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620 results on '"Michael Harold"'

1. Co-designing a personalised care plan for patients with rectal cancer: reflections and practical learnings

Author

Grace Gard, Jo Oakley, Kelsey Serena, Karla Gough, Michael Harold, Katya Gray, Helen Anderson, Judi Byrne, Jo Cockwill, Graeme Down, George Kiossoglou, and Peter Gibbs

Subjects
Consumer involvement, Cancer research, Research design and conduct, Medicine, Medicine (General), R5-920
Abstract

Abstract Background Consumer involvement is considered an essential component of contemporary cancer research, with a movement towards participatory methods, to the benefit of consumers and researchers. Overall, in-depth research on participant experiences and perceptions of their co-designer role—and how these may (or may not) change during a co-design project—is limited. The purpose of this paper was to synthesise the reflective accounts of consumers, project staff, and a researcher who partnered on a project to develop a personalised care plan template, with the aim of generating guidance for others looking to partner with consumers in health and medical research. Here, our team of researchers, project staff, and consumers reflect on the experience of working together using Gibbs’ Reflective Cycle, which was completed by team members with responses then undergoing inductive data analysis. Results Reflections are categorised under three core themes: (1) setting up the group and building relationships (2) measuring the value of consumer involvement, and (3) potential challenges for consumer involvement. Through reflection on our experiences of co-design, our team developed and identified practical strategies that contributed to the success of our partnership. These include setting expectations as a group; having experienced consumers on the team; having regular, pre-scheduled meetings that run to time; and working to overcome challenges identified by the group such as power imbalances, time commitment, and lack of diversity. Conclusion These practical reflections on creating a safe and supportive environment in which genuine consumer involvement can take place could inform other institutions and researchers looking to work meaningfully with consumers in research.

Published
2024
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2. Scoping the proximal and distal dimensions of climate change on health and wellbeing

Author

George Paterson Morris, Stefan Reis, Sheila Anne Beck, Lora Elderkin Fleming, William Neil Adger, Timothy Guy Benton, and Michael Harold Depledge

Subjects
Ecosystems, Food, Nutrition, Mobility, Migration, Concepts, Industrial medicine. Industrial hygiene, RC963-969, Public aspects of medicine, RA1-1270
Abstract

Abstract The impacts of climate on health and wellbeing occur in time and space and through a range of indirect, complicated mechanisms. This diversity of pathways has major implications for national public health planning and influence on interventions that might help to mitigate and adapt to rapidly changing environmental conditions, nationally and internationally. This paper draws upon evidence from public health and adverse impact studies across climate science, hydrology, agriculture, public health, and the social sciences. It presents a conceptual model to support decision-making by recognizing both the proximal and distal pathways from climate-induced environmental change to national health and wellbeing. The proximal and distal pathways associated with food security, migration and mobility illustrate the diverse climate change influences in different geographic locations over different timescales. We argue that greater realization and articulation of proximal and distal pathways should radically alter how climate change is addressed as a national and international public health challenge.

Published
2017
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3. SUPERCOMPUTER SIMULATION OF CRITICAL PHENOMENA IN COMPLEX SOCIAL SYSTEMS

Author

Petrus M.A. Sloot, Janusz Holyst, George Kampis, Michael Harold Lees, Sergey A. Mityagin, Sergey V. Ivanov, Klavdiya O. Bochenina, Valentina Yu. Guleva, Ksenia D. Mukhina, Denis A. Nasonov, Nikolay A. Butakov, Vasiliy N. Leonenko, and Anastasia A. Lantseva

Subjects
сritical phenomena, complex networks, supercomputer simulation, dynamical processes, parallel algorithm, epidemics spreading, criminal networks, financial networks, Optics. Light, QC350-467, Electronic computers. Computer science, QA75.5-76.95
Abstract

The paper describes a problem of computer simulation of critical phenomena in complex social systems on a petascale computing systems in frames of complex networks approach. The three-layer system of nested models of complex networks is proposed including aggregated analytical model to identify critical phenomena, detailed model of individualized network dynamics and model to adjust a topological structure of a complex network. The scalable parallel algorithm covering all layers of complex networks simulation is proposed. Performance of the algorithm is studied on different supercomputing systems. The issues of software and information infrastructure of complex networks simulation are discussed including organization of distributed calculations, crawling the data in social networks and results visualization. The applications of developed methods and technologies are considered including simulation of criminal networks disruption, fast rumors spreading in social networks, evolution of financial networks and epidemics spreading.

Published
2014
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7. A talk framework for problem-solving

Author

Hickman, Michael Harold, Monaghan, John, and McPherson, Maggie

Subjects
370
Abstract

Group discussion in primary school mathematical problem-solving provides potentially significant benefits to children's learning, especially when discussion becomes dialogue, in which students achieve common understanding through cumulative questioning. Arising out of a need to develop talk whilst problem-solving on a primary teacher training programme in the UK, this research employs a think-aloud protocol alongside digital audio technology to promote and capture dialogue in two distinct group problem-solving situations. It explores how thinking-aloud, and the resulting recordings, can be used to support student teachers' verbalisation of mathematical problem-solving strategies, including via 'follow-up' recall opportunities, exploiting connections between thinking-aloud and stimulated recall that are distinct to this work. In addition to using the recall situation to encourage reflection on performance, a Talk Framework, reflecting mathematical problem-solving stages, has been employed to analyse the participants' discourse. The Framework has been used to highlight potentially valuable contributions in the initial group situation whilst also identifying aspects to be revisited in the replay situation. The findings of this work demonstrate that the provision of a think-aloud protocol alone does not guarantee the productive engagement of student teachers. Attitudes to mathematics and the group situation itself may impact on individuals' expectations of success. The Talk Framework coding, informed by Mercer's notions of cumulative, exploratory and disputational dialogue, highlights the degree to which exploratory dialogue is perhaps lacking, with a newly proposed category, "supercumulative", identifying contributions intended to provoke further explanation. This work highlights techniques that may be of benefit to student teachers and teacher educators when developing mathematical talk. It proposes networking of think-aloud and recall techniques to encourage reflection. It demonstrates that the provision of digitally recorded animated annotations provokes more discussion of the underlying mathematics than audio alone. Ultimately, it proposes a Talk Framework that can be used to identify valuable dialogue in the original problem-solving situation that can then be productively built upon to aid collective understanding of mathematical strategies in the subsequent recall.

Published
2019

8. Cover

Author

Paulos, Michael Harold and Hansen, Konden Smith

Published
2021

11. Index

Author

Paulos, Michael Harold and Hansen, Konden Smith

Published
2021

19. Preface

Author

Paulos, Michael Harold and Hansen, Konden Smith

Published
2021

28. Quantitative Comparison Between Crowd Models for Evacuation Planning and Evaluation

Author

Viswanathan, Vaisagh, Lee, Chong Eu, Lees, Michael Harold, Cheong, Siew Ann, and Sloot, Peter M. A.

Subjects
Computer Science - Multiagent Systems, Computer Science - Computers and Society, I.2.11, I.6.4, I.6.5, I.6.6, J.2
Abstract

Crowd simulation is rapidly becoming a standard tool for evacuation planning and evaluation. However, the many crowd models in the literature are structurally different, and few have been rigorously calibrated against real-world egress data, especially in emergency situations. In this paper we describe a procedure to quantitatively compare different crowd models or between models and real-world data. We simulated three models: (1) the lattice gas model, (2) the social force model, and (3) the RVO2 model, and obtained the distributions of six observables: (1) evacuation time, (2) zoned evacuation time, (3) passage density, (4) total distance traveled, (5) inconvenience, and (6) flow rate. We then used the DISTATIS procedure to compute the compromise matrix of statistical distances between the three models. Projecting the three models onto the first two principal components of the compromise matrix, we find the lattice gas and RVO2 models are similar in terms of the evacuation time, passage density, and flow rates, whereas the social force and RVO2 models are similar in terms of the total distance traveled. Most importantly, we find that the zoned evacuation times of the three models to be very different from each other. Thus we propose to use this variable, if it can be measured, as the key test between different models, and also between models and the real world. Finally, we compared the model flow rates against the flow rate of an emergency evacuation during the May 2008 Sichuan earthquake, and found the social force model agrees best with this real data., Comment: 12 pages, 25 figures, accepted in EPJ B

Published
2014
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38. A Roadmap for High-Resolution Satellite Soil Moisture Applications - Confronting Product Characteristics with User Requirements

Author

Jian Peng, Clement Albergel, Anna Balenzano, Luca Brocca, Oliver Cartus, Michael Harold Cosh, Wade Crow, Katarzyna Dabrowska Zielinska, Simon Dadson, Malcolm W.J. Davidson, Patricia de Rosnay, Wouter Dorigo, Alexander Gruber, Stefan Hagemann, Martin Hirschi, Yann H. Kerr, Francesco Lovergine, Miguel D. Mahecha, Philip Marzahn, Francesco Mattia, Jan Pawel Musial, Swantje Preuschmann, Rolf H. Reichle, Giuseppe Satalino, Martyn Silgram, Peter M.van Bodegom, Niko E.C.Verhoest, Wolfgang Wagner, Jeffrey P.Walker, Urs Wegmuller, and Alexander Loew

Subjects
Earth Resources And Remote Sensing
Abstract

Soil moisture observations are of broad scientific interest and practical value for a wide range of applications. The scientific community has made significant progress in estimating soil moisture from satellite-based Earth observation data, particularly in operationalizing coarse-resolution (25-50 km) soil moisture products. This review summarizes existing applications of satellite-derived soil moisture products and identifies gaps between the characteristics of currently available soil moisture products and the application requirements from various disciplines. We discuss the efforts devoted to the generation of high-resolution soil moisture products from satellite Synthetic Aperture Radar (SAR) data such as Sentinel-1 C-band backscatter observations and/or through downscaling of existing coarse-resolution microwave soil moisture products. Open issues and future opportunities of satellite-derived soil moisture are discussed, providing guidance for further development of operational soil moisture products and bridging the gap between the soil moisture user and supplier communities.

Published
2020
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39. Field Evaluation of Portable Soil Water Content Sensors in a Sandy Loam

Author

Hyunglok Kim, Michael Harold Cosh, Rajat Bindlish, and Venkataraman Lakshmi

Subjects
Earth Resources And Remote Sensing
Abstract

Ground observations are critical in the validation of soil water content (SWC) estimates from both satellites and land surface models. Portable SWC sensors provide useful information to determine the amount of SWC in the topsoil layer for various applications; however, these probes are not accurate without site‐specific correction. In the present study, we examined and compared six different types of portable electromagnetic (EM) SWC sensors, including multiple sensors made by the same manufacturers, for a total of 16 EM‐based SWC probes equipped with portable data loggers. All SWC probes met the target accuracy after onsite correction—the RMSD was <0.025 m(exp 3) m(exp -3). Using the two‐sample t-tests, we observed that SWC data obtained from similar electrode lengths and from different manufacturers showed similar distributions over time with the same mean. Furthermore, using the maximize R method to combine SWC data from two different types of sensors increased the accuracy of the results. When datasets from two different types of sensors were combined, the Pearson's correlation coefficient (R value) and RMSD values were improved. The average R value improved from .930 to .945, and the RMSD decreased from 0.036 m(exp 3) m(exp -3) to 0.018 m(exp 3) m(exp −3). These results indicate that, along with site‐specific correction, synergetic use of multiple manufacturers’ EM‐based SWC probes can improve the R value and reduce systematic bias.

Published
2020
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41. Pertuzumab study in the neoadjuvant setting for HER2‐positive nonmetastatic breast cancer in Australia (PeRSIA)

Author

Sheau Wen Lok, Richard De Boer, Sally Baron‐Hay, Peter Button, Bianca Devitt, Benjamin C. Forster, Peter Fox, Michael Harold, Sahisha Ketheeswaran, Ganessan Kichenadasse, Belinda E. Kiely, Gavin Marx, Louise Nott, Laura Pellegrini, Ali Tafreshi, and Peter Gibbs

Subjects
Diarrhea, Cancer Research, Oncology, Australia, Humans, Persia, Female, Breast Neoplasms, Neoadjuvant Therapy
Abstract

The pertuzumab study in the neoadjuvant setting for HER2+ nonmetastatic breast cancer in Australia (PeRSIA-ML39622) is an analysis of safety and effectiveness data from the pertuzumab patient registry. Although the prognosis of patients with early stage HER2+ breast cancer has been greatly improved by advances in chemotherapy approximately 25% to 30% of patients develop recurrent disease. Our study aimed to examine the effectiveness of neoadjuvant pertuzumab on surgical outcomes, describe the medium-term effectiveness outcomes of patients treated with pertuzumab, and describe the planned and actual anticancer treatment regimens that patients received. Deidentified data were collected from the patients' medical records and entered into REDCap, between March 2018 and July 2019 (n = 95). The adverse events (AEs) reported most frequently were diarrhea (20; 21.1%), rash (4; 4.2%), and LVSD (4; 4.2%; two patients during neoadjuvant treatment and two patients during adjuvant treatment). AEs, ≥Grade 3 were diarrhea (2; 2.1%) and LVSD (1; 1.1%). Following surgery, a breast pathological complete response (bpCR) was achieved in 65 patients (70.7%; 95% CI: 60.2%-79.7%) and total pathological complete response (tpCR) in 59 patients (64.1%; 95% CI: 53.4%-73.9%). All patients who did not achieve a tpCR obtained a partial response (33/92, 35.9%). Our study is the first to capture real-world data on the use of pertuzumab in the neoadjuvant setting in Australia. The effectiveness and safety data are consistent with those reported in clinical trials of pertuzumab in patients with HER2+ breast cancer, with no new safety concerns.

Published
2022

44. Abstract P2-13-38: Pertuzumab study for HER2-positive non-metastatic breast cancer in the neoadjuvant setting in Australia

Author

Sheau Wen Lok, Richard De Boer, Sallt Baron-Hay, Peter Button, Bianca Devitt, Benjamin Forster, Peter Fox, Michael Harold, Sahisha Ketheeswaran, Ganessan Kichenadasse, Belinda E Kiely, Gavin Marx, Louise Nott, Laura Pellegrini, Ali Tafreshi, and Peter GIbbs

Subjects
Cancer Research, Oncology
Abstract

BACKGROUND Adding pertuzumab to trastuzumab in patients (pts) with HER2+ breast cancer improves pathological complete response (pCR) rates. Pertuzumab + trastuzumab + chemotherapy is approved in Australia as neoadjuvant therapy in early stage (>2 cm or node positive), locally advanced and inflammatory HER2+ breast cancer. This study captured real-world data on the safety and effectiveness of pertuzumab in the neoadjuvant setting. METHODS PeRSIA (ML39622) is a secondary data use non-interventional study of pts initiating neoadjuvant pertuzumab treatment for non-metastatic HER2+ breast cancer. The primary objective is to assess the effectiveness and safety of neoadjuvant pertuzumab when added to trastuzumab in the real-world setting. Deidentified data obtained from the pts’ medical notes were captured using REDCaP, hosted at the Walter and Eliza Hall Institute of Medical Research. This analysis reports the co-primary endpoints of breast pCR (bpCR) with or without in situ disease (ypT0/is or ypT0), total pCR (tpCR) with or without in situ disease (ypT0/is ypN0 or ypT0 ypN0), and the incidence of adverse events (AEs) related to pertuzumab. Secondary objectives include describing rates of breast and nodal surgery, relapse free survival (RFS) and overall survival (OS). RESULTS Ninety five pts receiving neoadjuvant pertuzumab were enrolled between March 2018 and July 2019, with data available for all pts. HER2-targeted neoadjuvant treatment was completed in 91 pts (95.8%) with a median number of 4 cycles [range 1-6] of pertuzumab and 5 cycles [range 1-6] of trastuzumab. Four pts did not complete the planned neoadjuvant therapy due to early CR (n=1), and pertuzumab-related AEs (n=3). The most common neoadjuvant chemotherapy regimens were sequential anthracyclines + taxanes (n=59, 62.1%) and single agent taxane (n=29, 30.5%). Surgery was performed in 92 pts (96.8%). Three pts did not proceed to surgery due to patient decision (n=1), physician decision (n=1), and development of a new non-breast cancer which resulted in death (n=1). Of those pts that underwent surgery, 65/92 (70.7%) had a bpCR and 59/92 (64.1%) had a tpCR. All pts who did not achieve a pCR obtained a partial response (33/92, 35.9%). Total pCR was seen in 27/34 (79.4%) pts with hormone receptor-negative and 32/58 (55.2%) pts with hormone receptor-positive cancers. 27/95 (28.4%) pts experienced an AE related to pertuzumab; diarrhea (21.1%) and rash (4.2%) were the most common AEs. Three pts (3.2%) discontinued pertuzumab due to an AE: cardiac toxicity, diarrhea and rash (n=1), cardiac toxicity (n=1), and diarrhea and sepsis (n=1). Following surgery, 93/95 (97.9%) patients received adjuvant HER2-directed therapy, and 4/95 (4.2%) received adjuvant chemotherapy. After a median follow-up from diagnosis of 21.2 [14.0-83.9] months, the RFS and OS were 92.6% and 99.0% respectively. Disease recurrence occurred in 6 pts (distant n=4, contralateral n=2). CONCLUSIONS This is the first multicenter, observational study of neoadjuvant therapy based on dual blockade with pertuzumab and trastuzumab for HER2+ non-metastatic breast cancer in Australia. The pCR rates achieved were numerically higher than previously reported in clinical trials. There were no significant safety findings outside of the expected safety profile for pertuzumab. Acknowledgments: Study sponsored by Roche Products, Pty. Limited. Theresa Wade (WriteSource Medical) provided medical writing. Table: Baseline Characteristics (n=95)CharacteristicNumber (%)Age, median (range)50.3 (24.4 -82.1)Charlson Comorbidity Index- 077 (81.1)- 19 (9.5)- 2 +9 (9.5)Tumour Size12 (12.6)- T156 (59.0)- T225 (26.3)- T3- Unreported2 (2.1)Tumour Grade- 10 (0)- 231 (32.6)- 362 (65.3)- Unreported2 (2.1)Nodal status- Positive63 (66.3)- Negative32 (33.7)Hormone Receptor Status- HR+60 (63.2)- HR-35 (36.8)Median baseline left ventricular ejection fraction (range)65.0% (35-79)Cardiac risk factors- 053 (55.8)- 122 (23.2)- 2+20 (21.1) Citation Format: Sheau Wen Lok, Richard De Boer, Sallt Baron-Hay, Peter Button, Bianca Devitt, Benjamin Forster, Peter Fox, Michael Harold, Sahisha Ketheeswaran, Ganessan Kichenadasse, Belinda E Kiely, Gavin Marx, Louise Nott, Laura Pellegrini, Ali Tafreshi, Peter GIbbs. Pertuzumab study for HER2-positive non-metastatic breast cancer in the neoadjuvant setting in Australia [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-38.

Published
2022

45. New methodology for the synthesis of fluorinated aromatics

Author

Rock, Michael Harold

Subjects
547, Organic chemistry
Abstract

This thesis is concerned with new methodology for the introduction of fluorine atoms, and trifluoromethyl groups into aromatic systems and the following approaches have been adopted: (i) The possibility of selective cleavage of the aryl-silicon bond of aryltrimethylsilanes by elemental fluorine to give the corresponding fluorinated aromatic compound was explored, and competing silicon and hydrogen substitution was observed. The affect of temperature and solvent upon this process was investigated. (ii) Attempts to modify the reactivity of dilute elemental fluorine (10% fluorine/nitrogen) towards aromatic systems at low reaction temperatures were made by the addition of pyridine and substituted pyridines. The effectiveness of this methodology was limited by the reactivity of the pyridine systems towards elemental fluorine.(Hi) The potential electrophilic fluorinating agents N-fluoro-2,3- bis(2H hexafluoropropyl) pyrrolidine and N-fluorosuccinimide have been synthesised by the direct fluorination of the corresponding N-trimethyl- silyl compounds.(iv) The cycloaddition reactions of hexafluorobut-2-yne with furan and 2-substituted furans have been employed to synthesise a series of benzenoid and heteroaromatic compounds containing two trifluoromethyl groups in high yield.(v) The synthesis of trifluoromethylpyridines by the cycloaddition of 3,3,3-trifluoropropene with oxazoles has also been investigated.

Published
1990

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