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1. Hypercalcemia in Small Lymphocytic Lymphoma with an Elevated Parathyroid Hormone-Related Peptide Associated with Early Richter Transformation

Author

Ashish Bains, Pedro Covas, Olga Timofeeva, and Michael Bromberg

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Hypercalcemia in malignancy is associated with multiple mechanisms and occurs in up to 20–30% of cancer patients. We report a case of small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) associated with hypercalcemia and an elevation in parathyroid hormone-related peptide (PTHrP) in the setting of a Richter transformation. Real-time reverse transcriptase PCR on lymph node biopsy specimens obtained before and after transformation showed an 8-fold increase in PTHrP mRNA levels and about 2-fold decrease in the levels of its cognate receptor PTHR1. The findings of this case suggest that parathyroid hormone-related peptide might be useful in monitoring a specific group of patients with SLL/CLL who develop hypercalcemia during the course of their disease and could suggest an autocrine-like mechanism involving PTHrP in Richter transformation.

Published
2021
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7. Preliminary predictive criteria for COVID-19 cytokine storm

Author

Roberto, Caricchio, Marcello, Gallucci, Chandra, Dass, Xinyan, Zhang, Stefania, Gallucci, David, Fleece, Michael, Bromberg, Gerard J, Criner, Zachary D, Repanshek, Caricchio, R, Gallucci, M, Dass, C, Zhang, X, Gallucci, S, Fleece, D, Bromberg, M, and Criner, G

Subjects
Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), immune system disease, Immunology, Logistic regression, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Cohort Studies, Rheumatology, Risk Factors, Internal medicine, Tissue damage, cytokine, medicine, Humans, Immunology and Allergy, Aged, SARS-CoV-2, business.industry, COVID-19, Middle Aged, medicine.disease, Cytokine release syndrome, inflammation, Macrophage activation syndrome, antirheumatic agent, Cohort, Female, Cytokine Release Syndrome, Cytokine storm, business, Cohort study
Abstract

ObjectivesTo develop predictive criteria for COVID-19-associated cytokine storm (CS), a severe hyperimmune response that results in organ damage in some patients infected with COVID-19. We hypothesised that criteria for inflammation and cell death would predict this type of CS.MethodsWe analysed 513 hospitalised patients who were positive for COVID-19 reverse transcriptase PCR and for ground-glass opacity by chest high-resolution CT. To achieve an early diagnosis, we analysed the laboratory results of the first 7 days of hospitalisation. We implemented logistic regression and principal component analysis to determine the predictive criteria. We used a ‘genetic algorithm’ to derive the cut-offs for each laboratory result. We validated the criteria with a second cohort of 258 patients.ResultsWe found that the criteria for macrophage activation syndrome, haemophagocytic lymphohistiocytosis and the HScore did not identify the COVID-19 cytokine storm (COVID-CS). We developed new predictive criteria, with sensitivity and specificity of 0.85 and 0.80, respectively, comprising three clusters of laboratory results that involve (1) inflammation, (2) cell death and tissue damage, and (3) prerenal electrolyte imbalance. The criteria identified patients with longer hospitalisation and increased mortality. These results highlight the relevance of hyperinflammation and tissue damage in the COVID-CS.ConclusionsWe propose new early predictive criteria to identify the CS occurring in patients with COVID-19. The criteria can be readily used in clinical practice to determine the need for an early therapeutic regimen, block the hyperimmune response and possibly decrease mortality.

Published
2020
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8. Severe Type B Lactic Acidosis in a Rare and Aggressive HIV-Related Lymphoma

Author

John Harwood Scott, Timothy D. Lindsay, Xiaofeng Zhao, Michael Bromberg, and Ashish Bains

Subjects
medicine.medical_specialty, medicine.medical_treatment, Human immunodeficiency virus (HIV), Case Report, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, medicine.disease_cause, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, law, hemic and lymphatic diseases, Internal medicine, medicine, Chemotherapy, business.industry, lcsh:Medical emergencies. Critical care. Intensive care. First aid, lcsh:RC86-88.9, medicine.disease, Intensive care unit, Lymphoma, 030220 oncology & carcinogenesis, Lactic acidosis, Complication, Severe lactic acidosis, business, Plasmablastic lymphoma
Abstract

We describe the prognostic implication and aggressive clinical course of lymphoma-related lactic acidosis in a rare HIV-related lymphoma. Patient was diagnosed with plasmablastic lymphoma and developed severe lactic acidosis, and was treated on the medical floor and in the medical intensive care unit. Her lactic acidosis was considered to be type B, secondary to her underlying lymphoma since she never had an infectious source, hypovolemic state, or low/high cardiac-output state. The mechanism of the lymphoma-related lactic acidosis is from altered cellular metabolism, thought to aid in lymphoma proliferation, rather than tissue hypoperfusion. It is a rare complication of aggressive lymphomas and signifies a poor prognosis. Patients having this complication should be considered for close monitoring and management in an intensive care unit until definitive treatment (i.e., chemotherapy) can be implemented.

Published
2019
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9. Response to: 'Correspondence on 'Preliminary predictive criteria for COVID-19 cytokine storm' by Tampe

Author

Roberto Caricchio, Marcello Gallucci, Chandra Dass, Stefania Gallucci, Michael Bromberg, Gerard J. Criner, Xinyan Zhang, David Fleece, Caricchio, R, Gallucci, M, Dass, C, Zhang, X, Gallucci, S, Fleece, D, Bromberg, M, and Criner, G

Subjects
030203 arthritis & rheumatology, 0301 basic medicine, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, COVID-19, Outcome assessment, medicine.disease, health care, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, inflammation, Internal medicine, Cohort, medicine, Immunology and Allergy, business, Cytokine storm, outcome assessment
Abstract

We thank Tampe et al 1 for their interest in our recent work, in which we describe criteria to predict worse outcome in hospitalised patients with COVID-19 and an hyperinflammatory response that we defined as cytokine storm.2 A limit of our work is that it was based on patients treated in a single hospital. It is, therefore, important that Tampe et al 1 successfully validated our criteria in an independent cohort, from a different continent and a different health system, and therefore it is a step toward criteria that can be applied to other cohorts around the world. We find interesting that when Tampe et al applied the criteria without ferritin and C-reactive protein (CRP), it further improved the ability of …

Published
2020

10. Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center

Author

Parth Rali, Oisin O'Corragain, Lawrence Oresanya, Daohai Yu, Omar Sheriff, Robert Weiss, Catherine Myers, Parag Desai, Nadia Ali, Anthony Stack, Michael Bromberg, Andrea L. Lubitz, Joseph Panaro, Riyaz Bashir, Vladimir Lakhter, Roberto Caricchio, Rohit Gupta, Chandra Dass, Kumaran Maruti, Xiaoning Lu, A. Koneti Rao, Gary Cohen, Gerard J. Criner, Eric T. Choi, Aaron Mishkin, Abbas Abba, Abhijit S. Pathak, Abhinav Rastogi, Adam Diamond, Aditi Satti, Adria Simon, Ahmed Soliman, Alan Braveman, Albert J. Mamary, Aloknath Pandya, Amy Goldberg, Amy Kambo, Andrew Gangemi, Anjali Vaidya, Ann Davison, Anuj Basil, Beata Kosmider, Charles T. Bakhos, Bill Cornwell, Brianna Sanguily, Brittany Corso, Carla Grabianowski, Carly Sedlock, Charles Bakhos, Chenna Kesava Reddy Mandapati, Cherie Erkmen, Chethan Gangireddy, Chih-ru Lin, Christopher T. Burks, Claire Raab, Deborah Crabbe, Crystal Chen, Daniel Edmundowicz, Daniel Sacher, Daniel Salerno, Daniele Simon, David Ambrose, David Ciccolella, Debra Gillman, Dolores Fehrle, Dominic Morano, Donnalynn Bassler, Edmund Cronin, Eduardo Dominguez, Ekam Randhawa, Ekamjeet Randhawa, Eman Hamad, Eneida Male, Erin Narewski, Francis Cordova, Frederic Jaffe, Frederich Kueppers, Fusun Dikengil, Jonathan Galli, Jamie Garfield, Gayle Jones, Gennaro Calendo, Gerard Criner, Gilbert D'Alonzo, Ginny Marmolejos, Matthew Gordon, Gregory Millio, Fernandez Gustavo, Hannah Simborio, Harwood Scott, Heidi Shore-Brown, Hernan Alvarado, Ho-Man Yeung, Ibraheem Yousef, Ifeoma Oriaku, Iris Jung-won Lee, Isaac Whitman, James Brown, Jamie L. Garfield, Janpreet Mokha, Jason Gallagher, Jeffrey Stewart, Jenna Murray, Jessica Tang, Jeyssa Gonzalez, Jichuan Wu, Jiji Thomas, Jim Murrett, Joanna Beros, John M. Travaline, Jolly Varghese, Jordan Senchak, Joseph Lambert, Joseph Ramzy, Joshua Cooper, Jun Song, Junad Chowdhury, Kaitlin Kennedy, Karim Bahmed, Karim Loukmane, Karthik Shenoy, Kathleen Brennan, Keith Johnson, Kevin Carney, Kraftin Schreyer, Kristin Criner, Maruti Kumaran, Lauren Miller, Laurie Jameson, Laurie Johnson, Laurie Kilpatrick, Lii-Yoong Criner, Lily Zhang, Lindsay K. McGann, Llera A. Samuels, Marc Diamon, Margaret Kerper, Maria Vega Sanchez, Mariola Marcinkienwicz, Maritza Pedlar, Mark Aksoy, Mark Weir, Marla R. Wolfson, Marla Wolfson, Robert Marron, Martin Keane, Massa Zantah, Mathew Zheng, Matthew Delfiner, Maulin Patel, Megan Healy, Melinda Darnell, Melissa Navaro, Meredith A. Brisco-Bacik, Michael Gannon, Michael Jacobs, Mira Mandal, Nanzhou Gou, Nathaniel Marchetti, Nathaniel Xander, Navjot Kaur, Neil Nadpara, Nicole Desai, Nicole Mills, Norihisa Shigemura, Ohoud Rehbini, Oneida Arosarena, Osheen Abramian, Paige Stanley, Patrick Mulhall, Pravin Patil, Priju Varghe, Puja Dubal, Puja Patel, Rachael Blair, Rajagopalan Rengan, Rami Alashram, Randol Hooper, Rebecca A. Armbruster, Regina Sheriden, Rogers Thomas, Rohit Soans, Roman Petrov, Roman Prosniak, Romulo Fajardo, Ruchi Bhutani, Ryan Townsend, Sabrina Islam, Samantha Pettigrew, Samantha Wallace, Sameep Sehgal, Samuel Krachman, Santosh Dhungana, Sarah Hoang, Sean Duffy, Seema Rani, Shapiro William, Sheila Weaver, Shelu Benny, Sheril George, Shuang Sun, Shubhra Srivastava-Malhotra, Stephanie Brictson, Stephanie Spivack, Stephanie Tittaferrante, Stephanie Yerkes, Stephen Priest, Steve Codella, Steven G. Kelsen, Steven Houser, Steven Verga, Sudhir Bolla, Sudhir Kotnala, Sunil Karhadkar, Sylvia Johnson, Tahseen Shariff, Tammy Jacobs, Thomas Hooper, Tom Rogers, Tony S. Reed, Tse-Shuen Ku, Uma Sajjan, Victor Kim, Whitney Cabey, Wissam Chatila, Wuyan Li, Zach Dorey-Stein, Zachariah Dorey-Stein, and Zachary D. Repanshek

Subjects
Male, medicine.medical_specialty, Computed Tomography Angiography, Deep vein, Hypercoagulable state in COVID-19, 030204 cardiovascular system & hematology, COVID-19 VTE, Article, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, COVID-19 coagulopathy, medicine, Humans, Thrombophilia, 030212 general & internal medicine, cardiovascular diseases, Prospective cohort study, Retrospective Studies, Philadelphia, Venous Thrombosis, Ultrasonography, Doppler, Duplex, business.industry, SARS-CoV-2, Incidence (epidemiology), Incidence, COVID-19, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Prognosis, equipment and supplies, Respiration, Artificial, Confidence interval, Pulmonary embolism, medicine.anatomical_structure, Cohort, Surgery, Female, Cardiology and Cardiovascular Medicine, business, Pulmonary Embolism
Abstract

Background Infection with the novel severe acute respiratory syndrome coronavirus 2 has been associated with a hypercoagulable state. Emerging data from China and Europe have consistently shown an increased incidence of venous thromboembolism (VTE). We aimed to identify the VTE incidence and early predictors of VTE at our high-volume tertiary care center. Methods We performed a retrospective cohort study of 147 patients who had been admitted to Temple University Hospital with coronavirus disease 2019 (COVID-19) from April 1, 2020 to April 27, 2020. We first identified the VTE (pulmonary embolism [PE] and deep vein thrombosis [DVT]) incidence in our cohort. The VTE and no-VTE groups were compared by univariable analysis for demographics, comorbidities, laboratory data, and treatment outcomes. Subsequently, multivariable logistic regression analysis was performed to identify the early predictors of VTE. Results The 147 patients (20.9% of all admissions) admitted to a designated COVID-19 unit at Temple University Hospital with a high clinical suspicion of acute VTE had undergone testing for VTE using computed tomography pulmonary angiography and/or extremity venous duplex ultrasonography. The overall incidence of VTE was 17% (25 of 147). Of the 25 patients, 16 had had acute PE, 14 had had acute DVT, and 5 had had both PE and DVT. The need for invasive mechanical ventilation (adjusted odds ratio, 3.19; 95% confidence interval, 1.07-9.55) and the admission D-dimer level ≥1500 ng/mL (adjusted odds ratio, 3.55; 95% confidence interval, 1.29-9.78) were independent markers associated with VTE. The all-cause mortality in the VTE group was greater than that in the non-VTE group (48% vs 22%; P = .007). Conclusions Our study represents one of the earliest reported from the United States on the incidence rate of VTE in patients with COVID-19. Patients with a high clinical suspicion and the identified risk factors (invasive mechanical ventilation, admission D-dimer level ≥1500 ng/mL) should be considered for early VTE testing. We did not screen all patients admitted for VTE; therefore, the true incidence of VTE could have been underestimated. Our findings require confirmation in future prospective studies.

Published
2020

12. Rational ergodicity of step function skew products

Author

Nishant Chandgotia, Michael Bromberg, and Jon Aaronson

Subjects
Pure mathematics, Mathematics::Dynamical Systems, Algebra and Number Theory, Mathematics - Number Theory, Applied Mathematics, Probability (math.PR), Mathematical analysis, Ergodicity, Skew, Stochastic matrix, Dynamical Systems (math.DS), 37A40, 11K38, 60F05, Random walk, Step function, Bounded function, FOS: Mathematics, Number Theory (math.NT), Affine transformation, Mathematics - Dynamical Systems, Mathematics - Probability, Analysis, Rotation number, Mathematics
Abstract

We study rational step function skew products over certain rotations of the circle proving ergodicity and bounded rational ergodicity when rotation number is a quadratic irrational. The latter arises from a consideration of the asymptotic temporal statistics of an orbit as modelled by an associated affine random walk., Comment: Revised version after refereeing

Published
2018
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13. Lymphoid malignancy-associated hemophagocytic lymphohistiocytosis: Search for the hidden source

Author

Michael Bromberg, Amandeep Aneja, Ashish Bains, and Linda Mamone

Subjects
Adult, Male, Secondary Hemophagocytic Lymphohistiocytosis, endocrine system, Pathology, medicine.medical_specialty, Lymphoma, Malignancy, medicine.disease_cause, Lymphohistiocytosis, Hemophagocytic, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Immune system, Bone Marrow, hemic and lymphatic diseases, Humans, Medicine, Retrospective Studies, Hemophagocytic lymphohistiocytosis, business.industry, fungi, Retrospective cohort study, General Medicine, Middle Aged, Immune dysregulation, musculoskeletal system, medicine.disease, Immunohistochemistry, 030220 oncology & carcinogenesis, Female, Hemophagocytosis, business, hormones, hormone substitutes, and hormone antagonists, 030215 immunology
Abstract

Secondary hemophagocytic lymphohistiocytosis (HLH) is an uncommon, but life-threatening syndrome of highly stimulated and ineffective immune dysregulation. It is not a disease entity by itself and the current diagnosis of secondary (acquired) HLH is based on constellation of nonspecific clinical and laboratory parameters indicative of overactive immune response. The presenting symptoms are often nonspecific and could potentially be missed, leading to a fatal outcome. Patients with malignancy-associated HLH have a relatively unfavorable overall survival compared with non-malignancy-associated HLH. In this retrospective study, nine adult patients with secondary HLH were identified. Of these four cases were associated with a malignancy and despite a high degree of suspicion, the underlying lymphoid malignancy was not initially evident. Three out of four patients with lymphoid malignancy-associated HLH died over a very short course of time following the diagnosis. The outcome was significantly different for the control group of patients with other underlying cause(s) for HLH. These cases emphasize the importance of a thorough search for a hidden malignant source in patients with secondary HLH for prompt diagnosis and institution of malignancy specific treatment.

Published
2017
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14. Response

Author

Maulin Patel, Eduardo Dominguez, Daniel Sacher, Parag Desai, Ashwin Chandar, Michael Bromberg, Roberto Caricchio, and Gerard J. Criner

Subjects
Pulmonary and Respiratory Medicine, Correspondence, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
Published
2021

15. First measurement of the W-boson mass in run II of the Tevatron

Author

T. AALTONEN, A. ABULENCIA, HELSINKI I.N.S.T. OF PHYS, J. ADELMAN, ILLINOIS U, URBANA, ANTHONY ALLEN AFFOLDER, CHICAGO U, EFI, T. AKIMOTO, SANTA BARBARA, MICHAEL G. ALBROW, TSUKUBA U, S. AMERIO, FERMILAB, DANTE E. AMIDEI, PADUA U, A. ANASTASSOV, MICHIGAN U, K. ANIKEEV, RUTGERS U, PISCATAWAY, A. ANNOVI, J. ANTOS, FRASCATI, M. AOKI, COMENIUS U, G. APOLLINARI, T. ARISAWA, A. ARTIKOV, WASEDA U, WILLIAM JOSEPH ASHMANSKAS, DUBNA, JINR, A. ATTAL, ADAM AURISANO, BARCELONA, IFAE, F. AZFAR, TEXAS A. M, P. AZZI BACCHETTA, OXFORD U, PAOLO AZZURRI, NICOLA BACCHETTA, PISA U, W. BADGETT, ANGELA BARBARO GALTIERI, V. E. BARNES, LBL, BERKELEY, BRUCE A. BARNETT, PURDUE U, S. BAROIANT, JOHNS HOPKINS U, V. BARTSCH, UC, DAVIS, G. BAUER, UNIVERSITY C.O.L.L. LONDON, P. H. BEAUCHEMIN, MIT, LNS, FRANCO BEDESCHI, MCGILL U, S. BEHARI, GIORGIO BELLETTINI, JAMES NUGENT BELLINGER, A. BELLONI, WISCONSIN U, MADISON, DOUGLAS P. BENJAMIN, ANDREW F. BERETVAS, DUKE U, JUERG BERINGER, T. BERRY, ANWAR AHMAD BHATTI, LIVERPOOL U, MORRIS BINKLEY, ROCKEFELLER U, DARIO BISELLO, ILIJA BIZJAK, ROBERT EUGENE BLAIR, CRAIG ALAN BLOCKER, ARGONNE, BARRY J. BLUMENFELD, BRANDEIS U, ANDREA BOCCI, ARIE BODEK, VERONIQUE BOISVERT, G. BOLLA, ROCHESTER U, A. BOLSHOV, D. BORTOLETTO, J. BOUDREAU, A. BOVEIA, PITTSBURGH U, BENJAMIN P. BRAU, LUCA BRIGLIADORI, CARL MICHAEL BROMBERG, BOLOGNA U, ERIK MATTHEWS BRUBAKER, MICHIGAN STATE U, J. BUDAGOV, H. S. BUDD, SARAH REBECCA BUDD, K. BURKETT, GIOVANNI BUSETTO, P. BUSSEY, A. BUZATU, GLASGOW U, K. L. BYRUM, S. CABRERA, M. CAMPANELLI, M. CAMPBELL, GENEVA U, MARIA FLORENCIA CANELLI, A. CANEPA, S. CARRILLO, PENNSYLVANIA U, DUNCAN L. CARLSMITH, FLORIDA U, R. CAROSI, S. CARRON, BRUNO CASAL, M. CASARSA, CANTABRIA U, SANTANDER, A. CASTRO, INFN, UDINE, PIERLUIGI CATASTINI, D. CAUZ, MATTEO CAVALLI SFORZA, ALESSANDRO CERRI, LUCIO CERRITO, SANGHYEON CHANG, Y. C. CHEN, KYUNGPOOK N.A.T.L. U, MAXWELL BENJAMIN CHERTOK, TAIWAN, I.N.S.T. PHYS, GIORGIO CHIARELLI, G. CHLACHIDZE, F. CHLEBANA, I. CHO, K. CHO, D. CHOKHELI, J. P. CHOU, GEORGIOS CHOUDALAKIS, HARVARD U, S. H. CHUANG, K. CHUNG, W. H. CHUNG, CARNEGIE MELLON U, YEON SEI CHUNG, M. CILIJAK, CATALIN IRINEL CIOBANU, M. A. CIOCCI, A. CLARK, D. CLARK, MIRCEA NOROCEL COCA, G. COMPOSTELLA, M. E. CONVERY, JOHN S. CONWAY, B. COOPER, KATHERINE COPIC, M. CORDELLI, G. CORTIANA, F. CRESCIOLI, C. CUENCA ALMENAR, J. CUEVAS, RAY L. CULBERTSON, J. C. CULLY, S. DARONCO, M. DATTA, SAVERIO D'AURIA, T. DAVIES, WILLIAM DAVID DAGENHART, P. DE BARBARO, S. DE CECCO, A. DEISHER, ROME U, G. DE LENTDECKER, G. DE LORENZO, MAURO DELL'ORSO, F. DELLI PAOLI, LUC DEMORTIER, J. DENG, M. DENINNO, D. DE PEDIS, P. F. DERWENT, G. P. DI GIOVANNI, C. DIONISI, PARIS U, VI VII, JAY R. DITTMANN, M. D'ONOFRIO, BAYLOR U, M.A.T.H. DEPT, CHRISTIAN DOERR, S. DONATI, KARLSRUHE U, EKP, P. DONG, J. DONINI, UCLA, T. DORIGO, S. DUBE, JONATHAN ZVI EFRON, ROBIN D. ERBACHER, OHIO STATE U, D. ERREDE, STEVEN MICHAEL ERREDE, RICARDO EUSEBI, H. C. FANG, SINEAD MARIE FARRINGTON, I. FEDORKO, W. T. FEDORKO, R. G. FEILD, MICHAEL FEINDT, YALE U, J. P. FERNANDEZ, R. FIELD, MADRID, CIEMAT, G. FLANAGAN, R. FORREST, S. FORRESTER, M. FRANKLIN, J. C. FREEMAN, I. FURIC, MICHELE GALLINARO, J. GALYARDT, J. E. GARCIA, F. GARBERSON, A. F. GARFINKEL, C. GAY, H. GERBERICH, DAVID W. GERDES, STEFANO GIAGU, P. GIANNETTI, K. GIBSON, JENNIFER LINDSAY GIMMELL, CAMILLE M. GINSBURG, N. GIOKARIS, MARIO PAOLO GIORDANI, P. GIROMINI, M. GIUNTA, GAVRIL A. GIURGIU, V. GLAGOLEV, DOUGLAS A. GLENZINSKI, M. GOLD, NATHAN JOEL GOLDSCHMIDT, NEW MEXICO U, JOEL GOLDSTEIN, ALEXANDER GOLOSSANOV, G. GOMEZ, G. GOMEZ CEBALLOS, MAXIM T. GONCHAROV, O. GONZALEZ, IGOR V. GORELOV, ALFRED T. GOSHAW, KONSTANTIN GOULIANOS, A. GRESELE, SEBASTIAN GRINSTEIN, C. GROSSO PILCHER, ROBERT CRAIG GROUP, ULYSSES GRUNDLER, JOAO PEDRO BARREIRO GUIMARAES DA COSTA, Z. GUNAY UNALAN, CARL H. HABER, K. HAHN, STEPHEN R. HAHN, E. HALKIADAKIS, A. HAMILTON, B. Y. HAN, J. Y. HAN, R. HANDLER, F. HAPPACHER, K. HARA, D. HARE, M. HARE, S. HARPER, TUFTS U, ROBERT FRANCIS HARR, R. M. HARRIS, WAYNE STATE U, M. HARTZ, KENICHI HATAKEYAMA, J. HAUSER, CHRISTOPHER PAUL HAYS, M. HECK, A. HEIJBOER, B. HEINEMANN, JOEL HEINRICH, C. HENDERSON, M. HERNDON, J. HEUSER, DEAN ANDREW HIDAS, CHRISTOPHER S. HILL, D. HIRSCHBUEHL, JAMES ANDREW HOCKER, A. HOLLOWAY, S. HOU, MICHAEL A. HOULDEN, S. C. HSU, BRIAN T. HUFFMAN, SAN DIEGO, R. E. HUGHES, ULRICH HUSEMANN, J. HUSTON, JOSEPH R. INCANDELA, G. INTROZZI, M. IORI, A. IVANOV, B. IYUTIN, ERIC B. JAMES, D. JANG, BODHITHA ANJALIKE JAYATILAKA, D. JEANS, E. J. JEON, SERGO JINDARIANI, W. JOHNSON, M. JONES, K. K. JOO, S. Y. JUN, J. E. JUNG, THOMAS R. JUNK, TERUKI KAMON, PAUL E. KARCHIN, Y. KATO, Y. KEMP, OSAKA CITY U, R. KEPHART, U. KERZEL, V. KHOTILOVICH, B. KILMINSTER, D. H. KIM, H. S. KIM, J. E. KIM, M. J. KIM, S. B. KIM, S. H. KIM, YOUNG KEE KIM, N. KIMURA, LAWRENCE E. KIRSCH, SERGEY KLIMENKO, MARKUS KLUTE, BRUCE OWEN KNUTESON, BYEONGROK KO, K. KONDO, DAE JUNG KONG, JACOBO KONIGSBERG, A. KORYTOV, ASHUTOSH VIJAY KOTWAL, AAFKE CHRISTINE KRAAN, J. KRAUS, M. KREPS, J. KROLL, N. KRUMNACK, MARK CHARLES KRUSE, VYACHESLAV E. KRUTELYOV, T. KUBO, S. E. KUHLMANN, T. KUHR, N. P. KULKARNI, Y. KUSAKABE, S. KWANG, ALVIN TOIVO LAASANEN, S. LAI, STEFANO LAMI, S. LAMMEL, M. LANCASTER, R. L. LANDER, K. LANNON, A. LATH, G. LATINO, I. LAZZIZZERA, THOMAS JOSEPH LECOMPTE, J. LEE, Y. J. LEE, SUNG WON LEE, R. LEFEVRE, NUNO T. LEONARDO, SANDRA LEONE, S. LEVY, JONATHAN D. LEWIS, C. LIN, CHENG JU STEPHEN LIN, MICHAEL ALLEN LINDGREN, E. LIPELES, TONY M. LISS, A. LISTER, D. O. LITVINTSEV, T. LIU, NIGEL S. LOCKYER, A. LOGINOV, MAURIZIO LORETI, R. S. LU, D. LUCCHESI, P. LUJAN, P. LUKENS, G. LUNGU, LOUIS LYONS, J. LYS, R. LYSAK, ELSE LYTKEN, P. MACK, D. MACQUEEN, ROBYN LEIGH MADRAK, KAORI MAESHIMA, KHALDOUN MAKHOUL, T. MAKI, PETAR MAKSIMOVIC, S. MALDE, S. MALIK, G. MANCA, A. MANOUSAKIS, F. MARGAROLI, RADU MARGINEAN, C. MARINO, C. P. MARINO, A. MARTIN, M. MARTIN, V. MARTIN, M. MARTINEZ, R. MARTINEZ BALLARIN, T. MARUYAMA, P. MASTRANDREA, TATSUYA MASUBUCHI, H. MATSUNAGA, M. E. MATTSON, R. MAZINI, PAOLO MAZZANTI, KEVIN S. MCFARLAND, PETER M. MCINTYRE, R. MCNULTY, A. MEHTA, P. MEHTALA, S. MENZEMER, A. MENZIONE, P. MERKEL, CHRISTINA MESROPIAN, A. MESSINA, TING MIAO, N. MILADINOVIC, J. MILES, R. MILLER, C. MILLS, MICHAEL MILNIK, A. MITRA, GUENAKH MITSELMAKHER, A. MIYAMOTO, S. MOED, KEK, TSUKUBA, N. MOGGI, B. MOHR, C. S. MOON, R. MOORE, M. MORELLO, PEDRO A. MOVILLA FERNANDEZ, J. MULMENSTADT, A. MUKHERJEE, T.H. MULLER, R. MUMFORD, P. MURAT, M. MUSSINI, JANE MARIE NACHTMAN, A. NAGANO, JUNJI NAGANOMA, K. NAKAMURA, I. NAKANO, AUSTIN NAPIER, OKAYAMA U, V. NECULA, CHRISTOPHER C. NEU, MARK STEPHEN NEUBAUER, JASON A. NIELSEN, L. NODULMAN, OLGA NORNIELLA, E. NURSE, S. H. OH, Y. D. OH, I. OKSUZIAN, T. OKUSAWA, RUDOLF OLDEMAN, RISTO ORAVA, K. OSTERBERG, C. PAGLIARONE, E. PALENCIA, VAIA PAPADIMITRIOU, A. PAPAIKONOMOU, A. A. PARAMONOV, B. 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L., Winer, Peter, Wittich, STEPHEN A., Wolber, CARL E., Wolfe, T., Wright, X., Wu, SARA MADGE VIOLETTE, Wynne, A., Yagil, K., Yamamoto, J., Yamaoka, T., Yamashita, C., Yang, UN KI, Yang, Y. C., Yang, W. M., Yao, GONG PING, Yeh, J., Yoh, Kohei, Yorita, T., Yoshida, GEUM BONG, Yu, I., Yu, SHIN SHAN, Yu, JAE CHUL, Yun, Lucia, Zanello, ANNA MARIA, Zanetti, I., Zaw, X., Zhang, J., Zhou, S., Zucchelli, CDF Collaboration, T. Aaltonen, A. Abulencia, J. Adelman, T. Affolder, T. Akimoto, M. G. Albrow, S. Amerio, D. Amidei, A. Anastassov, K. Anikeev, A. Annovi, J. Anto, M. Aoki, G. Apollinari, T. Arisawa, A. Artikov, W. Ashmanska, A. Attal, A. Aurisano, F. Azfar, P. Azzi-Bacchetta, P. Azzurri, N. Bacchetta, W. Badgett, A. Barbaro-Galtieri, V. E. Barne, B. A. Barnett, S. Baroiant, V. Bartsch, G. Bauer, P.-H. Beauchemin, F. Bedeschi, S. Behari, G. Bellettini, J. Bellinger, A. Belloni, D. Benjamin, A. Beretva, J. Beringer, T. Berry, A. Bhatti, M. Binkley, D. Bisello, I. Bizjak, R. E. Blair, C. Blocker, B. Blumenfeld, A. Bocci, A. Bodek, V. Boisvert, G. Bolla, A. Bolshov, D. Bortoletto, J. Boudreau, A. Boveia, B. Brau, L. Brigliadori, C. Bromberg, E. Brubaker, J. Budagov, H. S. Budd, S. Budd, K. Burkett, G. Busetto, P. Bussey, A. Buzatu, K. L. Byrum, S. Cabrera, M. Campanelli, M. Campbell, F. Canelli, A. Canepa, S. Carrillo, D. Carlsmith, R. Carosi, S. Carron, B. Casal, M. Casarsa, A. Castro, P. Catastini, D. Cauz, M. Cavalli-Sforza, A. Cerri, L. Cerrito, S. H. Chang, Y. C. Chen, M. Chertok, G. Chiarelli, G. Chlachidze, F. Chlebana, I. Cho, K. Cho, D. Chokheli, J. P. Chou, G. Choudalaki, S. H. Chuang, K. Chung, W. H. Chung, Y. S. Chung, M. Cilijak, C. I. Ciobanu, M. A. Ciocci, A. Clark, D. Clark, M. Coca, G. Compostella, M. E. Convery, J. Conway, B. Cooper, K. Copic, M. Cordelli, G. Cortiana, F. Crescioli, C. Cuenca Almenar, J. Cueva, R. Culbertson, J. C. Cully, S. DaRonco, M. Datta, S. D’Auria, T. Davie, D. Dagenhart, P. de Barbaro, S. De Cecco, A. Deisher, G. De Lentdecker, G. De Lorenzo, M. Dell’Orso, F. Delli Paoli, L. Demortier, J. Deng, M. Deninno, D. De Pedi, P. F. Derwent, G. P. Di Giovanni, C. Dionisi, B. Di Ruzza, J. R. Dittmann, M. D’Onofrio, C. Dörr, S. Donati, P. Dong, J. Donini, T. Dorigo, S. Dube, J. Efron, R. Erbacher, D. Errede, S. Errede, R. Eusebi, H. C. Fang, S. Farrington, I. Fedorko, W. T. Fedorko, R. G. Feild, M. Feindt, J. P. Fernandez, R. Field, G. Flanagan, R. Forrest, S. Forrester, M. Franklin, J. C. Freeman, I. Furic, M. Gallinaro, J. Galyardt, J. E. Garcia, F. Garberson, A. F. Garfinkel, C. Gay, H. Gerberich, D. Gerde, S. Giagu, P. Giannetti, K. Gibson, J. L. Gimmell, C. Ginsburg, N. Giokari, M. Giordani, P. Giromini, M. Giunta, G. Giurgiu, V. Glagolev, D. Glenzinski, M. Gold, N. Goldschmidt, J. Goldstein, A. Golossanov, G. Gomez, G. Gomez-Ceballo, M. Goncharov, O. González, I. Gorelov, A. T. Goshaw, K. Gouliano, A. Gresele, S. Grinstein, C. Grosso-Pilcher, R. C. Group, U. Grundler, J. Guimaraes da Costa, Z. Gunay-Unalan, C. Haber, K. Hahn, S. R. Hahn, E. Halkiadaki, A. Hamilton, B.-Y. Han, J. Y. Han, R. Handler, F. Happacher, K. Hara, D. Hare, M. Hare, S. Harper, R. F. Harr, R. M. Harri, M. Hartz, K. Hatakeyama, J. Hauser, C. Hay, M. Heck, A. Heijboer, B. Heinemann, J. Heinrich, C. Henderson, M. Herndon, J. Heuser, D. Hida, C. S. Hill, D. Hirschbuehl, A. Hocker, A. Holloway, S. Hou, M. Houlden, S.-C. Hsu, B. T. Huffman, R. E. Hughe, U. Husemann, J. Huston, J. Incandela, G. Introzzi, M. Iori, A. Ivanov, B. Iyutin, E. Jame, D. Jang, B. Jayatilaka, D. Jean, E. J. Jeon, S. Jindariani, W. Johnson, M. Jone, K. K. Joo, S. Y. Jun, J. E. Jung, T. R. Junk, T. Kamon, P. E. Karchin, Y. Kato, Y. Kemp, R. Kephart, U. Kerzel, V. Khotilovich, B. Kilminster, D. H. Kim, H. S. Kim, J. E. Kim, M. J. Kim, S. B. Kim, S. H. Kim, Y. K. Kim, N. Kimura, L. Kirsch, S. Klimenko, M. Klute, B. Knuteson, B. R. Ko, K. Kondo, D. J. Kong, J. Konigsberg, A. Korytov, A. V. Kotwal, A. C. Kraan, J. Krau, M. Krep, J. Kroll, N. Krumnack, M. Kruse, V. Krutelyov, T. Kubo, S. E. Kuhlmann, T. Kuhr, N. P. Kulkarni, Y. Kusakabe, S. Kwang, A. T. Laasanen, S. Lai, S. Lami, S. Lammel, M. Lancaster, R. L. Lander, K. Lannon, A. Lath, G. Latino, I. Lazzizzera, T. LeCompte, J. Lee, Y. J. Lee, S. W. Lee, R. Lefèvre, N. Leonardo, S. Leone, S. Levy, J. D. Lewi, C. Lin, C. S. Lin, M. Lindgren, E. Lipele, T. M. Li, A. Lister, D. O. Litvintsev, T. Liu, N. S. Lockyer, A. Loginov, M. Loreti, R.-S. Lu, D. Lucchesi, P. Lujan, P. Luken, G. Lungu, L. Lyon, J. Ly, R. Lysak, E. Lytken, P. Mack, D. MacQueen, R. Madrak, K. Maeshima, K. Makhoul, T. Maki, P. Maksimovic, S. Malde, S. Malik, G. Manca, A. Manousaki, F. Margaroli, R. Marginean, C. Marino, C. P. Marino, A. Martin, M. Martin, V. Martin, M. Martínez, R. Martínez-Ballarín, T. Maruyama, P. Mastrandrea, T. Masubuchi, H. Matsunaga, M. E. Mattson, R. Mazini, P. Mazzanti, K. S. McFarland, P. McIntyre, R. McNulty, A. Mehta, P. Mehtala, S. Menzemer, A. Menzione, P. Merkel, C. Mesropian, A. Messina, T. Miao, N. Miladinovic, J. Mile, R. Miller, C. Mill, M. Milnik, A. Mitra, G. Mitselmakher, A. Miyamoto, S. Moed, N. Moggi, B. Mohr, C. S. Moon, R. Moore, M. Morello, P. Movilla Fernandez, J. Mülmenstädt, A. Mukherjee, Th. Muller, R. Mumford, P. Murat, M. Mussini, J. Nachtman, A. Nagano, J. Naganoma, K. Nakamura, I. Nakano, A. Napier, V. Necula, C. Neu, M. S. Neubauer, J. Nielsen, L. Nodulman, O. Norniella, E. Nurse, S. H. Oh, Y. D. Oh, I. Oksuzian, T. Okusawa, R. Oldeman, R. Orava, K. Osterberg, C. Pagliarone, E. Palencia, V. Papadimitriou, A. Papaikonomou, A. A. Paramonov, B. Park, S. Pashapour, J. Patrick, G. Pauletta, M. Paulini, C. Pau, D. E. Pellett, A. Penzo, T. J. Phillip, G. Piacentino, J. Piedra, L. Pinera, K. Pitt, C. Plager, L. Pondrom, X. Portell, O. Poukhov, N. Pounder, F. Prakoshyn, A. Pronko, J. Proudfoot, F. Ptoho, G. Punzi, J. Pursley, J. Rademacker, A. Rahaman, V. Ramakrishnan, N. Ranjan, I. Redondo, B. Reisert, V. Rekovic, P. Renton, M. Rescigno, S. Richter, F. Rimondi, L. Ristori, A. Robson, T. Rodrigo, E. Roger, S. Rolli, R. Roser, M. Rossi, R. Rossin, P. Roy, A. Ruiz, J. Ru, V. Rusu, H. Saarikko, A. Safonov, W. K. Sakumoto, G. Salamanna, O. Saltó, L. Santi, S. Sarkar, L. Sartori, K. Sato, P. Savard, A. Savoy-Navarro, T. Scheidle, P. Schlabach, E. E. Schmidt, M. P. Schmidt, M. Schmitt, T. Schwarz, L. Scodellaro, A. L. Scott, A. Scribano, F. Scuri, A. Sedov, S. Seidel, Y. Seiya, A. Semenov, L. Sexton-Kennedy, A. Sfyrla, S. Z. Shalhout, M. D. Shapiro, T. Shear, P. F. Shepard, D. Sherman, M. Shimojima, M. Shochet, Y. Shon, I. Shreyber, A. Sidoti, P. Sinervo, A. Sisakyan, A. J. Slaughter, J. Slaunwhite, K. Sliwa, J. R. Smith, F. D. Snider, R. Snihur, M. Soderberg, A. Soha, S. Somalwar, V. Sorin, J. Spalding, F. Spinella, T. Spreitzer, P. Squillacioti, M. Stanitzki, A. Staveris-Polykala, R. St. Deni, B. Stelzer, O. Stelzer-Chilton, D. Stentz, J. Strologa, D. Stuart, J. S. Suh, A. Sukhanov, H. Sun, I. Suslov, T. Suzuki, A. Taffard, R. Takashima, Y. Takeuchi, R. Tanaka, M. Tecchio, P. K. Teng, K. Terashi, J. Thom, A. S. Thompson, E. Thomson, P. Tipton, V. Tiwari, S. Tkaczyk, D. Toback, S. Tokar, K. Tollefson, T. Tomura, D. Tonelli, S. Torre, D. Torretta, S. Tourneur, W. Trischuk, S. Tsuno, Y. Tu, N. Turini, F. Ukegawa, S. Uozumi, S. Vallecorsa, N. van Remortel, A. Varganov, E. Vataga, F. Vazquez, G. Velev, C. Vellidi, G. Veramendi, V. Veszpremi, M. Vidal, R. Vidal, I. Vila, R. Vilar, T. Vine, M. Vogel, I. Vollrath, I. Volobouev, G. Volpi, F. Würthwein, P. Wagner, R. G. Wagner, R. L. Wagner, J. Wagner, W. Wagner, R. Wallny, S. M. Wang, A. Warburton, D. Water, M. Weinberger, W. C. Wester, III, B. Whitehouse, D. Whiteson, A. B. Wicklund, E. Wicklund, G. William, H. H. William, P. Wilson, B. L. Winer, P. Wittich, S. Wolber, C. Wolfe, T. Wright, X. Wu, S. M. Wynne, A. Yagil, K. Yamamoto, J. Yamaoka, T. Yamashita, C. Yang, U. K. Yang, Y. C. Yang, W. M. Yao, G. P. Yeh, J. Yoh, K. Yorita, T. Yoshida, G. B. Yu, I. Yu, S. S. Yu, J. C. Yun, L. Zanello, A. Zanetti, I. Zaw, X. Zhang, J. Zhou, S. Zucchelli, and Ptohos, Fotios [0000-0002-3432-3452]

Subjects
13.38.Be, 14.70.Fm, 12.15.Ji, 13.85.Qk, Particle physics, Single measurement, Physics, Multidisciplinary, Tevatron, FOS: Physical sciences, General Physics and Astronomy, Elementary particle, Data recording, ddc:500.2, 01 natural sciences, Particle detector, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), [PACS] Decays of W bosons, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], W-boson mass, Fermilab, Measurement theory, 010306 general physics, Nuclear Experiment, +10+GeV%29%22">[PACS] Hadron-induced inclusive production with identified leptons, photons, or other nonhadronic particles (energy > 10 GeV), Bosons, Boson, Physics, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Detectors, [PACS] W bosons, High Energy Physics::Experiment, Bar (unit)
Abstract

7 pages, 4 figures.-- PACS nrs.: 14.70.Fm; 13.38.Be; 13.85.Qk.-- ISI Article Identifier: 000250140600014.-- ArXiv pre-print available at: http://arxiv.org/abs/0707.0085.-- et al., We present a measurement of the W-boson mass using 200 pb(-1) of data collected in p(p)over-bar collisions at sqrt{s}=1.96 TeV by the CDF II detector at run II of the Fermilab Tevatron. With a sample of 63 964 W --> e(nu) candidates and 51 128 W --> μ(nu) candidates, we measure M(W) = 80413 ± 34(stat) ± 34(syst) = 80 413 ± 48 MeV/c^2. This is the most precise single measurement of the W-boson mass to date., This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A.P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the Korean Science and Engineering Foundation and the Korean Research Foundation; the Science and Technology Facilities Council and the Royal Society, U.K.; the Institut National de Physique Nucleaire et Physique des Particules/CNRS; the Russian Foundation for Basic Research; the Comisión Interministerial de Ciencia y Tecnología, Spain; the European Community’s Human Potential Programme; the European Commission under the Marie Curie Programme; the Slovak R&D Agency; and the Academy of Finland.

Published
2016
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16. A temporal Central Limit Theorem for real-valued cocycles over rotations

Author

Corinna Ulcigrai, Michael Bromberg, and University of Zurich

Subjects
Statistics and Probability, 37E10, Renormalization, Dynamical Systems (math.DS), 01 natural sciences, Skew-products over irrational rotations, 010104 statistics & probability, 510 Mathematics, Ostrowski expansion, FOS: Mathematics, 37A50, 1804 Statistics, Probability and Uncertainty, 2613 Statistics and Probability, Mathematics - Dynamical Systems, 0101 mathematics, Discrepancy, Mathematics, Central limit theorem, Statistics, 010102 general mathematics, Limit theorems for dynamical systems, 37A50, 37C55 (Primary), 11K06, 11K38, 60F05 (Secondary), Single orbit dynamics, 11K06, 10123 Institute of Mathematics, Probability and Uncertainty, Statistics, Probability and Uncertainty, Humanities
Abstract

We consider deterministic random walks on the real line driven by irrational rotations, or equivalently, skew product extensions of a rotation by $\alpha$ where the skewing cocycle is a piecewise constant mean zero function with a jump by one at a point $\beta$. When $\alpha$ is badly approximable and $\beta$ is badly approximable with respect to $\alpha$, we prove a Temporal Central Limit theorem (in the terminology recently introduced by D.Dolgopyat and O.Sarig), namely we show that for any fixed initial point, the occupancy random variables, suitably rescaled, converge to a Gaussian random variable. This result generalizes and extends a theorem by J. Beck for the special case when $\alpha$ is quadratic irrational, $\beta$ is rational and the initial point is the origin, recently reproved and then generalized to cover any initial point using geometric renormalization arguments by Avila-Dolgopyat-Duryev-Sarig (Israel J., 2015) and Dolgopyat-Sarig (J. Stat. Physics, 2016). We also use renormalization, but in order to treat irrational values of $\beta$, instead of geometric arguments, we use the renormalization associated to the continued fraction algorithm and dynamical Ostrowski expansions. This yields a suitable symbolic coding framework which allows us to reduce the main result to a CLT for non homogeneous Markov chains., Comment: a few typos corrected, 28 pages, 4 figures

Published
2017
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17. Plasmacytic post-transplant lymphoproliferative disorder: a case series of nine patients

Author

Edward A. Stadtmauer, Thomas W. Faust, Stephen J. Schuster, Vivek N. Ahya, Omotayo Fasan, Meghan Karuturi, Dale Frank, Simin Goral, Ran Reshef, Nirav N. Shah, Michael Bromberg, and Donald E. Tsai

Subjects
Male, Epstein-Barr Virus Infections, Pathology, medicine.medical_specialty, Lymphoma, medicine.medical_treatment, Plasma Cells, Organ transplantation, Post-transplant lymphoproliferative disorder, hemic and lymphatic diseases, Humans, Medicine, Multiple myeloma, Aged, Retrospective Studies, Immunosuppression Therapy, CD20, Transplantation, biology, business.industry, Immunosuppression, Organ Transplantation, Middle Aged, medicine.disease, Lymphoproliferative Disorders, surgical procedures, operative, Monoclonal, biology.protein, Plasmacytoma, Female, Complication, business
Abstract

Summary Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation. Although PTLD typically has a B-cell histology, an uncommon variant, plasmacytic PTLD can present as a monoclonal plasma cell proliferation similar to plasmacytomas seen in multiple myeloma. A retrospective analysis was performed on nine patients at our center with plasmacytic PTLD as characterized by plasmacytic histology with the presence of CD138 and lack of CD20. Of the 210 adult solid organ transplant PTLD patients diagnosed between 1988 and 2012, 9 (4%) had a histological appearance consistent with plasmacytic PTLD. The median time from transplant to diagnosis was 3.7 years (range 8 months–24 years). All patients presented with extranodal and often subcutaneous solid tumors. Laboratory features included elevated LDH and beta-2 microglobulin levels, monoclonal gammopathy, and EBV positivity of the tumor. Unlike conventional multiple myeloma, patients had normal calcium levels and only mild anemia. Six patients who have completed treatment achieved complete responses with radiation therapy and/or reduction in immunosuppression with two patients now greater than 5 years in continuous complete response. Plasmacytic PTLD, despite its plasmacytic histology, is responsive to conventional therapies used for B-cell PTLD including reduction in immunosuppression and radiation therapy.

Published
2013
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18. Upregulation of tissue factor in monocytes by cleaved high molecular weight kininogen is dependent on TNF-α and IL-1β

Author

Sabina T. Khan, Mohammad M. Khan, Michael Bromberg, Munir E. Khan, Megan L. Gilman, Robert W. Colman, and Yuchuan Liu

Subjects
medicine.medical_specialty, Chemokine, Kininogen, High-Molecular-Weight, Time Factors, Physiology, High-molecular-weight kininogen, medicine.medical_treatment, Interleukin-1beta, Bradykinin, Monocytes, Thromboplastin, chemistry.chemical_compound, Tissue factor, Physiology (medical), Internal medicine, medicine, Humans, RNA, Messenger, Cells, Cultured, Mitogen-Activated Protein Kinase Kinases, Kininogen, Dose-Response Relationship, Drug, biology, Tumor Necrosis Factor-alpha, NF-kappa B, Antibodies, Monoclonal, Articles, Molecular biology, Up-Regulation, Endocrinology, Cytokine, chemistry, Chemokine secretion, biology.protein, Tumor necrosis factor alpha, Cardiology and Cardiovascular Medicine
Abstract

Inflammatory bowel disease and arthritis are associated with contact activation that results in cleavage of kininogen to form high molecular weight kininogen (HKa) and bradykinin. We have previously demonstrated that HKa can stimulate inflammatory cytokine and chemokine secretion from human monocytes. We now show that HKa can upregulate tissue factor antigen and procoagulant activity on human monocytes as a function of time (1-4 h) and HKa concentration (75-900 nM). The amino acid sequence responsible to block HKa effects is G440-H455. The HKa receptor macrophage-1 (Mac-1; CD11b18) is the binding site as shown by inhibition by a monoclonal antibody to CD11b/18. Chemical inhibitors of JNK, ERK, and p38 signaling pathways block cell signaling, as does an inhibitor to the transcription factor NF-kappaB. A combination of monoclonal antibodies to TNF-alpha and IL-1beta but neither alone inhibited the HKa induction of tissue factor. These results suggest that HKa mimics LPS by triggering a paracrine pathway in monocytes that depends on TNF-alpha and IL-1beta. Antibodies to kininogen or peptidomimetics might be a useful and safe therapy in inflammatory diseases or sepsis involving cytokines.

Published
2010
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19. Discrepancy Skew Products and Affine Random Walks

Author

Hitoshi Nakada, Jon Aaronson, and Michael Bromberg

Subjects
Pure mathematics, General Mathematics, 010102 general mathematics, Ergodicity, Probability (math.PR), Skew, Dynamical Systems (math.DS), 37A40, 11K38, 60F05, Random walk, 01 natural sciences, 010101 applied mathematics, Bounded function, FOS: Mathematics, Affine transformation, Mathematics - Dynamical Systems, 0101 mathematics, Algebra over a field, Mathematics - Probability, Rotation number, Mathematics
Abstract

We prove bounded rational ergodicity for some discrepancy skew products whose rotation number has bad rational approximation. This is done by considering the asymptotics of associated affine random walks., Comment: corrected MSC class, spelling & a remark on the temporal CLT

Published
2016
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20. Observation and Mass Measurement of the BaryonΞb−

Author

T. AALTONEN, A. ABULENCIA, HELSINKI I.N.S.T. OF PHYS, J. ADELMAN, ILLINOIS U, URBANA, ANTHONY ALLEN AFFOLDER, CHICAGO U, EFI, T. AKIMOTO, SANTA BARBARA, MICHAEL G. ALBROW, TSUKUBA U, S. AMERIO, FERMILAB, DANTE E. AMIDEI, PADUA U, A. ANASTASSOV, MICHIGAN U, K. ANIKEEV, RUTGERS U, PISCATAWAY, A. ANNOVI, J. ANTOS, FRASCATI, M. AOKI, COMENIUS U, G. APOLLINARI, T. ARISAWA, A. ARTIKOV, WASEDA U, WILLIAM JOSEPH ASHMANSKAS, DUBNA, JINR, A. ATTAL, ADAM AURISANO, BARCELONA, IFAE, F. AZFAR, TEXAS A. M, P. AZZI BACCHETTA, OXFORD U, PAOLO AZZURRI, NICOLA BACCHETTA, PISA U, W. BADGETT, ANGELA BARBARO GALTIERI, V. E. BARNES, LBL, BERKELEY, BRUCE A. BARNETT, PURDUE U, S. BAROIANT, JOHNS HOPKINS U, V. BARTSCH, UC, DAVIS, G. BAUER, UNIVERSITY C.O.L.L. LONDON, P. H. BEAUCHEMIN, MIT, LNS, FRANCO BEDESCHI, MCGILL U, S. BEHARI, GIORGIO BELLETTINI, JAMES NUGENT BELLINGER, A. BELLONI, WISCONSIN U, MADISON, DOUGLAS P. BENJAMIN, ANDREW F. BERETVAS, DUKE U, JUERG BERINGER, T. BERRY, ANWAR AHMAD BHATTI, LIVERPOOL U, MORRIS BINKLEY, ROCKEFELLER U, DARIO BISELLO, ILIJA BIZJAK, ROBERT EUGENE BLAIR, CRAIG ALAN BLOCKER, ARGONNE, BARRY J. BLUMENFELD, BRANDEIS U, ANDREA BOCCI, ARIE BODEK, VERONIQUE BOISVERT, G. BOLLA, ROCHESTER U, A. BOLSHOV, D. BORTOLETTO, J. BOUDREAU, A. BOVEIA, PITTSBURGH U, BENJAMIN P. BRAU, LUCA BRIGLIADORI, CARL MICHAEL BROMBERG, BOLOGNA U, ERIK MATTHEWS BRUBAKER, MICHIGAN STATE U, J. BUDAGOV, H. S. BUDD, SARAH REBECCA BUDD, K. BURKETT, GIOVANNI BUSETTO, P. BUSSEY, A. BUZATU, GLASGOW U, K. L. BYRUM, S. CABRERA, M. CAMPANELLI, M. CAMPBELL, GENEVA U, MARIA FLORENCIA CANELLI, A. CANEPA, S. CARRILLO, PENNSYLVANIA U, DUNCAN L. CARLSMITH, FLORIDA U, R. CAROSI, S. CARRON, BRUNO CASAL, M. CASARSA, CANTABRIA U, SANTANDER, A. CASTRO, INFN, UDINE, PIERLUIGI CATASTINI, D. CAUZ, MATTEO CAVALLI SFORZA, ALESSANDRO CERRI, LUCIO CERRITO, SANGHYEON CHANG, Y. C. CHEN, KYUNGPOOK N.A.T.L. U, MAXWELL BENJAMIN CHERTOK, TAIWAN, I.N.S.T. PHYS, GIORGIO CHIARELLI, G. CHLACHIDZE, F. CHLEBANA, I. CHO, K. CHO, D. CHOKHELI, J. P. CHOU, GEORGIOS CHOUDALAKIS, HARVARD U, S. H. CHUANG, K. CHUNG, W. H. CHUNG, CARNEGIE MELLON U, YEON SEI CHUNG, M. CILIJAK, CATALIN IRINEL CIOBANU, M. A. CIOCCI, A. CLARK, D. CLARK, MIRCEA NOROCEL COCA, G. COMPOSTELLA, M. E. CONVERY, JOHN S. CONWAY, B. COOPER, KATHERINE COPIC, M. CORDELLI, G. CORTIANA, F. CRESCIOLI, C. CUENCA ALMENAR, J. CUEVAS, RAY L. CULBERTSON, J. C. CULLY, S. DARONCO, M. DATTA, SAVERIO D'AURIA, T. DAVIES, WILLIAM DAVID DAGENHART, P. DE BARBARO, S. DE CECCO, A. DEISHER, ROME U, G. DE LENTDECKER, G. DE LORENZO, MAURO DELL'ORSO, F. DELLI PAOLI, LUC DEMORTIER, J. DENG, M. DENINNO, D. DE PEDIS, P. F. DERWENT, G. P. DI GIOVANNI, C. DIONISI, PARIS U, VI VII, JAY R. DITTMANN, M. D'ONOFRIO, BAYLOR U, M.A.T.H. DEPT, CHRISTIAN DOERR, S. DONATI, KARLSRUHE U, EKP, P. DONG, J. DONINI, UCLA, T. DORIGO, S. DUBE, JONATHAN ZVI EFRON, ROBIN D. ERBACHER, OHIO STATE U, D. ERREDE, STEVEN MICHAEL ERREDE, RICARDO EUSEBI, H. C. 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KONDO, DAE JUNG KONG, JACOBO KONIGSBERG, A. KORYTOV, ASHUTOSH VIJAY KOTWAL, AAFKE CHRISTINE KRAAN, J. KRAUS, M. KREPS, J. KROLL, N. KRUMNACK, MARK CHARLES KRUSE, VYACHESLAV E. KRUTELYOV, T. KUBO, S. E. KUHLMANN, T. KUHR, N. P. KULKARNI, Y. KUSAKABE, S. KWANG, ALVIN TOIVO LAASANEN, S. LAI, STEFANO LAMI, S. LAMMEL, M. LANCASTER, R. L. LANDER, K. LANNON, A. LATH, G. LATINO, I. LAZZIZZERA, THOMAS JOSEPH LECOMPTE, J. LEE, Y. J. LEE, SUNG WON LEE, R. LEFEVRE, NUNO T. LEONARDO, SANDRA LEONE, S. LEVY, JONATHAN D. LEWIS, C. LIN, CHENG JU STEPHEN LIN, MICHAEL ALLEN LINDGREN, E. LIPELES, A. LISTER, D. O. LITVINTSEV, T. LIU, NIGEL S. LOCKYER, A. LOGINOV, MAURIZIO LORETI, R. S. LU, D. LUCCHESI, P. LUJAN, P. LUKENS, G. LUNGU, LOUIS LYONS, J. LYS, R. LYSAK, ELSE LYTKEN, P. MACK, D. MACQUEEN, ROBYN LEIGH MADRAK, KAORI MAESHIMA, KHALDOUN MAKHOUL, T. MAKI, PETAR MAKSIMOVIC, S. MALDE, S. MALIK, G. MANCA, A. MANOUSAKIS, F. MARGAROLI, RADU MARGINEAN, C. MARINO, C. P. MARINO, A. MARTIN, M. MARTIN, V. 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SEMENOV, ELIZABETH SEXTON KENNEDY, A. SFYRLA, S. Z. SHALHOUT, M. D. SHAPIRO, T. SHEARS, P. F. SHEPARD, D. SHERMAN, M. SHIMOJIMA, MELVYN J. SHOCHET, Y. SHON, I. SHREYBER, A. SIDOTI, PEKKA K. SINERVO, A. SISAKYAN, A. JEAN SLAUGHTER, J. SLAUNWHITE, K. SLIWA, J. R. SMITH, F. D. SNIDER, R. SNIHUR, M. SODERBERG, A. SOHA, SUNIL V. SOMALWAR, MARIA VERONICA SORIN, J. SPALDING, F. SPINELLA, T. SPREITZER, P. SQUILLACIOTI, M. STANITZKI, A. STAVERIS POLYKALAS, RICHARD DANTE S.T. DENIS, BERND STELZER, OLIVER STELZER CHILTON, D. STENTZ, JOHN STROLOGAS, D. STUART, J. S. SUH, A. SUKHANOV, H. SUN, I. SUSLOV, T. SUZUKI, ANYES TAFFARD, RYUICHI TAKASHIMA, Y. TAKEUCHI, R. TANAKA, M. TECCHIO, P. K. TENG, KOJI TERASHI, JULIA THOM, ALAN STAN THOMPSON, E. THOMSON, PAUL LOUIS TIPTON, V. TIWARI, S. TKACZYK, DAVID A. TOBACK, S. TOKAR, K. TOLLEFSON, TOMONOBU TOMURA, DIEGO TONELLI, S. TORRE, D. TORRETTA, S. TOURNEUR, WILLIAM TRISCHUK, S. TSUNO, Y. TU, N. TURINI, FUMIHIKO UKEGAWA, S. UOZUMI, S. VALLECORSA, N. 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ZUCCHELLI, DI RUZZA, BENEDETTO, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), CDF, Aaltonen, T, Abulencia, A, Adelman, J, Affolder, T, Akimoto, T, Albrow, Mg, Amerio, S, Amidei, D, Anastassov, A, Anikeev, K, Annovi, A, Antos, J, Aoki, M, Apollinari, G, Arisawa, T, Artikov, A, Ashmanskas, W, Attal, A, Aurisano, A, Azfar, F, Azzi Bacchetta, P, Azzurri, P, Bacchetta, N, Badgett, W, Barbaro Galtieri, A, Barnes, Ve, Barnett, Ba, Baroiant, S, Bartsch, V, Bauer, G, Beauchemin, Ph, Bedeschi, F, Behari, S, Bellettini, G, Bellinger, J, Belloni, A, Benjamin, D, Beretvas, A, Beringer, J, Berry, T, Bhatti, A, Binkley, M, Bisello, D, Bizjak, I, Blair, Re, Blocker, C, Blumenfeld, B, Bocci, A, Bodek, A, Boisvert, V, Bolla, G, Bolshov, A, Bortoletto, D, 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Uozumi, S, Vallecorsa, S, van Remortel, N, Varganov, A, Vataga, E, Vazquez, F, Velev, G, Vellidis, C, Veramendi, G, Veszpremi, V, Vidal, M, Vidal, R, Vila, I, Vilar, R, Vine, T, Vogel, M, Vollrath, I, Volobouev, I, Volpi, G, Wurthwein, F, Wagner, P, Wagner, Rg, Wagner, Rl, Wagner, J, Wagner, W, Wallny, R, Wang, Sm, Warburton, A, Waters, D, Weinberger, M, Wester, Wc, Whitehouse, B, Whiteson, D, Wicklund, Ab, Wicklund, E, Williams, G, Williams, Hh, Wilson, P, Winer, Bl, Wittich, P, Wolbers, S, Wolfe, C, Wright, T, Wu, X, Wynne, Sm, Yagil, A, Yamamoto, K, Yamaoka, J, Yamashita, T, Yang, C, Yang, Uk, Yang, Yc, Yao, Wm, Yeh, Gp, Yoh, J, Yorita, K, Yoshida, T, Yu, Gb, Yu, I, Yu, S, Yun, Jc, Zanello, L, Zanetti, A, Zaw, I, Zhang, X, Zhou, J, Zucchelli, S., Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), 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Suslov, T. Suzuki, A. Taffard, R. Takashima, Y. Takeuchi, R. Tanaka, M. Tecchio, P. K. Teng, K. Terashi, J. Thom, A. S. Thompson, E. Thomson, P. Tipton, V. Tiwari, S. Tkaczyk, D. Toback, S. Tokar, K. Tollefson, T. Tomura, D. Tonelli, S. Torre, D. Torretta, S. Tourneur, W. Trischuk, S. Tsuno, Y. Tu, N. Turini, F. Ukegawa, S. Uozumi, S. Vallecorsa, N. van Remortel, A. Varganov, E. Vataga, F. Vazquez, G. Velev, C. Vellidi, G. Veramendi, V. Veszpremi, M. Vidal, R. Vidal, I. Vila, R. Vilar, T. Vine, M. Vogel, I. Vollrath, I. Volobouev, G. Volpi, F. Würthwein, P. Wagner, R. G. Wagner, R. L. Wagner, J. Wagner, W. Wagner, R. Wallny, S. M. Wang, A. Warburton, D. Water, M. Weinberger, W. C. Wester, III, B. Whitehouse, D. Whiteson, A. B. Wicklund, E. Wicklund, G. William, H. H. William, P. Wilson, B. L. Winer, P. Wittich, S. Wolber, C. Wolfe, T. Wright, X. Wu, S. M. Wynne, A. Yagil, K. Yamamoto, J. Yamaoka, T. Yamashita, C. Yang, U. K. Yang, Y. C. Yang, W. M. Yao, G. P. Yeh, J. Yoh, K. Yorita, T. Yoshida, G. B. Yu, I. Yu, S. S. Yu, J. C. Yun, L. Zanello, A. Zanetti, I. Zaw, X. Zhang, J. Zhou, S. Zucchelli, and (CDF Collaboration)

Subjects
Particle physics, Physics, Multidisciplinary, Hadron, Gaussian distribution, Mass measurement, General Physics and Astronomy, ddc:500.2, Lambda baryon, 01 natural sciences, High Energy Physics - Experiment, Xi baryon, Particle decay, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Measurement theory, Nuclear Experiment, 010306 general physics, Probability, Physics, Muon, 010308 nuclear & particles physics, Hyperon, Background fluctuation, Baryon, Crystallography, 14.20.Mr, 13.30.Eg, 13.60.Rj, High Energy Physics::Experiment, Nucleon
Abstract

We report the observation and measurement of the mass of the bottom, strange baryon $\Xi^-_b$ through the decay chain $\Xi^-_b \to J/\psi \Xi^-$, where $J/\psi \to \mu^+ \mu^-$, $\Xi^- \to \Lambda \pi^-$, and $\Lambda \to p \pi^-$. Evidence for observation is based on a signal whose probability of arising from the estimated background is 6.6 x 10^{-15}, or 7.7 Gaussian standard deviations. The $\Xi^-_b$ mass is measured to be $5792.9\pm 2.5$ (stat.) $\pm 1.7$ (syst.) MeV/$c^2$., Comment: Minor text changes for the second version. Accepted by Phys. Rev. Lett

Published
2007
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21. First observation of heavy baryons Sigma(b) and Sigma(b)*

Author

Aaltonen, T., Abulencia, A., OF PHYS, HELSINKI I. N. S. T., Adelman, J., Illinois, U, Urbana, ANTHONY ALLEN AFFOLDER, Chicago, U, Efi, Akimoto, T., Santa, Barbara, Albrow, MICHAEL G., Tsukuba, U, Amerio, S., Fermilab, Amidei, DANTE E., Padua, U, Anastassov, A., Michigan, U, Anikeev, K., Rutgers, U, Piscataway, Annovi, A., Antos, J., Frascati, Aoki, M., Comenius, U, Apollinari, G., Arisawa, T., Artikov, A., Waseda, U, WILLIAM JOSEPH ASHMANSKAS, Dubna, Jinr, Attal, A., Adam, Aurisano, Barcelona, Ifae, Azfar, F., Texas, A. M., AZZI BACCHETTA, P., Oxford, U, Paolo, Azzurri, Nicola, Bacchetta, Pisa, U, Badgett, W., ANGELA BARBARO GALTIERI, Barnes, V. E., Lbl, Berkeley, Barnett, BRUCE A., Purdue, U, Baroiant, S., JOHNS HOPKINS, U, Bartsch, V., Davis, Uc, Bauer, G., London, UNIVERSITY C. O. L. L., Beauchemin, P. 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Yamamoto, J. Yamaoka, T. Yamashita, C. Yang, U. K. Yang13,j, Y. C. Yang, W. M. Yao, G. P. Yeh, J. Yoh, K. Yorita, T. Yoshida, G. B. Yu, I. Yu, S. S. Yu, J. C. Yun, L. Zanello, A. Zanetti, I. Zaw, X. Zhang, J. Zhou, and S. Zucchelli

Abstract

We report an observation of new bottom baryons produced in pp̄ collisions at the Tevatron. Using 1.1fb-1 of data collected by the CDF II detector, we observe four Λb0π± resonances in the fully reconstructed decay mode Λb0→Λc+π-, where Λc+→pK-π+. We interpret these states as the Σb(*) ± baryons and measure the following masses: mΣb+=5807.8-2.2+2. 0(stat.)±1.7(syst.)MeV/c2, mΣb-=5815.2±1.0(stat.)±1. 7(syst.)MeV/c2, and m(Σb*)-m(Σb)=21.2-1.9+2.0(stat.)-0.3+0. 4(syst.)MeV/c2

Published
2007

22. Observation of B0(s) - anti-B0(s) Oscillations

Author

Abulencia, A., Illinois, U, Urbana, Adelman, J., Chicago, U, Efi, ANTHONY ALLEN AFFOLDER, Santa, Barbara, Akimoto, T., Tsukuba, U, Albrow, MICHAEL G., Fermilab, Ambrose, D., Amerio, S., Padua, U, Amidei, DANTE E., Michigan, U, Anastassov, A., Rutgers, U, Piscataway, Anikeev, K., Annovi, A., Frascati, Antos, J., Taiwan, Phys, I. N. S. T., Aoki, M., Apollinari, G., JEAN FRANCOIS ARGUIN, Mcgill, U, Arisawa, T., Waseda, U, Artikov, A., Dubna, Jinr, WILLIAM JOSEPH ASHMANSKAS, Attal, A., Ucla, Azfar, F., Oxford, U, AZZI BACCHETTA, P., Paolo, Azzurri, Pisa, U, Nicola, Bacchetta, Badgett, W., ANGELA BARBARO GALTIERI, Lbl, Berkeley, Barnes, V. E., Purdue, U, Barnett, BRUCE A., JOHNS HOPKINS, U, Baroiant, S., Davis, Uc, Bartsch, V., London, UNIVERSITY C. O. L. L., Bauer, G., Mit, Franco, Bedeschi, Behari, S., Stefano, Belforte, Infn, Udine, Giorgio, Bellettini, JAMES NUGENT BELLINGER, Wisconsin, U, Madison, Belloni, A., Benjamin, DOUGLAS P., Duke, U, Beretvas, ANDREW F., Juerg, Beringer, Berry, T., Liverpool, U, ANWAR AHMAD BHATTI, Rockefeller, U, Morris, Binkley, Dario, Bisello, ROBERT EUGENE BLAIR, Argonne, CRAIG ALAN BLOCKER, Brandeis, U, Blumenfeld, BARRY J., Andrea, Bocci, Arie, Bodek, Rochester, U, Veronique, Boisvert, Bolla, G., Bolshov, A., Bortoletto, D., Boudreau, J., Pittsburgh, U, Boveia, A., Brau, BENJAMIN P., Luca, Brigliadori, Bologna, U, CARL MICHAEL BROMBERG, MICHIGAN STATE, U, ERIK MATTHEWS BRUBAKER, Budagov, J., Budd, H. S., SARAH REBECCA BUDD, Budroni, S., Burkett, K., Giovanni, Busetto, Bussey, P., Glasgow, U, Byrum, K. L., Cabrera, S., Campanelli, M., Geneva, U, Campbell, M., MARIA FLORENCIA CANELLI, Canepa, A., Carrillo, S., Florida, U, Carlsmith, DUNCAN L., Carosi, R., Carron, S., Bruno, Casal, OF PHYS, CANTABRIA I. N. S. T., Casarsa, M., Castro, A., Pierluigi, Catastini, Cauz, D., MATTEO CAVALLI SFORZA, Barcelona, Autonoma, U, Alessandro, Cerri, Lucio, Cerrito, Sanghyeon, Chang, Kyungpook, N. A. T. L. U., Chen, Y. C., MAXWELL BENJAMIN CHERTOK, Giorgio, Chiarelli, Chlachidze, G., Chlebana, F., Cho, I., Cho, K., Chokheli, D., Chou, J. P., Harvard, U, Georgios, Choudalakis, Chuang, S. H., Chung, K., CARNEGIE MELLON, U, Chung, W. H., YEON SEI CHUNG, Ciljak, M., CATALIN IRINEL CIOBANU, Ciocci, M. A., Clark, A., Clark, D., MIRCEA NOROCEL COCA, Compostella, G., Convery, M. E., Conway, JOHN S., Cooper, B., Katherine, Copic, Cordelli, M., Cortiana, G., Crescioli, F., CUENCA ALMENAR, C., Cuevas, J., Culbertson, RAY L., Cully, J. C., Cyr, D., Daronco, S., Saverio, D'Auria, Davies, T., D'Onofrio, M., WILLIAM DAVID DAGENHART, DE BARBARO, P., DE CECCO, S., Infn, Rome, Deisher, A., DE LENTDECKER, G., Mauro, Dell'Orso, DELLI PAOLI, F., Luc, Demortier, Deng, J., Deninno, M., DE PEDIS, D., Derwent, P. 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F., Gay, C., Gerberich, H., Gerdes, DAVID W., Stefano, Giagu, Giannetti, P., Gibson, A., Gibson, K., JENNIFER LINDSAY GIMMELL, Ginsburg, CAMILLE M., Giokaris, N., MARIO PAOLO GIORDANI, Giromini, P., Giunta, M., Giurgiu, GAVRIL A., Glagolev, V., Glenzinski, DOUGLAS A., Gold, M., NEW MEXICO, U, NATHAN JOEL GOLDSCHMIDT, Joel, Goldstein, Gomez, G., GOMEZ CEBALLOS, G., Goncharov, MAXIM T., Texas, A. M., Gonzalez, O., Gorelov, IGOR V., Goshaw, ALFRED T., Konstantin, Goulianos, Gresele, A., Griffiths, M., Sebastian, Grinstein, GROSSO PILCHER, C., ROBERT CRAIG GROUP, Ulysses, Grundler, JOAO PEDRO BARREIRO GUIMARAES DA COSTA, GUNAY UNALAN, Z., Haber, CARL H., Hahn, K., Hahn, STEPHEN R., Halkiadakis, E., Hamilton, A., Han, B. Y., Han, J. Y., Handler, R., Happacher, F., Hara, K., Hare, M., Tufts, U, Harper, S., ROBERT FRANCIS HARR, WAYNE STATE, U, Harris, R. M., Hartz, M., Kenichi, Hatakeyama, Hauser, J., Heijboer, A., Pennsylvania, U, Heinemann, B., Joel, Heinrich, Henderson, C., Herndon, M., Heuser, J., DEAN ANDREW HIDAS, Hill, CHRISTOPHER S., Hirschbuehl, D., JAMES ANDREW HOCKER, Holloway, A., Hou, S., Houlden, MICHAEL A., Hsu, S. C., San, Diego, Huffman, BRIAN T., Hughes, R. E., Ulrich, Husemann, Huston, J., Incandela, JOSEPH R., Introzzi, G., Iori, M., Ishizawa, Y., Ivanov, A., Iyutin, B., James, ERIC B., Jang, D., BODHITHA ANJALIKE JAYATILAKA, Jeans, D., Jensen, H., Jeon, E. J., Sergo, Jindariani, Jones, M., Joo, K. K., Jun, S. Y., Jung, J. E., Junk, THOMAS R., Teruki, Kamon, Karchin, PAUL E., Kato, Y., OSAKA CITY, U, Kemp, Y., Kephart, R., Kerzel, U., Khotilovich, V., Kilminster, B., Kim, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., YOUNG KEE KIM, Kimura, N., Kirsch, LAWRENCE E., Sergey, Klimenko, Markus, Klute, BRUCE OWEN KNUTESON, Byeongrok, Ko, Kondo, K., DAE JUNG KONG, Jacobo, Konigsberg, Korytov, A., ASHUTOSH VIJAY KOTWAL, Kovalev, A., AAFKE CHRISTINE KRAAN, Kraus, J., Kravchenko, I., Kreps, M., Kroll, J., Krumnack, N., MARK CHARLES KRUSE, Krutelyov, VYACHESLAV E., Kubo, T., Kuhlmann, S. E., Kuhr, T., Kusakabe, Y., Kwang, S., ALVIN TOIVO LAASANEN, Lai, S., Stefano, Lami, Lammel, S., Lancaster, M., Lander, R. L., Lannon, K., Lath, A., Latino, G., Lazzizzera, I., THOMAS JOSEPH LECOMPTE, Lee, J., Lee, Y. J., SUNG WON LEE, Lefevre, R., Leonardo, NUNO T., Sandra, Leone, Levy, S., Lewis, JONATHAN D., Lin, C., CHENG JU STEPHEN LIN, MICHAEL ALLEN LINDGREN, Lipeles, E., Liss, TONY M., Lister, A., Litvintsev, D. O., Liu, T., Lockyer, NIGEL S., Loginov, A., Moscow, Itep, Maurizio, Loreti, Loverre, P., R. S., Lu, Lucchesi, D., Lujan, P., Lukens, P., Lungu, G., Louis, Lyons, Lys, J., Lysak, R., Else, Lytken, Mack, P., Macqueen, D., ROBYN LEIGH MADRAK, Kaori, Maeshima, Khaldoun, Makhoul, Maki, T., OF PHYS, HELSINKI I. N. S. T., Petar, Maksimovic, Malde, S., Manca, G., Margaroli, F., Radu, Marginean, Marino, C., Marino, C. P., Martin, A., Martin, M., Martin, V., Martinez, M., Maruyama, T., Mastrandrea, P., Tatsuya, Masubuchi, Matsunaga, H., Mattson, M. E., Mazini, R., Paolo, Mazzanti, Mcfarland, KEVIN S., Mcintyre, PETER M., Mcnulty, R., Mehta, A., Mehtala, P., Menzemer, S., Menzione, A., Merkel, P., Christina, Mesropian, Messina, A., Ting, Miao, Miladinovic, N., Miles, J., Miller, R., Mills, C., Michael, Milnik, Mitra, A., Guenakh, Mitselmakher, Miyamoto, A., Kek, Tsukuba, Moed, S., Moggi, N., Mohr, B., Moore, R., Morello, M., MOVILLA FERNANDEZ, PEDRO A., Mulmenstadt, J., Mukherjee, A., Muller, T. H., Mumford, R., Murat, P., JANE MARIE NACHTMAN, Nagano, A., Junji, Naganoma, Nahn, STEVEN C., Nakano, I., Okayama, U, Austin, Napier, Necula, V., Neu, CHRISTOPHER C., MARK STEPHEN NEUBAUER, Nielsen, JASON A., Nigmanov, T., Nodulman, L., Olga, Norniella, Nurse, E., S. H., Oh, Y. D., Oh, Oksuzian, I., Okusawa, T., Oldeman, R., Risto, Orava, Osterberg, K., Pagliarone, C., Palencia, E., Vaia, Papadimitriou, Paramonov, A. A., Parks, B., SHABNAZ PASHAPOUR ALAMDARI, Patrick, J., Pauletta, G., Paulini, M., Paus, CHRISTOPH M. E., Pellett, D. 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P., Schmitt, M., Northwestern, U, Schwarz, T., Scodellaro, L., ADAM LIDDLE SCOTT, Scribano, A., Scuri, F., Sedov, A., SALLY CAROL SEIDEL, Yoshihiro, Seiya, Semenov, A., ELIZABETH SEXTON KENNEDY, Sfyrla, A., Shapiro, M. D., Shears, T., Shepard, P. F., Sherman, D., Shimojima, M., Shochet, MELVYN J., Shon, Y., Shreyber, I., Sidoti, A., Sinervo, PEKKA K., Sisakyan, A., Sjolin, J., JEAN SLAUGHTER, A., Slaunwhite, J., Sliwa, K., Smith, J. R., Snider, F. D., Snihur, R., Soderberg, M., Soha, A., Somalwar, SUNIL V., MARIA VERONICA SORIN, Spalding, J., Spinella, F., Spreitzer, T., Squillacioti, P., Stanitzki, M., STAVERIS POLYKALAS, A., Denis, RICHARD DANTE S. T., Bernd, Stelzer, OLIVER STELZER CHILTON, Stentz, D., John, Strologas, Stuart, D., Suh, J. S., Sukhanov, A., Sun, H., Suzuki, T., Anyes, Taffard, Ryuichi, Takashima, Takeuchi, Y., Koji, Takikawa, Tanaka, M., Tanaka, R., Tecchio, M., Teng, P. K., Koji, Terashi, Julia, Thom, ALAN STAN THOMPSON, Thomson, E., PAUL LOUIS TIPTON, Tiwari, V., Tkaczyk, S., Toback, DAVID A., Tokar, S., Tollefson, K., Tomonobu, Tomura, Diego, Tonelli, Torre, S., Torretta, D., Tourneur, S., William, Trischuk, Tsuchiya, R., Tsuno, S., Turini, N., Fumihiko, Ukegawa, Unverhau, T., Uozumi, S., Denys, Usynin, Vallecorsa, S., VAN REMORTEL, N., Varganov, A., Vataga, E., ELSA FABIOLA VAZQUEZ VALENCIA, Velev, G., GREGORY FRANCISCO VERAMENDI, Viktor, Veszpremi, Vidal, R., Ivan, Vila, Rocio, Vilar, Vine, T., Vollrath, I., Volobouev, I., Volpi, G., Wuerthwein, FRANK K., Wagner, P., Wagner, ROBERT G., Wagner, R. L., Wagner, J., Wolfgang, Wagner, Wallny, R., Wang, S. M., Warburton, ANDREAS T., Simon, Waschke, David, Waters, Weinberger, M., WILLIAM CARL WESTER, Iii, Fermilab, Whitehouse, B., Whiteson, DANIEL O., ARTHUR BARRY WICKLUND, Wicklund, ERIC J., Williams, G., Williams, H. H., Wilson, P., Winer, B. L., Peter, Wittich, Wolbers, STEPHEN A., Wolfe, CARL E., Wright, T., Wu, X., SARA MADGE VIOLETTE WYNNE, Yagil, A., Yamamoto, K., Yamaoka, J., Yamashita, T., Yang, C., UN KI YANG, Yang, Y. C., Yao, W. M., GONG PING YEH, Yoh, J., Kohei, Yorita, Yoshida, T., GEUM BONG YU, Yu, I., SHIN SHAN YU, JAE CHUL YUN, Lucia, Zanello, ANNA MARIA ZANETTI, Zaw, I., Zhang, X., Zhou, J., Zucchelli, S., Bologna, U., A., Abulencia, Illinois, U, Urbana, J., Adelman, Chicago, U, Efi, ANTHONY ALLEN, Affolder, Uc, Santa, Barbara, T., Akimoto, Tsukuba, U, MICHAEL G., Albrow, Fermilab, D., Ambrose, S., Amerio, Padua, U, DANTE E., Amidei, Michigan, U, A., Anastassov, Rutgers, U, Piscataway, K., Anikeev, A., Annovi, Frascati, J., Anto, Taiwan, Phys, I. N. S. T., M., Aoki, G., Apollinari, JEAN FRANCOIS, Arguin, Mcgill, U, T., Arisawa, Waseda, U, A., Artikov, Dubna, Jinr, WILLIAM JOSEPH, Ashmanska, A., Attal, Ucla, F., Azfar, Oxford, U, P., AZZI BACCHETTA, Paolo, Azzurri, Pisa, U, Nicola, Bacchetta, W., Badgett, ANGELA BARBARO, Galtieri, Lbl, Berkeley, V. E., Barne, Purdue, U, BRUCE A., Barnett, JOHNS HOPKINS, U, S., Baroiant, Uc, Davi, V., Bartsch, London, UNIVERSITY C. O. L. L., G., Bauer, Mit, Franco, Bedeschi, S., Behari, Stefano, Belforte, Infn, Udine, Giorgio, Bellettini, JAMES NUGENT, Bellinger, Wisconsin, U, Madison, A., Belloni, DOUGLAS P., Benjamin, Duke, U, ANDREW F., Beretva, Juerg, Beringer, T., Berry, Liverpool, U, ANWAR AHMAD, Bhatti, Rockefeller, U, Morris, Binkley, Dario, Bisello, ROBERT EUGENE, Blair, Argonne, CRAIG ALAN, Blocker, Brandeis, U, BARRY J., Blumenfeld, Andrea, Bocci, Arie, Bodek, Rochester, U, Veronique, Boisvert, G., Bolla, A., Bolshov, D., Bortoletto, J., Boudreau, Pittsburgh, U, A., Boveia, BENJAMIN P., Brau, Luca, Brigliadori, Bologna, U, CARL MICHAEL, Bromberg, MICHIGAN STATE, U, ERIK MATTHEWS, Brubaker, J., Budagov, H. S., Budd, SARAH REBECCA, Budd, S., Budroni, K., Burkett, Giovanni, Busetto, P., Bussey, Glasgow, U, K. L., Byrum, S., Cabrera, M., Campanelli, Geneva, U, M., Campbell, MARIA FLORENCIA, Canelli, A., Canepa, S., Carrillo, Florida, U, DUNCAN L., Carlsmith, R., Carosi, S., Carron, Bruno, Casal, OF PHYS, CANTABRIA I. N. S. T., M., Casarsa, A., Castro, Pierluigi, Catastini, D., Cauz, MATTEO CAVALLI, Sforza, Barcelona, Autonoma, U, Alessandro, Cerri, Lucio, Cerrito, Sanghyeon, Chang, KYUNGPOOK N. A. T. L., U, Y. C., Chen, MAXWELL BENJAMIN, Chertok, Giorgio, Chiarelli, G., Chlachidze, F., Chlebana, I., Cho, K., Cho, D., Chokheli, J. P., Chou, Harvard, U, Georgios, Choudalaki, S. H., Chuang, K., Chung, CARNEGIE MELLON, U, W. H., Chung, YEON SEI, Chung, M., Ciljak, CATALIN IRINEL, Ciobanu, M. A., Ciocci, A., Clark, D., Clark, MIRCEA NOROCEL, Coca, G., Compostella, M. E., Convery, JOHN S., Conway, B., Cooper, Katherine, Copic, M., Cordelli, G., Cortiana, F., Crescioli, C., CUENCA ALMENAR, J., Cueva, RAY L., Culbertson, J. C., Cully, D., Cyr, S., Daronco, Saverio, D'Auria, T., Davie, M., D'Onofrio, WILLIAM DAVID, Dagenhart, P., DE BARBARO, S., DE CECCO, Infn, Rome, A., Deisher, G., DE LENTDECKER, Mauro, Dell'Orso, F., DELLI PAOLI, Luc, Demortier, J., Deng, M., Deninno, D., DE PEDIS, P. F., Derwent, G. P., DI GIOVANNI, Paris, U, Vi, Vii, C., Dionisi, DI RUZZA, Benedetto, JAY R., Dittmann, Baylor, U, Dept, M. A. T. H., P., Dituro, Christian, Doerr, Karlsruhe, U, Ekp, S., Donati, M., Donega, P., Dong, J., Donini, T., Dorigo, S., Dube, JONATHAN ZVI, Efron, OHIO STATE, U, ROBIN D., Erbacher, D., Errede, STEVEN MICHAEL, Errede, Ricardo, Eusebi, H. C., Fang, SINEAD MARIE, Farrington, I., Fedorko, W. T., Fedorko, R. G., Feild, Yale, U, Michael, Feindt, J. P., Fernandez, Madrid, Ciemat, R., Field, G., Flanagan, ANDREW DEAN, Foland, S., Forrester, G., WILLIAM FOSTER, M., Franklin, J. C., Freeman, HENRY J., Frisch, I., Furic, Michele, Gallinaro, J., Galyardt, J. E., Garcia, F., Garberson, A. F., Garfinkel, C., Gay, H., Gerberich, DAVID W., Gerde, Stefano, Giagu, P., Giannetti, A., Gibson, K., Gibson, JENNIFER LINDSAY, Gimmell, CAMILLE M., Ginsburg, N., Giokari, MARIO PAOLO, Giordani, P., Giromini, M., Giunta, GAVRIL A., Giurgiu, V., Glagolev, DOUGLAS A., Glenzinski, M., Gold, NEW MEXICO, U, NATHAN JOEL, Goldschmidt, Joel, Goldstein, G., Gomez, G., GOMEZ CEBALLOS, MAXIM T., Goncharov, TEXAS A., M, O., Gonzalez, IGOR V., Gorelov, ALFRED T., Goshaw, Konstantin, Gouliano, A., Gresele, M., Griffith, Sebastian, Grinstein, C., GROSSO PILCHER, ROBERT CRAIG, Group, Ulysses, Grundler, JOAO PEDRO BARREIRO GUIMARAES DA, Costa, Z., GUNAY UNALAN, CARL H., Haber, K., Hahn, STEPHEN R., Hahn, E., Halkiadaki, A., Hamilton, B. Y., Han, J. Y., Han, R., Handler, F., Happacher, K., Hara, M., Hare, Tufts, U, S., Harper, ROBERT FRANCIS, Harr, WAYNE STATE, U, R. M., Harri, M., Hartz, Kenichi, Hatakeyama, J., Hauser, A., Heijboer, Pennsylvania, U, B., Heinemann, Joel, Heinrich, C., Henderson, M., Herndon, J., Heuser, DEAN ANDREW, Hida, CHRISTOPHER S., Hill, D., Hirschbuehl, JAMES ANDREW, Hocker, A., Holloway, S., Hou, MICHAEL A., Houlden, S. C., Hsu, San, Diego, BRIAN T., Huffman, R. E., Hughe, Ulrich, Husemann, J., Huston, JOSEPH R., Incandela, G., Introzzi, M., Iori, Y., Ishizawa, A., Ivanov, B., Iyutin, ERIC B., Jame, D., Jang, BODHITHA ANJALIKE, Jayatilaka, D., Jean, H., Jensen, E. J., Jeon, Sergo, Jindariani, M., Jone, K. K., Joo, S. Y., Jun, J. E., Jung, THOMAS R., Junk, Teruki, Kamon, PAUL E., Karchin, Y., Kato, OSAKA CITY, U, Y., Kemp, R., Kephart, U., Kerzel, V., Khotilovich, B., Kilminster, D. H., Kim, H. S., Kim, J. E., Kim, M. J., Kim, S. B., Kim, S. H., Kim, YOUNG KEE, Kim, N., Kimura, LAWRENCE E., Kirsch, Sergey, Klimenko, Markus, Klute, BRUCE OWEN, Knuteson, Byeongrok, Ko, K., Kondo, DAE JUNG, Kong, Jacobo, Konigsberg, A., Korytov, ASHUTOSH VIJAY, Kotwal, A., Kovalev, AAFKE CHRISTINE, Kraan, J., Krau, I., Kravchenko, M., Krep, J., Kroll, N., Krumnack, MARK CHARLES, Kruse, VYACHESLAV E., Krutelyov, T., Kubo, S. E., Kuhlmann, T., Kuhr, Y., Kusakabe, S., Kwang, ALVIN TOIVO, Laasanen, S., Lai, Stefano, Lami, S., Lammel, M., Lancaster, R. L., Lander, K., Lannon, A., Lath, G., Latino, I., Lazzizzera, THOMAS JOSEPH, Lecompte, J., Lee, Y. J., Lee, SUNG WON, Lee, R., Lefevre, NUNO T., Leonardo, Sandra, Leone, S., Levy, JONATHAN D., Lewi, C., Lin, CHENG JU STEPHEN, Lin, MICHAEL ALLEN, Lindgren, E., Lipele, TONY M., Li, A., Lister, D. O., Litvintsev, T., Liu, NIGEL S., Lockyer, A., Loginov, Moscow, Itep, Maurizio, Loreti, P., Loverre, R. S., Lu, D., Lucchesi, P., Lujan, P., Luken, G., Lungu, Louis, Lyon, J., Ly, R., Lysak, Else, Lytken, P., Mack, D., Macqueen, ROBYN LEIGH, Madrak, Kaori, Maeshima, Khaldoun, Makhoul, T., Maki, OF PHYS, HELSINKI I. N. S. T., Petar, Maksimovic, S., Malde, G., Manca, F., Margaroli, Radu, Marginean, C., Marino, C. P., Marino, A., Martin, M., Martin, V., Martin, M., Martinez, T., Maruyama, P., Mastrandrea, Tatsuya, Masubuchi, H., Matsunaga, M. E., Mattson, R., Mazini, Paolo, Mazzanti, KEVIN S., Mcfarland, PETER M., Mcintyre, R., Mcnulty, A., Mehta, P., Mehtala, S., Menzemer, A., Menzione, P., Merkel, Christina, Mesropian, A., Messina, Ting, Miao, N., Miladinovic, J., Mile, R., Miller, C., Mill, Michael, Milnik, A., Mitra, Guenakh, Mitselmakher, A., Miyamoto, Kek, Tsukuba, S., Moed, N., Moggi, B., Mohr, R., Moore, M., Morello, PEDRO A., MOVILLA FERNANDEZ, J., Mulmenstadt, A., Mukherjee, Muller, T. H., R., Mumford, P., Murat, JANE MARIE, Nachtman, A., Nagano, Junji, Naganoma, STEVEN C., Nahn, I., Nakano, Okayama, U, Austin, Napier, V., Necula, CHRISTOPHER C., Neu, MARK STEPHEN, Neubauer, JASON A., Nielsen, T., Nigmanov, L., Nodulman, Olga, Norniella, E., Nurse, S. H., Oh, Y. D., Oh, I., Oksuzian, T., Okusawa, R., Oldeman, Risto, Orava, K., Osterberg, C., Pagliarone, E., Palencia, Vaia, Papadimitriou, A. A., Paramonov, B., Park, SHABNAZ PASHAPOUR, Alamdari, J., Patrick, G., Pauletta, M., Paulini, CHRISTOPH M. E., Pau, D. E., Pellett, A., Penzo, THOMAS J., Phillip, G., Piacentino, Jonatan, Piedra, L., Pinera, K., Pitt, Charles, Plager, Lee, Pondrom, X., Portell, O., Poukhov, N., Pounder, F., Prokoshin, A., Pronko, James, Proudfoot, F., Ptocho, G., Punzi, JENNIFER M., Pursley, J., Rademacker, A., Rahaman, N., Ranjan, S., Rappoccio, B., Reisert, V., Rekovic, Peter, Renton, Marco, Rescigno, S., Richter, F., Rimondi, L., Ristori, A., Robson, T., Rodrigo, E., Roger, Simona, Rolli, ROBERT M., Roser, M., Rossi, R., Rossin, A., Ruiz, J., Ru, V., Rusu, H., Saarikko, S., Sabik, ALEXEI NIKOLAYEVICH, Safonov, W. K., Sakumoto, G., Salamanna, O., Salto, DAVID PAUL, Saltzberg, C., Sanchez, L., Santi, S., Sarkar, L., Sartori, K., Sato, P., Savard, A., SAVOY NAVARRO, T., Scheidle, P., Schlabach, EUGENE E., Schmidt, M. P., Schmidt, M., Schmitt, Northwestern, U, T., Schwarz, L., Scodellaro, ADAM LIDDLE, Scott, A., Scribano, F., Scuri, A., Sedov, SALLY CAROL, Seidel, Yoshihiro, Seiya, A., Semenov, ELIZABETH SEXTON, Kennedy, A., Sfyrla, M. D., Shapiro, T., Shear, P. F., Shepard, D., Sherman, M., Shimojima, MELVYN J., Shochet, Y., Shon, I., Shreyber, A., Sidoti, PEKKA K., Sinervo, A., Sisakyan, J., Sjolin, A., JEAN SLAUGHTER, J., Slaunwhite, K., Sliwa, J. R., Smith, F. D., Snider, R., Snihur, M., Soderberg, A., Soha, SUNIL V., Somalwar, MARIA VERONICA, Sorin, J., Spalding, F., Spinella, T., Spreitzer, P., Squillacioti, M., Stanitzki, A., STAVERIS POLYKALAS, Denis, RICHARD DANTE S. T., Bernd, Stelzer, OLIVER STELZER, Chilton, D., Stentz, John, Strologa, D., Stuart, J. S., Suh, A., Sukhanov, H., Sun, T., Suzuki, Anyes, Taffard, Ryuichi, Takashima, Y., Takeuchi, Koji, Takikawa, M., Tanaka, R., Tanaka, M., Tecchio, P. K., Teng, Koji, Terashi, Julia, Thom, ALAN STAN, Thompson, E., Thomson, PAUL LOUIS, Tipton, V., Tiwari, S., Tkaczyk, DAVID A., Toback, S., Tokar, K., Tollefson, Tomonobu, Tomura, Diego, Tonelli, S., Torre, D., Torretta, S., Tourneur, William, Trischuk, R., Tsuchiya, S., Tsuno, N., Turini, Fumihiko, Ukegawa, T., Unverhau, S., Uozumi, Denys, Usynin, S., Vallecorsa, N., VAN REMORTEL, A., Varganov, E., Vataga, ELSA FABIOLA VAZQUEZ, Valencia, G., Velev, GREGORY FRANCISCO, Veramendi, Viktor, Veszpremi, R., Vidal, Ivan, Vila, Rocio, Vilar, T., Vine, I., Vollrath, I., Volobouev, G., Volpi, FRANK K., Wuerthwein, P., Wagner, ROBERT G., Wagner, R. L., Wagner, J., Wagner, Wolfgang, Wagner, R., Wallny, S. M., Wang, ANDREAS T., Warburton, Simon, Waschke, David, Water, M., Weinberger, WILLIAM CARL, Wester, Iii, Fermilab, B., Whitehouse, DANIEL O., Whiteson, ARTHUR BARRY, Wicklund, ERIC J., Wicklund, G., William, H. H., William, P., Wilson, B. L., Winer, Peter, Wittich, STEPHEN A., Wolber, CARL E., Wolfe, T., Wright, X., Wu, SARA MADGE VIOLETTE, Wynne, A., Yagil, K., Yamamoto, J., Yamaoka, T., Yamashita, C., Yang, UN KI, Yang, Y. C., Yang, W. M., Yao, GONG PING, Yeh, J., Yoh, Kohei, Yorita, T., Yoshida, GEUM BONG, Yu, I., Yu, SHIN SHAN, Yu, JAE CHUL, Yun, Lucia, Zanello, ANNA MARIA, Zanetti, I., Zaw, X., Zhang, J., Zhou, S., Zucchelli, and Bologna, U.

Subjects
tellurium compounds, oscillations, observation
Published
2006

23. Immune Thrombocytopenic Purpura — The Changing Therapeutic Landscape

Author

Michael Bromberg

Subjects
Immune system, Chronic disease, business.industry, Immunology, Medicine, General Medicine, business, medicine.disease, Thrombocytopenic purpura, Therapeutic strategy
Abstract

Thrombopoietic agents represent a promising new therapeutic strategy for ITP that is refractory to second- and third-line therapies. Dr. Michael Bromberg describes the pathogenesis of this chronic disease and the evolution of therapeutic options.

Published
2006
Full Text
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24. Measurement of R=B(t→Wb)/B(t→Wq) in Top--Quark--Pair Decays using Dilepton Events and the Full CDF Run II Data Set

Author

Cdf, Collaboration, Silvia, Amerio, Amidei, Dante E., Anton Iankov Anastassov, Alberto, Annovi, Jaroslav, Antos, Giorgio, Apollinari, Appel, Jeffrey A., Tetsuo, Arisawa, Akram Muzafarovich Artikov, Asaadi, Jonathan A., William Joseph Ashmanskas, Benjamin, Auerbach, Aurisano, Adam J., Azfar, Farrukh A., William Farris Badgett, Taegil, Bae, Angela Barbaro Galtieri, Barnes, Virgil E., Bruce Arnold Barnett, Patrizia, Barria, Pavol, Bartos, Matteo, Bauce, Franco, Bedeschi, Satyajit, Behari, Giorgio, Bellettini, James Nugent Bellinger, Benjamin, Douglas P., Beretvas, Andrew F., Anwar Ahmad Bhatti, Karen Renee Bland, Blumenfeld, Barry J., Andrea, Bocci, Arie, Bodek, Daniela, Bortoletto, Joseph Francis Boudreau, Antonio, Boveia, Luca, Brigliadori, Carl Michael Bromberg, Erik, Brucken, Budagov, Ioulian A., Howard Scott Budd, Kevin Alan Burkett, Giovanni, Busetto, Peter John Bussey, Pierfrancesco, Butti, Adrian, Buzatu, Aristotle, Calamba, Stefano, Camarda, Mario, Campanelli, Florencia, Canelli, Benjamin, Carls, Carlsmith, Duncan L., Roberto, Carosi, Salvador Carrillo Moreno, Bruno Casal Larana, Massimo, Casarsa, Andrea, Castro, Pierluigi, Catastini, Cauz, Diego, Viviana, Cavaliere, Matteo Cavalli Sforza, Alessandro, Cerri, Lucio, Cerrito, Yen Chu Chen, Maxwell Benjamin Chertok, Giorgio, Chiarelli, Gouram, Chlachidze, Kihyeon, Cho, Davit, Chokheli, Allan Geoffrey Clark, Christopher Joseph Clarke, Mary Elizabeth Convery, John Stephen Conway, Matteo, Corbo, Marco, Cordelli, Charles Alexander Cox, David Jeremy Cox, Matteo, Cremonesi, Daniel Cruz Alonso, Javier Cuevas Maestro, Raymond Lloyd Culbertson, Nicola, D'Ascenzo, Mousumi, Datta, Pawel de Barbaro, Demortier, Luc M., Maria Maddalena Deninno, Maria, D'Errico, Francesco, Devoto, Angelo Di Canto, Benedetto Di Ruzza, Jay Richard Dittmann, Simone, Donati, Monica, D'Onofrio, Mirco, Dorigo, Anna, Driutti, Koji, Ebina, Ryan Christopher Edgar, Elagin, Andrey L., Erbacher, Robin D., Steven Michael Errede, Benjamin, Esham, Sinead Marie Farrington, Juan Pablo Fernández Ramos, Field, Richard D., Flanagan, Gene U., Robert David Forrest, Melissa EB Franklin, John Christian Freeman, Frisch, Henry J., Yujiro, Funakoshi, Camilla, Galloni, Garfinkel, Arthur F., Paola, Garosi, Heather Kay Gerberich, Gerchtein, Elena A., Stefano, Giagu, Viktoria Athina Giakoumopoulou, Karen Ruth Gibson, Camille Marie Ginsburg, Giokaris, Nikos D., Paolo, Giromini, Giurgiu, Gavril A., Vladimir, Glagolev, Douglas Andrew Glenzinski, Gold, Michael S., Daniel, Goldin, Alexander, Golossanov, Gervasio, Gomez, Guillelmo Gomez Ceballos, Goncharov, Maxim T., Oscar González López, Gorelov, Igor V., Goshaw, Alfred T., Goulianos, Konstantin A., Elena, Gramellini, Sebastian, Grinstein, Carla Grosso Pilcher, Robert Craig Group, Joao Guimaraes da Costa, Hahn, Stephen R., Ji Yeon Han, Fabio, Happacher, Kazuhiko, Hara, Matthew Frederick Hare, Robert Francis Harr, Timothy Harrington Taber, Kenichi, Hatakeyama, Christopher Paul Hays, Heinrich, Joel G., Matthew Fairbanks Herndon, James Andrew Hocker, Ziqing, Hong, Walter Howard Hopkins, Suen Ray Hou, Richard Edward Hughes, Ulrich, Husemann, Mohammad, Hussein, Joey Walter Huston, Gianluca, Introzzi, Maurizio, Iori, Andrew Gennadievich Ivanov, James, Eric B., Dongwook, Jang, Bodhitha Anjalike Jayatilaka, Eun Ju Jeon, Sergo Robert Jindariani, Jones, Matthew T., Kyung Kwang Joo, Soon Yung Jun, Junk, Thomas R., Manuel, Kambeitz, Teruki, Kamon, Paul Edmund Karchin, Azeddine, Kasmi, Yukihiro, Kato, Wesley Robert Ketchum, Justin Kien Keung, Benjamin John Kilminster, Donghee, Kim, Hyunsoo, Kim, Jieun, Kim, Min Jeong Kim, Shin Hong Kim, Soo Bong Kim, Young Jin Kim, Young Kee Kim, Naoki, Kimura, Kirby, Michael H., Kyle James Knoepfel, Kunitaka, Kondo, Dae Jung Kong, Jacobo, Konigsberg, Ashutosh Vijay Kotwal, Michal, Kreps, Ijoseph, Kroll, Mark Charles Kruse, Thomas, Kuhr, Masakazu, Kurata, Alvin Toivo Laasanen, Stephan, Lammel, Mark, Lancaster, Kevin Patrick Lannon, Giuseppe, Latino, Hyun Su Lee, Jaison, Lee, Sabato, Leo, Sandra, Leone, Lewis, Jonathan D., Antonio, Limosani, Elliot David Lipeles, Alison, Lister, Hao, Liu, Qiuguang, Liu, Tiehui Ted Liu, Lockwitz, Sarah E., Andrey Borisovich Loginov, Donatella, Lucchesi, Alessandra, Lucà, Jan, Lueck, Paul Joseph Lujan, Patrick Thomas Lukens, Gheorghe, Lungu, Lys, Jeremy E., Roman, Lysak, Robyn Leigh Madrak, Paolo, Maestro, Sarah Alam Malik, Giulia, Manca, Arkadios Manousakis Katsikakis, Luigi Marchese Marchese, Fabrizio, Margaroli, Christopher Phillip Marino, Mario Martínez Perez, Keith, Matera, Mark Edward Mattson, Anna, Mazzacane, Paolo, Mazzanti, Ronan, Mcnulty, Andrew, Mehta, Petteri, Mehtala, Christina, Mesropian, Ting, Miao, David John Mietlicki, Ankush, Mitra, Hideki, Miyake, Shulamit, Moed, Niccolo, Moggi, Chang Seong Moon, Ronald Scott Moore, Michael Joseph Morello, Aseet, Mukherjee, Thomas, Muller, Murat, Pavel A., Manuel, Mussini, Jane Marie Nachtman, Yoshikazu, Nagai, Junji, Naganoma, Itsuo, Nakano, Austin, Napier, Jason Michael Nett, Christopher Carl Neu, Nigmanov, Turgun S., Nodulman, Lawrence J., Seoyoung, Noh, Olga Norniella Francisco, Louise Beth Oakes, Seog Hwan Oh, Young do Oh, Iuri Artur Oksuzian, Toru, Okusawa, Risto Olavi Orava, Lorenzo, Ortolan, Carmine Elvezio Pagliarone, Jose Enrique Palencia, Prabhakar, Palni, Vaia, Papadimitriou, William Chesluk Parker, Pauletta, Giovanni, Manfred, Paulini, Christoph Maria Ernst Paus, Phillips, Thomas J., Piacentino, Giovanni M., Elisabetta, Pianori, Justin Robert Pilot, Pitts, Kevin T., Charles, Plager, Pondrom, Lee G., Stephen, Poprocki, Karolos Jozef Potamianos, Aliaksandr Pavlovich Pranko, Fedor, Prokoshin, Ptohos, Fotios K., Giovanni, Punzi, Niharika, Ranjan, Ignacio Redondo Fernández, Renton, Peter B., Marco, Rescigno, Franco, Rimondi, Luciano, Ristori, Aidan, Robson, Tatiana Isabel Rodriguez, Simona, Rolli, Manfredi, Ronzani, Robert Martin Roser, Rosner, Jonathan L., Fabrizio, Ruffini, Alberto Ruiz Jimeno, Russ, James S., Vadim Liviu Rusu, Willis Kazuo Sakumoto, Yuki, Sakurai, Santi, Lorenzo Gianni, Koji, Sato, Valeri, Saveliev, Aurore Savoy Navarro, Philip, Schlabach, Schmidt, Eugene E., Schwarz, Thomas A., Luca, Scodellaro, Fabrizio, Scuri, Seidel, Sally C., Yoshihiro, Seiya, Alexei, Semenov, Federico, Sforza, Shalhout Zaki Shalhout, Shears, Tara G., Shepard, Paul F., Makoto, Shimojima, Shochet, Melvyn J., Irina Shreyber Tecker, Simonenko, Alexander V., Krzysztof Jan Sliwa, John Rodgers Smith, Frederick Douglas Snider, Hao, Song, Maria Veronica Sorin, Richard Dante St Denis, Michelle Dawn Stancari, Dale James Stentz, John, Strologas, Yuji, Sudo, Sukhanov, Alexander I., Suslov, Igor M., Ken ichi Takemasa, Yuji, Takeuchi, Jian, Tang, Monica, Tecchio, Ping Kun Teng, Julia, Thom, Evelyn Jean Thomson, Vaikunth, Thukral, Toback, David A., Stanislav, Tokar, Kirsten Anne Tollefson, Tomonobu, Tomura, Diego, Tonelli, Stefano, Torre, Donatella, Torretta, Pierluigi, Totaro, Marco, Trovato, Fumihiko, Ukegawa, Satoru, Uozumi, Gueorgui, Velev, Konstantinos, Vellidis, Caterina, Vernieri, Miguel Vidal Marono, Rocio Vilar Cortabitarte, Jesus Manuel Vizán Garcia, Marcelo, Vogel, Guido, Volpi, Elsa Fabiola Vázquez Valencia, Peter, Wagner, Wallny, Rainer S., Song Ming Wang, Waters, David S., William Carl Wester, Whiteson, Daniel O., Arthur Barry Wicklund, Scott, Wilbur, Williams, Hugh H., Jonathan Samuel Wilson, Peter James Wilson, Winer, Brian L., Peter, Wittich, Wolbers, Stephen A., Homer, Wolfe, Thomas Roland Wright, Xin, Wu, Zhenbin, Wu, Kazuhiro, Yamamoto, Daisuke, Yamato, Tingjun, Yang, Un Ki Yang, Yu Chul Yang, Wei Ming Yao, Gong Ping Yeh, Kai, Yi, John, Yoh, Kohei, Yorita, Takuo, Yoshida, Geum Bong Yu, Intae, Yu, Anna Maria Zanetti, Zeng, Yu, Chen, Zhou, and Stefano, Zucchelli

Published
2014

25. Tissue factor as a novel target for treatment of breast cancer

Author

Marion E. Cole and Michael Bromberg

Subjects
Cancer Research, Cell signaling, Angiogenesis, Inflammation, Breast Neoplasms, Factor VIIa, Metastasis, Thromboplastin, Tissue factor, Mice, Breast cancer, microRNA, Breast Cancer, medicine, Animals, Humans, Receptor, PAR-2, Molecular Targeted Therapy, Neoplasm Metastasis, skin and connective tissue diseases, Neovascularization, Pathologic, business.industry, medicine.disease, Oncology, Immunology, Cancer research, Female, medicine.symptom, Signal transduction, business, Signal Transduction
Abstract

CME Learning Objectives Explain the process by which tissue factor (TF) initiates blood coagulation and is implicated in tumor progression. Describe the proposed mechanisms of targeting TF in malignancy. Discuss the applications of TF targets in developing new treatments for aggressive cancers including triple-negative breast cancer. Tissue factor (TF), a 47-kDa transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa (FVIIa), is expressed in several tumor types. TF has been shown to play a role in cell signaling, inflammation, angiogenesis, as well as tumor growth and metastasis. Activation of the TF signaling pathway has been implicated in mediating the function of many tumor cell types and has led to TF as a potential target in the treatment of several malignancies. Formation of the TF-FVIIa complex in breast cancer cells has been shown to exert an antiapoptotic effect and play a key role in tumor growth and metastasis. Breast cancer growth is suppressed by inhibition of TF-mediated PAR2 signaling, and deficiency in PAR2 delays spontaneous breast cancer development in mice. TF is expressed in triple-negative breast cancer (TNBC), an aggressive type of breast cancer in which there is currently a paucity of available targets. Various methods of targeting TF have been investigated and include immunoconjugates or icons, anti-TF antibodies, TF pathway inhibitors, targeted photodynamic therapy, and microRNAs. These investigations may give way to promising clinical therapies for breast cancer, especially in TNBC, for which there are relatively few effective treatment options.

Published
2013

26. Evidence for a bottom baryon resonance Λ∗0b in CDF data

Author

Cdf, Collaboration, Silvia, Amerio, Amidei, Dante E., Anton Iankov Anastassov, Alberto, Annovi, Jaroslav, Antos, Giorgio, Apollinari, Appel, Jeffrey A., Tetsuo, Arisawa, Akram Muzafarovich Artikov, Asaadi, Jonathan A., William Joseph Ashmanskas, Benjamin, Auerbach, Aurisano, Adam J., Azfar, Farrukh A., William Farris Badgett, Taegil, Bae, Angela Barbaro Galtieri, Barnes, Virgil E., Bruce Arnold Barnett, Patrizia, Barria, Pavol, Bartos, Matteo, Bauce, Franco, Bedeschi, Satyajit, Behari, Giorgio, Bellettini, James Nugent Bellinger, Benjamin, Douglas P., Beretvas, Andrew F., Anwar Ahmad Bhatti, Karen Renee Bland, Blumenfeld, Barry J., Andrea, Bocci, Arie, Bodek, Daniela, Bortoletto, Joseph Francis Boudreau, Antonio, Boveia, Luca, Brigliadori, Carl Michael Bromberg, Erik, Brucken, Budagov, Ioulian A., Howard Scott Budd, Kevin Alan Burkett, Giovanni, Busetto, Peter John Bussey, Pierfrancesco, Butti, Adrian, Buzatu, Aristotle, Calamba, Stefano, Camarda, Mario, Campanelli, Florencia, Canelli, Benjamin, Carls, Carlsmith, Duncan L., Roberto, Carosi, Salvador Carrillo Moreno, Bruno Casal Larana, Massimo, Casarsa, Andrea, Castro, Pierluigi, Catastini, Cauz, Diego, Viviana, Cavaliere, Matteo Cavalli Sforza, Alessandro, Cerri, Lucio, Cerrito, Yen Chu Chen, Maxwell Benjamin Chertok, Giorgio, Chiarelli, Gouram, Chlachidze, Kihyeon, Cho, Davit, Chokheli, Allan Geoffrey Clark, Christopher Joseph Clarke, Mary Elizabeth Convery, John Stephen Conway, Matteo, Corbo, Marco, Cordelli, Charles Alexander Cox, David Jeremy Cox, Matteo, Cremonesi, Daniel Cruz Alonso, Javier Cuevas Maestro, Raymond Lloyd Culbertson, Nicola, D'Ascenzo, Mousumi, Datta, Pawel de Barbaro, Demortier, Luc M., Luigi Marchese Marchese, Maria Maddalena Deninno, Francesco, Devoto, Maria, D'Errico, Angelo Di Canto, Benedetto Di Ruzza, Jay Richard Dittmann, Monica, D'Onofrio, Simone, Donati, Mirco, Dorigo, Anna, Driutti, Koji, Ebina, Ryan Christopher Edgar, Elagin, Andrey L., Erbacher, Robin D., Steven Michael Errede, Benjamin, Esham, Sinead Marie Farrington, Juan Pablo Fernández Ramos, Field, Richard D., Flanagan, Gene U., Robert David Forrest, Melissa EB Franklin, John Christian Freeman, Frisch, Henry J., Yujiro, Funakoshi, Camilla, Galloni, Garfinkel, Arthur F., Paola, Garosi, Heather Kay Gerberich, Gerchtein, Elena A., Stefano, Giagu, Viktoria Athina Giakoumopoulou, Karen Ruth Gibson, Camille Marie Ginsburg, Giokaris, Nikos D., Paolo, Giromini, Giurgiu, Gavril A., Vladimir, Glagolev, Douglas Andrew Glenzinski, Gold, Michael S., Daniel, Goldin, Alexander, Golossanov, Gervasio, Gomez, Guillelmo Gomez Ceballos, Goncharov, Maxim T., Oscar González López, Gorelov, Igor V., Goshaw, Alfred T., Goulianos, Konstantin A., Elena, Gramellini, Sebastian, Grinstein, Carla Grosso Pilcher, Robert Craig Group, Joao Barreiro Guimaraes da Costa, Hahn, Stephen R., Ji Yeon Han, Fabio, Happacher, Kazuhiko, Hara, Matthew Frederick Hare, Robert Francis Harr, Timothy Harrington Taber, Kenichi, Hatakeyama, Christopher Paul Hays, Heinrich, Joel G., Matthew Fairbanks Herndon, James Andrew Hocker, Ziqing, Hong, Walter Howard Hopkins, Suen Ray Hou, Richard Edward Hughes, Ulrich, Husemann, Mohammad, Hussein, Joey Walter Huston, Gianluca, Introzzi, Maurizio, Iori, Andrew Gennadievich Ivanov, James, Eric B., Dongwook, Jang, Bodhitha Anjalike Jayatilaka, Eun Ju Jeon, Sergo Robert Jindariani, Jones, Matthew T., Kyung Kwang Joo, Soon Yung Jun, Junk, Thomas R., Manuel, Kambeitz, Teruki, Kamon, Paul Edmund Karchin, Azeddine, Kasmi, Yukihiro, Kato, Wesley Robert Ketchum, Justin Kien Keung, Benjamin John Kilminster, Donghee, Kim, Hyunsoo, Kim, Jieun, Kim, Min Jeong Kim, Soo Bong Kim, Shin Hong Kim, Young Kee Kim, Young Jin Kim, Naoki, Kimura, Kirby, Michael H., Kyle James Knoepfel, Kunitaka, Kondo, Dae Jung Kong, Jacobo, Konigsberg, Ashutosh Vijay Kotwal, Michal, Kreps, Ijoseph, Kroll, Mark Charles Kruse, Thomas, Kuhr, Masakazu, Kurata, Alvin Toivo Laasanen, Stephan, Lammel, Mark, Lancaster, Kevin Patrick Lannon, Giuseppe, Latino, Hyun Su Lee, Jaison, Lee, Sabato, Leo, Sandra, Leone, Lewis, Jonathan D., Antonio, Limosani, Elliot David Lipeles, Alison, Lister, Hao, Liu, Qiuguang, Liu, Tiehui Ted Liu, Lockwitz, Sarah E., Andrey Borisovich Loginov, Alessandra, Lucà, Donatella, Lucchesi, Jan, Lueck, Paul Joseph Lujan, Patrick Thomas Lukens, Gheorghe, Lungu, Lys, Jeremy E., Roman, Lysak, Robyn Leigh Madrak, Paolo, Maestro, Sarah Alam Malik, Giulia, Manca, Arkadios Manousakis Katsikakis, Fabrizio, Margaroli, Christopher Phillip Marino, Mario Martínez Perez, Keith, Matera, Mark Edward Mattson, Anna, Mazzacane, Paolo, Mazzanti, Ronan, Mcnulty, Andrew, Mehta, Petteri, Mehtala, Christina, Mesropian, Ting, Miao, David John Mietlicki, Ankush, Mitra, Hideki, Miyake, Shulamit, Moed, Niccolo, Moggi, Chang Seong Moon, Ronald Scott Moore, Michael Joseph Morello, Aseet, Mukherjee, Thomas, Muller, Murat, Pavel A., Manuel, Mussini, Jane Marie Nachtman, Yoshikazu, Nagai, Junji, Naganoma, Itsuo, Nakano, Austin, Napier, Jason Michael Nett, Christopher Carl Neu, Nigmanov, Turgun S., Nodulman, Lawrence J., Seoyoung, Noh, Olga Norniella Francisco, Louise Beth Oakes, Seog Hwan Oh, Young do Oh, Iuri Artur Oksuzian, Toru, Okusawa, Risto Olavi Orava, Lorenzo, Ortolan, Carmine Elvezio Pagliarone, Jose Enrique Palencia, Prabhakar, Palni, Vaia, Papadimitriou, William Chesluk Parker, Pauletta, Giovanni, Manfred, Paulini, Christoph Maria Ernst Paus, Phillips, Thomas J., Piacentino, Giovanni M., Elisabetta, Pianori, Justin Robert Pilot, Pitts, Kevin T., Charles, Plager, Pondrom, Lee G., Stephen, Poprocki, Karolos Jozef Potamianos, Fedor, Prokoshin, Aliaksandr Pavlovich Pranko, Ptohos, Fotios K., Giovanni, Punzi, Niharika, Ranjan, Ignacio Redondo Fernández, Renton, Peter B., Marco, Rescigno, Franco, Rimondi, Luciano, Ristori, Aidan, Robson, Tatiana Isabel Rodriguez, Simona, Rolli, Manfredi, Ronzani, Robert Martin Roser, Rosner, Jonathan L., Fabrizio, Ruffini, Alberto Ruiz Jimeno, Russ, James S., Vadim Liviu Rusu, Willis Kazuo Sakumoto, Yuki, Sakurai, Santi, Lorenzo Gianni, Koji, Sato, Valeri, Saveliev, Aurore Savoy Navarro, Philip, Schlabach, Schmidt, Eugene E., Schwarz, Thomas A., Luca, Scodellaro, Fabrizio, Scuri, Seidel, Sally C., Yoshihiro, Seiya, Alexei, Semenov, Federico, Sforza, Shalhout Zaki Shalhout, Shears, Tara G., Shepard, Paul F., Makoto, Shimojima, Shochet, Melvyn J., Irina Tecker Shreyber, Simonenko, Alexander V., Krzysztof Jan Sliwa, John Rodgers Smith, Frederick Douglas Snider, Maria Veronica Sorin, Hao, Song, Michelle Dawn Stancari, Richard Dante St Denis, Dale James Stentz, John, Strologas, Yuji, Sudo, Sukhanov, Alexander I., Suslov, Igor M., Ken ichi Takemasa, Yuji, Takeuchi, Jian, Tang, Monica, Tecchio, Ping Kun Teng, Julia, Thom, Evelyn Jean Thomson, Vaikunth, Thukral, Toback, David A., Stanislav, Tokar, Kirsten Anne Tollefson, Tomonobu, Tomura, Diego, Tonelli, Stefano, Torre, Donatella, Torretta, Pierluigi, Totaro, Marco, Trovato, Fumihiko, Ukegawa, Satoru, Uozumi, Elsa Fabiola Vázquez Valencia, Gueorgui, Velev, Konstantinos, Vellidis, Caterina, Vernieri, Miguel Vidal Marono, Rocio Vilar Cortabitarte, Jesus Manuel Vizán Garcia, Marcelo, Vogel, Guido, Volpi, Peter, Wagner, Wallny, Rainer S., Song Ming Wang, Waters, David S., William Carl Wester, Whiteson, Daniel O., Arthur Barry Wicklund, Scott, Wilbur, Williams, Hugh H., Jonathan Samuel Wilson, Peter James Wilson, Winer, Brian L., Peter, Wittich, Wolbers, Stephen A., Homer, Wolfe, Thomas Roland Wright, Xin, Wu, Zhenbin, Wu, Kazuhiro, Yamamoto, Daisuke, Yamato, Tingjun, Yang, Un Ki Yang, Yu Chul Yang, Wei Ming Yao, Gong Ping Yeh, Kai, Yi, John, Yoh, Kohei, Yorita, Takuo, Yoshida, Geum Bong Yu, Intae, Yu, Anna Maria Zanetti, Zeng, Yu, Chen, Zhou, and Stefano, Zucchelli

Published
2013

27. Hypercoagulability in end-stage liver disease: prevalence and its correlation with severity of liver disease and portal vein thrombosis

Author

Ellen Daly, Ashok Jain, Michael Bromberg, Andreas Karachristos, Ashish Singhal, and Manoj Maloo

Subjects
Male, medicine.medical_specialty, Pathology, Budd-Chiari Syndrome, Chronic liver disease, Thrombophilia, Gastroenterology, Severity of Illness Index, Protein S, End Stage Liver Disease, Liver disease, Internal medicine, medicine, Prevalence, Humans, Antithrombin Proteins, Aged, Retrospective Studies, biology, business.industry, Portal Vein, Factor V, Hematology, General Medicine, Hepatitis C, Middle Aged, medicine.disease, Portal vein thrombosis, Bleeding diathesis, biology.protein, Budd–Chiari syndrome, Female, business, Protein C
Abstract

Contrary to well-recognized bleeding diathesis in chronic liver disease, thrombotic events can occur in these patients due to reduction or loss of synthesis of anticoagulant proteins. Forty-seven consecutive patients with end-stage liver disease (ESLD) were investigated for activity of protein C, protein S, antithrombin, and factor V Leiden mutation. Forty-two (89.4%) patients had low levels of at least 1 while 33 (70.2%) patients were deficient for all anticoagulant proteins studied. Forty-six (97.9%) patients were negative for factor V Leiden mutation. The deficiencies were more marked in hepatitis C virus–positive patients and patients with model for end-stage liver disease (MELD) score >15. Six (12.8%) patients had portal vein thrombosis (PVT), and all had diminished protein S activity. In conclusions, deficiency of anticoagulant proteins occur in early phase of chronic liver disease. The severity of deficiency is proportional to the severity of liver disease. Despite the high prevalence of hypercoagulability, the incidence of PVT is low. Further studies with larger cohort of patients are needed to support these conclusions and to study other associated factors.

Published
2012

28. Weak invariance principle for the local times of partial sums of Markov Chains

Author

Zemer Kosloff and Michael Bromberg

Subjects
Statistics and Probability, Discrete mathematics, Sequence, Invariance principle, Markov chain, General Mathematics, Probability (math.PR), 60F17, 60J10, Space (mathematics), Combinatorics, Distribution (mathematics), Local time, FOS: Mathematics, Finite state, Statistics, Probability and Uncertainty, Brownian motion, Mathematics - Probability, Mathematics
Abstract

Let X_{n} be an integer valued Markov Chain with finite state space. Let S_{n}=\sum_{k=0}^{n}X_{k} and let L_{n}(x) be the number of times S_{k} hits x up to step n. Define the normalized local time process t_{n}(x) by t_{n}(x)=\frac{L_{n}(\sqrt{n}(x)}{\sqrt{n}}. The subject of this paper is to prove a functional, weak invariance principle for the normalized sequence t_{n}, i.e. we prove that under some assumptions about the Markov Chain, the normalized local times converge in distribution to the local time of the Brownian Motion., Comment: This is the pre galley proof version of the article; Journal of Theoretical Probability 2012

Published
2011
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29. Targeting the Tissue Factor-Factor VIIa Signaling Pathway to Enhance Activity of mTOR Inhibitors in the Treatment of Breast Cancer

Author

Michael Bromberg

Subjects
Tissue factor, Cell growth, RPTOR, medicine, Biology, Signal transduction, medicine.disease, mTORC2, Protein kinase B, PI3K/AKT/mTOR pathway, Metastasis, Cell biology
Abstract

Tissue factor (TF) is a 47 kDa transmembrane glycoprotein that complexes with activated factor VII (FVIIa) to initiate blood coagulation. Breast cancer tumors and cell lines that have high expression of TF appear to be aggressive and have high metastatic potentia. Formation of the TF-FVIIa complex induces signaling that leads to activation of p44/42 mitogen-activated protein kinase and protein kinase B (Akt) pathways and inhibition of apoptosis in breast cancer cells. The Akt-mammalian target of rapamycin (mTOR) pathway regulates cell growth and survival and plays a major role in the pathogenesis of breast cancer. Inhibition of mTOR has been shown to increase TF expression in some cell types which might increase tumor TF expression leading to enhanced TF-mediated signaling as well as an increased hypercoagulable state. Inhibition of mTOR, downstream of Akt, is a recent, emerging strategy in the treatment of breast cancer. In this proposal we test the hypothesis that the TF-VIIa signaling pathway interacts with the mTOR pathway to play a critical role in promoting dysregulated proliferation of breast cancer cells. In the present study, we show that formation of TF-FVIIa-FXa complex induces phosphorylation of mammalian target of rapamycin (mTOR) and p70 S6 kinase in a human breast cancer cell line, Adr-MCF-7. Activation of the mTOR pathway, which is probably mediated by PAR1 and/or PAR2, was associated with enhanced cell migration, a key step in the metastatic cascade. Inhibition of this pathway with the specific mTOR inhibitor, rapamycin, markedly decreased cell migration induced by formation of TF-FVIIa-FXa complex and modestly increased tumor cell TF expression. Targeting the TF-mediated cell signaling pathway along with mTOR inhibition might represent a novel strategy for the treatment of breast cancer.

Published
2009
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30. Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway

Author

Mario Fusaro, Yuchuan Liu, Robin A. Pixley, Michael Bromberg, Gustavo Godoy, Erin Kim, and Robert W. Colman

Subjects
MAPK/ERK pathway, Male, Cancer Research, medicine.medical_specialty, Kininogen, High-Molecular-Weight, High-molecular-weight kininogen, EGFR, Basic fibroblast growth factor, Biology, Article, Receptors, Urokinase Plasminogen Activator, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, DU145, Cell Movement, Internal medicine, Cell Line, Tumor, Genetics, medicine, Humans, Neoplasm Invasiveness, Epidermal growth factor receptor, Molecular Biology, Protein kinase B, 030304 developmental biology, 0303 health sciences, Kininogen, Prostatic Neoplasms, Tyrphostins, prostate cancer, Protein Structure, Tertiary, Urokinase receptor, ErbB Receptors, HKa, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Quinazolines, Fibroblast Growth Factor 2, uPAR, Signal Transduction
Abstract

Upregulation and activation of epidermal growth factor receptor and/or urokinase-type plasminogen activator receptor in a variety of cancers have been shown to be associated with poor prognosis. High-molecular-weight kininogen can be hydrolysed by plasma kallikrein to bradykinin and cleaved high-molecular-weight kininogen (HKa). HKa and its domain 5 (D5) both have been shown to have potent anti-angiogenic activity. We now show that HKa blocks human prostate cancer cell (DU145) migration by 76.0+/-2.4% at 300 nM and invasion by 78.0+/-12.9% at 11.1 nM. D5 inhibits tumor migration and invasion in a concentration-dependent manner. Stimulation by basic fibroblast growth factor (bFGF) or vascular endothelial growth factor results in clustering of urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) on the surface of DU145 cells. The co-localization of uPAR and EGFR is prevented by HKa. Immunoprecipitation suggests that uPAR, EGFR and alpha5beta1 integrin formed a ternary complex. Immunoblotting shows that HKa significantly decreases the bFGF-transactivated phosphorylation of EGFR at Tyr 1173 between 30 min and 4 h. The phosphorylation of extracellular signal-regulated kinase (ERK) and AKT, which are downstream effectors of EGFR, is also inhibited by HKa. These novel data indicate that HKa and D5 inhibit migration and invasion of human prostate cancer cells through an EGFR/uPAR pathway, suggesting the therapeutic potential of HKa and D5 to decrease metastasis of human prostate cancer.

Published
2009

31. Mucosa-Associated Lymphoid Tissue Lymphoma of the Sigmoid Colon Discovered on Routine Screening Colonoscopy in Patient with Hepatitis C and Helicobacter pylori Infection

Author

Ashish Bains, Rajiv Bhuta, Michael Bromberg, and Ron Schey

Subjects
medicine.medical_specialty, Colon, Colonoscopy, Case Report, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, biology, medicine.diagnostic_test, business.industry, Stomach, Sigmoid colon, MALT lymphoma, General Medicine, Hepatitis C, Helicobacter pylori, medicine.disease, biology.organism_classification, digestive system diseases, Lymphoma, Lymphatic system, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business
Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is predominantly found in the stomach. Rarely, it is found in the proximal colon and even less so in the sigmoid colon. We present a rare case of primary sigmoid colon MALT lymphoma in a patient with concomitant Helicobacter pylori and hepatitis C infection. We also review current imaging, staging, and therapeutic modalities. To our knowledge, this is the first sigmoid colon MALT lymphoma reported in the United States.

Published
2016
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32. Hic-5 promotes endothelial cell migration to lysophosphatidic acid

Author

John P. Gaughan, C. Avraamides, T. S. Panetti, Michael Bromberg, S. M. Thomas, and Alexander Y. Tsygankov

Subjects
MAPK/ERK pathway, endocrine system, Physiology, Angiogenesis, Biology, Pulmonary Artery, Focal adhesion, chemistry.chemical_compound, Cell Movement, Physiology (medical), Lysophosphatidic acid, Animals, Paxillin, Cells, Cultured, Dose-Response Relationship, Drug, Endothelial Cells, Cell migration, LIM Domain Proteins, Cell biology, Endothelial stem cell, DNA-Binding Proteins, Cytoskeletal Proteins, chemistry, Biochemistry, biology.protein, lipids (amino acids, peptides, and proteins), Pseudopodia, Cattle, Lysophospholipids, Cardiology and Cardiovascular Medicine
Abstract

Endothelial cell migration is critical for proper blood vessel development. Signals from growth factors and matrix proteins are integrated through focal adhesion proteins to alter cell migration. Hydrogen peroxide-inducible clone 5 (Hic-5), a paxillin family member, is enriched in the focal adhesions in bovine pulmonary artery endothelial (BPAE) cells, which migrate to lysophosphatidic acid (LPA) on denatured collagen. In this study, we investigate the role of Hic-5 in LPA-stimulated endothelial cell migration. LPA recruits Hic-5 to the focal adhesions and to the pseudopodia in BPAE cells plated on collagen, suggesting that recruitment of Hic-5 to focal adhesions is associated with endothelial cell migration. Knockdown of endogenous Hic-5 significantly decreases migration toward LPA, confirming involvement of Hic-5 in migration. To address the role of Hic-5 in endothelial cell migration, we exogenously expressed wild-type (WT) Hic-5 and green fluorescent protein Hic-5 C369A/C372A (LIM3 mutant) constructs in BPAE cells. WT Hic-5 expression increases chemotaxis of BPAE cells to LPA, whereas migration toward LPA of the green fluorescent protein Hic-5 C369A/C372A-expressing cells is similar to that shown in vector control cells. Additionally, ERK phosphorylation is enhanced in the presence of LPA in WT Hic-5 cells. A pharmacological inhibitor of MEK activity inhibits LPA-stimulated WT Hic-5 cell migration and ERK phosphorylation, suggesting Hic-5 enhances migration via MEK activation of ERK. Together, these studies indicate that Hic-5, a focal adhesion protein in endothelial cells, is recruited to the pseudopodia in the presence of LPA and enhances migration.

Published
2007

33. ROLE OF HIC-5 IN ENDOTHELIAL CELL MIGRATION

Author

Christie Avraamides, Michael Bromberg, and Tracee S Panetti

Subjects
Endothelial stem cell, Chemistry, General Medicine, Cardiology and Cardiovascular Medicine, Pathology and Forensic Medicine, Cell biology
Published
2004
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34. LACK of ASSOCIATION BETWEEN Race and Probability of TRANSPLANT AMONG PATIENTS Referred for Hematopoietic CELL TRANSPLANTATION (HCT) for MULTIPLE Myeloma

Author

Mary Ellen Martin, Thomas R. Klumpp, Michael Bromberg, Robert Emmons, Patricia Kropf, Manish Sharma, and Mangan Kf

Subjects
medicine.medical_specialty, Hematopoietic cell, Referral, business.industry, medicine.medical_treatment, Delayed time, Immunology, Cell Biology, Hematology, Disease, Hematopoietic stem cell transplantation, medicine.disease, Biochemistry, Transplantation, Race (biology), surgical procedures, operative, Internal medicine, Medicine, business, Multiple myeloma
Abstract

Abstract 3129 Background: As documented in recently published large database reviews, race appears to be a barrier to the access to HCT. Hypotheses as to why this may be the case include (but are not limited to): 1. patient preference; 2. delayed time to referral from community physicians to transplant centers; 3. delays in transplant once evaluated by a transplant center; 4. Possible increased prevalence of comorbidities among racial minorities referred for transplant. We attempt to address some of these issues by reviewing our 20-year experience with transplantation for multiple myeloma. Methods: We queried our core clinical database for potential associations between race and the following parameters: 1. Median interval between date of diagnosis and date of referral; 2. Median interval between date of initial visit and date of transplant 3. Probability of actually receiving a transplant following formal evaluation by a transplant physician by race; 4. Type of transplant recommended 5. Reasons for not receiving a transplant. Results: Between January 1990 and June 2011, 441 patients with multiple myeloma were referred to our center for consideration of HCT, of whom 293 (66%) were Caucasian, 94 (21%) were African American (AA), 27 (6%) were of unknown race, and 27 (6%) were of other races. The median interval from diagnosis to referral for transplant for AA patients was 145 days, versus 137 days for Caucasian patients (p=0.32). Fifty-three of the 94 AA patients (56%), versus 157 of the 293 Caucasian patients (54%) have received at least one transplant to date (p=0.72). The median interval between the date of the initial visit to our transplant center and the occurrence of an initial transplant was 120 days for AA, versus 150 days for Caucasians (p=0.39). The probability of being transplanted on an allogeneic or hybrid (auto-allo) initial transplant protocol was 0% for AA making it to transplant vs 6% for Caucasions making it to transplant (p=0.07). Reasons for not receiving a transplant are indicated in Table 1 (global p-value = 0.94). Conclusions: African American and Caucasian patients with myeloma have similar intervals from diagnosis to referral, similar intervals from referral to transplant, and are equally likely to actually receive a transplant once referral to the transplant center took place. Therefore, the reported barrier to transplantation for myeloma patients appears to be prior to referral to the transplant center. Disclosures: No relevant conflicts of interest to declare.

Published
2011
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35. Tissue Factor Is Frequently Expressed in Multiple Myeloma Cells

Author

Sameer Gupta, Matthew T. Hurford, Tanisha R Hayes, Charalambos C. Solomides, Michael Bromberg, and Yuchuan Liu

Subjects
Pathology, medicine.medical_specialty, Angiogenesis, Immunology, Cell, Cell Biology, Hematology, Biology, Immunoglobulin light chain, medicine.disease, Biochemistry, Molecular biology, Tissue factor, medicine.anatomical_structure, Cell culture, medicine, Immunohistochemistry, Bone marrow, Multiple myeloma
Abstract

Abstract 2132 Poster Board II-109 Tissue factor (TF) is a 47 kDa transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa. TF is constitutively expressed in a variety of tumor cells and has been shown to have a role in cellular signaling, angiogenesis and solid tumor progression. However, the role of TF in the hematologic malignancies is poorly defined. Multiple myeloma (MM) is associated with an increased risk of venous thromboembolic disease. However, whether increased TF expression contributes to the hypercoagulable state associated with MM remains controversial. In this study, we determined the expression of TF on archived bone marrow biopsies and plasmacytomas, and human MM cell lines. Immunohistochemical staining of TF was carried out on paraffin-embedded specimens from eighteen advanced stage MM patients. Staining for TF expression was scored as 0 (null), 1+ (weak), 2+ (moderate) and 3+ (strong). TF expression for the MM cell lines (U266B1, MM1.RL and MM1.S) was carried out by semi-quantitative real time RT-PCR. TF mRNA levels were normalized to 18S ribosomal mRNA levels. The TF: 18S ratios were then compared to that of a low TF expressing human breast cancer cell line cell line, MCF-7. Paraprotein distribution in the MM patient specimens was: IgG kappa (7), IgG lambda (5), IgA kappa (3), lambda light chain (2) kappa light chain (1). Overall, TF expression was observed in 10/18 (56%) of the patient specimens. Six specimens stained 1+, and two each stained 2+ and 3+. Staining was mainly cytoplasmic and did not correlate with the type of secreted paraprotein. TF expression (relative to MCF-7) was 17.3, 1.97 and 0.77 for the U266B1, MM1.RL and MM1.S cell lines, respectively. Results from these studies suggest that TF is frequently expressed in MM cells and might contribute to the hypercoagulability associated with this disease. In addition, TF may play a role in MM cell progression. Disclosures: No relevant conflicts of interest to declare.

Published
2009
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36. Formation of Tissue Factor-Factor VIIa Complex and Generation of Factor Xa Induce Activation of the mTOR Pathway Which Regulates Migration of Human Breast Cancer Cells

Author

Michael Bromberg, Shimei Zhu, Xiaofeng Jiang, and Tracee S. Panetti

Subjects
Cell signaling, Immunology, Cell migration, Cell Biology, Hematology, Biology, Biochemistry, Cell biology, Tissue factor, Cell culture, Cancer cell, Phosphorylation, Protein kinase A, PI3K/AKT/mTOR pathway
Abstract

Tissue factor (TF) is a 47 kDa transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa (FVIIa). TF is constitutively expressed in a variety of tumor cells and has been shown to have roles in cellular signaling and tumor progression. We showed previously that formation of TF-FVIIa-Factor Xa (FXa) complex induces cellular signaling in the Adr-MCF-7 cell line, a multidrug-resistant subline of the human breast cancer cell line, MCF-7, that leads to enhanced cell migration and inhibition of apoptosis. The Adr-MCF-7 cell line has high endogenous expression of TF and expression of protease-activated receptor 1 (PAR1) and protease-activated receptor 2 (PAR2). Treatment of the Adr-MCF-7 cells with the combination of FVIIa (10 nM) and FX (150 nM) induces phosphorylation of p44/42 mitogen-activated protein kinase and protein kinase B. In the present study, we investigated the role of TF-FVIIa-mediated signaling in activation of the mammalian target of rapamycin (mTOR) pathway. Treatment of the Adr-MCF-7 cells with the combination of FVIIa (10 nM) and FX (150 nM) induced phosphorylation of mTOR and p70 S6 kinase (p70S6K) by 2 and 2.5 fold, respectively, compared with untreated cells. Phosphorylation of these proteins could be inhibited by pretreatment of the cells with either anti-TF antibody (TF85G9) or TAP, a specific FXa inhibitor. No increase in the basal level of phosphorylation of these proteins occurred with treatment of the cells with FVIIa (10 nM) alone. Moreover, phosphorylation of mTOR and p70S6K was probably mediated by PAR1 and/or PAR2 activation. Using a modified Boyden chamber chemotaxis assay, activation of the mTOR pathway with the combination of FVIIa (10 nM) and FX (150 nM) promoted migration of the Adr-MCF-7 cells. Inhibition of this pathway with the specific mTOR inhibitor, rapamycin, markedly decreased cell migration. Results from these studies suggest that TF-FVIIa-mediated signaling modulates mTOR pathway activation, which in turn regulates breast cancer cell migration.

Published
2006
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37. The Cytoplasmic Domain of Tissue Factor Inhibits Migration and Enhances Adhesion of Human Breast Cancer Cells

Author

Xiaofeng Jiang, Tracee S. Panetti, and Michael Bromberg

Subjects
Cell signaling, medicine.diagnostic_test, Immunology, Cell migration, Cell Biology, Hematology, Transfection, Biology, Biochemistry, Molecular biology, Flow cytometry, Cytoplasm, Cell culture, Cancer cell, medicine, Cell adhesion
Abstract

Tissue factor (TF) is a 47 kDa transmembrane glycoprotein that when complexed with its cofactor, factor VIIa (FVIIa), initiates blood coagulation. Apart from hemostasis, TF has been shown to have roles in cellular signaling, development, inflammation, metastasis and angiogenesis. We showed previously that both the cytoplasmic and extracellular domains of TF are required for the full metastatic effect of TF. Recently, we showed that TF-FVIIa-FXa complex induces cellular signaling in human breast cancer cells and is associated with enhanced cell migration and prevention of apoptosis. However, the role of the cytoplasmic domain of TF in tumor cell function is not fully known. In the present study, the role of the cytoplasmic domain of TF in cell migration and adhesion was investigated using the Adr-MCF-7 cell line, a multidrug resistant subline of the human breast cancer cell line, MCF-7. The Adr-MCF-7 cell line has high endogenous expression of TF and expression of PAR1 and PAR2. Adr-MCF-7 cells were retrovirally transfected with either a cDNA construct encoding a FLAG epitope tag fused to the transmembrane and cytoplasmic domains of TF (known as FLAG-TFCD) or vector (LXSN) alone as a control, and stable, polyclonal cell lines selected using G418. Expression of the FLAG-TFCD construct was verified by RT-PCR, Western blot analysis and flow cytometry. To test the effect of overexpression of the FLAG-TFCD construct on cell motility a modified Boyden chamber chemotaxis assay was used. The control LXSN cell line had a nearly 9 fold increase in cell migration [33.5± 3.2 cells/hpf (mean± SEM)]using the combination of rFVIIa (10 nM) and FX (150 nM) as the chemoattractant compared with 0.1% bovine serum albumin (BSA) [3.9± 1.2 cells/hpf]. In contrast, the FLAG-TFCD cell line had no increase in migration of using the combination of rFVIIa and FX [6.6± 0.57 cells/hpf] compared with BSA [5.4± 0.67 cells/hpf]. We then examined the ability of the transfected cell lines to adhere to type IV collagen. The number of adherent cells for the transfected cell line, FLAG-TFCD, was nearly 3 fold higher than that for the LXSN line using a colorimetric MTS assay (0.295± 0.041 vs 0.119± 0.011). Moreover, treatment of the FLAG-TFCD cells with the combination of rFVIIa and FX increased the adhesion by nearly 2 fold compared with untreated FLAG-TFCD cells (0.561±0.055 vs 0.296±0.044). In summary, overexpression of TF cytoplasmic domain leads to inhibition of tumor cell migration and enhancement of cell adhesion and potentially acts as a dominant negative in these cellular processes. These data suggest that a function of the cytoplasmic domain of TF in metastasis is to regulate tumor cell migration and adhesion.

Published
2005
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38. Formation of Tissue Factor-Factor VIIa-Factor Xa Complex Promotes Survival of Human Breast Cancer Cells by Inhibition of Apoptosis

Author

Yan-Lin Guo, Xiaofeng Jiang, and Michael Bromberg

Subjects
Cell signaling, Immunology, Cell Biology, Hematology, Biology, Biochemistry, Molecular biology, Tissue factor, Cell culture, Apoptosis, Cancer cell, Survivin, Signal transduction, Protein kinase B
Abstract

Tissue factor (TF) is a transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa (FVIIa). TF is constitutively expressed by a variety of tumor cells. Recently, TF has been shown to induce cellular signaling and promote tumor growth, angiogenesis, and metastasis. We showed previously that formation of TF-FVIIa-Factor Xa (FXa) complex induces cellular signaling in the Adr-MCF-7 cell line, a multidrug-resistant subline of the human breast cancer cell line, MCF-7 (Jiang et al. J. Thromb Haemost2: 2004; 93–101). This cell line has high endogenous expression of TF. Treatment of the Adr-MCF-7 cells with the combination of FVIIa (10 nM) and FX (150 nM) induces phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) and protein kinase B (PKB), whereas no increase in the basal level of phosphorylation of these proteins occurs with treatment of the cells with FVIIa (10 nM) alone. In the present study, we investigated whether TF-FVIIa-induced signaling might alter apoptosis in human breast cancer cells. Apoptosis of the Adr-MCF-7 cells was induced by serum starvation for 5–7 days. Treatment of the cells with the combination of FVIIa (10 nM) and FX (150 nM), reduced apoptosis of the cells by nearly 50% compared with untreated, control cells using an ELISA that detects histone-DNA fragments. In contrast, FVIIa (10 nM) alone did not significantly prevent apoptosis. Pre-treatment of the Adr-MCF-7 cells with hirudin did not inhibit the anti-apoptotic effect of the combination of FVIIa and FX, whereas this effect could be completely blocked by either U0126 (10 μM), which inhibits p44/42 MAPK phosphorylation, or LY294002 (50 μM), which inhibits PKB phosphorylation. In addition, treatment of the Adr-MCF cells with the combination of FVIIa and FX led to a 50% increase in the level of the anti-apoptotic protein, survivin, compared with untreated cells by Western blot analysis. Results from this study indicate that formation of TF-FVIIa-FXa complex prevents apoptosis of breast cancer cells by a thrombin-independent pathway. Moreover, the anti-apoptotic effect of this signaling pathway involves both phosphorylation of p44/42 MAPK and PKB and might be mediated in part by an increase in cell survivin levels.

Published
2004
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39. Clotting and cancer progression: platelets count

Author

Michael Bromberg

Subjects
biology, Chemistry, Immunology, Cancer, Cell Biology, Hematology, medicine.disease, Fibrinogen, Biochemistry, Fibrin, Metastasis, Endothelial stem cell, Tumor progression, Knockout mouse, medicine, biology.protein, Cancer research, Platelet, medicine.drug
Abstract

In knockout mice models of metastasis, platelets, activation of platelet protease-activated receptor 4 (PAR4), and fibrinogen/fibrin formation play key roles in the blood-borne metastasis of tumor cells with procoagulant activity, whereas activation of endothelial cell PAR1 and PAR2 does not appear

Published
2004
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40. Perspectives: Flexibility In Antitrust Enforcement

Author

Michael Bromberg

Subjects
Warrant, Competition (economics), business.industry, Health Policy, Consumer choice, Health care, Managed care, Business, Enforcement, Best interests, Managed Competition, Law and economics
Abstract

Sen. Howard Metzenbaum has presented a thoughtful defense of the need to retain strong antitrust oversight of the health care industry. I agree with his desire to assure the best interests of consumers through continued application of antitrust laws, although some of his rhetoric is unfortunate. As we move toward managed competition, we should recognize that there has been a revolution in the health care industry, especially with regard to the structure of health insurance plans. Managed care in various forms has replaced indemnity insurance in recent years, and that trend will continue with or without comprehensive health reform. Enactment of significant reforms at the state and federal levels will help to accelerate the trend. This new environment warrants a reassessment of the application of antitrust laws to provider-organized health plans and provider arrangements with health plans. Instead of head-to-head competition on a hospital-by-hospital basis, managed competition will primarily involve competition among networks of providers and insurers for contracts with health insurance purchasing cooperatives (HIPCs) or with large employers outside the HIPC structure. Some arrangements will require enforcement of traditional antitrust policy, while others will warrant a new policy. The general rule should be that antitrust laws must be used to ensure consumer choice based on quality and price competition among health plans. If some easing of antitrust enforcement encourages the formation of competing health plans, thus increasing consumer choice, that should be supported; however, antitrust laws must protect consumers against undue consolidation that reduces competition among plans. While antitrust policy needs to show increased flexibility, as Senator Metzenbaum

Published
1993
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