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The calc-alkalic Mitchell Au-Cu-Ag-Mo porphyry deposit, hosted in intrusive rocks of the Stikine volcanic arc terrane of northwestern British Columbia, is the largest undeveloped gold resource in Canada, with 40.72 Moz of contained gold. It lies within the KSM trend, a 12-km-long linear porphyry array in the Sulphurets district. It is genetically related to Early Jurassic Sulphurets stocks: phase 1 diorite to monzodiorite hosts Cu-Au mineralization in potassic assemblages (stage 1), a phase 2 granodiorite plug cores a molybdenum halo (190.3 ± 0.8 Ma, 191.3 ± 0.7 Ma; Re-Os, molybdenite) that is accompanied by phyllic alteration (stage 2), and a poorly mineralized phase 3 diorite plug temporally overlaps with quartz-pyrophyllite alteration at shallow levels (stage 3). Two deformation events (D1 and D2), attributed to orogen-scale mid-Cretaceous transpression, structurally modified Mitchell. D1 deformation, expressed as steep E-striking pressure solution cleavage (S1) and related W-plunging folded veins (F1), is heterogeneously developed as a function of alteration type. D2 is divided into two progressive events: D2a, defined by N-plunging, folded veins (F2a), and D2b, defined by E-vergent thrust faults, including the Mitchell thrust fault, which offsets the updip continuation of Mitchell (the Snowfield deposit, 192.0 ± 1.0 Ma, 191.1 ± 0.8 Ma; Re-Os, molybdenite) ~1,600 m to the east-southeast. Host structures for the KSM trend may have been long-lived, N-striking basement lineaments that provided transcrustal magma and fluid pathways. East-trending intrusions, hydrothermal veins, alteration and metal distribution at Mitchell are attributed to subsidiary E-striking cross faults. These original anisotropies in turn influenced the geometry of Cretaceous faults and flattening domains within the deposit.