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245 results on '"Meunier, Etienne"'

1. Learning to generate physical ocean states: Towards hybrid climate modeling

Author

Meunier, Etienne, Kamm, David, Gachon, Guillaume, Lguensat, Redouane, and Deshayes, Julie

Subjects
Computer Science - Machine Learning
Abstract

Ocean General Circulation Models require extensive computational resources to reach equilibrium states, while deep learning emulators, despite offering fast predictions, lack the physical interpretability and long-term stability necessary for climate scientists to understand climate sensitivity (to greenhouse gas emissions) and mechanisms of abrupt % variability such as tipping points. We propose to take the best from both worlds by leveraging deep generative models to produce physically consistent oceanic states that can serve as initial conditions for climate projections. We assess the viability of this hybrid approach through both physical metrics and numerical experiments, and highlight the benefits of enforcing physical constraints during generation. Although we train here on ocean variables from idealized numerical simulations, we claim that this hybrid approach, combining the computational efficiency of deep learning with the physical accuracy of numerical models, can effectively reduce the computational burden of running climate models to equilibrium, and reduce uncertainties in climate projections by minimizing drifts in baseline simulations.

Published
2025

2. Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation

Author

Gorse, Léana, Plessis, Loïc, Wearne, Stephen, Paradis, Margaux, Pinilla, Miriam, Chua, Rae, Lim, Seong Soo, Pelluz, Elena, TOH, Gee-Ann, Mazars, Raoul, Bomfim, Caio, Hervé, Fabienne, Lhaute, Korian, Réveillon, Damien, Suire, Bastien, Ravon-Katossky, Léa, Benoist, Thomas, Fromont, Léa, Péricat, David, Neil Mertens, Kenneth, Derrien, Amélie, Terre-Terrillon, Aouregan, Chomérat, Nicolas, Bilien, Gwenaël, Séchet, Véronique, Carpentier, Liliane, Fall, Mamadou, Sonko, Amidou, Hakim, Hadi, Sadio, Nfally, Bourdeaux, Jessie, Cougoule, Céline, Henras, Anthony K, Perez-Oliva, Ana Belen, Brehmer, Patrice, Roca, Francisco J, Zhong, Franklin L, Common, John, Meunier, Etienne, and Hess, Philipp

Published
2025
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3. Segmenting the motion components of a video: A long-term unsupervised model

Author

Meunier, Etienne and Bouthemy, Patrick

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Human beings have the ability to continuously analyze a video and immediately extract the motion components. We want to adopt this paradigm to provide a coherent and stable motion segmentation over the video sequence. In this perspective, we propose a novel long-term spatio-temporal model operating in a totally unsupervised way. It takes as input the volume of consecutive optical flow (OF) fields, and delivers a volume of segments of coherent motion over the video. More specifically, we have designed a transformer-based network, where we leverage a mathematically well-founded framework, the Evidence Lower Bound (ELBO), to derive the loss function. The loss function combines a flow reconstruction term involving spatio-temporal parametric motion models combining, in a novel way, polynomial (quadratic) motion models for the spatial dimensions and B-splines for the time dimension of the video sequence, and a regularization term enforcing temporal consistency on the segments. We report experiments on four VOS benchmarks, demonstrating competitive quantitative results, while performing motion segmentation on a whole sequence in one go. We also highlight through visual results the key contributions on temporal consistency brought by our method.

Published
2023

4. EM-driven unsupervised learning for efficient motion segmentation

Author

Meunier, Etienne, Badoual, Anaïs, and Bouthemy, Patrick

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

In this paper, we present a CNN-based fully unsupervised method for motion segmentation from optical flow. We assume that the input optical flow can be represented as a piecewise set of parametric motion models, typically, affine or quadratic motion models. The core idea of our work is to leverage the Expectation-Maximization (EM) framework in order to design in a well-founded manner a loss function and a training procedure of our motion segmentation neural network that does not require either ground-truth or manual annotation. However, in contrast to the classical iterative EM, once the network is trained, we can provide a segmentation for any unseen optical flow field in a single inference step and without estimating any motion models. We investigate different loss functions including robust ones and propose a novel efficient data augmentation technique on the optical flow field, applicable to any network taking optical flow as input. In addition, our method is able by design to segment multiple motions. Our motion segmentation network was tested on four benchmarks, DAVIS2016, SegTrackV2, FBMS59, and MoCA, and performed very well, while being fast at test time., Comment: Accepted to : IEEE Transactions on Pattern Analysis and Machine Intelligence (TPAMI)

Published
2022
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6. A druggable copper-signalling pathway that drives inflammation

Author

Solier, Stéphanie, Müller, Sebastian, Cañeque, Tatiana, Versini, Antoine, Mansart, Arnaud, Sindikubwabo, Fabien, Baron, Leeroy, Emam, Laila, Gestraud, Pierre, Pantoș, G. Dan, Gandon, Vincent, Gaillet, Christine, Wu, Ting-Di, Dingli, Florent, Loew, Damarys, Baulande, Sylvain, Durand, Sylvère, Sencio, Valentin, Robil, Cyril, Trottein, François, Péricat, David, Näser, Emmanuelle, Cougoule, Céline, Meunier, Etienne, Bègue, Anne-Laure, Salmon, Hélène, Manel, Nicolas, Puisieux, Alain, Watson, Sarah, Dawson, Mark A., Servant, Nicolas, Kroemer, Guido, Annane, Djillali, and Rodriguez, Raphaël

Published
2023
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9. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Author

Planès, Rémi, Pinilla, Miriam, Santoni, Karin, Hessel, Audrey, Passemar, Charlotte, Lay, Kenneth, Paillette, Perrine, Valadão, Ana-Luiza Chaves, Robinson, Kim Samirah, Bastard, Paul, Lam, Nathaniel, Fadrique, Ricardo, Rossi, Ida, Pericat, David, Bagayoko, Salimata, Leon-Icaza, Stephen Adonai, Rombouts, Yoann, Perouzel, Eric, Tiraby, Michèle, Zhang, Qian, Cicuta, Pietro, Jouanguy, Emmanuelle, Neyrolles, Olivier, Bryant, Clare E., Floto, Andres R., Goujon, Caroline, Lei, Franklin Zhong, Martin-Blondel, Guillaume, Silva, Stein, Casanova, Jean-Laurent, Cougoule, Céline, Reversade, Bruno, Marcoux, Julien, Ravet, Emmanuel, and Meunier, Etienne

Published
2022
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13. Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response

Author

Rahabi, Mouna, Jacquemin, Godefroy, Prat, Mélissa, Meunier, Etienne, AlaEddine, Mohamad, Bertrand, Bénédicte, Lefèvre, Lise, Benmoussa, Khaddouj, Batigne, Philippe, Aubouy, Agnès, Auwerx, Johan, Kirzin, Sylvain, Bonnet, Delphine, Danjoux, Marie, Pipy, Bernard, Alric, Laurent, Authier, Hélène, and Coste, Agnès

Published
2020
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14. Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome

Author

Rozario, Pritisha, Pinilla, Miriam, Gorse, Leana, Vind, Anna Constance, Robinson, Kim S., Toh, Gee Ann, Firdaus, Muhammad Jasrie, Martínez, José Francisco, Kerk, Swat Kim, Lin, Zhewang, Chambers, John C., Bekker-Jensen, Simon, Meunier, Etienne, Zhong, Franklin, Rozario, Pritisha, Pinilla, Miriam, Gorse, Leana, Vind, Anna Constance, Robinson, Kim S., Toh, Gee Ann, Firdaus, Muhammad Jasrie, Martínez, José Francisco, Kerk, Swat Kim, Lin, Zhewang, Chambers, John C., Bekker-Jensen, Simon, Meunier, Etienne, and Zhong, Franklin

Published
2024

15. Mechanistic basis for potassium efflux–driven activation of the human NLRP1 inflammasome

Author

Rozario, Pritisha, primary, Pinilla, Miriam, additional, Gorse, Leana, additional, Vind, Anna Constance, additional, Robinson, Kim S., additional, Toh, Gee Ann, additional, Firdaus, Muhammad Jasrie, additional, Martínez, José Francisco, additional, Kerk, Swat Kim, additional, Lin, Zhewang, additional, Chambers, John C., additional, Bekker-Jensen, Simon, additional, Meunier, Etienne, additional, and Zhong, Franklin, additional

Published
2024
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18. Leishmania infantum-exploited Nrf2 transcription factor as a virulence process to escape macrophage-driven ferroptosis-like leishmanicidal process

Author

Coste, Agnès, primary, Blot, Clément, additional, Coulson, Kimberley, additional, Salon, Marie, additional, Tertrais, Margot, additional, Planes, Remi, additional, Santoni, Karin, additional, Authier, Hélène, additional, Jacquemin, Godefroy, additional, Rahabi, Mouna, additional, Parny, Mélissa, additional, Raymond-Letron, Isabelle, additional, Meunier, Etienne, additional, and Lefèvre, Lise, additional

Published
2023
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22. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

Author

Pinilla, Miriam, primary, Mazars, Raoul, additional, Vergé, Romain, additional, Gorse, Leana, additional, Paradis, Margaux, additional, Suire, Bastien, additional, Santoni, Karin, additional, Robinson, Kim Samirah, additional, Toh, Gee Ann, additional, Prouvensier, Laure, additional, Leon-Icaza, Stephen Adonai, additional, Hessel, Audrey, additional, Péricat, David, additional, Murris, Marlène, additional, Guet-Revillet, Hélène, additional, Henras, Anthony, additional, Buyck, Julien, additional, Ravet, Emmanuel, additional, Zhong, Franklin L., additional, Cougoule, Céline, additional, Planès, Rémi, additional, and Meunier, Etienne, additional

Published
2023
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23. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Author

Leon-Icaza, Stephen Adonai, primary, Bagayoko, Salimata, additional, Vergé, Romain, additional, Iakobachvili, Nino, additional, Ferrand, Chloé, additional, Aydogan, Talip, additional, Bernard, Célia, additional, Sanchez Dafun, Angelique, additional, Murris-Espin, Marlène, additional, Mazières, Julien, additional, Bordignon, Pierre Jean, additional, Mazères, Serge, additional, Bernes-Lasserre, Pascale, additional, Ramé, Victoria, additional, Lagarde, Jean-Michel, additional, Marcoux, Julien, additional, Bousquet, Marie-Pierre, additional, Chalut, Christian, additional, Guilhot, Christophe, additional, Clevers, Hans, additional, Peters, Peter J., additional, Molle, Virginie, additional, Lugo-Villarino, Geanncarlo, additional, Cam, Kaymeuang, additional, Berry, Laurence, additional, Meunier, Etienne, additional, and Cougoule, Céline, additional

Published
2023
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25. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Author

Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Sanchez Dafun, Angelique, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean-Michel, Marcoux, Julien, Bousquet, Marie-Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J, Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, Cougoule, Céline, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Sanchez Dafun, Angelique, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean-Michel, Marcoux, Julien, Bousquet, Marie-Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J, Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, and Cougoule, Céline

Abstract

Mycobacterium abscessus (Mabs) drives life-shortening mortality in cystic fibrosis (CF) patients, primarily because of its resistance to chemotherapeutic agents. To date, our knowledge on the host and bacterial determinants driving Mabs pathology in CF patient lung remains rudimentary. Here, we used human airway organoids (AOs) microinjected with smooth (S) or rough (R-)Mabs to evaluate bacteria fitness, host responses to infection, and new treatment efficacy. We show that S Mabs formed biofilm, and R Mabs formed cord serpentines and displayed a higher virulence. While Mabs infection triggers enhanced oxidative stress, pharmacological activation of antioxidant pathways resulted in better control of Mabs growth and reduced virulence. Genetic and pharmacological inhibition of the CFTR is associated with better growth and higher virulence of S and R Mabs. Finally, pharmacological activation of antioxidant pathways inhibited Mabs growth, at least in part through the quinone oxidoreductase NQO1, and improved efficacy in combination with cefoxitin, a first line antibiotic. In conclusion, we have established AOs as a suitable human system to decipher mechanisms of CF-driven respiratory infection by Mabs and propose boosting of the NRF2-NQO1 axis as a potential host-directed strategy to improve Mabs infection control.

Published
2023

26. Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Author

CMM, Cancer, Hubrecht Institute with UMC, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Dafun, Angelique Sanchez, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean Michel, Marcoux, Julien, Bousquet, Marie Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J., Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, Cougoule, Céline, CMM, Cancer, Hubrecht Institute with UMC, Leon-Icaza, Stephen Adonai, Bagayoko, Salimata, Vergé, Romain, Iakobachvili, Nino, Ferrand, Chloé, Aydogan, Talip, Bernard, Célia, Dafun, Angelique Sanchez, Murris-Espin, Marlène, Mazières, Julien, Bordignon, Pierre Jean, Mazères, Serge, Bernes-Lasserre, Pascale, Ramé, Victoria, Lagarde, Jean Michel, Marcoux, Julien, Bousquet, Marie Pierre, Chalut, Christian, Guilhot, Christophe, Clevers, Hans, Peters, Peter J., Molle, Virginie, Lugo-Villarino, Geanncarlo, Cam, Kaymeuang, Berry, Laurence, Meunier, Etienne, and Cougoule, Céline

Published
2023

27. Supplementary table 1 from IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Author

Alaeddine, Mohamad, primary, Prat, Mélissa, primary, Poinsot, Véréna, primary, Gouazé-Andersson, Valérie, primary, Authier, Hélène, primary, Meunier, Etienne, primary, Lefèvre, Lise, primary, Alric, Camille, primary, Dardenne, Christophe, primary, Bernad, José, primary, Alric, Laurent, primary, Segui, Bruno, primary, Balard, Patricia, primary, Couderc, François, primary, Couderc, Bettina, primary, Pipy, Bernard, primary, and Coste, Agnès, primary

Published
2023
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28. Data from IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Author

Alaeddine, Mohamad, primary, Prat, Mélissa, primary, Poinsot, Véréna, primary, Gouazé-Andersson, Valérie, primary, Authier, Hélène, primary, Meunier, Etienne, primary, Lefèvre, Lise, primary, Alric, Camille, primary, Dardenne, Christophe, primary, Bernad, José, primary, Alric, Laurent, primary, Segui, Bruno, primary, Balard, Patricia, primary, Couderc, François, primary, Couderc, Bettina, primary, Pipy, Bernard, primary, and Coste, Agnès, primary

Published
2023
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29. Supplementary Figures from IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Author

Alaeddine, Mohamad, primary, Prat, Mélissa, primary, Poinsot, Véréna, primary, Gouazé-Andersson, Valérie, primary, Authier, Hélène, primary, Meunier, Etienne, primary, Lefèvre, Lise, primary, Alric, Camille, primary, Dardenne, Christophe, primary, Bernad, José, primary, Alric, Laurent, primary, Segui, Bruno, primary, Balard, Patricia, primary, Couderc, François, primary, Couderc, Bettina, primary, Pipy, Bernard, primary, and Coste, Agnès, primary

Published
2023
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31. Establishing 20S Proteasome Genetic, Translational and Post-Translational Status from Precious Biological and Patient Samples with Top-Down MS

Author

Dafun, Angelique Sanchez, primary, Zivković, Dušan, additional, Leon-Icaza, Stephen Adonai, additional, Möller, Sophie, additional, Froment, Carine, additional, Bonnet, Delphine, additional, de Jesus, Adriana Almeida, additional, Alric, Laurent, additional, Quaranta-Nicaise, Muriel, additional, Ferrand, Audrey, additional, Cougoule, Céline, additional, Meunier, Etienne, additional, Burlet-Schiltz, Odile, additional, Ebstein, Frédéric, additional, Goldbach-Mansky, Raphaela, additional, Krüger, Elke, additional, Bousquet, Marie-Pierre, additional, and Marcoux, Julien, additional

Published
2023
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32. EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption uponPseudomonasinfection

Author

Pinilla, Miriam, primary, Mazars, Raoul, additional, Vergé, Romain, additional, Gorse, Leana, additional, Santoni, Karin, additional, Robinson, Kim Samirah, additional, Toh, Gee Ann, additional, Prouvensier, Laure, additional, LeonIcaza, Stephen Adonai, additional, Hessel, Audrey, additional, Péricat, David, additional, Murris, Marlène, additional, Henras, Anthony, additional, Buyck, Julien, additional, Cougoule, Céline, additional, Ravet, Emmanuel, additional, Zhong, Franklin L., additional, Planès, Rémi, additional, and Meunier, Etienne, additional

Published
2023
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34. Apprentissage profond non supervisé fondé sur l'algorithme EM pour la segmentation du mouvement

Author

Meunier, Etienne, Badoual, Anaïs, Bouthemy, Patrick, Meunier, Etienne, Space-timE RePresentation, Imaging and cellular dynamics of molecular COmplexes (SERPICO), Inria Rennes – Bretagne Atlantique, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)

Subjects
optical flow, [INFO.INFO-CV] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], flot optique, algorithme EM, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Segmentation du mouvement, Motion segmentation, EM algorithm, CNN, réseau de neurones
Abstract

This paper presents a CNN-based fully unsupervised method for motion segmentation from optical flow. We assume that the input optical flow can be represented as a piecewise set of parametric motion models, typically, affine or quadratic motion models. The core idea of this work is to leverage the Expectation-Maximization (EM) framework. It enables us to design in a well-founded manner the loss function and the training procedure of our motion segmentation neural network. However, in contrast to the classical iterative EM, once the network is trained, we can provide a segmentation for any unseen optical flow field in a single inference step, with no dependence on the initialization of the motion model parameters since they are not estimated in the inference stage. Our method outperforms comparable unsupervised methods and is very efficient., Cet article présente une méthode entièrement non supervisée basée sur un réseau neuronal convolutionnel pour la segmentation du mouvement à partir du flot optique. Nous supposons que le flot optique d'entrée peut être représenté par un ensemble de modèles de mouvement paramétriques, typiquement des modèles de mouvement affines ou quadratiques. L'idée centrale de ce travail est d'exploiter le cadre de l'Espérance-Maximisation (EM). Il nous permet de concevoir d'une manière bien fondée la fonction de perte et la procédure d'apprentissage de notre réseau de neurones de segmentation du mouvement. Contrairement à la méthode EM itérative classique, une fois le réseau entraîné, nous pouvons fournir une segmentation pour tout nouveau champ de flot optique en une seule étape d'inférence et sans avoir avoir à estimer de modèles de mouvement. Notre méthode surpasse les méthodes non supervisées comparables et est très efficace en temps de calcul. Mots Clés Segmentation du mouvement, flot optique, réseau de neurones, algorithme EM.

Published
2022

35. Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model

Author

Péricat, David, primary, Leon-Icaza, Stephen Adonai, additional, Sanchez Rico, Marina, additional, Mühle, Christiane, additional, Zoicas, Iulia, additional, Schumacher, Fabian, additional, Planès, Rémi, additional, Mazars, Raoul, additional, Gros, Germain, additional, Carpinteiro, Alexander, additional, Becker, Katrin Anne, additional, Izopet, Jacques, additional, Strub-Wourgaft, Nathalie, additional, Sjö, Peter, additional, Neyrolles, Olivier, additional, Kleuser, Burkhard, additional, Limosin, Frédéric, additional, Gulbins, Erich, additional, Kornhuber, Johannes, additional, Meunier, Etienne, additional, Hoertel, Nicolas, additional, and Cougoule, Céline, additional

Published
2022
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36. Topical Aspirin administration improves cutaneous wound healing in diabetic mice through a phenotypic switch of wound macrophages toward an anti-inflammatory and pro-resolutive profile characterized by LXA4 release

Author

Dardenne, Christophe, primary, Salon, Marie, primary, Authier, Hélène, primary, Meunier, Etienne, primary, AlaEddine, Mohamad, primary, Bernad, José, primary, Bouschbacher, Marielle, primary, Lefèvre, Lise, primary, Pipy, Bernard, primary, and Coste, Agnès, primary

Published
2022
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39. Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa

Author

Santoni, Karin, primary, Pericat, David, additional, Gorse, Leana, additional, Buyck, Julien, additional, Pinilla, Miriam, additional, Prouvensier, Laure, additional, Bagayoko, Salimata, additional, Hessel, Audrey, additional, Leon-Icaza, Stephen Adonai, additional, Bellard, Elisabeth, additional, Mazères, Serge, additional, Doz-Deblauwe, Emilie, additional, Winter, Nathalie, additional, Paget, Christophe, additional, Girard, Jean-Philippe, additional, Pham, Christine T. N., additional, Cougoule, Céline, additional, Poincloux, Renaud, additional, Lamkanfi, Mohamed, additional, Lefrançais, Emma, additional, Meunier, Etienne, additional, and Planès, Rémi, additional

Published
2022
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40. Topical Aspirin Administration Improves Cutaneous Wound Healing in Diabetic Mice Through a Phenotypic Switch of Wound Macrophages Toward an Anti-inflammatory and Proresolutive Profile Characterized by LXA4 Release

Author

Dardenne, Christophe, primary, Salon, Marie, additional, Authier, Hélène, additional, Meunier, Etienne, additional, AlaEddine, Mohamad, additional, Bernad, José, additional, Bouschbacher, Marielle, additional, Lefèvre, Lise, additional, Pipy, Bernard, additional, and Coste, Agnès, additional

Published
2022
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41. Jeffrey Escoffier.

Author

Stein, Arlene and Meunier, Etienne

Subjects
*COLLEGE curriculum, *LGBTQ+ history, *LGBTQ+ culture, *LGBTQ+ studies, *GAY identity, *SOCIAL science research
Abstract

Jeffrey Escoffier, a prolific scholar, teacher, public health advocate, and community builder, passed away in New York on May 20, 2022, at the age of 79. He published numerous books and articles on topics such as homosexuality, sexual revolution, pornography, and dance. Escoffier played a significant role in the emergence of gay identity and the study of gay and lesbian history in the United States. He was also involved in government service, where he advocated for sexual health campaigns that focused on facilitating sexual health rather than discouraging certain behaviors. Escoffier's work was grounded in a concern for social structure and the power of economic markets, and he was known for his ability to connect people, ideas, and institutions. He was a founder of OUT/LOOK, a national gay and lesbian quarterly, and remained committed to documenting gay sexual life from the 1960s to the present. Escoffier's contributions to the field of sexuality studies were widely recognized, and he continued to be involved in academic and community-based work until his passing. [Extracted from the article]

Published
2024
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42. Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes

Author

Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Kiner, Evgeny, Willie, Elijah, Vijaykumar, Brinda, Chowdhary, Kaitavjeet, Schmutz, Hugo, Chandler, Jodie, Schnell, Alexandra, Thakore, Pratiksha I., LeGros, Graham, Mostafavi, Sara, Mathis, Diane, Benoist, Christophe, Aguilar, Oscar, Allan, Rhys, Astarita, Jilian, Austen, K. Frank, Barrett, Nora, Baysoy, Alev, Brown, Brian D., Buechler, Matthew, Buenrostro, Jason, Casanova, Maria Acebes, Choi, Kyunghee, Colonna, Marco, Crowl, Ty, Deng, Tianda, Desai, Jigar V., Desland, Fiona, Dhainaut, Maxime, Ding, Jiarui, Dominguez, Claudia, Dwyer, Daniel, Frascoli, Michela, Gal-Oz, Shani, Goldrath, Ananda, Grieshaber-Bouyer, Ricardo, Jia, Baosen, Johanson, Tim, Jordan, Stefan, Kang, Joonsoo, Kapoor, Varun, Kenigsberg, Ephraim, Kim, Joel, wook Kim, Ki, Kronenberg, Mitchell, Lanier, Lewis, Laplace, Catherine, Lareau, Caleb, Leader, Andrew, Lee, Jisu, Magen, Assaf, Maier, Barbara, Maslova, Alexandra, McFarland, Adelle, Merad, Miriam, Meunier, Etienne, Monach, Paul, Muller, Soren, Muus, Christoph, Ner-Gaon, Hadas, Nguyen, Quyhn, Nigrovic, Peter A., Novakovsky, German, Nutt, Stephen, Omilusik, Kayla, Ortiz-Lopez, Adriana, Paynich, Mallory, Peng, Vincent, Potempa, Marc, Pradhan, Rachana, Quon, Sara, Ramirez, Ricardo, Ramanan, Deepshika, Randolph, Gwendalyn, Regev, Aviv, Rose, Samuel A., Seddu, Kumba, Shay, Tal, Shemesh, Avishai, Shyer, Justin, Smilie, Christopher, Spidale, Nick, Subramanian, Ayshwarya, Sylvia, Katelyn, Tellier, Julie, Turley, Shannon, Wagers, Amy, Wang, Chendi, Wang, Peter L., Wroblewska, Aleksandra, Yang, Liang, Yim, Aldrin, Yoshida, Hideyuki, Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Kiner, Evgeny, Willie, Elijah, Vijaykumar, Brinda, Chowdhary, Kaitavjeet, Schmutz, Hugo, Chandler, Jodie, Schnell, Alexandra, Thakore, Pratiksha I., LeGros, Graham, Mostafavi, Sara, Mathis, Diane, Benoist, Christophe, Aguilar, Oscar, Allan, Rhys, Astarita, Jilian, Austen, K. Frank, Barrett, Nora, Baysoy, Alev, Brown, Brian D., Buechler, Matthew, Buenrostro, Jason, Casanova, Maria Acebes, Choi, Kyunghee, Colonna, Marco, Crowl, Ty, Deng, Tianda, Desai, Jigar V., Desland, Fiona, Dhainaut, Maxime, Ding, Jiarui, Dominguez, Claudia, Dwyer, Daniel, Frascoli, Michela, Gal-Oz, Shani, Goldrath, Ananda, Grieshaber-Bouyer, Ricardo, Jia, Baosen, Johanson, Tim, Jordan, Stefan, Kang, Joonsoo, Kapoor, Varun, Kenigsberg, Ephraim, Kim, Joel, wook Kim, Ki, Kronenberg, Mitchell, Lanier, Lewis, Laplace, Catherine, Lareau, Caleb, Leader, Andrew, Lee, Jisu, Magen, Assaf, Maier, Barbara, Maslova, Alexandra, McFarland, Adelle, Merad, Miriam, Meunier, Etienne, Monach, Paul, Muller, Soren, Muus, Christoph, Ner-Gaon, Hadas, Nguyen, Quyhn, Nigrovic, Peter A., Novakovsky, German, Nutt, Stephen, Omilusik, Kayla, Ortiz-Lopez, Adriana, Paynich, Mallory, Peng, Vincent, Potempa, Marc, Pradhan, Rachana, Quon, Sara, Ramirez, Ricardo, Ramanan, Deepshika, Randolph, Gwendalyn, Regev, Aviv, Rose, Samuel A., Seddu, Kumba, Shay, Tal, Shemesh, Avishai, Shyer, Justin, Smilie, Christopher, Spidale, Nick, Subramanian, Ayshwarya, Sylvia, Katelyn, Tellier, Julie, Turley, Shannon, Wagers, Amy, Wang, Chendi, Wang, Peter L., Wroblewska, Aleksandra, Yang, Liang, Yim, Aldrin, and Yoshida, Hideyuki

Published
2022

43. Mycobacteria-host interactions in human bronchiolar airway organoids

Author

Iakobachvili, Nino, Leon-Icaza, Stephen Adonai, Knoops, Kèvin, Sachs, Norman, Mazères, Serge, Simeone, Roxane, Peixoto, Antonio, Bernard, Célia, Murris-Espin, Marlène, Mazières, Julien, Cam, Kaymeuang, Chalut, Christian, Guilhot, Christophe, López-Iglesias, Carmen, Ravelli, Raimond B G, Neyrolles, Olivier, Meunier, Etienne, Lugo-Villarino, Geanncarlo, Clevers, Hans, Cougoule, Céline, Peters, Peter J, Iakobachvili, Nino, Leon-Icaza, Stephen Adonai, Knoops, Kèvin, Sachs, Norman, Mazères, Serge, Simeone, Roxane, Peixoto, Antonio, Bernard, Célia, Murris-Espin, Marlène, Mazières, Julien, Cam, Kaymeuang, Chalut, Christian, Guilhot, Christophe, López-Iglesias, Carmen, Ravelli, Raimond B G, Neyrolles, Olivier, Meunier, Etienne, Lugo-Villarino, Geanncarlo, Clevers, Hans, Cougoule, Céline, and Peters, Peter J

Abstract

Respiratory infections remain a major global health concern. Tuberculosis is one of the top 10 causes of death worldwide, while infections with Non-Tuberculous Mycobacteria are rising globally. Recent advances in human tissue modeling offer a unique opportunity to grow different human "organs" in vitro, including the human airway, that faithfully recapitulates lung architecture and function. Here, we have explored the potential of human airway organoids (AOs) as a novel system in which to assess the very early steps of mycobacterial infection. We reveal that Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mabs) mainly reside as extracellular bacteria and infect epithelial cells with very low efficiency. While the AO microenvironment was able to control, but not eliminate Mtb, Mabs thrives. We demonstrate that AOs responded to infection by modulating cytokine, antimicrobial peptide, and mucin gene expression. Given the importance of myeloid cells in mycobacterial infection, we co-cultured infected AOs with human monocyte-derived macrophages and found that these cells interact with the organoid epithelium. We conclude that adult stem cell (ASC)-derived AOs can be used to decipher very early events of mycobacteria infection in human settings thus offering new avenues for fundamental and therapeutic research.

Published
2022

44. Mycobacteria–host interactions in human bronchiolar airway organoids

Author

Cancer, CMM, Hubrecht Institute with UMC, Iakobachvili, Nino, Leon-Icaza, Stephen Adonai, Knoops, Kèvin, Sachs, Norman, Mazères, Serge, Simeone, Roxane, Peixoto, Antonio, Bernard, Célia, Murris-Espin, Marlène, Mazières, Julien, Cam, Kaymeuang, Chalut, Christian, Guilhot, Christophe, López-Iglesias, Carmen, Ravelli, Raimond B.G., Neyrolles, Olivier, Meunier, Etienne, Lugo-Villarino, Geanncarlo, Clevers, Hans, Cougoule, Céline, Peters, Peter J., Cancer, CMM, Hubrecht Institute with UMC, Iakobachvili, Nino, Leon-Icaza, Stephen Adonai, Knoops, Kèvin, Sachs, Norman, Mazères, Serge, Simeone, Roxane, Peixoto, Antonio, Bernard, Célia, Murris-Espin, Marlène, Mazières, Julien, Cam, Kaymeuang, Chalut, Christian, Guilhot, Christophe, López-Iglesias, Carmen, Ravelli, Raimond B.G., Neyrolles, Olivier, Meunier, Etienne, Lugo-Villarino, Geanncarlo, Clevers, Hans, Cougoule, Céline, and Peters, Peter J.

Published
2022

46. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

Author

Meunier, Etienne, Dick, Mathias S., Dreier, Roland F., Schurmann, Nura, Broz, Daniela Kenzelmann, Warming, Soren, Roose-Girma, Merone, Bumann, Dirk, Kayagaki, Nobuhiko, Takeda, Kiyoshi, Yamamoto, Masahiro, and Broz, Petr

Subjects
Physiological aspects, Research, Properties, Vacuoles -- Physiological aspects, Physiological research, Immune response -- Research, Caspases -- Properties
Abstract

Lipopolysaccharide from Gram-negative bacteria is sensed in the host cell cytoplasm by a non-canonical inflammasome pathway that ultimately results in caspase-11 activation and cell death (1-3). In mouse macrophages, activation [...]

Published
2014

47. Druggable redox pathways against M. abscessus in cystic fibrosis patient-derived airway organoids

Author

Leon-Icaza, Stephen Adonai, primary, Bagayoko, Salimata, additional, Vergé, Romain, additional, Iakobachvili, Nino, additional, Ferrand, Chloé, additional, Aydogan, Talip, additional, Bernard, Celia, additional, Dafun, Angelique Sanchez, additional, Murris-Espin, Marlène, additional, Mazières, Julien, additional, Bordignon, Pierre Jean, additional, Mazères, Serge, additional, Bernes-Lasserre, Pascale, additional, Ramé, Victoria, additional, Lagarde, Jean-Michel, additional, Marcoux, Julien, additional, Bousquet, Marie Pierre, additional, Chalut, Christian, additional, Guilhot, Christophe, additional, Clevers, Hans, additional, Peters, Peter J., additional, Molle, Virginie, additional, Lugo-Villarino, Geanncarlo, additional, Cam, Kaymeuang, additional, Berry, Laurence, additional, Meunier, Etienne, additional, and Cougoule, Céline, additional

Published
2022
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48. Human NLRP1 Is a Sensor of Pathogenic Coronavirus 3CL Proteases in Lung Epithelial Cells

Author

Planès, Rémi, primary, Pinilla, Miriam, additional, Santoni, Karin, additional, Hessel, Audrey, additional, Passemar, Charlotte, additional, Lay, Kenneth, additional, Paillette, Perrine, additional, Valadao, Ana-Luiza, additional, Robinson, Kim Samirah, additional, Bastard, Paul, additional, Lam, Nathaniel L., additional, Fradique, Ricardo, additional, Rossi, Ida, additional, Pericat, David, additional, Bagayoko, Salimata, additional, Leon-Icaza, Stephen Adonai, additional, Rombouts, Yoann, additional, Perouzel, Eric, additional, Tiraby, Michele, additional, Effort, COVID Human Genetic, additional, Zhang, Qian, additional, Cicuta, Pietro, additional, Jouanguy, Emmanuelle, additional, Neyrolles, Olivier, additional, Bryant, Clare, additional, Floto, Rodrigo A., additional, Goujon, Caroline, additional, Zhong, Franklin Lei, additional, Martin-Blondel, Guillaume, additional, Silva, Stein, additional, Casanova, Jean-Laurent, additional, Cougoule, Celine, additional, Reversade, Bruno, additional, Marcoux, Julien, additional, Ravet, Emmanuel, additional, and Meunier, Etienne, additional

Published
2022
Full Text
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50. Pseudomonas aeruginosa infection reveals a Caspase-1-dependent neutrophil pyroptosis pathway that restrains damaging Histone release

Author

Planès, Rémi, Santoni, Karin, Bagayoko, Salimata, Pericat, David, Bordignon, Pierre-Jean, Hessel, Audrey, Pinilla, Miriam, Leon-Icaza, Stephen-Andonai, Bellard, Elisabeth, Mazères, Serge, Abdderrahim, Rim, Doz-Deblauwe, Emilie, Aylward, Frances, Rombouts, Yoann, Winter, Nathalie, Girard, Jean-Philippe, Burlet-Schiltz, Odile, Pham, Christine T.N., Lamkanfi, Mohamed, Paget, Christophe, Cougoule, Céline, Gonzalez-De-Peredo, Anne, Lefrancais, Emma, Poincloux, Renaud, Meunier, Etienne, Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

Neutrophils mediate essential immune and microbicidal processes. Consequently, to counteract neutrophil attack, pathogens have developed various virulence strategies. Here, we showed that Pseudomonas aeruginosa ( P. aeruginosa ) phospholipase ExoU drives pathological NETosis in neutrophils. Surprisingly, inhibition of ExoU activity uncovered a fully functional Caspase-1-driven pyroptosis pathway in neutrophils. Mechanistically, activated NLRC4 inflammasome promoted Caspase-1-dependent Gasdermin-D activation, IL-1β cytokine release and neutrophil pyroptosis. Whereas both pyroptotic and netotic neutrophils released alarmins, only NETosis liberated the destructive DAMPs Histones, which exacerbated Pseudomonas -induced mouse lethality. To the contrary, subcortical actin allowed pyroptotic neutrophils to physically limit poisonous inflammation by keeping Histones intracellularly. Finally, mouse models of infection highlighted that both NETosis and neutrophil Caspase-1 contributed to P. aeruginosa spreading. Overall, we established the host deleterious consequences of Pseudomonas -induced-NETosis but also uncovered an unsuspected ability of neutrophils to undergo Caspase-1-dependent pyroptosis, a process where neutrophils exhibit a self-regulatory function that limit Histone release. Graphical abstract P.aeruginosa ExoU (right) triggers phospholipid degradation and subsequent neutrophil lysis that associates to NETosis through F-Actin collapse/degradation and PAD4-dependent DNA decondensation. P.aeruginosa ExoU- (left) triggers NLRC4-dependent pyroptosis in neutrophils, which leads to PAD4- depndent DNA decondensation but not expulsion due to a still function subcortical F- Actin network. Created with Biorender.com.

Published
2021

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