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Mounting evidence demonstrates that hydrogen sulfide (H2S) promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells (ECs). This study aims to investigate the favorable action of H2S on endothelial function in senescence by inhibiting the production of inflammatory molecules. Senescent ECs exhibit a reduction in H 2S, endothelial nitric oxide synthase (eNOS) and peroxisome proliferator-activated receptor δ (PPARδ), coupled with increased inflammatory molecules, sodium glucose transporter type 2 (SGLT2) and phosphorylation of STAT3, which could be reversed by the administration of a slow but sustained release agent of H2S, GYY4137. Decreased production of eNOS and upregulated p-STAT3 and SGLT2 levels in senescent ECs are reversed by replenishment of the SGLT2 inhibitor EMPA and the PPARδ agonist GW501516. The PPARδ antagonist GSK0660 attenuates eNOS expression and increases the production of p-STAT3 and SGLT2. However, supplementation with GYY4137 has no beneficial effect on GSK0660-treated ECs. GYY4137, GW501516 and EMPA preserve endothelial-dependent relaxation (EDR) in D-gal-treated aortae, while GSK0660 destroys aortic relaxation even with GYY4137 supplementation. In summary, senescent ECs manifest aggravated the expressions of the inflammatory molecules SGLT2 and p-STAT3 and decreased the productions of PPARδ, eNOS and CSE. H2S ameliorates endothelial dysfunction through the anti-inflammatory effect of the PPARδ/SGLT2/p-STAT3 signaling pathway in senescent ECs and may be a potential therapeutic target for anti-ageing treatment.

To promote the construction of ecological civilization and fundamentally solve ecological and environmental problems, it is necessary to form green and low-carbon production and lifestyle. This article focuses on the cognitive system of green and low-carbon production methods and lifestyles, analyzes the key elements of green and low-carbon production methods and lifestyle systems, and proposes typical scenarios and models of energy and electricity promoting terminal green energy consumption from an energy perspective. Based on economic and social perspectives, it constructs green cost guidance mechanisms and green behavior training mechanisms to comprehensively support the development of green and low-carbon production methods and lifestyles, and accelerate the construction of a green background for ecological civilization.

Contrast-induced acute kidney injury (CI-AKI) is an important complication following the use of iodinated contrast media. Bilirubin has a protective effect but may also aggravate CI-AKI. The purpose of this systematic review was to assess whether bilirubin is a risk factor for CI-AKI. We searched the databases PubMed, Embase, Web of Science, Cochrane Library, Scopus, Ovid Medline, CNKI (China National Knowledge Infrastructure), VPCS (Vip Paper Check System), Wanfang, and CBM (Chinese BioMedical Literature Database) from the initial date to May 6, 2023. We summarized the results by directly combining the effect-size odds ratio (OR) and 95% confidence interval (CI) and identified sources of heterogeneity through subgroup analysis, sensitivity analysis, and meta-regression analysis. A total of 10 studies (14 data sets) were included: 7 retrospective studies (10 data sets) and 3 prospective studies (4 data sets), involving 12776 participants. The incidence of CI-AKI of 16% (95% CI: 14-19%). Total bilirubin was positively associated with the occurrence of CI-AKI (OR = 1.80; 95% CI: 1.36-2.38). Both low and high bilirubin concentrations were risk factors for CI-AKI. The incidence of CI-AKI was higher in the low bilirubin group than in the high bilirubin group. [ABSTRACT FROM AUTHOR]

This paper summarized the nursing experience of a patient with nerve-root type cervical spondylosis treated by acupoint application therapy, including clinical observation, nursing assessment and operation methods of acupoint application. The Chinese herbal medicine acupoint application is effective to relieve the symptoms of nerve-root type cervical spondylosis, and it has advantages of simple operation, short-term operation period, obvious curative effect, fewer side effects, low cost and higher patient acceptance. (本文总结穴位贴敷疗法干预1例神经根型颈椎病患者的护理经验, 包括临床症状观察、护理评估、穴位贴敷操作方法等。中药穴位贴敷疗法能有效改善患者症状, 且操作简单、效果显著、不良反应少、价格低廉, 易被患者接受。)

The aim of this paper was to share the construction and implementation experience of the green nursing outpatient clinic of Traditional Chinese Medicine (TCM). The TCM nursing outpatient clinic mainly provides appropriate TCM technology, establishes personalized TCM health management archives, carries out health promotion, and improves patient satisfaction. The implementation of nursing clinic meets the diversified needs of patients and improves the level of nursing service and traditional Chinese medicine nursing. (本文探讨了中医护理门诊的建设及实施方法。中医护理门诊主要为患者实施中医适宜技术, 建立个性化中医健康管理档案, 开展健康促进工作, 提高患者满意度。中医护理门诊的建设与实施满足了患者多元化的需求, 有助于提高护理服务质量及中医护理水平。)