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3. Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

Author

Williams, Wilton B., Meyerhoff, R. Ryan, Edwards, R.J., Li, Hui, Manne, Kartik, Nicely, Nathan I., Henderson, Rory, Zhou, Ye, Janowska, Katarzyna, Mansouri, Katayoun, Gobeil, Sophie, Evangelous, Tyler, Hora, Bhavna, Berry, Madison, Abuahmad, A. Yousef, Sprenz, Jordan, Deyton, Margaret, Stalls, Victoria, Kopp, Megan, Hsu, Allen L., Borgnia, Mario J., Stewart-Jones, Guillaume B.E., Lee, Matthew S., Bronkema, Naomi, Moody, M. Anthony, Wiehe, Kevin, Bradley, Todd, Alam, S. Munir, Parks, Robert J., Foulger, Andrew, Oguin, Thomas, Sempowski, Gregory D., Bonsignori, Mattia, LaBranche, Celia C., Montefiori, David C., Seaman, Michael, Santra, Sampa, Perfect, John, Francica, Joseph R., Lynn, Geoffrey M., Aussedat, Baptiste, Walkowicz, William E., Laga, Richard, Kelsoe, Garnett, Saunders, Kevin O., Fera, Daniela, Kwong, Peter D., Seder, Robert A., Bartesaghi, Alberto, Shaw, George M., Acharya, Priyamvada, and Haynes, Barton F.

Published
2021
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7. Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

Author

Bonsignori, Mattia, Kreider, Edward F., Fera, Daniela, Meyerhoff, R. Ryan, Bradley, Todd, Wiehe, Kevin, Alam, S. Munir, Aussedat, Baptiste, Walkowicz, William E., Hwang, Kwan-Ki, Saunders, Kevin O., Zhang, Ruijun, Gladden, Morgan A., Monroe, Anthony, Kumar, Amit, Xia, Shi-Mao, Cooper, Melissa, Louder, Mark K., McKee, Krisha, Bailer, Robert T., Pier, Brendan W., Jette, Claudia A., Kelsoe, Garnett, Williams, Wilton B., Morris, Lynn, Kappes, John, Wagh, Kshitij, Kamanga, Gift, Cohen, Myron S., Hraber, Peter T., Montefiori, David C., Trama, Ashley, Liao, Hua-Xin, Kepler, Thomas B., Moody, M. Anthony, Gao, Feng, Danishefsky, Samuel J., Mascola, John R., Shaw, George M., Hahn, Beatrice H., Harrison, Stephen C., Korber, Bette T., and Haynes, Barton F.

Published
2017
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9. Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

Author

Williams, Wilton B., primary, Meyerhoff, R. Ryan, additional, Edwards, RJ, additional, Li, Hui, additional, Nicely, Nathan I., additional, Henderson, Rory, additional, Zhou, Ye, additional, Janowska, Katarzyna, additional, Mansouri, Katayoun, additional, Manne, Kartik, additional, Stalls, Victoria, additional, Hsu, Allen L., additional, Borgnia, Mario J., additional, Stewart-Jones, Guillaume, additional, Lee, Matthew S., additional, Bronkema, Naomi, additional, Perfect, John, additional, Moody, M. Anthony, additional, Wiehe, Kevin, additional, Bradley, Todd, additional, Kepler, Thomas B., additional, Alam, S. Munir, additional, Parks, Robert J., additional, Foulger, Andrew, additional, Bonsignori, Mattia, additional, LaBranche, Celia C., additional, Montefiori, David C., additional, Seaman, Michael, additional, Santra, Sampa, additional, Francica, Joseph R., additional, Lynn, Geoffrey M., additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Laga, Richard, additional, Kelsoe, Garnett, additional, Saunders, Kevin O., additional, Fera, Daniela, additional, Kwong, Peter D., additional, Seder, Robert A., additional, Bartesaghi, Alberto, additional, Shaw, George M., additional, Acharya, Priyamvada, additional, and Haynes, Barton F., additional

Published
2020
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10. A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

Author

Acharya, Priyamvada, primary, Williams, Wilton, additional, Henderson, Rory, additional, Janowska, Katarzyna, additional, Manne, Kartik, additional, Parks, Robert, additional, Deyton, Margaret, additional, Sprenz, Jordan, additional, Stalls, Victoria, additional, Kopp, Megan, additional, Mansouri, Katayoun, additional, Edwards, Robert J, additional, Meyerhoff, R. Ryan, additional, Oguin, Thomas, additional, Sempowski, Gregory, additional, Saunders, Kevin, additional, and Haynes, Barton F., additional

Published
2020
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12. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, primary, Lee, Matthew S., additional, Wiehe, Kevin, additional, Meyerhoff, R. Ryan, additional, Piai, Alessandro, additional, Bonsignori, Mattia, additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Ton, Therese, additional, Zhou, Jeffrey O., additional, Danishefsky, Samuel, additional, Haynes, Barton F., additional, and Harrison, Stephen C., additional

Published
2018
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13. Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

Author

Wiehe, Kevin, primary, Bradley, Todd, additional, Meyerhoff, R. Ryan, additional, Hart, Connor, additional, Williams, Wilton, additional, Easterhoff, David, additional, Faison, William J., additional, Kepler, Thomas B., additional, Saunders, Kevin, additional, Alam, S. Munir, additional, Bonsignori, Mattia, additional, and Haynes, Barton F., additional

Published
2018
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14. HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies

Author

Meyerhoff, R. Ryan, primary, Scearce, Richard M., additional, Ogburn, Damon F., additional, Lockwood, Brad, additional, Pickeral, Joy, additional, Kuraoka, Masa, additional, Anasti, Kara, additional, Eudailey, Joshua, additional, Eaton, Amanda, additional, Cooper, Melissa, additional, Wiehe, Kevin, additional, Montefiori, David C., additional, Tomaras, Georgia, additional, Ferrari, Guido, additional, Alam, S. Munir, additional, Liao, Hua-Xin, additional, Korber, Bette, additional, Gao, Feng, additional, and Haynes, Barton F., additional

Published
2017
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15. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

Author

Alam, S. Munir, primary, Aussedat, Baptiste, additional, Vohra, Yusuf, additional, Meyerhoff, R. Ryan, additional, Cale, Evan M., additional, Walkowicz, William E., additional, Radakovich, Nathan A., additional, Anasti, Kara, additional, Armand, Lawrence, additional, Parks, Robert, additional, Sutherland, Laura, additional, Scearce, Richard, additional, Joyce, M. Gordon, additional, Pancera, Marie, additional, Druz, Aliaksandr, additional, Georgiev, Ivelin S., additional, Von Holle, Tarra, additional, Eaton, Amanda, additional, Fox, Christopher, additional, Reed, Steven G., additional, Louder, Mark, additional, Bailer, Robert T., additional, Morris, Lynn, additional, Abdool-Karim, Salim S., additional, Cohen, Myron, additional, Liao, Hua-Xin, additional, Montefiori, David C., additional, Park, Peter K., additional, Fernández-Tejada, Alberto, additional, Wiehe, Kevin, additional, Santra, Sampa, additional, Kepler, Thomas B., additional, Saunders, Kevin O., additional, Sodroski, Joseph, additional, Kwong, Peter D., additional, Mascola, John R., additional, Bonsignori, Mattia, additional, Moody, M. Anthony, additional, Danishefsky, Samuel, additional, and Haynes, Barton F., additional

Published
2017
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16. Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

Author

Saunders, Kevin O., primary, Nicely, Nathan I., additional, Wiehe, Kevin, additional, Bonsignori, Mattia, additional, Meyerhoff, R. Ryan, additional, Parks, Robert, additional, Walkowicz, William E., additional, Aussedat, Baptiste, additional, Wu, Nelson R., additional, Cai, Fangping, additional, Vohra, Yusuf, additional, Park, Peter K., additional, Eaton, Amanda, additional, Go, Eden P., additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Barouch, Dan H., additional, Zhang, Ruijun, additional, Von Holle, Tarra, additional, Overman, R. Glenn, additional, Anasti, Kara, additional, Sanders, Rogier W., additional, Moody, M. Anthony, additional, Kepler, Thomas B., additional, Korber, Bette, additional, Desaire, Heather, additional, Santra, Sampa, additional, Letvin, Norman L., additional, Nabel, Gary J., additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Liao, Hua-Xin, additional, Alam, S. Munir, additional, Danishefsky, Samuel J., additional, and Haynes, Barton F., additional

Published
2017
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17. Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques

Author

Moody, M. Anthony, primary, Santra, Sampa, additional, Vandergrift, Nathan A., additional, Sutherland, Laura L., additional, Gurley, Thaddeus C., additional, Drinker, Mark S., additional, Allen, Ashley A., additional, Xia, Shi-Mao, additional, Meyerhoff, R. Ryan, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Easterhoff, David, additional, Alam, S. Munir, additional, Liao, Hua-Xin, additional, Ward, Brandy M., additional, Ferrari, Guido, additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Seder, Robert A., additional, Letvin, Norman L., additional, and Haynes, Barton F., additional

Published
2014
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18. HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

Author

Moody, M. Anthony, primary, Yates, Nicole L., additional, Amos, Joshua D., additional, Drinker, Mark S., additional, Eudailey, Joshua A., additional, Gurley, Thaddeus C., additional, Marshall, Dawn J., additional, Whitesides, John F., additional, Chen, Xi, additional, Foulger, Andrew, additional, Yu, Jae-Sung, additional, Zhang, Ruijun, additional, Meyerhoff, R. Ryan, additional, Parks, Robert, additional, Scull, Julia Cavanaugh, additional, Wang, Lu, additional, Vandergrift, Nathan A., additional, Pickeral, Joy, additional, Pollara, Justin, additional, Kelsoe, Garnett, additional, Alam, S. Munir, additional, Ferrari, Guido, additional, Montefiori, David C., additional, Voss, Gerald, additional, Liao, Hua-Xin, additional, Tomaras, Georgia D., additional, and Haynes, Barton F., additional

Published
2012
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19. H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination

Author

Moody, M. Anthony, primary, Zhang, Ruijun, additional, Walter, Emmanuel B., additional, Woods, Christopher W., additional, Ginsburg, Geoffrey S., additional, McClain, Micah T., additional, Denny, Thomas N., additional, Chen, Xi, additional, Munshaw, Supriya, additional, Marshall, Dawn J., additional, Whitesides, John F., additional, Drinker, Mark S., additional, Amos, Joshua D., additional, Gurley, Thaddeus C., additional, Eudailey, Joshua A., additional, Foulger, Andrew, additional, DeRosa, Katherine R., additional, Parks, Robert, additional, Meyerhoff, R. Ryan, additional, Yu, Jae-Sung, additional, Kozink, Daniel M., additional, Barefoot, Brice E., additional, Ramsburg, Elizabeth A., additional, Khurana, Surender, additional, Golding, Hana, additional, Vandergrift, Nathan A., additional, Alam, S. Munir, additional, Tomaras, Georgia D., additional, Kepler, Thomas B., additional, Kelsoe, Garnett, additional, Liao, Hua-Xin, additional, and Haynes, Barton F., additional

Published
2011
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20. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, Wiehe, Kevin, Meyerhoff, R. Ryan, Bonsignori, Mattia, Aussedat, Baptiste, Walkowicz, William E., Ton, Therese, Zhou, Jeffrey O., Danishefsky, Samuel, Haynes, Barton F., Lee, Matthew, Piai, Alessandro, and Harrison, Stephen

Abstract

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage (“DH270”), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs—the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen., Version of Record

Published
2018
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21. A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies.

Author

Acharya P, Williams W, Henderson R, Janowska K, Manne K, Parks R, Deyton M, Sprenz J, Stalls V, Kopp M, Mansouri K, Edwards RJ, Meyerhoff RR, Oguin T, Sempowski G, Saunders K, and Haynes BF

Abstract

The COVID-19 pandemic caused by SARS-CoV-2 has escalated into a global crisis. The spike (S) protein that mediates cell entry and membrane fusion is the current focus of vaccine and therapeutic antibody development efforts. The S protein, like many other viral fusion proteins such as HIV-1 envelope (Env) and influenza hemagglutinin, is glycosylated with both complex and high mannose glycans. Here we demonstrate binding to the SARS-CoV-2 S protein by a category of Fab-dimerized glycan-reactive (FDG) HIV-1-induced broadly neutralizing antibodies (bnAbs). A 3.1 Å resolution cryo-EM structure of the S protein ectodomain bound to glycan-dependent HIV-1 bnAb 2G12 revealed a quaternary glycan epitope on the spike S2 domain involving multiple protomers. These data reveal a new epitope on the SARS-CoV-2 spike that can be targeted for vaccine design., Highlights: Fab-dimerized, glycan-reactive (FDG) HIV-1 bnAbs cross-react with SARS-CoV-2 spike.3.1 Å resolution cryo-EM structure reveals quaternary S2 epitope for HIV-1 bnAb 2G12.2G12 targets glycans, at positions 709, 717 and 801, in the SARS-CoV-2 spike.Our studies suggest a common epitope for FDG antibodies centered around glycan 709.

Published
2020
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