterman J., Lin T., Mays B., Rizvi A., Sonnier C., Twining C., Wang S., Hix M., Schenck J., Baigent C., Landray M., Reith C., Dasgupta T., Emberson J., Herrington W., Lewis D., Mafham M., Collins R., Bray C., Chen Y., Baxter A., Young A., Hill M., Knott C., Cass A., Feldt-Rasmussen B., Fellstrom B., Grobbee R., Gronhagen-Riska C., Haas M., Holdaas H., Hooi L.S., Jiang L., Kasiske B., Krairittichai U., Levin A., Massy Z., Tesar V., Walker R., Wanner C., Wheeler D., Wiecek A., Majoni W., Simpson D., Strony J., Musliner T., Agodoa L., Armitage J., Chen Z., Craig J., De Zeeuw D., Gaziano M., Grimm R., Krane V., Neal B., Ophascharoensuk V., Pedersen T., Sleight P., Tobert J., Tomson C., Sandercock P., Keech A., Whelton P., Yusuf S., Peto R., Parish S., Dolph L., Bahu T., Booth-Davey E., Brewster A., Yau F., Denis E., Frederick K., Haywood D., Heineman J., Howard S., Jayne K., Madgwick Z., Michell S., Murphy K., Ning L., Nolan J., Nunn M., Roberts J., Wickman M., Bowman L., Bulbulia R., Haynes R., Rahimi K., Rahman N., Ait-Sadi R., Barton I., Zhu W., Clark S., Kourellias K., Radley M., Brown K., Worthing D., Coates G., Goodenough B., Lucas N., Carreras A., Currie R., Donaldson O., Fjalling E., Gallagher M., Gibson K., Goddard J., Healy J., Hones L., Jardine M., Kwong I., Merai M., Murray S., Perkovic V., Rendina A., Gallo K., Caron S., Carlson K., Foley K., Matzek S., Mewhort L., O'Donoghue S., Perel-Winkler A., Terins T., Nie Q., Yu H., Ge L., Hao D., Li L., Pang X., Wei X., Yan G., Certikova Chabova V., Holst H., Molvadgaard T., Munksgaard D., Peltonen Y., Liabeuf S., Lebel C., Ouabou L., Bauer B., Bergmann K., Beusch M., Cavitt D., Drechsler C., Dulau I., Hugen K., Kempf S., Kuchenmeister B., Pscheidl V., Schmiedeke D., Schwarz M., Speerschneider K., Stahl B., Lim B.C., Nadia H., Zishareena M.F., Vasuthavan S., Ganesapillai A.T., Yuen S., Grobbee D., Bobbink I., Groot K., Sikking I., Raley J., Colban M., Smerud K., Trygg N., Waagaard E., Westad H., Rotkegel S., Spiechowicz U., Domoradzka M., Gawlowska M., Flygar A., Odmark I., Pettersson A., Blackwood S., Barclay J., Benham J., Brown R., Cureton L., Jackson D., Kennedy I., Leaper C., Taylor A., Winter C., Wise C., Nash M., Taylor Bennett A., Donaldson D., Chalmers K., Corderoy H., Bartkoske M., Bjerk C., Camarena A., Herskovitz L., Heuer C., Levin J., Robinson R., Wicklund B., Bentzel D., Cohen S., Costa C., Scranton R., Auwardt R., Boyer M., Cogdell P., Menahem S., Sheldrake J., Mount P., Fraenkel M., Bisscheroux P., Dempester J., Gleeson P., Harris G., Holmes C., Hyett K., Linton A., Miach P., Booth D., Druce L., Mantha M., Borg E., Green S., Killen J., Lynch Y., Colquhoun D., Herzig K., Row G., Addison J., Asa J., Beatson G., Calvird D., Edmunds J., Ferreira-Jardim A., Gwynne A., Mackay D., McLoughlin L., Wightwick C., Williams L., Ferrari P., Barry J., Hodson S., Zakrzewska W., Meagher E., Mulcahy M., Parnham A., Carney S., Garvey L., Gillies A., Hayes S., Mathew M., Fassett R., Anderson L., Clingeleffer C., Curnock A., Mayne L., Richardson D., Smith M., Smith S., Suranyi M., Howlin K., Chow J., Cleland B., Rayment G., Spicer T., Wong J., Wong M., Packham D., Alison C., Fraser I., Mitchell J., Nagle J., Brown F., Ellery C., Monkhouse J., Nandkumar J., Reith-Myers L., Gray N., Cocks C., Courtney M., Hollett P., Johnston C., Larsen H., Pollock A., Stewart S., Styles G., Wyndham R., Fanning M., Gibson W., Jackson S., Mannering M., Mercado E., Oliphant R., Sud K., Ubera N., Wood C., Karrasch J., Brinkley T., Estensen K., Moroney A., Sutton J., Warren R., Saltissi D., Jahke H., Roach H., Saltissi J., Wiederroth O'Brien M., Johnson D., Bali V., Evans M., Franzen K., Halbish S., Helyar J., Martin A., Mudge D., Sonnenburg K., Sudak J., Roger S., Almeida S., Andrews H., Bohringer L., Bouwhuis L., Brady L., Carpenter A., Warren S., Elias T., Bannister K., Chew G., Clarke J., Faull R., Hooper A., Jeffs L., Napier A., Peh C., Pirone K., Skilton F., Ranganathan D., Best J., Hart L., Healy H., Morgan C., Ratanjee S., Salisbury A., Jose M., Freeman J., Hamilton R., Kirkland G., Read G., Anderson H., Boekel K., Farrell M., Foreman A., Iliev K., Pedagogos E., Raspudic T., Pollock C., Cooper B., Kesselhut J., Macadam C., Pearse J., Rowland C., Tully H., Irish A., Dogra G., Coutts P., Hayes L., Khoo D., Nathoo B., Shakespeare K., Warger A., Gillin A., Burman J., George C., Sherwood S., Snelling P., Stevens C., Hutchison B., Luxton G., Devenny N., Herson H., Pellicano S., Kelly J., Coutelas J., Garlinge C., McClelland A., Pirabhahar S., Saleh H., Langham R., Englebright B., Giang M., Lanteri M., Mullins K., Turner C., Collett P., Stokoe S., Sutherland K., Talafua D., Talaulikar G., Clarkson A., Rees C., Carney G., Falk M., Gracey D., Jadeer A., Johnson P., Karpe K., Singer R., Walters G., McDonald S., Burgess J., Fischer K., Gentgall M., Hockley M., Veitch D., De Jersey P., Gillam A., Hartig V., Holland K., McArdle J., Washington W., Rangan G., Mikaheal M., Murie P., Perez N., Punnoose N., Smolonogov T., Taler N., Williams G., Wen C., Kohlhagen J., Wessels J., Johnson S., Reid A., Ryan J., Taprell D., Auinger M., Eigner M., Kodras K., Leithner C., Magpantay L., Marterer C., Prager R., Prinz C., Seiringer E., Kramar R., Mitter E., Stummvoll H., Dieplinger G., Wenzel R., Stolz G., Drose S., Edlinger E., Headlam-Leitner E., Miska H., Then M., Weninger S., Lhotta K., Neyer U., Dickie H., Smodek S., Sprenger-Mahr H., Rosenkranz A., Zitt E., Mayr B., Schinner A., Soltys G., Begin V., Brunet S., Cournoyer S., Gelinas M., Giroux C., Martineau J., Roy M., Savoie L., Agharazii M., Blouin J., Desmeules S., Langlois S., Samson F., Wong G., Constantini L., Jing J., Malko J., Rivers C., Rochester D., Skilling C., Wadgymar A., Wu G., Kates D., Husch J., Mantle M., Turri L., Barrett B., Curtis B., Greeley B., Hannaford M., Harnett J., Kelly M., Langille E., Morgan J., Murphy S., Karim M., Arbo T., Carpenito G., Chan V., DaRoza G., Friesen M., Kraus D., Lam S., Lange B., Minhas S., Starko R., Torng S., Vela K., Madore F., Roy P., Troyanov S., Bonnardeaux A., Lauzon L., Pichette V., Yeates K., Mahoney K., Myers C., Pilkey R., Moist L., Edgar M., House A., Kortas C., Mindorff S., Tam P., Chow S., Fung J., Nagai G., Ng P., Sikaneta T., Ting R., Forzley B., Clouatre Y., Cooper S., DaCosta H., Granger S., Valley S., Karunakaran S., Abdulhadi M., Altwasser C., Anderson S., Bergquist L., Wijeyesinghe C., Berst L., Horgan K., Coles K., Lotter T., Robson L., Barre P., Golden J., Golden M., Tanguay N., Rigatto C., Armstrong S., Fine A., Fontaine B., Friesen D., Henry S., Kraushar M., Reslerova M., Verrelli M., Rabbat C., Clase C., Suva G., Winegard N., Goldstein M., Curvelo S., Donnelly S., Huckle J., Marticorena R., Chan-Yan C., Chiu A., DeLuca L., Flamer D., Gill J., Jamal A., Jung B., Kiaii M., Landsberg D., Rozen N., Taylor P., Werb R., Pylypchuk G., Ahmed A., Barton J., Hundseth M., Kappel J., Keindel I., Klassen J., Pylypchuk S., Rindall M., Tobe S., Naimark D., Agelopoulos M., Chessman M., Hladunewich M., Perkins N., Sainsbury S., McCready W., Adams B., Tonelli M., Caldwell S., Kumar U., McMahon A., Nikitin S., Restall J., Treit S., Wysocki Y., Duncan J., Copland M., Jastrzebski J., Keown P., Kwan S., Rogers D., Shapiro J., Singh S., Sioson L., Yee K., Yeung C., Zacharias J., Bueti J., Dizon B., Lam H., Miller L., Ross M., Zarrillo M., Li Z., Wang C., Liu L., Hong M., Zheng H., Zuo W., Ge Z., Liu Q., Li Y., Sun K., Zhao R., Sun G., Wang F., Cui Z., Lou F., Du Y., Song L., Huang H., Song Z., Wang J., Zhou L., Wu R., Xiao R., Zhang Q., Duan N., Ju N., Wang A., Xu Z., Lu Z., Zhang Y., Zhao L., Zhang C., Mo Z., Xie Y., Xiong J., Chen J., Guo L., Zhao S., Peiskerova M., Jancova E., Kazderova M., Kobrova L., Gorun P., Kmentova T., Burgelova M., Lyerova L., Viklicky O., Berdych M., Nydlova Z., Jelinkova G., Moltas J., Pauzar T., Knetl P., Cahova J., Simkova J., Zakova M., Vankova S., Safarova R., Hruby M., Karlova R., Prikaska V., Sellenberg P., Vesela E., Malanova L., Vlasak J., Kaprova P., Novakova D., Kotherova K., Studenovska M., Christensen J., Solling J., Jepsen M., Kristensen 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M., Sichez H., Cristol J., Canaud B., Morena M., Rodriguez A., Kessler M., Mizejewski B., Risse B., Urena Torres P., Bou-Bekr M.A., Arezki C., Ras El Qdim P., Vela C., Borsato F., Talairach A., Normand M., Normand V., Rieu P., Gauthier B., Vigneron-Foy C., Wolak A., Menoyo V., Alos L., Caillette-Beaudoin A., Berger V., Al-Sarraf S., Konnerth I., Urban C., Weiner S., Boesken W., Jochum E., Kiefer C., Wagner A., Krumme B., Bohler J., Bonow B., Hohenstatt U., Mettang T., Rockel A., Langanke J., Lipponer H., Dunschen-Weimar G., Dunst R., Hubel E., Petrik R., Rengel R., Schmidgen M., Mayr H., Garschhammer C., Weirauch S., Anger H., Goock T., Mai A., Bast I., Suptitz C., Iwig B., Florschutz K., Hasselbacher R., Sauerbrey G., Delrieux S., Rau S., Poley M., Laux R., Schonfelder O., Kunowski G., Fuchs G., Hoffmann K., Schurger R., Brensing K., Guven Z., Immenkamp C., Kottmann C., Schmitt H., Schulz M., Arnold P., Knaup R., Schneider H., Siemsen H., Pyriki P., Korkemeyer F., Pyriki R., Siebrecht A., Schulz E., Krumwiede A., Kruse D., Lucke S., Keim H., Fink H., Fischer S., Klingbeil A., Kuhlmei K., Ortwein-Horn N., Merker L., Bayer B., Benamar K., Emmert S., Floten E., Holzheuer K., Lummer M., Ossendorf E., Scholz M., Oppitz M., Georgiew L., Tripps C., Wendehake M., Lange D., Pingel V., Brause M., Schanze W., Duygulu E., Dellanna F., Heinemann-Nieberding S., Sturmer C., Wieczorek K., Zarga O., Kullmer B., Kullmer S., Akin M., Gondolf M., Schutterle S., Walker G., Bertsch R., Seul M., Allendorff J., Siehler R., Stemmler S., Baldus M., Adler A., Harter S., Wurmell W., Moller M., Hame C., Muller M., Schreiber M., Schurfeld C., Millington-Herrmann M., Benschneider A., Gaffal J., Sprunken U., Bohling M., Wunderlich S., Schramm L., Kollenbrath C., Netzer K., Sieber T., Zimmermann J., Bellersen M., Uerkvitz M., David-Walek T., Hauschildt B., Leimenstoll G., Lonnemann G., Hilfenhaus M., Benedetto C., Stockmann S., Ichtiaris P., Jungmann A., Neumeier K., Stoof A., Bohmer K., Kirpal A., Knogl A., Flege F., Franke K., Groth P., Parensen E., Bockmann M., Przyklenk P., Piazolo L., Thinius-Jaudas L., Versen A., Hettich R., Arendt R., Geiger K., Hoppe H., Schwarting A., Beyer T., Faust J., Hazenbiller A., Tschirner S., Grupp C., Dorsch O., Eigner-Schmidtchen M., Michler K., Roth J., Schramm S., Waldmuller G., Riedl B., Vogele-Dirks H., Linz J., Biggar P., Hennemann H., Bauer G., Buchholz J., Fischer P., Bihlmaier W., Baumann A., Peichl B., Roser S., Ludewig S., Ricksgers M., Szendzielorz M., Baus A., Baust K., Schaller P., Schnellbacher G., Sorensen S., Buschges-Seraphin B., Hauenstein L., Hofmann B., Nikolay J., Merkel F., Nebel M., Petersen J., Schweb S., Zeissler H., Baumhackel K., Krauss A., Schafer R., Pastor A., Zielinski B., Strauss H., Theis H., Burkhardt K., Heckel M., Hussendorfer K., Bahner U., Brandl M., Hammerl-Kraus B., Herrmann D., Kramer H., Baudenbacher H., Blaser C., Buschmann G., Eckert G., Ehrich H., Hofmann K., Huller U., Geiger H., Becker B., Hoischen 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Mathisen U., Pedersen M., Rumsfeld M., Toft I., Berget K., Landsverk K., Tveiten G., Wamstad H., Klinger M., Krajewska M., Golebiowski T., Kusztal M., Spiechowicz-Zaton U., Rutkowski B., Renke M., Tylicki L., Czekalski S., Koziol L., Wanic-Kossowska M., Wasik-Olejnik A., Nowicki M., Dryja P., Kurnatowska I., Zawiasa A., Ciszek M., Gomolka M., Mysliwiec M., Brzosko S., Mazerska M., Hruby Z., Koscielniak K., Stanek-Piotrowska M., Mesjasz J., Rudka R., Baranski M., Jupowiecki J., Klein D., Switalski M., Kuriga M., Ostrowski M., Lidman A., Linde T., Waltersson K., Weiss L., Andersson G., Lindell C., Welander G., Jacobson S., Edensjo P., Wallin J., Linder M., Karsberg M., Hellgren K., Lonn I., Frisenette-Fich C., Johansson A., Lundstrom A., Mauritz N., Stahl-Nilsson A., Tobafard N., Hellberg O., Ejemar E., Von Schmalensee N., Gunne T., Eriksson A., Ostberg S., Svensson C., Mulec H., Jacobsson A., Karlsson M., Onnermalm L., Osagie S., Ekengren U., Larsson M., Lindberger K., Olofsson A., Samuelsson O., Beagan L., Dezfoolian H., Just M., Ortegren L., Saeed A., Strand U., Ramsauer B., Hultstrom D., Nordlinder K., Sundberg I., Oqvist B., Green C., Fernstrom A., Cassel A., Goransson I., Gylling M., Jorgensen A., Sterner G., Christensson A., Hjelmstedt P., Nystrom A., Sundin P., Samuelsson I., Tidman M., Johansson M., Lofgren Andersson M., Ohman M., Andersson P., Hallberg Karlsson A., Ringstad L., Chittinandana A., Chailimpamontree W., Gojaseni P., Singprasert R., Tungsanga K., Amphun W., Intim P., Kanjanabuch T., Poowarattanakul D., Treratha C., Wongvan P., Jittikanont S., Suriya T., Indrasthitya P., Sumethkul V., Ingsathit A., Jansomwong J., Lertchalorarn K., Phachiyanukul V., Phiromkit T., Saengsri S., Vareesangthip K., Chawanasuntorapoj R., Kiattisunthorn K., Larpkitkachorn R., Webster J., Henderson J., Jayne D., Hollis J., Townsend K., Harron C., Bleakley N., Hanley N., Morgan S., Brittney L., Brown H., Maxwell P., Murtagh H., Thomas M., Burke E., Carmody M., Cox G., Dasgin J., Ali G., Whitehouse L., Williams V., Brown E., Dlelana G., Esson A., Fagerbrink S., Marshall F., Mazibuko B., Nelson C., Russell E., Williams R., Altmann P., McNichols-Thomas C., Parsons K., MacGregor M., McGowan J., Mead P., Gilbanks K., Sanderson M., Fluck R., Chandler G., Hulme L., Smith J., Tse Y., West C., Taylor J., Breakspear S., Burgess B., Isles C., Bell J., Duignan J., Gorman J., Swainson C., Beveridge C., Cairns A., Miller D., Paterson F., Smith L., Kumwenda M., Glover R., Geddes C., Gemmell C., Grieve I., Matthews E., McLaren B., Meyer B., Spiers A., Banks R., Apperley P., Patterson T., Paynter H., Scoble J., Thom D., Watkins J., Kalra P., Gowland S., Haydock L., Smart I., Bhandari S., Gillett P., James K., Lewis R., Melville H., Tamimi A., Williams P., Heath T., Small S., Paterson A., Gibson N., Laven C., Wilson T., Cairns H., Casley-Ready K., Warwick G., Fentum B., James J., Kumar T., Marshall R., Ratcliffe F., Shenton A., Warwicker P., Bowser M., Mumford C., Mitra S., Woolfson R., Yang R., Williams A., Richards K., Turner A., Odum J., Rylance P., Smallwood A., Ward J., Henderson I., McMahon M., Ross C., Burrows M., Morais J., Rajan S., Tindall H., Barrett C., Kelly F., El-Nahas M., Bartholomew J., Edwards L., Okhuoya F., Bebb C., Cassidy M., Brand S., Quashie-Howard M., Taggart C., Capps N., Tonks L., Mason J., Powell S., Watkins L., Ball S., Dutton M., Fifer L., McGlynn F., Wood M., Jenkins D., Allan N., Fahal I., Elhag-Ali H., King J., Peel R., Potts L., Logie I., McGhie F., Naik R., Parry R., Andain K., Durkin S., D'Souza R., Harrison D., Cooke J., Kinyanjui R., Harper J., Algate K., McCarthy M., Van Eker D., Thuraisingham R., Chinodya M., Deelchand V., Garcia R., Ngango R., Rolfe C., Williams K., Solomon L., Heap T., MacDowall P., Saunderson Smith L., MacDiarmaid-Gordon A., Harman W., Smithson H., Robertson D., Gammon B., O'Grady D., Verow C., Rogerson M., Berry L., Gough C., Hayward E., Jones C., Payne T., Rowe L., Sibley C., 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- Abstract
Background: Lowering low-density lipoprotein (LDL) cholesterol with statin therapy has been shown to reduce the incidence of atherosclerotic events in many types of patient, but it remains uncertain whether it is of net benefit among people with chronic kidney disease (CKD). Method(s): Patients with advanced CKD (blood creatinine >=1.7 mg/dL [>= 150 mumol/L] in men or >=1.5 mg/dL [ >= 130 mumol/L] in women) with no known history of myocardial infarction or coronary revascularization were randomized in a ratio of 4:4:1 to ezetimibe 10 mg plus simvastatin 20 mg daily versus matching placebo versus simvastatin 20 mg daily (with the latter arm rerandomized at 1 year to ezetimibe 10 mg plus simvastatin 20 mg daily vs placebo). The key outcome will be major atherosclerotic events, defined as the combination of myocardial infarction, coronary death, ischemic stroke, or any revascularization procedure. Results A total of 9,438 CKD patients were randomized, of whom 3,056 were on dialysis. Mean age was 61 years, two thirds were male, one fifth had diabetes mellitus, and one sixth had vascular disease. Compared with either placebo or simvastatin alone, allocation to ezetimibe plus simvastatin was not associated with any excess of myopathy, hepatic toxicity, or biliary complications during the first year of follow-up. Compared with placebo, allocation to ezetimibe 10 mg plus simvastatin 20 mg daily yielded average LDL cholesterol differences of 43 mg/dL (1.10 mmol/L) at 1 year and 33 mg/dL (0.85 mmol/L) at 2.5 years. Follow-up is scheduled to continue until August 2010, when all patients will have been followed for at least 4 years. Conclusions SHARP should provide evidence about the efficacy and safety of lowering LDL cholesterol with the combination of ezetimibe and simvastatin among a wide range of patients with CKD.Copyright © 2010, Mosby, Inc. All rights reserved.
- Published
- 2010
38. Prevalence of Chronic Itch and Associated Factors in Haemodialysis Patients: A Representative Cross-sectional Study
- Author
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Weiss, M, primary, Mettang, T, additional, Tschulena, U, additional, Passlick-Deetjen, J, additional, and Weisshaar, E, additional
- Published
- 2014
- Full Text
- View/download PDF
39. European Guideline on Chronic Pruritus
- Author
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Weisshaar, E, primary, Szepietowski, J, additional, Darsow, U, additional, Misery, L, additional, Wallengren, J, additional, Mettang, T, additional, Gieler, U, additional, Lotti, T, additional, Lambert, J, additional, Maisel, P, additional, Streit, M, additional, Greaves, M, additional, Carmichael, A, additional, Tschachler, E, additional, Ring, J, additional, and Ständer, S, additional
- Published
- 2012
- Full Text
- View/download PDF
40. In vitro effects of bicarbonate- versus lactate-buffered continuous ambulatory peritoneal dialysis fluids on peritoneal macrophage function
- Author
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Fischer, FP Schenk, U Kiefer, T Hubel, E Thomas, S and Yatzidis, H Mettang, T Kuhlmann, U
- Abstract
At present, lactate is the most commonly used buffer in peritoneal dialysis fluids (PDFs), The high lactate concentration in combination with low original pH was demonstrated to suppress phagocytic function, We evaluated the in vitro effects of a newly formulated bicarbonate;buffered PDF containing glycylglycine (BiGG15 and BiGG40; Pierre Fabre Medicament, Castres, France) on peritoneal macrophage (PM0) function, and compared them with those of equiosmolar lactate-buffered PDF (1.5% and 4.25% glucose; pH 5.4 and pH 7.4) and control buffer, Peritoneal macrophages were isolated from the effluents of 10 continuous ambulatory peritoneal dialysis patients and tested for luminol- and lucigenin-enhanced chemiluminescence, superoxide (O-2(-)) generation measured by cytochrome c reduction, killing capacity, and phagocytosis after incubation in the PDF used, Exposure of PM0 to lactate-buffered PDF with an original pH of 5.4 resulted in a significant suppression of all PM0 functions measured, compared with bicarbonate- and lactate-buffered PDFs with a pH of 7.4, At physiological pH (7.4), chemiluminescence generation of PM0 exposed to BiGG15/40 was significantly higher compared with the corresponding equiosmolar lactate-buffered PDF (1,992 +/- 858 x 10(3) cpm/10(4) cells v 856 +/- 398 x 10(3) cpm/10(4) cells; P < 0.004), O-2(-) generation, killing capacity, and phagocytosis were not significantly different after PM0 exposure to bicarbonate compared with exposure to lactate-buffered PDF with a neutral pH, Irrespective of the buffer used, high-osmolality PDFs suppressed PM0 function significantly more than low-osmolar PDFs, In conclusion, bicarbonate-buffered PDFs are less detrimental to PM0) function than lactate-containing PDFs; these preliminary in vitro results need to be confirmed in vivo. (C) 1995 by the National Kidney Foundation, Inc.
- Published
- 1995
41. Novel Ratio of Renal Doppler Index for the Detection of Renal Disease
- Author
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Krumme, B., primary, Strutz, F., additional, Boehler, J., additional, and Mettang, T., additional
- Published
- 2011
- Full Text
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42. Pathophysiology and clinical studies in CKD 1-5.
- Author
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El Sharkawy, M., primary, Elsaeed, K., additional, Kamel, M., additional, Aziz, A., additional, Del Pozo, C., additional, Balk, A., additional, Castello-Banyuls, J., additional, Navarro, D., additional, Pere, B., additional, Faura, C. C., additional, Ballesta, J. J., additional, Rodig, N., additional, Vilalta, R., additional, Hernandez, J., additional, Camacho Diaz, J., additional, Lapeyraque, A.- L., additional, Sherwinter, J., additional, Gruppo, R., additional, Fremont, O., additional, Baudouin, V., additional, Langman, C., additional, Simonetti, G. D., additional, Loirat, C., additional, Muus, P., additional, Legendre, C., additional, Douglas, K., additional, Hourmant, M., additional, Delmas, Y., additional, Herthelius, M., additional, Trivelli, A., additional, Goodship, T., additional, Bedrosian, C., additional, Licht, C., additional, Schlesinger, N., additional, Lin, H.- Y., additional, De Meulemeester, M., additional, Rovensky, J., additional, Krammer, G., additional, Balfour, A., additional, So, A., additional, Carrero, J. J., additional, Sonmez, A., additional, Saglam, M., additional, Stenvinkel, P., additional, Yaman, H., additional, Quresi, A. R., additional, Yenicesu, M., additional, Yilmaz, M. I., additional, McQuarrie, E., additional, Freel, M., additional, Mark, P., additional, Patel, R., additional, Steedman, T., additional, Fraser, R., additional, Dargie, H., additional, Connell, J., additional, Jardine, A., additional, Oh, S. W., additional, Chin, H. J., additional, Na, K. Y., additional, Chae, D. W., additional, Alfieri, C., additional, Vettoretti, S., additional, Cafforio, C., additional, Floreani, R., additional, Bonanomi, C., additional, Danzi, G., additional, Messa, P., additional, Whelton, A., additional, MacDonald, P., additional, Hunt, B., additional, Gunawardhana, L., additional, Rusu, E., additional, Voiculescu, M., additional, Zilisteanu, D., additional, Ecobici, M., additional, Arsenescu, I., additional, Ismail, G., additional, Macarie, C., additional, Chan, D., additional, Irish, A., additional, Watts, G., additional, Dogra, G., additional, Krueger, T., additional, Schlieper, G., additional, Cozzolino, M., additional, Eckardt, K. U., additional, Jadoul, M., additional, Ketteler, M., additional, Leunissen, K., additional, Rump, L. C., additional, Wiecek, A., additional, Westenfeld, R., additional, Hilgers, R. D., additional, Mahnken, A. H., additional, Schurgers, L. J., additional, Floege, J., additional, Onuigbo, M., additional, Onuigbo, N., additional, Trevisani, F., additional, Sciarrone Alibrandi, M. T., additional, Bertini, R., additional, Montorsi, F., additional, Delli Carpini, S., additional, Camerota, T. C., additional, Antoniolli, S., additional, Citterio, L., additional, Querques, M., additional, Merlino, L., additional, Manunta, P., additional, Ebah, L., additional, Morgan, J., additional, Brenchley, P., additional, Mitra, S., additional, Krumme, B., additional, Boehler, J., additional, Mettang, T., additional, Strutz, F., additional, Georginova, O., additional, Rykova, S., additional, Gafarova, M., additional, Smyr, K., additional, Sokolova, I., additional, Krasnova, T., additional, and Kozlovskaya, L., additional
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- 2011
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43. Erhöhte Autotaxin-Serumaktivität ist spezifisch für cholestatischen Pruritus
- Author
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Kremer, AE, primary, Kuiper, EM, additional, Mettang, T, additional, Reiners, KS, additional, van Buuren, HR, additional, van Erpecum, KJ, additional, Williamson, C, additional, van der Post, JA, additional, Beuers, U, additional, and Oude Elferink, R, additional
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- 2011
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44. Uraemic pruritus--new perspectives and insights from recent trials
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Mettang, T and Mettang, T
- Published
- 2002
45. Lacking evidence for calcium-binding protein fetuin-A to be linked with chronic kidney disease-related pruritus (CKD-rP)
- Author
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Mettang, T., primary, Matterne, U., additional, Roth, H. J., additional, and Weisshaar, E., additional
- Published
- 2009
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46. Reply
- Author
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Mettang, T., primary, Matterne, U., additional, and Weisshaar, E., additional
- Published
- 2009
- Full Text
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47. How do nephrologists in haemodialysis units consider the symptom of itch? Results of a survey in Germany
- Author
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Weisshaar, E., primary, Matterne, U., additional, and Mettang, T., additional
- Published
- 2008
- Full Text
- View/download PDF
48. Schweres nephrotisches Syndrom mit reversiblem akuten Nierenversagen bei lupusassoziierter membranöser Nephropathie
- Author
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Pauli-Magnus, C., primary, Mettang, T., additional, and Kuhlmann, U., additional
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- 2008
- Full Text
- View/download PDF
49. Urämischer Pruritus: Pathophysiologische und therapeutische Konzepte
- Author
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Mettang, T., primary, Fischer, F.-P., additional, and Kuhlmann, U., additional
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- 2008
- Full Text
- View/download PDF
50. Akutes Nierenversagen durch Hantavirus-Infektion
- Author
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Mettang, T., primary, Weber, J., additional, and Kuhlmann, U., additional
- Published
- 2008
- Full Text
- View/download PDF
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