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Objective I am a 92-year-old personification of Nature’s wordless attraction (love) to begin life. As an Applied Ecopsychology ADP, commencing 1959, I spent 16 years directing year-long, utopian, Nature-Connected Psychology expeditions independently and for the National Audubon Society. Travel-camping across the USA, we organized ourselves to create unifying natural area moments that let Nature’s life teach and heal us via its space-time essence instead of from our suicidal war with Nature. Methodology Since 1985, after initiating the world’s first “Is the Earth a Living Organism?” International Gaia Symposium, I created today’s Project Nature Connect online Organic Psychology activities,courses, and degree programs. They let Nature’s heartfelt essence (Natureness) interlace our 54-senses with Nature’s unconditional love, backyard, or backcountry. This 850% increases personal, social, and environmental well-being as it transforms the abusive cause and pain of our problems into Nature’s balance and beauty. “You become Youness” as this article unites folks through evidence-based Natureness truths. Discussion Professional journals and field experiences validate my 1965 hypothesis: “Teaching myself and others to teach Natureness achieves my Objective, (above.)” This article/tool adds global wellness to the indisputable truth that “ You are reading these words here and now.” In 1965, in a wilderness area, that truth demonstrated that because I (humanity) can speak with words and Nature cannot, without Natureness, our stories excessively disconnect us from Nature. To compensate for this hurtful abandonment we constantly crave artificial satisfaction from Earth’s natural resources/metabolism around, in, and as us. Tragically, this has 45% bankrupted our person/planet life and counting. Conclusion This article creates natural area moments that let our 54-sensible end with Nature’s wordless love to begin life. Its organic wisdom remedies our eco-suicide through therapeutic practices that make our experiences become beneficial person/planet relationships when we relate to the natural essence of things instead of just their stories.

Dental enamel is a principal component of teeth.[1] It has evolved to bear large masticatory forces, resist mechanical fatigue, and withstand wear over decades of use.[2] Functional impairment or loss, as a consequence of developmental defects or tooth decay (caries), has a dramatic impact on health and quality of life, with significant costs to society.[3] While the last decade has seen great progress in our understanding of enamel formation (amelogenesis) and the functional properties of mature enamel, attempts to repair enamel lesions or synthesize enamel in vitro have had limited success.[4–6] This is partly due to the highly hierarchical structure of enamel and the additional complexities arising from chemical gradients that we are only beginning to understand.[7–9] Herein, we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (OHAp; Ca5(PO4)3(OH)) that are the fundamental building blocks of enamel are comprised of two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride, and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. A mechanical model based on DFT calculations and X-ray diffraction data predicts that significant residual stresses arise as a consequence of the chemical gradients, in agreement with preferential dissolution of the crystallite core. Further, stresses may impact the mechanical resilience of enamel. Finally, the two additional layers of hierarchy suggest a new model for biological control over crystal growth during amelogenesis and have implications for the preservation of biomarkers during tooth development.

This report summarizes podium presentations and breakout sessions from the second day of the 2019 M-CERSI workshop on In Vitro Dissolution Similarity Assessment in Support of Drug Product Quality: What, How, and When? Presenters from the U.S. Food and Drug Administration (FDA), Health Canada (HC), European Medicines Agency (EMA), Brazilian Health Surveillance Agency (ANVISA), and the pharmaceutical industry shared experiences/concerns with dissolution profile similarity assessment supporting minor/moderate Chemistry, Manufacturing and Control (CMC) changes. Members from regulatory agencies explained that dissolution profile similarity testing is only part of the overall assessment of the acceptability of the proposed changes; decisions are usually made based on aggregate weight of evidence. Scientific shortcomings of f

Despite widespread use of learning collaboratives, few randomized trials have evaluated their effectiveness as a strategy for implementing evidence based practices. This randomized trial evaluated the effectiveness of a virtual learning collaborative (VLC) in the implementation of a health promotion program for persons with serious mental illness (SMI) aimed at reducing cardiovascular risk reduction in routine mental health settings, compared to routine technical assistance (TA).Fifty-five mental health provider organizations were recruited to participate in a Hybrid Type 3 cluster randomized implementation-effectiveness trial of the InSHAPE health promotion program for persons with SMI. Sites were stratified by size and randomized prior to implementation to an 18-month group-based VLC with monthly learning sessions or individual site TA with four scheduled conference calls over 18 months. Primary implementation and service outcomes were InSHAPE program fidelity, participation, and reach. Primary clinical outcomes were weight loss, cardiorespiratory fitness, and cardiovascular risk reduction (≥ 5% weight loss or 50 m increase on the 6-Minute Walk Test). Program fidelity was assessed at 6, 12, and 24 months; program participation and participant-level outcomes were assessed at 3, 6, 9, and 12 months.VLC (N = 27) and TA (N = 28) sites were similar in organizational characteristics (all p 0.05). At 12-month follow-up mean program fidelity score was higher in VLC compared to TA (90.5 vs. 79.1; p = 0.002), with over double the proportion with good fidelity (VLC = 73.9% vs. TA = 34.8%; p = 0.009). Over half of individuals in both VLC and TA achieved cardiovascular risk-reduction at 6-month follow-up (VLC: 51.0%; TA: 53.5%; p = 0.517) and at 12-month follow-up (62% VLC and TA; p = 0.912). At 12-month follow-up VLC compared to TA was associated with greater participation (VLC 69.5% vs. TA 56.4% attending at least 50% of sessions, p = 0.002); larger caseloads (VLC = 16 vs. TA = 11; p = 0.024); greater reach consisting of 45% greater number of participants receiving InSHAPE (VLC = 368 vs. TA = 253), and 58% greater number of participants achieving cardiovascular risk reduction (VLC = 150 vs. TA = 95).Virtual learning collaboratives compared to routine technical assistance as an implementation strategy for evidence-based health promotion promote greater intervention fidelity, greater levels of intervention participation, greater reach, and a greater number of participants achieving clinically significant risk reduction outcomes, while achieving similarly high levels of intervention effectiveness for participants who completed at least 6 months of the program.

The author of this book, Michael D. Berdine, is a Los Angeles-born, retired history lecturer. He taught at the University of Arizona, the University of Texas at El Paso, and Pima Community College,...

The purpose of this study was to evaluate health outcomes of a state-supported implementation in community mental health settings of an evidence-based lifestyle intervention for overweight and obese adults with serious mental illness.Weight and fitness outcomes were evaluated for 122 overweight or obese adults with serious mental illness in four community mental health centers (CMHCs) that were participating in a phased statewide implementation of the In SHAPE lifestyle intervention. Six- and 12-month outcomes were compared between two CMHCs that implemented In SHAPE in the first 12 months and two CMHCs with similar characteristics that implemented In SHAPE in a subsequent phase in the statewide implementation 12 months later.Participants in the two In SHAPE sites (N=63 participants) lost significantly more weight (p=.003) and showed greater improvement in fitness (p=.011) compared with participants at the two usual care control sites (N=59 participants). At six months, nearly half (49%) of In SHAPE participants and at 12 months more than half (60%) of In SHAPE participants showed clinically significant cardiovascular risk reduction defined as ≥5% weight loss or improved fitness (50 m [164 feet] increase on the six-minute walk test). The difference between the In SHAPE and control groups was not statistically significant.This natural experiment demonstrated promising public health benefits of a practical implementation of health promotion programming for overweight and obese adults with serious mental illness and offers a potential model for reducing risk of early mortality among individuals served by state-funded mental health centers nationwide.

This is a problematic book to review. Henkin, a military historian at the Israeli Defense Force's (IDF) Command and General Staff College, argues that ‘interviews and memories’ are insufficient, an...

During World War One, both Arabs and Zionists sought to become “the tools of British imperialism.” The British exploited both as their own interests dictated, without giving a thought for future consequences. In 1915, the MacMahon-Husayn correspondence – conducted between Britain's High Commissioner in Cairo and a non-representative Arab Bedouin leader from the Arabian Peninsula – ended inconclusively, without agreement. In contrast, the Balfour Declaration - the culmination of 6 months of British-initiated negotiations with the Zionists, was published in order to further Britain's military, strategic and propaganda interests. At the time, the British considered it to have been a ‘brilliant coup’.

Background Despite widespread use of learning collaboratives in health care, few randomized trials have evaluated their effectiveness. The primary aim of this cluster randomized implementation trial is to evaluate the effectiveness of a virtual learning collaborative (VLC) in the implementation of a lifestyle intervention for persons with serious mental illness (SMI) in routine mental health settings, compared to standard individual technical assistance. Methods Forty-eight mental health provider organizations from across the United States will be recruited to participate in the trial. The evidence-based practice to be implemented is the InSHAPE health promotion intervention for persons with SMI. Sites will be stratified by size and randomized to receive an 18-month intensive group-based VLC with monthly learning sessions or individual technical assistance with four scheduled conference calls over 18 months. Sites will be enrolled in three blocks of 16 sites each. The primary outcomes are InSHAPE program participation and fidelity, and participant weight loss; secondary outcomes are program operation, program uptake, participant health behaviors of physical activity and nutrition, organizational change, and program sustainment. Implementation outcomes are measured at 3, 6, 12, 18, and 24 months after the program start-up. Participant-level outcomes are measured at fixed intervals every 3 months after each participant enrolls in the study. Discussion This study will determine whether VLCs are an effective implementation strategy among resource-limited providers when the new practice necessitates a shift in mission, scope of practice, type of services delivered, and new financing. Trial registration ClinicalTrials.gov identifier: NCT03891368 Registered 25 March 2019, retrospectively registered. https://clinicaltrials.gov/ct2/show/NCT03891368?term=NCT03891368&rank=1

The publication of Bruce Hoffman's book presents us with a timely opportunity to revisit the debate about which Jewish underground should be credited with driving the British out of Palestine, or a...

This manuscript represents the perspective of the Dissolution Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) and of two focus groups of the American Association of Pharmaceutical Scientists (AAPS): Process Analytical Technology (PAT) and In Vitro Release and Dissolution Testing (IVRDT). The intent of this manuscript is to show recent progress in the field of in vitro predictive dissolution modeling and to provide recommended general approaches to developing in vitro predictive dissolution models for both early- and late-stage formulation/process development and batch release. Different modeling approaches should be used at different stages of drug development based on product and process understanding available at those stages. Two industry case studies of current approaches used for modeling tablet dissolution are presented. These include examples of predictive model use for product development within the space explored during formulation and process optimization, as well as of dissolution models as surrogate tests in a regulatory filing. A review of an industry example of developing a dissolution model for real-time release testing (RTRt) and of academic case studies of enabling dissolution RTRt by near-infrared spectroscopy (NIRS) is also provided. These demonstrate multiple approaches for developing data-rich empirical models in the context of science- and risk-based process development to predict in vitro dissolution. Recommendations of modeling best practices are made, focused primarily on immediate-release (IR) oral delivery products for new drug applications. A general roadmap is presented for implementation of dissolution modeling for enhanced product understanding, robust control strategy, batch release testing, and flexibility toward post-approval changes.