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3. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

Author

Carvalheiro, Tiago, Marut, Wioleta, Pascoal Ramos, M. Inês, García, Samuel, Fleury, Devan, Affandi, Alsya J., Meijers, Aniek S., Giovannone, Barbara, Tieland, Ralph G., Elshof, Eline, Ottria, Andrea, Cossu, Marta, Meizlish, Matthew L., Veenendaal, Tineke, Ramanujam, Meera, Moreno-García, Miguel E., Klumperman, Judith, Liv, Nalan, Radstake, Timothy R.D.J., and Meyaard, Linde

Published
2024
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4. Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice

Author

Singh, Akashdip, Mommers-Elshof, Eline T. A. M., Vijver, Saskia V., Jansen, J. H. Marco, Gonder, Susanne, Lebbink, Robert Jan, Bihan, Dominique, Farndale, Richard W., Boon, Louis, Langermann, Solomon, Leusen, Jeanette H. W., Flies, Dallas, Meyaard, Linde, and Pascoal Ramos, M. Ines

Published
2024
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12. This title is unavailable for guests, please login to see more information.

Author

CTI, CTI Van der Vlist, Cancer, Infection & Immunity, CTI Bont, Medisch Oncologische Disciplines, MS Medische Oncologie, CTI Kuball, MS Hematologie, Regenerative Medicine and Stem Cells, MS MDL 1, CTI Leusen, Timmerman, Laura M., Hensen, Lobke C.M., van Eijs, Mick J.M., Verheijden, Rik J., Suijkerbuijk, Karijn P.M., Meyaard, Linde, van der Vlist, Michiel, on behalf of the UNICIT consortium, CTI, CTI Van der Vlist, Cancer, Infection & Immunity, CTI Bont, Medisch Oncologische Disciplines, MS Medische Oncologie, CTI Kuball, MS Hematologie, Regenerative Medicine and Stem Cells, MS MDL 1, CTI Leusen, Timmerman, Laura M., Hensen, Lobke C.M., van Eijs, Mick J.M., Verheijden, Rik J., Suijkerbuijk, Karijn P.M., Meyaard, Linde, van der Vlist, Michiel, and on behalf of the UNICIT consortium

Published
2024

13. Mechanosensing regulates tissue repair program in macrophages

Author

CTI, Cancer, Infection & Immunity, Meizlish, Matthew L., Kimura, Yoshitaka, Pope, Scott D., Matta, Rita, Kim, Catherine, Philip, Naomi H., Meyaard, Linde, Gonzalez, Anjelica, Medzhitov, Ruslan, CTI, Cancer, Infection & Immunity, Meizlish, Matthew L., Kimura, Yoshitaka, Pope, Scott D., Matta, Rita, Kim, Catherine, Philip, Naomi H., Meyaard, Linde, Gonzalez, Anjelica, and Medzhitov, Ruslan

Published
2024

14. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

Author

CTI Nierkens, Infection & Immunity, CTI, Lab Reumatologie/Klinische Immunologie, Lab Dermatologie/Allergologie, CTI Peperzak, Translationele immunologie, Stem cell and organoid biology, CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, CMM groep Liv, CTI Radstake, Carvalheiro, Tiago, Marut, Wioleta, Pascoal Ramos, M. Inês, García, Samuel, Fleury, Devan, Affandi, Alsya J., Meijers, Aniek S., Giovannone, Barbara, Tieland, Ralph G., Elshof, Eline, Ottria, Andrea, Cossu, Marta, Meizlish, Matthew L., Veenendaal, Tineke, Ramanujam, Meera, Moreno-García, Miguel E., Klumperman, Judith, Liv, Nalan, Radstake, Timothy R.D.J., Meyaard, Linde, CTI Nierkens, Infection & Immunity, CTI, Lab Reumatologie/Klinische Immunologie, Lab Dermatologie/Allergologie, CTI Peperzak, Translationele immunologie, Stem cell and organoid biology, CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Regenerative Medicine and Stem Cells, CMM groep Liv, CTI Radstake, Carvalheiro, Tiago, Marut, Wioleta, Pascoal Ramos, M. Inês, García, Samuel, Fleury, Devan, Affandi, Alsya J., Meijers, Aniek S., Giovannone, Barbara, Tieland, Ralph G., Elshof, Eline, Ottria, Andrea, Cossu, Marta, Meizlish, Matthew L., Veenendaal, Tineke, Ramanujam, Meera, Moreno-García, Miguel E., Klumperman, Judith, Liv, Nalan, Radstake, Timothy R.D.J., and Meyaard, Linde

Published
2024

16. Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice

Author

CTI Ramos, Infection & Immunity, CTI Meyaard, Cancer, CTI Leusen, MMB Research line 3a, CTI, Singh, Akashdip, Mommers-Elshof, Eline T A M, Vijver, Saskia V, Jansen, J H Marco, Gonder, Susanne, Lebbink, Robert Jan, Bihan, Dominique, Farndale, Richard W, Boon, Louis, Langermann, Solomon, Leusen, Jeanette H W, Flies, Dallas, Meyaard, Linde, Pascoal Ramos, M Ines, CTI Ramos, Infection & Immunity, CTI Meyaard, Cancer, CTI Leusen, MMB Research line 3a, CTI, Singh, Akashdip, Mommers-Elshof, Eline T A M, Vijver, Saskia V, Jansen, J H Marco, Gonder, Susanne, Lebbink, Robert Jan, Bihan, Dominique, Farndale, Richard W, Boon, Louis, Langermann, Solomon, Leusen, Jeanette H W, Flies, Dallas, Meyaard, Linde, and Pascoal Ramos, M Ines

Published
2024

23. VSTM1-v2 does not drive human Th17 cell differentiation: A replication study

Author

CTI Meyaard, Infection & Immunity, CTI, Cancer, von Richthofen, Helen J., Hafkamp, Florianne M.J., van Haperen, Anouk, de Jong, Esther C., Meyaard, Linde, CTI Meyaard, Infection & Immunity, CTI, Cancer, von Richthofen, Helen J., Hafkamp, Florianne M.J., van Haperen, Anouk, de Jong, Esther C., and Meyaard, Linde

Published
2023

24. Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

Author

CTI Meyaard, Infection & Immunity, CTI, Arts-assistenten Kinderen, CTI Bont, MMB, CTI Research, Cancer, MS Reumatologie/Immunologie/Infectie, Infectieziekten onderzoek1 (Bont), Child Health, MMB Research line 1, von Richthofen, Helen J., Westerlaken, Geertje H.A., Gollnast, Doron, Besteman, Sjanna, Delemarre, Eveline M., Rodenburg, Karlijn, Moerer, Petra, Stapels, Daphne A.C., Andiappan, Anand K., Rötzschke, Olaf, Nierkens, Stefan, Leavis, Helen L., Bont, Louis J., Rooijakkers, Suzan H.M., Meyaard, Linde, CTI Meyaard, Infection & Immunity, CTI, Arts-assistenten Kinderen, CTI Bont, MMB, CTI Research, Cancer, MS Reumatologie/Immunologie/Infectie, Infectieziekten onderzoek1 (Bont), Child Health, MMB Research line 1, von Richthofen, Helen J., Westerlaken, Geertje H.A., Gollnast, Doron, Besteman, Sjanna, Delemarre, Eveline M., Rodenburg, Karlijn, Moerer, Petra, Stapels, Daphne A.C., Andiappan, Anand K., Rötzschke, Olaf, Nierkens, Stefan, Leavis, Helen L., Bont, Louis J., Rooijakkers, Suzan H.M., and Meyaard, Linde

Published
2023

25. Toxicity-specific peripheral blood T and B cell dynamics in anti-PD-1 and combined immune checkpoint inhibition.

Author

van Eijs, Mick J. M., Verheijden, Rik J., van der Wees, Stefanie A., Nierkens, Stefan, van Lindert, Anne S. R., Suijkerbuijk, Karijn P. M., van Wijk, Femke, the UNICIT consortium, Meyaard, Linde, Kuball, Jürgen H. E., Oldenburg, Bas, and Leusen, Jeanette H. W.

Subjects
IMMUNE checkpoint inhibitors, B cells, T cells, T helper cells, DRUG side effects
Abstract

Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of advanced malignancies, but come with a diverse spectrum of immune-related adverse events (irAEs). Mechanistic studies can aid the transition from expert-opinion to evidence-based irAE treatment strategies. We aimed to longitudinally characterize peripheral blood T and B cell dynamics in ICI-treated patients by multicolor flow cytometry and serum multiplex immunoassay at baseline, ± 3 weeks and ± 6 weeks or upon clinically relevant irAEs. We analyzed samples from 44 ICI-treated patients (24 anti-PD-1 monotherapy, 20 combined anti-PD-1/anti-CTLA-4; cICI), of whom 21 developed irAEs, and 10 healthy donors. IrAEs after cICI were characterized by significantly enhanced proliferation of Th1-associated, mainly (CD4+) CD27− effector memory T cells, as well as Th17-associated immune responses and germinal center activation (reflected by CXCL13 and IL-21 increases). We observed no changes in CD21lo, memory, class-switched or newly activated B cell subsets. Particularly double-positive PD-1+LAG-3+ CD8+ T cells showed enhanced cytotoxic capacity in patients with irAEs after cICI. Within anti-PD-1 monotherapy, irAEs were associated with modestly enhanced Th1-associated responses reflected by increased serum CXCL9 and CXCL10. In conclusion, ICI-induced toxicity is dominated by enhanced Th1-associated responses, but in cICI we also found evidence for Th17-associated responses and germinal center activation. Together, our data add to the growing body of evidence that irAEs may be driven by newly activated CD4+ helper T cells, specifically after cICI. This study also supports tailored irAE treatment, based on ICI regimen, and to deploy specific strategies such as Th17 inhibition especially in cICI-associated irAEs. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

Author

von Richthofen, Helen J., primary, Westerlaken, Geertje H.A., additional, Gollnast, Doron, additional, Besteman, Sjanna, additional, Delemarre, Eveline M., additional, Rodenburg, Karlijn, additional, Moerer, Petra, additional, Stapels, Daphne A.C., additional, Andiappan, Anand K., additional, Rötzschke, Olaf, additional, Nierkens, Stefan, additional, Leavis, Helen L., additional, Bont, Louis J., additional, Rooijakkers, Suzan H.M., additional, and Meyaard, Linde, additional

Published
2023
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32. Long‐term expanding human airway organoids for disease modeling

Author

Sachs, Norman, Papaspyropoulos, Angelos, Zomer‐van Ommen, Domenique D, Heo, Inha, Böttinger, Lena, Klay, Dymph, Weeber, Fleur, Huelsz‐Prince, Guizela, Iakobachvili, Nino, Amatngalim, Gimano D, de Ligt, Joep, van Hoeck, Arne, Proost, Natalie, Viveen, Marco C, Lyubimova, Anna, Teeven, Luc, Derakhshan, Sepideh, Korving, Jeroen, Begthel, Harry, Dekkers, Johanna F, Kumawat, Kuldeep, Ramos, Emilio, van Oosterhout, Matthijs FM, Offerhaus, G Johan, Wiener, Dominique J, Olimpio, Eduardo P, Dijkstra, Krijn K, Smit, Egbert F, van der Linden, Maarten, Jaksani, Sridevi, van de Ven, Marieke, Jonkers, Jos, Rios, Anne C, Voest, Emile E, van Moorsel, Coline HM, van der Ent, Cornelis K, Cuppen, Edwin, van Oudenaarden, Alexander, Coenjaerts, Frank E, Meyaard, Linde, Bont, Louis J, Peters, Peter J, Tans, Sander J, van Zon, Jeroen S, Boj, Sylvia F, Vries, Robert G, Beekman, Jeffrey M, and Clevers, Hans

Published
2019
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39. CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Author

Pascoal Ramos, M. Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, van der Vlist, Michiel, Pascoal Ramos, M. Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, and van der Vlist, Michiel

Published
2022

40. CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Author

Sub Theoretical Biology, Theoretical Biology and Bioinformatics, Pascoal Ramos, M. Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, van der Vlist, Michiel, Sub Theoretical Biology, Theoretical Biology and Bioinformatics, Pascoal Ramos, M. Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, and van der Vlist, Michiel

Published
2022

42. Differential isoform expression of Allergin-1 during acute and chronic inflammation

Author

CTI Meyaard, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, CTI, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Cancer, Geerdink, Ruben J., Pascoal Ramos, Maria Inês, van den Hoogen, Luuk L., Radstake, Timothy R.D.J., Shibayama, Shiro, Shibuya, Akira, Bont, Louis, Meyaard, Linde, CTI Meyaard, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, CTI, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Cancer, Geerdink, Ruben J., Pascoal Ramos, Maria Inês, van den Hoogen, Luuk L., Radstake, Timothy R.D.J., Shibayama, Shiro, Shibuya, Akira, Bont, Louis, and Meyaard, Linde

Published
2022

43. Recurrent respiratory syncytial virus infection in a CD14 deficient patient

Author

Arts-assistenten Kinderen, Longziekten onderzoek 2, Child Health, CTI Meyaard, Genetica Groep Van Haaften, Cancer, Genetica Sectie Research, Onderzoek, Regenerative Medicine and Stem Cells, CTI, Infection & Immunity, CDL Patiëntenzorg MI, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, Bont, Louis J, Arts-assistenten Kinderen, Longziekten onderzoek 2, Child Health, CTI Meyaard, Genetica Groep Van Haaften, Cancer, Genetica Sectie Research, Onderzoek, Regenerative Medicine and Stem Cells, CTI, Infection & Immunity, CDL Patiëntenzorg MI, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, and Bont, Louis J

Published
2022

44. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Author

CTI Eijkelkamp, CTI Van der Vlist, Infection & Immunity, Pathologie Opleiding, Cancer, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, CTI, Child Health, van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, Eijkelkamp, Niels, CTI Eijkelkamp, CTI Van der Vlist, Infection & Immunity, Pathologie Opleiding, Cancer, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, CTI, Child Health, van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, and Eijkelkamp, Niels

Published
2022

45. CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Author

Cancer, Infection & Immunity, CTI Ramos, CTI Meyaard, CTI, CTI Van der Vlist, Pascoal Ramos, M Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, van der Vlist, Michiel, Cancer, Infection & Immunity, CTI Ramos, CTI Meyaard, CTI, CTI Van der Vlist, Pascoal Ramos, M Inês, Keşmir, Can, Stok, Jorn E., Geerdink, Ruben, Satravelas, Nikolaos, Westerlaken, Geertje H.A., Meyaard, Linde, and van der Vlist, Michiel

Published
2022

47. Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient

Author

Besteman, Sjanna B, primary, Phung, Emily, additional, Raeven, Henriette H M, additional, Amatngalim, Gimano D, additional, Rumpret, Matevž, additional, Crabtree, Juliet, additional, Schepp, Rutger M, additional, Rodenburg, Lisa W, additional, Siemonsma, Susanna G, additional, Verleur, Nile, additional, van Slooten, Rianne, additional, Duran, Karen, additional, van Haaften, Gijs W, additional, Beekman, Jeffrey M, additional, Chang, Lauren A, additional, Meyaard, Linde, additional, van der Bruggen, Tjomme, additional, Berbers, Guy A M, additional, Derksen, Nicole, additional, Nierkens, Stefan, additional, Morabito, Kaitlyn M, additional, Ruckwardt, Tracy J, additional, Kurt-Jones, Evelyn A, additional, Golenbock, Douglas, additional, Graham, Barney S, additional, and Bont, Louis J, additional

Published
2022
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48. Soluble signal inhibitory receptor on leukocytes-1 is released from activated neutrophils by proteinase 3 cleavage

Author

von Richthofen, Helen J., primary, Westerlaken, Geertje H.A., additional, Gollnast, Doron, additional, Besteman, Sjanna, additional, Delemarre, Eveline M., additional, Rodenburg, Karlijn, additional, Moerer, Petra, additional, Stapels, Daphne A.C., additional, Andiappan, Anand K., additional, Rötzschke, Olaf, additional, Nierkens, Stefan, additional, Leavis, Helen L., additional, Bont, Louis J., additional, Rooijakkers, Suzan H.M., additional, and Meyaard, Linde, additional

Published
2022
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