385 results on '"Michels, Paul A. M."'
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2. Metabolic Control Analysis for Drug Target Selection Against Human Diseases
3. Metabolic Control Analysis for Drug Target Selection Against Human Diseases
4. Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
5. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell
6. Antimicrobial Peptides (AMPs): Potential Therapeutic Strategy against Trypanosomiases?
7. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-formTrypanosoma bruceicell
8. Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes
9. Carbon Metabolism as a Drug Target in Leishmania
10. Delineating transitions during the evolution of specialised peroxisomes: Glycosome formation in kinetoplastid and diplonemid protists
11. Biogenesis and metabolic homeostasis of trypanosomatid glycosomes: New insights and new questions
12. Using Metabolic Control Analysis To Improve The Selectivity and Effectiveness of Drugs Against Parasitic Diseases
13. Anonaine from Annona Crassiflora Inhibits Glutathione S-Transferase and Improves Cypermethrin Activity on Rhipicephalus Microplus
14. Introduction: The Evolution of Organellar Metabolism in Unicellular Eukaryotes
15. Rewiring and Regulation of Cross-Compartmentalized Metabolism in Protists
16. Compartmentation Prevents a Lethal Turbo-Explosion of Glycolysis in Trypanosomes
17. TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
18. Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase
19. Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs
20. Exploring the active site of Trypanosoma brucei phosphofructokinase by inhibition studies: specific irreversible inhibition
21. Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase
22. The NAD+ metabolism of Leishmania, notably the enzyme nicotinamidase involved in NAD+ salvage, offers prospects for development of anti-parasite chemotherapy
23. A domino effect in drug action: from metabolic assault towards parasite differentiation
24. Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi
25. Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis
26. The silicon trypanosome
27. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei
28. Regulation and control of compartmentalized glycolysis in bloodstream formTrypanosoma brucei
29. Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: An evolutionary scenario of subcellular compartmentation in Kinetoplastida
30. Structure, function, and biogenesis of glycosomes in Kinetoplastida
31. The evolution of kinetoplastid glycosomes
32. 6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae: Molecular characterization, database searches, modelling studies and evolutionary analysis
33. Peroxisomes, glyoxysomes and glycosomes (Review)
34. The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features
35. Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana: Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification
36. Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase
37. Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins
38. Leishmania donovani phosphofructokinase: Gene characterization, biochemical properties and structure-modelling studies
39. An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
40. Protein structure-based design of anti-protozoal drugs
41. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation
42. Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
43. A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex
44. Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
45. Biogenesis and Evolutionary Origin of Peroxisomes
46. The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism
47. The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction.
48. Compartmentation protects trypanosomes from the dangerous design of glycolysis
49. The SCP2-thiolase-like protein (SLP) ofTrypanosoma bruceiis an enzyme involved in lipid metabolism
50. Effects of the medium composition on the components of the electrochemical proton gradient in Rhodopseudomonas sphaeroides
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