1. Coronary artery disease in adults with anomalous aortic origin of a coronary arteryCentral MessagePerspective
- Author
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Michael X. Jiang, MD, MEng, Ellen K. Brinza, MS, Joanna Ghobrial, MD, Dominique L. Tucker, BS, Sohini Gupta, BA, Jeevanantham Rajeswaran, PhD, Tara Karamlou, MD, MSc, Eugene H. Blackstone, MD, Elizabeth V. Saarel, MD, Miza Salim Hammoud, MD, Kiran A. Vaidya, BS, Michael J. Haupt, BS, Joshua W. Cockrum, BS, Christiane Mhanna, DO, Munir Ahmad, MD, Paul Schoenhagen, MD, Gösta B. Pettersson, MD, PhD, Hani K. Najm, MD, MSc, and Robert D. Stewart, MD, MPH
- Subjects
congenital heart disease ,adult congenital heart disease ,coronary artery disease ,coronary artery imaging ,coronary surgery ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Surgery ,RD1-811 - Abstract
Objectives: This study sought to characterize coronary artery disease (CAD) among adults diagnosed with an anomalous aortic origin of a coronary artery (AAOCA). We hypothesized that coronaries with anomalous origins have more severe CAD stenosis than coronaries with normal origins. Methods: This single-center study of 763 adults with AAOCA consisted of 620 patients from our cardiac catheterization database (1958-2009) and 273 patients from electronic medical records query (2010-2021). Within left main, anterior descending, circumflex, and right coronary arteries, the CAD stenosis severity, assessed by invasive or computer tomography angiography, was modeled with coronary-level variables (presence of an anomalous origin) and patient-level variables (age, sex, comorbidities, and which of the four coronaries was anomalous). Results: Of the 763 patients, 472 (60%) had obstructive CAD, of whom, 142/472 (30%) had obstructive CAD only in the anomalous coronary. Multivariable modeling showed similar CAD stenosis severity between coronaries with anomalous versus normal origins (P = .8). Compared with AAOCA of other coronaries, the anomalous circumflex was diagnosed at older ages (59.7 ± 11.1 vs 54.3 ± 15.8 years, P
- Published
- 2022
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