1. NMDA receptor binding in focal epilepsies
- Author
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McGinnity, CJ, Koepp, MJ, Hammers, A, Barros, DA Riaño, Pressler, RM, Luthra, S, Jones, PA, Trigg, W, Micallef, C, Symms, MR, Brooks, DJ, and Duncan, JS
- Subjects
Biomedical Imaging ,Epilepsy ,Clinical Research ,Neurosciences ,Brain Disorders ,Neurodegenerative ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Antidepressive Agents ,Brain Mapping ,Carbazoles ,Cross-Sectional Studies ,Drug Interactions ,Drug Resistant Epilepsy ,Electroencephalography ,Epilepsies ,Partial ,Female ,Humans ,Male ,Middle Aged ,Radionuclide Imaging ,Radiopharmaceuticals ,Receptors ,N-Methyl-D-Aspartate ,Young Adult ,DEPRESSION ,EPILEPSY ,NMDA ,PET ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveTo demonstrate altered N-methyl-d-aspartate (NMDA) receptor availability in patients with focal epilepsies using positron emission tomography (PET) and [(18)F]GE-179, a ligand that selectively binds to the open NMDA receptor ion channel, which is thought to be overactive in epilepsy.MethodsEleven patients (median age 33 years, 6 males) with known frequent interictal epileptiform discharges had an [(18)F]GE-179 PET scan, in a cross-sectional study. MRI showed a focal lesion but discordant EEG changes in two, was non-localising with multifocal EEG abnormalities in two, and was normal in the remaining seven patients who all had multifocal EEG changes. Individual patient [(18)F]GE-179 volume-of-distribution (VT) images were compared between individual patients and a group of 10 healthy controls (47 years, 7 males) using Statistical Parametric Mapping.ResultsIndividual analyses revealed a single cluster of focal VT increase in four patients; one with a single and one with multifocal MRI lesions, and two with normal MRIs. Post hoc analysis revealed that, relative to controls, patients not taking antidepressants had globally increased [(18)F]GE-179 VT (+28%; p
- Published
- 2015