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A 74-year-old female was found hemiplegic in a public restroom. After arrival in our stroke unit, a computed tomography (CT) was performed, and she was diagnosed with bilateral carotid artery and right vertebral artery occlusion due to an acute type A aortic dissection. The patient deteriorated quickly to a GCS of 3 and was brought to the operating room, where a salvage replacement of the ascending aorta and the proximal aortic arch was performed with unilateral antegrade cerebral perfusion. Three days later, a significant decrease in left ventricular function and increase in cardiac biomarkers were observed. Coronary CT displayed residual dissection of the aortic root, extending into the left main coronary artery. The patient underwent an intravascular ultrasound-guided stenting of the left main, resulting in total recovery of heart function. She was extubated on the fourth postoperative day, with no residual neurological impairment. This case report advocates for the proper management of patients with ATAAD with severe neurological impairment, emphasizing the importance of a robust multidisciplinary approach in their care.

Before introducing new treatment techniques, an investigation of hazards due to unintentional radiation exposures is a reasonable activity for proactively increasing patient safety. As dedicated software is scarce, we developed a tool for risk assessment to design a quality management program based on best practice methods, i.e., process mapping, failure modes and effects analysis and fault tree analysis. Implemented as a web database application, a single dataset was used to describe the treatment process and its failure modes. The design of the system and dataset allowed failure modes to be represented both visually as fault trees and in a tabular form. Following the commissioning of the software for our department, previously conducted risk assessments were migrated to the new system after being fully re-assessed which revealed a shift in risk priorities. Furthermore, a weighting factor was investigated to bring risk levels of the migrated assessments into perspective. The compensation did not affect high priorities but did re-prioritize in the midrange of the ranking. We conclude that the tool is suitable to conduct multiple risk assessments and concomitantly keep track of the overall quality management activities.

This study investigates the impact of water ratio on the direct aqueous recycling of NMC811. Three different ratios of NMC811 to water were examined. The results demonstrate that the water ratio significantly affects the electrochemical performance of NMC811. Capacity fading is observed in all water-exposed samples, with the sample having the lowest water ratio showing less fading compared to the samples processed with higher water ratios. Both samples with higher water ratios exhibit similar performance, suggesting an equilibrium at the NMC811-water interface is established. Characterization of the cathode materials reveals variations in the amount and type of surface species. The pristine sample, not exposed to water, only shows Li2CO3 and NiO as surface species, while the water-exposed NMC811 samples exhibit nickel carbonates and hydroxides along with associated water. The poorer performance of samples exposed to higher water ratios is likely due to higher amounts of these species forming on the particle surface. Additionally, lithium, cobalt, and manganese carbonates, as well as lithium hydroxide with associated water, are detected and could further contribute to the poorer performance.

With neutron diffraction, the local stress and texture of metallic components can be analyzed non-destructively. For both, highly accurate positioning of the sample is essential, requiring the measurement at the same sample location from different directions. Current sample-positioning systems in neutron diffraction instruments combine XYZ tables and Eulerian cradles to enable the accurate six-degree-of-freedom (6DoF) handling of samples. However, these systems are not flexible enough. The choice of the rotation center and their range of motion are limited. Industrial six-axis robots have the necessary flexibility, but they lack the required absolute accuracy. This paper proposes a visual servoing system consisting of an industrial six-axis robot enhanced with a high-precision multi-camera tracking system. Its goal is to achieve an absolute positioning accuracy of better than 50μm. A digital twin integrates various data sources from the instrument and the sample in order to enable a fully automatic measurement procedure. This system is also highly relevant for other kinds of processes that require the accurate and flexible handling of objects and tools, e.g., robotic surgery or industrial printing on 3D surfaces.

For the duplex stainless steel X2CrNiMoN22-5-3, phase-specific strain pole figures (strain PFs) for the phases ferrite (bcc) and austenite (fcc) were analysed under uniaxial tensile loading for various loading states in purely elastic and elasto-plastic regimes. Experimentally, strain PFs were determined by means of in situ neutron diffraction strain measurements under defined uniaxial loading. These experimental results were compared with strain PFs calculated using elasto-plastic self-consistent (EPSC) modelling. The comparison was performed for two different {hkl} planes per phase. While classic load stress and load partitioning analyses for multi-phase materials are often limited to the load direction and a selected direction transverse to it, the results illustrate the added value of determining a strain PF, especially when a phase-specific texture is present. The comparison with experimental data shows how well the load partitioning behaviour can be predicted using common EPSC models, using the example of a duplex stainless steel. The EPSC model used was validated with the software ISODEC in its elastic range. Based on the results of the EPSC model, and taking into account the local phase-specific crystallographic texture, a prediction can be made as to what extent intergranular stresses and phase-specific textures could affect the results of a (residual) stress analysis by means of the diffraction method. This makes it possible to assess whether, for technical applications, meaningful residual stress results can be expected in certain component directions.

The thermoelastic effect indicates the dependency of temperature and volume change in the material and, due to the heat released during plastic deformation, a temperature minimum occurs in the region of the onset of yielding. An experimental setup is presented for the microscopic analysis of the thermoelastic effect, which allows high precision measurements of specimen. In-situ diffraction experiments were performed for a single phase low carbon steel HC260Y using synchrotron diffraction at the High Energy Material Science beamline P07 in Petra III, DESY. This allows a direct comparison of the onset of yielding by observing the evolution of lattice strains and dislocations densities with the specimen temperature in a continuous cyclic test having high measuring frequency and accuracy. Therefore, the lattice strains are evaluated based on the peak shift of several lattice planes and the dislocation density is estimated based on the micro strain due to peak broadening. The results prove existing assumptions about the relation between the thermoelastic effect and the onset of yielding and clearly qualify the temperature-based determination method for material characterization on a microstructural basis. The usefulness of the temperature elasticity parameters is shown exemplarily with the determination of loading moduli and compared to existing methods.

Abstract Phase-locking to the temporal envelope of speech is associated with envelope processing and speech perception. The phase-locked activity of the auditory pathway, across modulation frequencies, is generally assessed at group level and shows a decrease in response magnitude with increasing modulation frequency. With the exception of increased activity around 40 and 80 to 100 Hz. Furthermore, little is known about the phase-locked response patterns to modulation frequencies ≤ 20 Hz, which are modulations predominately present in the speech envelope. In the present study we assess the temporal modulation transfer function (TMTFASSR) of the phase-locked activity of the auditory pathway, from 0.5 to 100 Hz at a high-resolution and by means of auditory steady-state responses. Although the group-averaged TMTFASSR corresponds well with those reported in the literature, the individual TMTFASSR shows a remarkable intersubject variability. This intersubject variability is especially present for ASSRs that originate from the cortex and are evoked with modulation frequencies ≤ 20 Hz. Moreover, we found that these cortical phase-locked activity patterns are robust over time. These results show the importance of the individual TMTFASSR when assessing phase-locked activity to envelope fluctuations, which can potentially be used as a marker for auditory processing.

The aerospace alloy Ti-6246 was subjected to inductive heat treatments with high heating and quenching rates (up to 1500 K/s) while being applied to an in situ diffraction study at the HEMS beamline P07B at DESY. Thereby, the characterization of the emerging phases was possible at any point in the process. The heat treatment schedules include the preparation of Ti-6246 samples by means of a homogenization treatment and subsequent quenching to trigger α″-martensite formation. In order to simulate fast reheating within the scope of application, the samples were reheated to the upper range of possible service temperatures (550–650 °C) with a heating rate of 100 K/s. In a second heat treatment design, the homogenized and quenched sample state was exposed to high-temperature tempering at 840 °C, which aims for the elimination of α″. Again, fast reheating to the same service temperatures was executed. With the aim of this approach, the stability of the microstructure consisting of α-Ti, β-Ti and α″-martensite was characterized. Further, the martensite decomposition path was analyzed. It shows a two-tier nature, firstly approaching the bcc β-unit cell in the low-temperature range (

Idiopathic pulmonary fibrosis (IPF) represents the most aggressive form of pulmonary fibrosis (PF) and is a highly debilitating disorder with a poorly understood etiology. The lung epithelium seems to play a critical role in the initiation and progression of the disease. A repeated injury of lung epithelial cells prompts type II alveolar cells to secrete pro-fibrotic cytokines, which induces differentiation of resident mesenchymal stem cells into myofibroblasts, thus promoting aberrant deposition of extracellular matrix (ECM) and formation of fibrotic lesions. Reactivation of developmental pathways such as the Wnt-β-catenin signaling cascade in lung epithelial cells plays a critical role in this process, but the underlying mechanisms are still enigmatic. Here, we demonstrate that the membrane-associated protein NUMB is required for pathological activation of β-catenin signaling in lung epithelial cells following bleomycin-induced injury. Importantly, depletion of Numb and Numblike reduces accumulation of fibrotic lesions, preserves lung functions, and increases survival rates after bleomycin treatment of mice. Mechanistically, we demonstrate that NUMB interacts with casein kinase 2 (CK2) and relies on CK2 to activate β-catenin signaling. We propose that pharmacological inhibition of NUMB signaling may represent an effective strategy for the development of novel therapeutic approaches against PF.

Ubiquitous carbonic acid, H2CO3, a key molecule in biochemistry, geochemistry, and also extraterrestrial chemistry, is known from a plethora of physicochemical studies. Its crystal structure has now been determined from neutron-diffraction data on a deuterated sample in a specially built hybrid clamped cell. At 1.85 GPa, D2CO3 crystallizes in the monoclinic space group P21/c with a = 5.392(2), b = 6.661(4), c = 5.690(1) Å, β = 92.66(3)°, Z = 4, with one symmetry-inequivalent anti-anti shaped D2CO3 molecule forming dimers, as previously predicted. Quantum chemistry evidences π bonding within the CO3 molecular core, very strong hydrogen bonding between the molecules, and a massive influence of the crystal field on all bonds; phonon calculations emphasize the locality of the vibrations, being rather insensitive to the extended structure.

In the present work, neutronographic in situ diffraction stress analyses during uniaxial loading and subsequent unloading were carried out on the two duplex stainless steels X2CrNiMoN22-5-3 and X3CrNiMoN27-5-2 with nominal phase fractions for ferrite:austenite of 50:50% and 70:30%, respectively. In addition to the different phase fractions, the two steels also differed in their phase-specific crystallographic texture. The load-partitioning behaviour and the phase-specific micro (residual) stress evolution for total strains up to about 9% were investigated. The results indicated that for both materials under load, the phase-specific stress in the ferrite phase was significantly higher than in the austenite phase, while no texture development through the plastic deformation could be observed.

Several locally acting colon-targeted products to treat colonic diseases have been recently developed and marketed, taking advantage of gastrointestinal physiology to target delivery. Main mechanisms involve pH-dependent, time-controlled and/or enzymatic-triggered release. With site of action located before systemic circulation and troublesome colonic sampling, there is room for the introduction of meaningful in vitro methods for development, quality control (QC) and regulatory applications of these formulations. A one-size-fits-all method seems unrealistic, as the selection of experimental conditions should resemble the physiological features exploited to trigger the release. This article reviews the state of the art for bio-predictive dissolution testing of colon-targeted products. Compendial methods overlook physiological aspects, such as buffer molarity and fluid composition. These are critical for pH-dependent products and time-controlled systems containing ionizable drugs. Moreover, meaningful methods for enzymatic-triggered products including either bacteria or enzymes are completely ignored by pharmacopeias. Bio-predictive testing may accelerate the development of successful products, although this may require complex methodologies. However, for high-throughput routine testing (e.g., QC), simplified methods can be used where balance is struck between simplicity, robustness and transferability on one side and bio-predictivity on the other. Ultimately, bio-predictive methods can occupy a special niche in terms of supplementing plasma concentration data for regulatory approval.

Polycrystalline Ni-based superalloys are one of the most frequently used materials for high temperature load-bearing applications due to their superior mechanical strength and chemical resistance. In this paper, we presented an in situ diffraction study on the tensile deformation behavior of the polycrystalline Ni-based superalloy VDM® Alloy 780 at temperatures up to 500 °C performed at the STRESS-SPEC neutron diffractometer at the Heinz Maier-Leibnitz Zentrum. A detailed microstructural investigation was carried out by electron microscopy before and after testing. The results of these studies allowed us to determine the deformation mechanism in the differently orientated grains. It is shown that the deformation behavior, which is mainly dislocation motion and shearing of the γ′-precipitates, does not change at this temperature range. The deformation is strongly anisotropic and depends on the grain orientation. The macroscopic hardening can mainly be attributed to plastic deformation in grains, where the (200) lattice planes were orientated perpendicular to the loading direction. Accordingly, a remaining lattice strain and high dislocation density were detected predominantly in these grains.