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1. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial

Author

LAMAURY, Isabelle, BANI-SADR, Firouzé, FORCE, Gilles, CHABROL, Amélie, CABY, Fabienne, PATEY, Olivier, FRESARD, Anne, GAGNEUX-BRUNON, Amandine, CHIROUZE, Catherine, DUVIVIER, Claudine, LOURENCO, Jérémie, TOLSMA, Violaine, JANSSEN, Cécile, LEROLLE, Nathalie, CATALAN, Pilartxo, RAMI, Agathe, DE PONTHAUD, Lucile, PICHANCOURT, Gilles, NASRI, Safa, LANDOWSKI, Stéphanie, BOTTERO, Julie, MFUTILA KAYKAY, Flory, PIALOUX, Gilles, BOUCHAUD, Olivier, ABGRALL, Sophie, GATEY, Caroline, WEISS, Laurence, PAVIE, Juliette, SALMON-CERON, Dominique, ZUCMAN, David, LELIEVRE, Jean-Daniel, PALICH, Romain, SIMON, Anne, MEYOHAS, Marie-Caroline, GRAS, Julien, CABIE, André, PIRCHER, Mathilde, MORLAT, Philippe, HESSAMFAR, Mojgam, NEAU, Didier, CAZENAVE, Charles, GENET, Claire, FAUCHER, Jean-François, MAKHLOUFI, Djamila, BOIBIEUX, André, BREGIGEON-RONOT, Sylvie, LAROCHE, Hélène, SAUTEREAU, Aurélie, REYNES, Jacques, MAKINSON, Alain, RAFFI, François, BOLLENGIER-STRAGIER, Olivier, NAQVI, Alissa, CUA, Eric, ROSENTHAL, Eric, ARVIEUX, Cédrick, BUZELE, Rodolphe, REY, David, BATARD, Marie-Laure, BERNARD, Louis, DELOBEL, Pierre, PIFFAUT, Marie, VERDON, Renaud, PIROTH, Lionel, BLOT, Mathieu, LECLERCQ, Pascale, SIGNORI-SCHMUCK, Anne, HULEUX, Thomas, MEYBECK, Agnès, MAY, Thierry, MIAILHES, Patrick, PERPOINT, Thomas, GREDER-BELAN, Alix, ELHARRAR, Brigitte, KHUONG, Marie-Aude, POUPARD, Marie, BLUM, Laurent, MICHAU, Christophe, PRAZUCK, Thierry, PHILIBERT, Patrick, SLAMA, Laurence, HIKOMBO, Hitoto, DARASTEANU, Iuliana, GIRARD, Pierre-Marie, ALVAREZ, Jean-Claude, MATHEZ, Dominique, DE TRUCHIS, Pierre, LANDMAN, Roland, MEYNARD, Jean-Luc, MORAND-JOUBERT, Laurence, LAMBERT, Sidonie, LE DU, Damien, PERRONNE, Christian, ASSOUMOU, Lambert, COSTAGLIOLA, Dominique, MELCHIOR, Jean-Claude, DURACINSKI, Martin, PETROV-SANCHEZ, Ventzislava, AMAT, Karine, BENALYCHERIF, Aïda, SYLLA, Babacar, GELLEY, Ambre, GIBOWSKI, Séverine, LE MEUT, Guillaume, THIEBAUT, Rodolphe, CLUMECK, Nathan, LECLERCQ, Vincent, CECCHERINI-SILBERSTEIN, Francesca, DECOSTER, Laurent, Landman, Roland, de Truchis, Pierre, Assoumou, Lambert, Lambert, Sidonie, Bellet, Jonathan, Amat, Karine, Lefebvre, Bénédicte, Allavena, Clotilde, Katlama, Christine, Yazdanpanah, Yazdan, Molina, Jean-Michel, Petrov-Sanchez, Ventzislava, Gibowski, Séverine, Alvarez, Jean-Claude, Leibowitch, Jacques, Capeau, Jacqueline, Fellahi, Soraya, Duracinsky, Martin, Morand-Joubert, Laurence, Costagliola, Dominique, and Girard, Pierre-Marie more...

Published
2022
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3. In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Author

Trémeaux, Pauline, primary, Lemoine, Frédéric, additional, Mélard, Adeline, additional, Gousset, Marine, additional, Boufassa, Faroudy, additional, Orr, Sylvie, additional, Monceaux, Valérie, additional, Gascuel, Olivier, additional, Lambotte, Olivier, additional, Hocqueloux, Laurent, additional, Saez-Cirion, Asier, additional, Rouzioux, Christine, additional, Avettand-Fenoel, Véronique, additional, Bani-Sadr, Firouzé, additional, Hentzien, Maxime, additional, Berger, Jean-Luc, additional, Kmiec, Isabelle, additional, Pichancourt, Gilles, additional, Nasri, Safa, additional, Hittinger, Gilles, additional, Lambry, Véronique, additional, Beaudrey, Anne-Cécile, additional, Pialoux, Gilles, additional, Chas, Julie, additional, Palacios, Christia, additional, Adda, Anne, additional, Viard, Jean Paul, additional, Dulucq, Marie-Josée, additional, Weiss, Laurence, additional, Karmochkine, Marina, additional, Meghadecha, Mohamed, additional, Salmon-Ceron, Dominique, additional, Piétri, Marie-Pierre, additional, Blanche, Philippe, additional, Molina, Jean-Michel, additional, Taulera, Olivier, additional, Ponscarme, Diane, additional, Delgado Bertaut, Jeannine, additional, Makhloufi, Djamila, additional, Godinot, Matthieu, additional, Artizzu, Valérie, additional, Miailhes, Patrick, additional, Cotte, Laurent, additional, Pailhes, Sophie, additional, Conrad, Anne, additional, Karkowski, Ludovic, additional, Ogoudjobi, Stanislas, additional, Yazdanpanah, Yazdan, additional, Matheron, Sophie, additional, Godard, Cindy, additional, Bernard, Louis, additional, Bastides, Frédéric, additional, Bourgault, Olivier, additional, Jacomet, Christine, additional, Goncalves, Emilie, additional, Chavanet, Pascal, additional, Piroth, Lionel, additional, Gohier, Sandrine, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Cornavin, Pauline, additional, Debab, Yasmine, additional, Théron, David, additional, Prazuck, Thierry, additional, De Dieuleveult, Barbara, additional, Faller, Jean-Pierre, additional, Eglinger, Patricia, additional, Roblot, Pascal, additional, Plainchamp, David, additional, Aumaître, Hugues, additional, Malet, Martine, additional, Rouger, Christine, additional, Rémy, Gérard, additional, Isabelle, Melle Kmiec, additional, Delassus, Jean-Luc, additional, Devidas, Alain, additional, Froguel, Eric, additional, Tassi, Sylvie, additional, Genet, Philippe, additional, Gerbe, Juliette, additional, Patey, Olivier, additional, Laurent, Richier, additional, Drobacheff, Marie-Christine, additional, Proust, Aurélie, additional, Gil, Helder, additional, Gérard, Laurence, additional, Oksenhendler, Eric, additional, Lascoux, Caroline, additional, Parlier, Sylvie, additional, Lucht, Frédéric, additional, Ronat, Véronique, additional, Dupon, Michel, additional, Dutronc, Hervé, additional, Le Puil, Séverine, additional, Neau, Didier, additional, Mercié, Patrick, additional, Morlat, Philippe, additional, Caldato, Sabrina, additional, Schmit, Jean-Luc, additional, Decaux, Nathalie, additional, Bru, Jean-Pierre, additional, Clavere, Gaëlle, additional, Delfraissy, Jean-François, additional, Goujard, Cécile, additional, Bourdic, Katia, additional, Vittecoq, Daniel, additional, Bolliot, Claudine, additional, Lambert, Thierry, additional, Bergmann, Jean-François, additional, Parrinello, Maguy, additional, Welker, Yves, additional, Lafeuillade, Alain, additional, Philip, Gisèle, additional, Rapp, Christophe, additional, Lerondel, Melle, additional, de Truchis, Pierre, additional, Huguette, Berthe, additional, Jeantils, Vincent, additional, Mchangama, Fatouma, additional, Consigny, Paul Henri, additional, Touam, Fatima, additional, le Nagat, Sophie, additional, Bouchaud, Olivier, additional, Honoré, Patricia, additional, Boué, François, additional, Raho-Moussa, Mariem, additional, Viard, Jean-Paul, additional, Cros, Agnès, additional, Salmon-Céron, Dominique, additional, Pietri, Marie-Pierre, additional, Collias, Lio, additional, Zucman, David, additional, Blétry, Olivier, additional, Bornarel, Dominique, additional, Mortier, Emmanuel, additional, Feng, Zeng, additional, Lelièvre, Jean-Daniel, additional, Katlama, Christine, additional, Dudoit, Yasmine, additional, Simon, Anne, additional, Lupin, Catherine, additional, Girard, Pierre-Marie, additional, Pauchard, Michèle, additional, Abel, Sylvie, additional, Cabié, André, additional, Fialaire, Pascale, additional, Chennebault, Jean-Marie, additional, Rehaiem, Sami, additional, de Saint Martin, Luc, additional, Perfezou, ••••, additional, Duthe, Jean-Charles, additional, Weinbreck, Pierre, additional, Genet, Claire, additional, Garnier, Florence, additional, Poizot-Martin, Isabelle, additional, Fauche, Olivia, additional, Ivanova, Alena, additional, Philibert, Patrick, additional, Penda Sow, Mame, additional, Yeni, Patrick, additional, Godard, Cyndi, additional, Raffi, François, additional, Hüe, Hervé, additional, Perré, Philippe, additional, Roger, Pierre Marie, additional, Joulie, Aline, additional, Rosenthal, Éric, additional, Michelet, Christian, additional, Souala, Faouzi, additional, Ratajczak, Maja, additional, Partisani, Marialuisa, additional, Fischer, Patricia, additional, Nau, Pascale, additional, Delobel, Pierre, additional, Balsarin, Florence, additional, De Lavaissiere, Marc, additional, Verdon, Renaud, additional, Feret, Philippe, additional, Leclercq, Pascale, additional, Gerberon, ••••, additional, Meybeck, Agnés, additional, Biekre, Raphaël, additional, May, Thierry, additional, Bouillon, ••••, additional, Caron, François, additional, Theron, David, additional, Gatfosse, Marc, additional, Martinot, Martin, additional, Pachart, Anne, additional, Poubeau, Patrice, additional, Gaud, Catherine, additional, Uludag, Agnès, additional, Arsac, Philippe, additional, Bouaraba, Lydia, additional, de Dieulevault, Barbara, additional, De Lacroix Szmania, Isabelle, additional, Richier, Laurent, additional, Daneluzzi, Vincent, additional, Rouveix, Elisabeth, additional, Beck-Wirth, Geneviève, additional, Romand, Philippe, additional, Blum, Laurent, additional, Deschaud, Martine, additional, Michau, Christophe, additional, Bernard, Christian, additional, Salaun, Florence, additional, Muller, Philippe, additional, Poinsignon, Yves, additional, Lepretre, Annie, additional, Sotto, Albert, additional, Doncesco, ••••, additional, Perfezou, Pascale, additional, Duthe, Jean Charles, additional, Niault, Mathilde Aurore, additional, Mouton-Rioux, Virginie, additional, Talarmin, Jean-Philippe, additional, Duthé, Jean Charles, additional, Dupont, Mathilde, additional, Natur, Stéphane, additional, Hitoto, Hikombo, additional, and Ibrahim, Ali Mahamadou, additional more...

Published
2023
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5. Clinical Features and Outcome of Multidrug-Resistant Osteoarticular Tuberculosis: A 12-Year Case Series from France

Author

Bonnet, Isabelle, primary, Haddad, Elie, additional, Guglielmetti, Lorenzo, additional, Bémer, Pascale, additional, Bernard, Louis, additional, Bourgoin, Anne, additional, Brault, Rachel, additional, Catho, Gaud, additional, Caumes, Eric, additional, Escaut, Lélia, additional, Fourniols, Eric, additional, Fréchet-Jachym, Mathilde, additional, Gaudart, Alice, additional, Guillot, Hélène, additional, Lafon-Desmurs, Barthélémy, additional, Lanoix, Jean-Philippe, additional, Lanotte, Philippe, additional, Lemaignen, Adrien, additional, Lemaire, Bénédicte, additional, Lemaitre, Nadine, additional, Michau, Christophe, additional, Morand, Philippe, additional, Mougari, Faiza, additional, Marigot-Outtandy, Dhiba, additional, Patrat-Delon, Solène, additional, Perpoint, Thomas, additional, Piau, Caroline, additional, Pourcher, Valérie, additional, Zarrouk, Virginie, additional, Zeller, Valérie, additional, Veziris, Nicolas, additional, Jauréguiberry, Stéphane, additional, and Aubry, Alexandra, additional more...

Published
2022
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7. A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial

Author

Landman, Roland, primary, de Truchis, Pierre, additional, Assoumou, Lambert, additional, Lambert, Sidonie, additional, Bellet, Jonathan, additional, Amat, Karine, additional, Lefebvre, Bénédicte, additional, Allavena, Clotilde, additional, Katlama, Christine, additional, Yazdanpanah, Yazdan, additional, Molina, Jean-Michel, additional, Petrov-Sanchez, Ventzislava, additional, Gibowski, Séverine, additional, Alvarez, Jean-Claude, additional, Leibowitch, Jacques, additional, Capeau, Jacqueline, additional, Fellahi, Soraya, additional, Duracinsky, Martin, additional, Morand-Joubert, Laurence, additional, Costagliola, Dominique, additional, Girard, Pierre-Marie, additional, LAMAURY, Isabelle, additional, BANI-SADR, Firouzé, additional, FORCE, Gilles, additional, CHABROL, Amélie, additional, CABY, Fabienne, additional, PATEY, Olivier, additional, FRESARD, Anne, additional, GAGNEUX-BRUNON, Amandine, additional, CHIROUZE, Catherine, additional, DUVIVIER, Claudine, additional, LOURENCO, Jérémie, additional, TOLSMA, Violaine, additional, JANSSEN, Cécile, additional, LEROLLE, Nathalie, additional, CATALAN, Pilartxo, additional, RAMI, Agathe, additional, DE PONTHAUD, Lucile, additional, PICHANCOURT, Gilles, additional, NASRI, Safa, additional, LANDOWSKI, Stéphanie, additional, BOTTERO, Julie, additional, MFUTILA KAYKAY, Flory, additional, PIALOUX, Gilles, additional, BOUCHAUD, Olivier, additional, ABGRALL, Sophie, additional, GATEY, Caroline, additional, WEISS, Laurence, additional, PAVIE, Juliette, additional, SALMON-CERON, Dominique, additional, ZUCMAN, David, additional, LELIEVRE, Jean-Daniel, additional, PALICH, Romain, additional, SIMON, Anne, additional, MEYOHAS, Marie-Caroline, additional, GRAS, Julien, additional, CABIE, André, additional, PIRCHER, Mathilde, additional, MORLAT, Philippe, additional, HESSAMFAR, Mojgam, additional, NEAU, Didier, additional, CAZENAVE, Charles, additional, GENET, Claire, additional, FAUCHER, Jean-François, additional, MAKHLOUFI, Djamila, additional, BOIBIEUX, André, additional, BREGIGEON-RONOT, Sylvie, additional, LAROCHE, Hélène, additional, SAUTEREAU, Aurélie, additional, REYNES, Jacques, additional, MAKINSON, Alain, additional, RAFFI, François, additional, BOLLENGIER-STRAGIER, Olivier, additional, NAQVI, Alissa, additional, CUA, Eric, additional, ROSENTHAL, Eric, additional, ARVIEUX, Cédrick, additional, BUZELE, Rodolphe, additional, REY, David, additional, BATARD, Marie-Laure, additional, BERNARD, Louis, additional, DELOBEL, Pierre, additional, PIFFAUT, Marie, additional, VERDON, Renaud, additional, PIROTH, Lionel, additional, BLOT, Mathieu, additional, LECLERCQ, Pascale, additional, SIGNORI-SCHMUCK, Anne, additional, HULEUX, Thomas, additional, MEYBECK, Agnès, additional, MAY, Thierry, additional, MIAILHES, Patrick, additional, PERPOINT, Thomas, additional, GREDER-BELAN, Alix, additional, ELHARRAR, Brigitte, additional, KHUONG, Marie-Aude, additional, POUPARD, Marie, additional, BLUM, Laurent, additional, MICHAU, Christophe, additional, PRAZUCK, Thierry, additional, PHILIBERT, Patrick, additional, SLAMA, Laurence, additional, HIKOMBO, Hitoto, additional, DARASTEANU, Iuliana, additional, GIRARD, Pierre-Marie, additional, ALVAREZ, Jean-Claude, additional, MATHEZ, Dominique, additional, DE TRUCHIS, Pierre, additional, LANDMAN, Roland, additional, MEYNARD, Jean-Luc, additional, MORAND-JOUBERT, Laurence, additional, LAMBERT, Sidonie, additional, LE DU, Damien, additional, PERRONNE, Christian, additional, ASSOUMOU, Lambert, additional, COSTAGLIOLA, Dominique, additional, MELCHIOR, Jean-Claude, additional, DURACINSKI, Martin, additional, PETROV-SANCHEZ, Ventzislava, additional, AMAT, Karine, additional, BENALYCHERIF, Aïda, additional, SYLLA, Babacar, additional, GELLEY, Ambre, additional, GIBOWSKI, Séverine, additional, LE MEUT, Guillaume, additional, THIEBAUT, Rodolphe, additional, CLUMECK, Nathan, additional, LECLERCQ, Vincent, additional, CECCHERINI-SILBERSTEIN, Francesca, additional, and DECOSTER, Laurent, additional more...

Published
2022
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8. Supporting Patient-Clinician Interaction in Chronic HIV Care: Design and Development of a Patient-Reported Outcomes Software Application

Author

Herrmann, Susan, primary, Power, Brad, additional, Rashidi, Amineh, additional, Cypher, Mark, additional, Mastaglia, Frank, additional, Grace, Amy, additional, McKinnon, Elizabeth, additional, Sarrot, Pierre, additional, Michau, Christophe, additional, Skinner, Matthew, additional, Desai, Renae, additional, and Duracinsky, Martin, additional more...

Published
2021
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9. Supporting patient-clinician interaction in chronic HIV care: Design and development of a patient-reported outcomes software application

Author

Herrmann, Susan, Power, Brad, Rashidi, Amineh, Cypher, Mark, Mastaglia, Frank, Grace, Amy, McKinnon, Elizabeth, Sarrot, Pierre, Michau, Christophe, Skinner, Matthew, Desai, Renae, Duracinsky, Martin, Herrmann, Susan, Power, Brad, Rashidi, Amineh, Cypher, Mark, Mastaglia, Frank, Grace, Amy, McKinnon, Elizabeth, Sarrot, Pierre, Michau, Christophe, Skinner, Matthew, Desai, Renae, and Duracinsky, Martin more...

Abstract

Background: The consideration of health-related quality of life (HRQL) is a hallmark of best practice in HIV care. Information technology offers an opportunity to more closely engage patients with chronic HIV infection in their long-term management and support a focus on HRQL. However, the implementation of patient-reported outcome (PRO) measures, such as HRQL in routine care, is challenged by the need to synthesize data generated by questionnaires, the complexity of collecting data between patient visits, and the integration of results into clinical decision-making processes. Objective: Our aim is to design and pilot-test a multimedia software platform to overcome these challenges and provide a vehicle to increase focus on HRQL issues in HIV management. Methods: A multidisciplinary team in France and Australia conducted the study with 120 patients and 16 doctors contributing to the design and development of the software. We used agile development principles, user-centered design, and qualitative research methods to develop and pilot the software platform. We developed a prototype application to determine the acceptability of the software and piloted the final version with 41 Australian and 19 French residents using 2 validated electronic questionnaires, the Depression, Anxiety and Stress Scale-21 Items, and the Patient Reported Outcomes Quality of Life-HIV. Results: Testing of the prototype demonstrated that patients wanted an application that was intuitive and without excessive instruction, so it felt effortless to use, as well as secure and discreet. Clinicians wanted the PRO data synthesized, presented clearly and succinctly, and clinically actionable. Safety concerns for patients and clinicians included confidentiality, and the potential for breakdown in communication if insufficient user training was not provided. The final product, piloted with patients from both countries, showed that most respondents found the application easy to use and comprehend. The usa more...

Published
2021

10. Measles seroprevalence in human immunodeficiency virus-infected adults born in the era of measles vaccination.

Author

Lefebvre, Maeva, Secher, Solène, Bouchez, Sabelline, Vandamme, Yves-Marie, Fialaire, Pascale, Leautez, Sophie, Blanchi, Sophie, Michau, Christophe, Coste-Burel, Marianne, Brunet-Cartier, Cécile, Reliquet, Véronique, Gregoire, Antoine, Raffi, François, Allavena, Clotilde, on behalf of the VIHStaRouge study group, and VIHStaRouge study group more...

Published
2022
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11. Supporting Patient-Clinician Interaction in Chronic HIV Care: Design and Development of a Patient-Reported Outcomes Software Application (Preprint)

Author

Herrmann, Susan, primary, Power, Brad, additional, Rashidi, Amineh, additional, Cypher, Mark, additional, Mastaglia, Frank, additional, Grace, Amy, additional, McKinnon, Elizabeth, additional, Sarrot, Pierre, additional, Michau, Christophe, additional, Skinner, Matthew, additional, Desai, Renae, additional, and Duracinsky, Martin, additional more...

Published
2021
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13. Assessment of drug–drug interaction in an elderly human immunodeficiency virus population: Comparison of 3 expert databases

Author

Ruellan, Anne‐Lise, primary, Bourneau‐Martin, Delphine, additional, Joyau, Caroline, additional, Secher, Solène, additional, Fialaire, Pascale, additional, Hitoto, Hikombo, additional, Leautez, Sophie, additional, Michau, Christophe, additional, Vatan, Rémi, additional, Billaud, Eric, additional, Briet, Marie, additional, Jolliet, Pascale, additional, Raffi, François, additional, and Allavena, Clotilde, additional more...

Published
2020
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15. Assessment of drug–drug interaction in an elderly human immunodeficiency virus population: Comparison of 3 expert databases.

Author

Ruellan, Anne‐Lise, Bourneau‐Martin, Delphine, Joyau, Caroline, Secher, Solène, Fialaire, Pascale, Hitoto, Hikombo, Leautez, Sophie, Michau, Christophe, Vatan, Rémi, Billaud, Eric, Briet, Marie, Jolliet, Pascale, Raffi, François, and Allavena, Clotilde more...

Subjects
SOCIAL interaction, DATABASES, ANTIRETROVIRAL agents, MEDICAL personnel
Abstract

Aims: Polypharmacy increase the risk of drug–drug interactions (DDIs) in the elderly population living with human immunodeficiency virus (HIV). Several expert databases can be used to evaluate DDIs. The aim of the study was to describe actual DDIs between antiretroviral drugs and comedications in an elderly population and to compare grading of the DDIs in 3 databases. Methods: All treatments of HIV‐infected subjects aged 65 years and older were collected in 6 French HIV centres. Summary of Product Characteristic (SPC), French DDI Thesaurus (THES), and Liverpool HIV DDI website (LIV) were used to define each DDI and specific grade. DDIs were classified in yellow flag interaction (undefined grade in SPC and THES or potential weak interaction in LIV), amber flag interaction (to be considered/precaution of use in SPC and THES and potential interaction in LIV) and red flag interaction (not recommended/contraindication in SPC and THES and do not administer/contraindication in LIV). Results: Among 239 subjects included, 60 (25.1%) had at least 1 DDI for a total of 126 DDIs: 23/126 red flag DDIs were identified in 17 patients. All these 23 DDIs were identified in LIV. THES and SPC missed 6 and 1 red flag DDIs, respectively. Seven of 23 red flag DDIs were identified in the 3 databases concomitantly. Conclusion: Polypharmacy is frequent in this elderly HIV population leading to DDI in a quarter of the subjects. The discrepancies between databases can be explained by differences in analysis methods. A consensus between databases would be helpful for clinicians. [ABSTRACT FROM AUTHOR] more...

Published
2021
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16. Tenofovir DF/emtricitabine/rilpivirine as HIV post-exposure prophylaxis: results from a multicentre prospective study.

Author

Chauveau, Marie, Billaud, Eric, Bonnet, Bénédicte, Merrien, Dominique, Hitoto, Hikombo, Bouchez, Sabelline, Michau, Christophe, Hall, Nolwenn, Perez, Lucia, Sécher, Solène, Raffi, François, Allavena, Clotilde, and COREVIH Pays de la Loire Study Group more...

Subjects
HIV-positive persons, PREVENTIVE medicine, TENOFOVIR, MEDICAL care, EMTRICITABINE
Abstract

Objectives: Since 2016, French guidelines have recommended the single-tablet regimen of tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)/rilpivirine (RPV) as HIV post-exposure prophylaxis (PEP), but few data support this usage. We evaluated the tolerability, treatment completion and occurrence of HIV seroconversion associated with this combination in occupational and non-occupational PEP.Patients and Methods: We conducted an observational, prospective, multicentre, open-label, non-randomized study in five French HIV centres. Adults requiring PEP according to national French guidelines were prescribed TDF/FTC/RPV one pill once a day for 28 days. Clinical and biological tolerability was assessed at week 4; occurrence of HIV seroconversion was evaluated after week 16.Results: From March 2016 to March 2017, 163 courses of PEP were prescribed for 150 sexual exposures (44% heterosexual and 56% MSM) and 13 non-sexual exposures. Five participants stopped PEP after a few days because the source person was HIV uninfected. Of the remaining 158 individuals, 15 (9.5%) were lost to follow-up at week 4, 7 (4.4%) prematurely discontinued PEP [patient's decision/non-adherence (n = 3) or adverse events (gastrointestinal intolerance n = 3, fatigue n = 1)] and 136 (86.1%) completed the 28 day treatment. Overall, 69.6% of participants declared at least one adverse event, mostly of mild to moderate intensity and no serious adverse events or hepatic or renal toxicity occurred. No HIV seroconversion occurred at week 16.Conclusions: The low rate of premature treatment interruption, the good tolerability and the absence of documented HIV seroconversion support the current French guidelines of a 28 day course of TDF/FTC/RPV for sexual and non-sexual PEP. [ABSTRACT FROM AUTHOR] more...

Published
2019
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17. Prévalence et facteurs de risque de troubles du sommeil dans une grande cohorte de patients adultes vivant avec le VIH (PVVIH)

Author

De La Tullaye, Sylvie, primary, Leclair-Visonneau, Laurène, additional, Pineau, Solène, additional, Chennebault, Jean-Marie, additional, Guimard, Thomas, additional, Hitoto, Hikombo, additional, Michau, Christophe, additional, Vatan, Rémi, additional, Billaud, Eric, additional, and Allavena, Clotilde, additional more...

Published
2016
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18. Prevalence and risk factors of sleep disturbances in a large HIV-infected adult population

Author

Allavena, Clotilde, primary, Guimard, Thomas, additional, Billaud, Eric, additional, de la Tullaye, Sylvie, additional, Reliquet, Véronique, additional, Pineau, Solène, additional, Hüe, Hervé, additional, Supiot, Christelle, additional, Marie Chennebault, Jean, additional, Michau, Christophe, additional, Hitoto, Hikombo, additional, Vatan, Rémi, additional, and Raffi, François, additional more...

Published
2014
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21. Phaeohyphomycosis due to Exophiala xenobiotica as a cause of fungal arthritis in an HIV-infected patient.

Author

Morio, Florent, Berre, Jean-Yves Le, Garcia-Hermoso, Dea, Najafzadeh, Mohammad Javad, de Hoog, Sybren, Benard, Laurent, and Michau, Christophe

Abstract

Black yeasts including Exophiala species are increasingly recognized as agents of human disease. In recent years, progress in molecular phylogeny and taxonomy of the genus Exophiala has led to the description of numerous novel species. The 'classical' but highly variable species Exophiala jeanselmei was split into a number of morphological siblings, which, however, were phylogenetically and clinically remote from each other. E. jeanselmei was restricted to an uncommon species causing subcutaneous infections. Hence only limited information is available on the segregants, among which is E. xenobiotica. We describe a case of an HIV-patient presenting with fungal arthritis and subcutaneous nodules caused by the latter species, which was identified by means of phenotypic and molecular methods. [ABSTRACT FROM AUTHOR] more...

Published
2012
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22. Supporting patient-clinician interaction in chronic HIV care: Design and development of a patient-reported outcomes software application

Author

<p>GILEAD Sciences Europe Limited goSHAPE grant</p>, Herrmann, Susan, Power, Brad, Rashidi, Amineh, Cypher, Mark, Mastaglia, Frank, Grace, Amy, McKinnon, Elizabeth, Sarrot, Pierre, Michau, Christophe, Skinner, Matthew, Desai, Renae, Duracinsky, Martin, <p>GILEAD Sciences Europe Limited goSHAPE grant</p>, Herrmann, Susan, Power, Brad, Rashidi, Amineh, Cypher, Mark, Mastaglia, Frank, Grace, Amy, McKinnon, Elizabeth, Sarrot, Pierre, Michau, Christophe, Skinner, Matthew, Desai, Renae, and Duracinsky, Martin more...

Abstract

Herrmann, S., Power, B., Rashidi, A., Cypher, M., Mastaglia, F., Grace, A., ... Duracinsky, M. (2021). Supporting patient-clinician interaction in chronic HIV care: Design and development of a patient-reported outcomes software application. Journal of Medical Internet Research, 23(7), article e27861. https://doi.org/10.2196/27861 more...