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Dyslipidemia due to genetic and multifactorial dyslipidemia has a predisposition to early-onset atherosclerotic cardiovascular disease (ASCVD), and consensus and guidelines regarding lipid lowering in adults are well established, but the benefits of lipid screening and treatment in childhood and adolescence for this population are not well established. The United States Preventive Medicine Task Force (USPSTF) issued the Recommendation Statement: Screening for Dyslipidemia in Children and Adolescents based on a systematic review of evidence with meta-analysis conducted in a large number of randomized controlled trials, large cohort studies in European and American countries, with the aim of assessing evidences whether initiation of lipid screening and early initiation of treatment in childhood and adolescence has long-term benefits for this population. This article provides a detailed interpretation of the guideline, which aims to provide reference to clinical healthcare workers to improve the understanding of dyslipidaemia in children and to decide whether to screen them with a view to reducing the incidence of cardiovascular disease in adulthood.

In order to study the effect of heat treatment in air on the hydrogen permeation in/through Pd membrane, Pd membrane was deposited via the electroless plating method and the hydrogen permeation flux of Pd membrane before and after heat treatment in air at 573 K was measured. The membranes were characterized by XRD, SEM, AFM and hydrogen permeation tests. The results show that Pd membrane is compact and defect-free and has a thickness of 5 μm. The hydrogen permeability of Pd membrane at 673 K, 723 K and 773 K are 3.62×10-9, 5.12×10-9 mol/(m·s·Pa0.5) and 6.80×10-9 mol/(m·s·Pa0.5), respectively. The membrane treated in air at 573 K has higher surface roughness, larger surface area and more dissociation adsorption sites than the as-deposited membrane, thus improving the hydrogen permeability of the Pd membrane. After heat treatment, the hydrogen permeability of Pd membrane at 673, 723 K and 773 K are 5.32×10-9, 6.44×10-9 mol/(m·s·Pa0.5) and 7.31×10-9 mol/(m·s·Pa0.5), respectively. The hydrogen permeability of such Pd membrane is 1.1-1.5 times higher than that of the as-deposited one.

By connecting the consumption and demand of the city and the countryside through the use of e-commerce platforms and logistics as an intermediary bridge, this study creates a model for the synergistic growth of rural e-commerce and logistics. A multi-dimensional index system is created by combining the actual state of rural e-commerce and logistics, using Shaanxi Province as an example. The degree of coordination between logistics and e-commerce can be ascertained by applying the coupling coordination model. Determine the weights of the indicators to solve for the level of coordinated development, the degree of linked coordination, the degree of rural e-commerce and logistics coupling, and the coordination level of each year using the entropy value technique. Together with the gray correlation degree, we will examine the crucial elements of optimizing the logistics chain for rural e-commerce. According to the study, rural e-commerce and logistics have a coupling coordination degree of 0.0913 in 2010 and 0.6347 in 2019. The degree of coupling coordination between the two is increasing, indicating a major coordination degree in 2019.

Over the past few decades, there have been advancements in the development of high‐performance tissue adhesives as alternatives to traditional sutures and staples for rapid and effective wound closure post‐surgery. While tissue adhesives offer advantages such as ease of use, short application time, and minimal tissue damage, they also face challenges related to biocompatibility, biodegradability, and adhesive strength. In this study, L‐lysine diisocyanate (LDI) and trimethylolpropane (TMP) were utilized as the primary raw materials to produce a prepolymer terminated with NCO, resulting in the development of a new biocompatible polyurethane tissue adhesive (TMP‐LDI). Additionally, SiO2 nanoparticles were incorporated into the prepolymer, significantly enhancing the adhesive strength of the TMP‐LDI tissue adhesive through the "nanobridging effect," achieving a strength of 170.4 kPa. Furthermore, the SiO2/TMP‐LDI tissue adhesive exhibited satisfactory temperature change during curing and degradation performance. In vitro and in vivo studies demonstrated that SiO2/TMP‐LDI exhibited good biocompatibility, efficient hemostasis, antimicrobial properties, and the ability to promote wound healing. This research presents a novel approach for the development of tissue adhesives with superior adhesive performance. [ABSTRACT FROM AUTHOR]

BACKGROUND: Endurance training can have a negative impact on strength training and may lead to reduced strength gains, known as the interference effect. However, high-intensity interval training (HIIT) as an endurance training mode may reduce this interference effect. OBJECTIVE: This systematic review and meta-analysis aim to investigate the effects of concurrent HIIT and resistance training (RT) on lower body explosive strength and maximum strength. METHODS: Five electronic databases were searched. Subgroup analyses were performed to assess the effects of HIIT modality, training status, and training duration on strength development following concurrent HIIT and RT. RESULTS: Meta-analysis showed that compared to RT alone, concurrent HIIT and RT will not affect the development of countermovement jump (CMJ) (WMD = - 0.17, 95%CI = - 1.45 to - 1.11) and half squat (WMD = - 0.05, 95%CI = - 2.42 to 2.32). Further, subgroup analysis revealed that HIIT-running workout was conducive to the development of both CMJ and half squat. Longer training duration was found to be more effective in developing CMJ, while shorter training duration was more suitable for developing half squat. Additionally, athletes showed greater improvement than non-athletes. CONCLUSIONS: Combining HIIT and RT can enhance CMJ and half squat. The results of intervention are moderated by training variables and training status. [ABSTRACT FROM AUTHOR]

The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an in vivo selection strategy to identify RNA aptamers (targeting motifs) that could localize to tumor in situ. One of the selected molecules is an aptamer that binds to the protein DHX9, an RNA helicase that is known to be upregulated in colorectal cancer. Upon systemic administration, the aptamer preferentially localized to the nucleus of cancer cells in vivo and thus has the potential to be used for targeted delivery.