1. The Evolution of Kidney Graft Preservation Through the Years.
- Author
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Calva Lopez, Andres, Robles Garcia, Jose Enrique, Yanez Ruiz, Carlos Andres, Tapia Tapia, Mario Daniel, Talavera Cobo, Vanessa, Muñoz Bastidas, Carmina Alejandra, Sanchez Zalabardo, Daniel, and Miñana Lopez, Bernardino
- Subjects
CHRONIC kidney failure ,TECHNOLOGICAL innovations ,KIDNEY transplantation ,COLD storage ,GRAFT survival - Abstract
Chronic kidney disease (CKD) is a prevalent disease affecting almost 10% of the world's population, with many cases progressing to end-stage kidney disease (ESKD). Kidney transplantation (KT) is the gold-standard treatment for ESKD. Due to growing KT waitlists, the deceased kidney donor (DKDs) criteria have expanded to increase the number of available kidney grafts. Kidney graft preservation ensures optimal graft function after KT. Static cold storage (SCS) as a preservation method is still widely used. Hypothermic machine perfusion (HMP) has proven to decrease delayed graft function (DGF) and increase graft survival. Most recent studies advocate for the use of HMP regardless of donor type. However, emerging technologies, such as hypothermic oxygenated machine perfusion (HOPE) and normothermic machine perfusion (NMP), have shown promising results in specific scenarios. This review aims to provide a summary of the well-established kidney graft preservation methods and their outcomes, as well as novel technological advances that allow for newer preservation strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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