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Most children in the United States will spend at least part of their childhood living apart from one of their parents; the child support system is designed to ensure that they nonetheless receive financial support. While the system is largely effective when noncustodial parents have substantial regular earnings, many noncustodial parents, including a disproportionate share of those whose children live in poverty, have limited earnings and ability to pay child support. The system's response to nonpayment is primarily "sticks," that is, threats and punishments. Nonexperimental evaluations of alternative approaches have shown promise. The National Child Support Noncustodial Parent Employment Demonstration (CSPED), a large-scale random-assignment evaluation enrolling more than 10,000 noncustodial parents across 18 locations in eight states, was designed to test the effectiveness of an alternative approach--adjusting child support orders, reducing punitive enforcement, and offering employment and parenting services. We find that CSPED, using carrots in place of sticks, substantially increased the satisfaction of noncustodial parents with child support services, lowered the amount of support owed, and increased noncustodial parents' sense of responsibility for their children. However, CSPED had limited to no effects on child support compliance, child support payments, or employment outcomes.

Second-generation or lignocellulosic biofuels are a tangible source of renewable energy, which is critical to combat climate change by reducing the carbon footprint. Filamentous fungi secrete cellulose-degrading enzymes called cellulases, which are used for production of lignocellulosic biofuels. However, inefficient production of cellulases is a major obstacle for industrial-scale production of second-generation biofuels. We used computational simulations to design and implement synthetic positive feedback loops to increase gene expression of a key transcription factor, CLR-2, that activates a large number of cellulases in a filamentous fungus, Neurospora crassa. Overexpression of CLR-2 reveals previously unappreciated roles of CLR-2 in lignocellulosic gene network, which enabled simultaneous induction of approximately 50% of 78 lignocellulosic degradation-related genes in our engineered Neurospora strains. This engineering results in dramatically increased cellulase activity due to cooperative orchestration of multiple enzymes involved in the cellulose degradation pathway. Our work provides a proof of principle in utilizing mathematical modeling and synthetic biology to improve the efficiency of cellulase synthesis for second-generation biofuel production.

Objective and Background: Previous research shows the benefits of formal child support to children during their childhood; however, the long‐term effect of child support receipt on outcomes as adults has not been studied. This inquiry examines whether adults who received formal child support as children have different labor market outcomes than those who did not. Method: We conducted two sets of analyses with complementary strengths to examine young adults' earnings and employment status. Our primary method exploited experimental variation in child support receipt among welfare participants, as part of the Wisconsin Child Support Demonstration Evaluation; the secondary analyses used propensity score matching to construct statistically equivalent comparison groups drawn from a broader population included in Wisconsin Court Record Data. Results: Across both studies, we found the receipt of child support was associated with a substantive and statistically significant increase in adult earnings; results for employment status were mixed. Conclusion: Findings suggest that formal child support may disrupt patterns of intergenerational disadvantage, reducing the economic vulnerability of children living with resident mothers, and then improving those children's earnings as adults. In addition to contributing to our understanding of the relationship between childhood economic status and adult outcomes, the findings provide critical new information to policymakers assessing family policy. [ABSTRACT FROM AUTHOR]