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2 results on '"Michelle Zajko"'

1. Comparative genomics of Cluster O mycobacteriophages.

Author

Steven G Cresawn, Welkin H Pope, Deborah Jacobs-Sera, Charles A Bowman, Daniel A Russell, Rebekah M Dedrick, Tamarah Adair, Kirk R Anders, Sarah Ball, David Bollivar, Caroline Breitenberger, Sandra H Burnett, Kristen Butela, Deanna Byrnes, Sarah Carzo, Kathleen A Cornely, Trevor Cross, Richard L Daniels, David Dunbar, Ann M Findley, Chris R Gissendanner, Urszula P Golebiewska, Grant A Hartzog, J Robert Hatherill, Lee E Hughes, Chernoh S Jalloh, Carla De Los Santos, Kevin Ekanem, Sphindile L Khambule, Rodney A King, Christina King-Smith, Karen Klyczek, Greg P Krukonis, Christian Laing, Jonathan S Lapin, A Javier Lopez, Sipho M Mkhwanazi, Sally D Molloy, Deborah Moran, Vanisha Munsamy, Eddie Pacey, Ruth Plymale, Marianne Poxleitner, Nathan Reyna, Joel F Schildbach, Joseph Stukey, Sarah E Taylor, Vassie C Ware, Amanda L Wellmann, Daniel Westholm, Donna Wodarski, Michelle Zajko, Thabiso S Zikalala, Roger W Hendrix, and Graham F Hatfull

Subjects
Medicine, Science
Abstract

Mycobacteriophages--viruses of mycobacterial hosts--are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails. We describe here a group of five closely related mycobacteriophages--Corndog, Catdawg, Dylan, Firecracker, and YungJamal--designated as Cluster O with long flexible tails but with unusual prolate capsids. Proteomic analysis of phage Corndog particles, Catdawg particles, and Corndog-infected cells confirms expression of half of the predicted gene products and indicates a non-canonical mechanism for translation of the Corndog tape measure protein. Bioinformatic analysis identifies 8-9 strongly predicted SigA promoters and all five Cluster O genomes contain more than 30 copies of a 17 bp repeat sequence with dyad symmetry located throughout the genomes. Comparison of the Cluster O phages provides insights into phage genome evolution including the processes of gene flux by horizontal genetic exchange.

Published
2015
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2. Comparative genomics of Cluster O mycobacteriophages

Author

Daniel E. Westholm, Joel F. Schildbach, Joseph Stukey, Chernoh S. Jalloh, Nathan S. Reyna, Rodney A. King, Christina King-Smith, Daniel A. Russell, David Dunbar, Welkin H. Pope, Steven G. Cresawn, Grant A. Hartzog, Caroline A. Breitenberger, Eddie Pacey, Roger W. Hendrix, Lee E. Hughes, Carla De Los Santos, Trevor Cross, Kathleen Cornely, Chris R. Gissendanner, Amanda L. Wellmann, Greg P. Krukonis, Jonathan S. Lapin, Kristen A. Butela, Vanisha Munsamy, Sarah Carzo, Sarah E. Taylor, Deanna Byrnes, Vassie C. Ware, Kirk R. Anders, Tamarah L. Adair, Donna Wodarski, Sarah Ball, Graham F. Hatfull, A. Javier Lopez, Thabiso S. Zikalala, Charles A. Bowman, Ruth Plymale, Kevin Ekanem, Richard L. Daniels, Marianne K. Poxleitner, Rebekah M. Dedrick, Sandra H. Burnett, Sipho M. Mkhwanazi, Christian Laing, Karen K. Klyczek, Sphindile L. Khambule, Deborah Moran, David Bollivar, J. Robert Hatherill, Deborah Jacobs-Sera, Urszula Golebiewska, Michelle Zajko, Sally D. Molloy, Ann M. Findley, and van Raaij, Mark J

Subjects
Genome evolution, General Science & Technology, lcsh:Medicine, Genomics, Genome, Viral, Genome, 03 medical and health sciences, Caudovirales, MD Multidisciplinary, Genetics, Viral, lcsh:Science, Dyad symmetry, Gene, Phylogeny, 030304 developmental biology, Comparative genomics, 0303 health sciences, Multidisciplinary, Mycobacteriophages, biology, 030306 microbiology, Human Genome, lcsh:R, Genetic Variation, DNA, biology.organism_classification, DNA, Viral, lcsh:Q, Generic health relevance, Infection, Biotechnology, Research Article
Abstract

Mycobacteriophages – viruses of mycobacterial hosts – are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails. We describe here a group of five closely related mycobacteriophages – Corndog, Catdawg, Dylan, Firecracker, and YungJamal – designated as Cluster O with long flexible tails but with unusual prolate capsids. Proteomic analysis of phage Corndog particles, Catdawg particles, and Corndog-infected cells confirms expression of half of the predicted gene products and indicates a non-canonical mechanism for translation of the Corndog tape measure protein. Bioinformatic analysis identifies 8–9 strongly predicted SigA promoters and all five Cluster O genomes contain more than 30 copies of a 17 bp repeat sequence with dyad symmetry located throughout the genomes. Comparison of the Cluster O phages provides insights into phage genome evolution including the processes of gene flux by horizontal genetic exchange.

Published
2014

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