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198 results on '"Meyer, J.E."'

12. Safety of Dose Escalation for Pancreatic Cancer Using a Uni-Directional, Pd-103 Implantable Radiation Device: Results of a Phase I Trial

Author

Meyer, J.E., primary, Wang, D., additional, Reddy, S.S., additional, Todor, D.A., additional, Amini, A., additional, Fields, E.C., additional, Price, R.A., additional, Gnerlich, J.L., additional, Sckolnik, S.E., additional, Smith, E., additional, Kaplan, B., additional, Zakris, E.L., additional, Sanford, R., additional, Turian, J.V., additional, Crossan, P.D., additional, Mesleh, M.G., additional, and Laureckas, R.P., additional

Published
2021
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20. Adaptive Radiation Therapy (ART) of Spinal Metastases: Motion between a Rock and a Hard Place.

Author

Freeman, R.H., Meyer, J.E., Hallman, M.A., Horwitz, E.M., Shulman, R.M., Kumar, S.S., Wong, J.K., Ma, C.M.C., Eldib, A., Panetta, J., Lukez, A., and Galloway, T.J.

Subjects
*STEREOTACTIC radiotherapy, *THORACIC vertebrae, *CAUDA equina, *LARGE intestine, *DRUG dosage
Abstract

Online adaptive radiation therapy (ART) is a treatment technique in which imaging and replanning is performed in the treatment room with the patient in the treatment position immediately prior to each fraction. A scheduled plan (developed using the treatment plan from simulation and on-board imaging) is then compared to an adaptive plan (created with updated contours based on this imaging) for final selection dependent on clinical goals. Whether this would be meaningful in the treatment of spine targets is unknown. We retrospectively review the ART delivered to patients with spinal metastases at our institution and hypothesize that adaptation would decrease dose to organs at risk (OARs). This was a single institution retrospective analysis of patients with vertebral body metastases treated with Online Adaptive Stereotactic Body Radiation Therapy (OA-SBRT) on an online adaptive CT-guided linear accelerator from 3/21/23 to 8/25/23. The prescribed dose per fraction (d/fx) ranged from 6 to 10 Gy and patients received either 3 or 5 fractions total. In our analysis, comparisons were made among each fraction with an assessment of both the scheduled and adaptive plans for target coverage and dose to OARs. A total of 28 fractions were delivered. A majority of the fractions were to the thoracic spine (n = 19, 68%). The adaptive plan was chosen in 20/28 (71%) treatments including 14/19 (74%) of patients with T-spine targets. The most common recorded reason for adaptation was less dose to the esophagus (55% of the adapted fractions) followed by superior target coverage (45%). The mean percentage of the d/fx achieved was 100.2% (90.5 - 110.4%) for scheduled and 99.5% (94.9 – 103.1%) for adaptive plans. The mean reduction in maximum point dose to the esophagus, when comparing scheduled to adaptive plans for each adapted fraction chosen, was 11.4% (0.9 – 22.6%, 0.1 – 1.72 Gy). 16/19 (84.2%) of the fractions delivered to the T-spine had a reduced dose to the esophagus in the adaptive plan when compared to the scheduled (regardless of whether the adaptive plan or scheduled plan was selected). 2/19 (10.5%) fractions were adapted for less maximum point dose to the spinal cord and the mean dose reduction when comparing the adaptive to scheduled plans were 4.6% and 19.3% (.35 and 1.4 Gy) for these fractions. Other OARs that were adapted for reduced dose included trachea, lung, cauda equina, and stomach. The following OARs were not adapted for given negligible differences in dose between the scheduled and adapted plans: heart, skin, bronchial tree, small bowel, and large bowel. OA-SBRT decreases the dose to the esophagus in a majority of T-spine targets. Almost half of patients achieve better target coverage with ART to an extent deemed meaningful by the treating physician. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Prospective Blinded Study of The Validity of Radiation Oncology Chart Rounds as an Effective Quality Assurance Process

Author

Hansen, C.C., primary, Paly, J.J., additional, Wong, J.K., additional, Price, R.A., additional, Konopka, M.A., additional, Young, M., additional, Cohen, R.J., additional, Anderson, P.R., additional, Howell, K.J., additional, Hallman, M.A., additional, Sobczak, M.L., additional, Kumar, S.S., additional, Meyer, J.E., additional, Hayes, S.B., additional, Galloway, T.J., additional, Weiss, S.E., additional, and Horwitz, E.M., additional

Published
2020
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23. Hypofractionated Short Course Radiation Treatment Results in Systemic Immune Activation and Upregulation of the PD-1/PD-L1 Exhaustion Axis: A Prospective Pilot Study in Early Stage Prostate Cancer Patients

Author

Wong, J.K., primary, MacFarlane, A., additional, Devarajan, K., additional, Shulman, R.M., additional, Alpaugh, R.K., additional, Burbure, N., additional, Hallman, M.A., additional, Geynisman, D.M., additional, Horwitz, E.M., additional, Campbell, K., additional, and Meyer, J.E., additional

Published
2020
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27. Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors

Author

Lee, J.C., Villanueva-Meyer, J.E., Ferris, S.P., Cham, E.M., Zucker, J., Cooney, T., Gilani, A., Kleinschmidt-DeMasters, B.K., Trembath, D., Mafra, M., Chiang, J., Ellison, D.W., Cho, S.J., Horvai, A.E., Ziffle, J. Van, Onodera, C., Devine, P., Grenert, J.P., Voijs, C.M.A., Blokland, W.T.M. van, Leng, W.W.J. de, Ploegmakers, M.J., Flucke, U.E., Pekmezci, M., Bollen, A.W., Tihan, T., Koelsche, C., Deimling, A. von, Wesseling, P., Solomon, D.A., Perry, A., Lee, J.C., Villanueva-Meyer, J.E., Ferris, S.P., Cham, E.M., Zucker, J., Cooney, T., Gilani, A., Kleinschmidt-DeMasters, B.K., Trembath, D., Mafra, M., Chiang, J., Ellison, D.W., Cho, S.J., Horvai, A.E., Ziffle, J. Van, Onodera, C., Devine, P., Grenert, J.P., Voijs, C.M.A., Blokland, W.T.M. van, Leng, W.W.J. de, Ploegmakers, M.J., Flucke, U.E., Pekmezci, M., Bollen, A.W., Tihan, T., Koelsche, C., Deimling, A. von, Wesseling, P., Solomon, D.A., and Perry, A.

Abstract

Contains fulltext : 219243.pdf (Publisher’s version ) (Closed access), Desmoplastic small round cell tumors (DSRCTs) are highly aggressive sarcomas that most commonly occur intra-abdominally, and are defined by EWSR1-WT1 gene fusion. Intracranial DSRCTs are exceptionally rare with only seven previously reported fusion-positive cases. Herein, we evaluate the clinical, morphologic, immunohistochemical and molecular features of five additional examples. All patients were male (age range 6-25 years; median 11 years), with four tumors located supratentorially and one within the posterior fossa. The histologic features were highly variable including small cell, embryonal, clear cell, rhabdoid, anaplastic and glioma-like appearances. A prominent desmoplastic stroma was seen in only two cases. The mitotic index ranged from <1 to 12/10 HPF (median 5). While all tumors showed strong desmin positivity, epithelial markers such as EMA, CAM 5.2 and other keratins were strongly positive in only one, focally positive in two and negative in two cases. EWSR1-WT1 gene fusion was present in all cases, with accompanying mutations in the TERT promoter or STAG2 gene in individual cases. Given the significant histologic diversity, in the absence of genetic evaluation these cases could easily be misinterpreted as other entities. Desmin immunostaining is a useful initial screening method for consideration of a DSRCT diagnosis, prompting confirmatory molecular testing. Demonstrating the presence of an EWSR1-WT1 fusion provides a definitive diagnosis of DSRCT. Genome-wide methylation profiles of intracranial DSRCTs matched those of extracranial DSRCTs. Thus, despite the occasionally unusual histologic features and immunoprofile, intracranial DSRCTs likely represent a similar, if not the same, entity as their soft tissue counterpart based on the shared fusion and methylation profiles.

Published
2020

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