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1. Expression of endothelin-converting enzyme, endothelin-1 and endothelin receptors at the site of percutaneous coronary intervention in humans

Author

Takahiko Naruko, Kazuo Haze, Minoru Yoshiyama, Yoshimi Sugama, Takeshi Inoue, Masahiko Ohsawa, Akira Itoh, Shoichi Ehara, Chizuko Kitabayashi, Yoshihiro Ikura, Junichi Yoshikawa, Kazuhiko Tanzawa, Makiko Ueda, Nobuyuki Shirai, and Michihiko Hirayama

Subjects
Atherectomy, Coronary, Male, medicine.medical_specialty, Physiology, Endothelin converting enzyme 1, Myocytes, Smooth Muscle, Endothelin-Converting Enzymes, Pathogenesis, Restenosis, Internal medicine, Internal Medicine, medicine, Aspartic Acid Endopeptidases, Humans, Myocyte, Angioplasty, Balloon, Coronary, education, Receptor, Aged, Aged, 80 and over, education.field_of_study, Endothelin-1, Receptors, Endothelin, business.industry, Metalloendopeptidases, Middle Aged, respiratory system, Receptor, Endothelin A, musculoskeletal system, medicine.disease, Coronary Vessels, Immunohistochemistry, Receptor, Endothelin B, Endothelin 1, Endocrinology, cardiovascular system, Female, Autopsy, medicine.symptom, Tunica Intima, Cardiology and Cardiovascular Medicine, Endothelin receptor, business, Vasoconstriction, circulatory and respiratory physiology
Abstract

The repair process at the site of injury after percutaneous coronary intervention (PCI) is dominated by neointimal formation composed mainly of smooth muscle cells (SMC). Endothelin-1 (ET-1) is a powerful vasoconstrictor and SMC mitogen. Endothelin-converting enzyme (ECE) is the final key enzyme of endothelin processing. The effects of ET-1 are mediated by binding to endothelin type A (ETA) and endothelin type B (ETB) receptors. The ligand/receptor/ligand-producing system (ET system) could be involved in the pathogenesis of neointimal formation in humans.Fifteen post-PCI sites obtained at autopsy and eight atherectomy specimens obtained from restenotic sites were investigated using immunohistochemical single and double staining techniques. Frozen sections were stained with antibodies against ECE, ET-1, ETA and ETB receptors, SMC, macrophages and endothelial cells.At the early stage, less than 3 months after PCI, neointimal SMC were positive for ECE, ET-1, ETA and ETB receptors. The expression of ECE, ET-1, ETA and ETB receptors in these neointimal SMC decreased markedly from 6 months onwards. The ECE, ET-1, ETA and ETB receptor-positive cell areas were significantly (P0.005) greater in the first 3 months after PCI compared with 6 months or more after PCI. Atherectomy specimens also showed similar positivity.These observations strongly suggest that the expression of ECE, ET-1, ETA and ETB receptors is enhanced in neointimal SMC at early stages after PCI injury in human coronary arteries. The increased expression of the ET system may contribute to SMC proliferation/migration and vasoconstriction in human post-PCI coronary lesions.

Published
2006
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2. Expression of angiotensin II type 1 receptor in human cirrhotic livers: Its relation to fibrosis and portal hypertension

Author

Michihiko Hirayama, Takahiko Naruko, Takehisa Suekane, Hiroko Fukushima, Nobuyuki Shirai, Shoichi Ehara, Masahiko Ohsawa, Yoshihiro Ikura, Makiko Ueda, and Yoshimi Sugama

Subjects
medicine.medical_specialty, Angiotensin II receptor type 1, Cirrhosis, Vascular smooth muscle, Hepatology, Chymase, Biology, medicine.disease, Angiotensin II, Infectious Diseases, Endocrinology, Fibrosis, Internal medicine, cardiovascular system, Hepatic stellate cell, medicine, Portal hypertension, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology
Abstract

Angiotensin II (ANG-II) and its receptor (AT1) have been potential targets of therapy for liver cirrhosis. However, AT1 expression in human cirrhotic livers has not been clarified. We studied AT1 and ANG-II generating enzymes in human autopsy (20 cirrhotics and 20 normal controls) and biopsy (10 cirrhotics) livers. AT1 immunoreactivity in tissue sections was quantified by computer-aided morphometry. AT1 protein and mRNA levels were assessed by Western blotting and real-time polymerase chain reaction. Concerning ANG-II generating system, angiotensin-converting enzyme (ACE) and mast cell chymase were examined. AT1 expression was seen not only in vascular smooth muscle cells, but also in activated stellate cells/myofibroblasts and liver parenchymal cells. AT1-positive vessels and myofibroblasts were significantly increased in fibrous septa of cirrhosis, although overall hepatic AT1 expression was reduced in the cirrhotic livers compared with the controls. Augmentation of AT1-positive vessels was related to severity of portal hypertension. Expressions of ACE and chymase were enhanced in the cirrhotic livers. These results suggest that hepatic AT1 expression is shifted to and concentrated in vessels and myofibroblasts in cirrhotic settings, and increased ANG-II generation by ACE and chymase contributes to portal hypertension and liver fibrosis via binding to AT1 expressed on vessels and myofibroblasts.

Published
2005
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3. Contents Vol. 68, 2005

Author

Takashi Sugita, Takaaki Kondo, Karina Fincati, Alberto Chiappori, G. De Cataldis, Tadahiko Kubo, S. Spada, Jayesh A. Prajapati, Hideaki Toyoshima, Christoph Rochlitz, Anthony T.C. Chan, Patrick J. Loehrer, Dong Kyun Park, Marcella Occelli, Laura Bertolotti, Anna Mastrosimini, Donato F. Altomare, L. Capussotti, Michele Milella, Cecilia Nisticò, Ming Gao, Nitin Chakravarti, Carter W.N. Cheng, Masayuki Hino, Eun Kyung Cho, Yoshimi Sugama, Mario Correale, Gabriella Uhercsák, Krisztina Boda, Masafumi Ikeda, Chih-Hsin Yang, Eustachio Ruggieri, Neal J. Meropol, Christina Liossi, Shinkan Tokudome, Gabriel Civiello, Masayo Kojima, Robert C. F. Leonard, Nicola Marzano, Luisa Barzon, Vincenzo De Rosa, S. Palmeri, R. Martí, Kazuhiro Yasuda, Alfred Rademaker, Paolo Carlini, Prabhudas S. Patel, Daniel Fink, Chih-Yen Chien, Louis W.C. Chow, A. Farris, Toshihiro Matsuo, Luciano Frontini, Marc Salzberg, Shinichi Tsutsui, Eric Francois, P. Gabriele, Giulia Masi, Woon Ki Lee, Shigeru Tatebe, Pasquale Comella, Dayna S. Early, Serafino Conforti, Helmut Messmann, Anthony P.C. Yim, Yu-Chie Yu, Mitsuo Ochi, Ann-Lii Cheng, M. Danova, Takuji Okusaka, Hui-Chun Chen, Hiroko Fukushima, Min-Chun Chen, Jae Hoon Lee, Gerardo Botti, M. Vera, Amit Verma, Pan-Chyr Yang, Ornella Garrone, Henry N. Wagner, H. Bourgeois, E. Sperti, A. Misino, Sudhir Bahadur, H. Perrier, Upendra M. Rawal, J.-P. Wiksten, M. Hebbar, Sadao Suzuki, E. Dorval, Daniel K.H. Tong, Yu-Fei Jiao, B. Massidda, Benedetta D'Attoma, Jacqueline Whang-Peng, Hidefumi Higashi, Norihiko Hayakawa, Seok-Ah Im, Federica Cuppone, Lucia Del Mastro, M. Cajozzo, L. Palmeri, Michihiko Hirayama, Tilmann Steinmetz, J.Y. Douillard, V. Leonardi, Kenichi Yamaguchi, George R. Simon, See Ching Chan, Ranju Ralhan, Hiroshi Inoue, Yoriko Takezako, A. Mangiameli, Giuseppe Comella, Conrad Lee, Paolo Vallone, M. Karthaus, Se Hoon Park, A. Magnino, Nootan Kumar Shukla, Pankaj M. Shah, S. Puig, Chih-Hung Hsu, G. Filippelli, Chong-Jong Wang, F. Ferraù, G. Comella, Koji Tamakoshi, Pei-Yen Yeh, Al B. Benson, Shunichi Tsujitani, Hiroyuki Tsuchiya, Roland Greinwald, Kun-Huei Yeh, Jatinder Kaur, Hiroshi Yatsuya, Ching-Yeh Hsiung, C. Conill, J. Malvehy, Shin-ichi Nakamura, Giuseppe Frasci, Fu-Min Fang, Soon Nam Lee, Caio Rocha-Lima, J.J. Grau, Sandro Barni, Nobuyuki Shirai, Lai Ngor Wong, Bruce E. Johnson, Benny Zee, Toru Mukohara, Beat Thürlimann, Shotaro Oro, Massimiliano D’Aiuto, Herng-Chia Chiu, P. Barthélemy, Keiji Sato, S. Nordling, M. Aglietta, Akinori Takagane, Li Zhang, Harald Ballo, Winnie Yeo, M. Vaglica, Wolgang Abenhardt, Maria Notarnicola, Hiroshi Ikeda, Scott J. Antonia, R. Thomas, Gianluigi Ferretti, J. Domingo-Domènech, Ulrich Kleeberg, Shoichi Era, Rüdiger Behrens, Takehisa Suekane, Charles Williams, Kwok Chi Lam, Anupam Kumar, M. Gatti, B. Mellado, Masahiko Ohsawa, T. Castel, Hideki Ueno, Maria Gabriella Caruso, Miyuki Kawado, Tetsuo Hotta, Antonio Febbraro, Meera Mathur, Mary F. Mulcahy, M. Lundin, Gianfilippo Bertelli, Kotaro Ozasa, Gerold Bepler, Young S. Oh, Tony Mok, Dirk Behringer, Roger von Moos, Suryanaryana V.S. Deo, Kosuke Suzuki, Rozalia Hajnal-Papp, R. Molina, Monia Pacenti, Vito Guerra, Yoshinori Ito, R. Faggiuolo, Yoshikazu Kagami, E. Iannitto, Francesco Cognetti, Siddhartha Datta Gupta, Makiko Ueda, Tamotsu Sugai, J. Isola, Giorgio Palù, Yeonho Park, László Thurzó, P. Gascón, Chi-Long Chen, Renato Giordano, Yoshiyuki Watanabe, C. Martin, Karen Chak, Hans-Peter Boeck, Hiroaki Saito, Herman Wong, Thomas Geer, Soo Mee Bang, Jörg Schimke, Masahide Ikeguchi, Hervé Bonnefois, C. Haglund, Hans-Jörg Senn, D. Regge, Pasi A. Jänne, C. Montagut, Beena P. Patel, Giuseppe D'Aiuto, Shilpi Soni, Kenji Wakai, J.M. Auge, Tina K. Dave, Carlo Garufi, Riad R. Azar, J. Bennouna, Dong Bok Shin, Emilio Bria, Koji Suzuki, Manfred Kindler, G. Condemi, Shoji Shimose, Anna-Lisa Stefani, Barbara Vanni, M.C. Macaluso, P. Massucco, Wen-Ling Tsai, Rakesh Rawal, Zsuzsanna Kahán, Eric B. Haura, Maurizio Di Bonito, Masaki Mori, S.V.S. Deo, Edmondo Terzoli, D. Mayeur, J. Lundin, Liliana Lapenta, Dietrich Braumann, Akiko Tamakoshi, Yoshihiro Ikura, Masamichi Suzuki, Wataru Habano, Shuji Hashimoto, Roberta D’Aniello, and Chigusa Morizane

Subjects
Cancer Research, Oncology, General Medicine
Published
2005
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4. [Temporary effective treatment with L-asparaginase for a patient with refractory nasal NK/T-cell lymphoma]

Author

Erina, Sakamoto, Takahisa, Yamane, Takahiko, Nakane, Yasunobu, Takeoka, Asao, Hirose, Kiyoyuki, Hagihara, Hirohisa, Nakamae, Kensuke, Ohta, Michihiko, Hirayama, Yoshihiro, Ikura, Masahiko, Ohsawa, Toru, Sawada, Toshiyuki, Kitoh, and Masayuki, Hino

Subjects
Male, Fatal Outcome, Liver Neoplasms, Nose Neoplasms, Asparaginase, Humans, Antineoplastic Agents, Neoplasm Invasiveness, Middle Aged, Lymphoma, T-Cell, Combined Modality Therapy, Drug Administration Schedule, Kidney Neoplasms
Abstract

A 48-year-old man was referred to Sakai Municipal Hospital with nasal discharge and right facial swelling. The pathological findings of a nasal cavity tumor revealed stage IIB NK/T-cell lymphoma. He was admitted to our hospital and received CHOP therapy, resulting in progressive disease. Irradiation therapy combined with DeVIC chemotherapy also could not shrink his lymphoma. Then, two courses of L-asparaginase(L-Asp) were administered, resulting in partial improvement of the nasal and pharynx lesions, resolution of the fever and improvement of his performance status. On the day before a third course of L-Asp, he again developed a lowgrade fever. Although L-Asp was administered for several days, marked elevation of serum LDH, AST, ALT level, and thrombocytopenia persisted, and he died. Post-mortem examinations revealed hemophagocytosis in the bone marrow and liver, and infiltration of lymphoma cells into multiple organs including left lower lung, liver, spleen and kidneys. Although L-Asp was effective against nasal NK/T-cell lymphoma resistant to combination chemotherapy and irradiation therapy, the effectiveness of the single agent with L-Asp was only transient. L-Asp based regimen should be used as first-line therapy if asparagine synthetase protein expression is low using an immunohistochemical method.

Published
2005

5. Expression of the hepatic endothelin system in human cirrhotic livers

Author

Hiroko Fukushima, Masahiko Ohsawa, Nobuyuki Shirai, Takehisa Suekane, Noriko Yoshimi, Takahiko Naruko, Kazuhiko Tanzawa, Soichiro Kayo, Makiko Ueda, Shoichi Ehara, Michihiko Hirayama, Yoshihiro Ikura, Takashi Muraguchi, and Yoshimi Sugama

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Endothelin-Converting Enzymes, Polymerase Chain Reaction, Severity of Illness Index, Pathology and Forensic Medicine, Downregulation and upregulation, Internal medicine, medicine, Aspartic Acid Endopeptidases, Humans, RNA, Messenger, Aged, chemistry.chemical_classification, Endothelin-1, business.industry, Receptors, Endothelin, Metalloendopeptidases, Anatomical pathology, medicine.disease, Receptor, Endothelin A, Endothelin 1, Immunohistochemistry, Receptor, Endothelin B, Endocrinology, Enzyme, chemistry, Liver, cardiovascular system, Portal hypertension, Female, business, Endothelin receptor
Abstract

It is considered that endothelin-1 participates in the development of liver cirrhosis and it has been recognized that every component of the endothelin system is upregulated in cirrhotic livers. However, the expression pattern of this system, including interaction between its components, is not fully understood in human livers. In this study, the expression pattern of the endothelin system was examined. Immunohistochemical analysis for endothelin-1, endothelin receptors and endothelin-converting enzyme was performed in 16 cirrhotic and 17 normal human liver tissues. Peptides, proteins, and RNAs extracted from the livers were also investigated using quantitative assays for the components of the hepatic endothelin system. Hepatic endothelin-1 levels were significantly higher in cirrhotic livers (0.084 ± 0.052 pg/mg wet liver) than in normal livers (0.041 ± 0.032 pg/mg; p < 0.01), and were closely related to the severity of liver fibrosis and portal hypertension. Immunoreactivity for endothelin-1, endothelin receptors, and endothelin-converting enzyme was detected mainly in fibrous areas and in the hepatic vasculature, and was enhanced in cirrhosis. Although there was a negative correlation between the expression of receptor mRNA and the hepatic endothelin-1 level, the amounts of the mRNAs were greater in cirrhotic livers than in normal livers. However, expression of endothelin-converting enzyme in cirrhotic livers was increased at the protein level but was relatively reduced at the mRNA level. These findings suggest that the hepatic endothelin system is activated in human cirrhotic livers in association with worsening of the disease, but that the regulation of the components of this system in this disorder is complex. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Published
2004

6. Immunohistochemical expression of multidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma

Author

Takehisa Suekane, Masayuki Hino, Makiko Ueda, Nobuyuki Shirai, Yoshihiro Ikura, Masahiko Ohsawa, Hiroko Fukushima, Michihiko Hirayama, and Yoshimi Sugama

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Lymphoma, B-Cell, medicine.medical_treatment, Multidrug Resistance Protein 1, Predictive Value of Tests, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Lymph node, P-glycoprotein, Aged, Vault Ribonucleoprotein Particles, Chemotherapy, biology, business.industry, Large-cell lymphoma, Anatomical pathology, General Medicine, Middle Aged, medicine.disease, Prognosis, Drug Resistance, Multiple, Neoplasm Proteins, Survival Rate, medicine.anatomical_structure, Treatment Outcome, Oncology, Drug Resistance, Neoplasm, biology.protein, Cancer research, Immunohistochemistry, lipids (amino acids, peptides, and proteins), Female, Lymph Nodes, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma
Abstract

Background/Aims: The aim of this study was to determine whether expression of P-glycoprotein (P-gp), multidrug-resistance-related protein 1 (MRP1), and lung resistance protein (LRP) was related to the response to induction chemotherapy and prognosis in untreated diffuse large B-cell lymphoma (DLBCL). Methods: We assessed immunohistochemical expression of P-gp, MRP1 and LRP, using formalin-fixed and paraffin-embedded specimens of lymph node in 41 patients with DLBCL. Association between expression of these three proteins and their impact on clinical outcome and prognosis was statistically evaluated. Results: P-gp was positive in 37% of subjects, MRP1 in 63%, and LRP in 68%. The complete remission rates achieved in the group expressing these multidrug resistance (MDR) proteins was significantly lower than in the group not expressing them (20 versus 58%; p = 0.025 in P-gp, 23 versus 80%; p < 0.001 in MRP1 and 32 versus 69%, p = 0.043 in LRP, respectively). Furthermore, the patients expressing LRP had a shorter overall survival rate than those that did not (median of 26 months versus median not reached; p = 0.013). Conclusions: These findings suggest that the three MDR proteins are important predictive factors for the clinical outcome and prognosis in patients with DLBCL.

Published
2004

7. Subject Index Vol. 68, 2005

Author

Donato F. Altomare, M. Vaglica, Cecilia Nisticò, Ming Gao, Masayuki Hino, Eun Kyung Cho, Yoshimi Sugama, Mario Correale, B. Mellado, Chih-Hsin Yang, Gabriella Uhercsák, Renato Giordano, Hideki Ueno, Antonio Febbraro, Meera Mathur, Gerold Bepler, Masahide Ikeguchi, Karen Chak, Hans-Peter Boeck, Gianfilippo Bertelli, M. Lundin, Mary F. Mulcahy, Hervé Bonnefois, Young S. Oh, Kotaro Ozasa, Kwok Chi Lam, Dirk Behringer, Suryanaryana V.S. Deo, Herman Wong, Hiroaki Saito, Yu-Fei Jiao, D. Regge, Pasi A. Jänne, C. Montagut, Rozalia Hajnal-Papp, Giuseppe D'Aiuto, R. Molina, Kenji Wakai, Li Zhang, Monia Pacenti, Kosuke Suzuki, Pankaj M. Shah, J.M. Auge, Winnie Yeo, Vito Guerra, Yoshinori Ito, M. Vera, Carlo Garufi, Pei-Yen Yeh, Caio Rocha-Lima, B. Massidda, T. Castel, Tina K. Dave, Maria Notarnicola, Luisa Barzon, Prabhudas S. Patel, Chih-Yen Chien, Beat Thürlimann, Thomas Geer, George R. Simon, Jörg Schimke, Pan-Chyr Yang, C. Haglund, A. Farris, Toshihiro Matsuo, G. De Cataldis, Kenichi Yamaguchi, Nobuyuki Shirai, Lai Ngor Wong, S. Spada, Krisztina Boda, Toru Mukohara, Gianluigi Ferretti, Soo Mee Bang, Christoph Rochlitz, G. Comella, Louis W.C. Chow, Wataru Habano, Sudhir Bahadur, Upendra M. Rawal, Kazuhiro Yasuda, Shuji Hashimoto, Roberta D’Aniello, P. Gascón, Masahiko Ohsawa, U.R. Kleeberg, Dayna S. Early, Marc Salzberg, Masayo Kojima, J.J. Grau, Woon Ki Lee, Shigeru Tatebe, Giulia Masi, Lucia Del Mastro, Anupam Kumar, Soon Nam Lee, Tony Mok, Anthony P.C. Yim, Robert C. F. Leonard, Chigusa Morizane, László Thurzó, Hiroshi Ikeda, Min-Chun Chen, Jae Hoon Lee, Emilio Bria, Riad R. Azar, Al B. Benson, M. Danova, Takuji Okusaka, Hui-Chun Chen, Tilmann Steinmetz, Shin-ichi Nakamura, G. Filippelli, Giuseppe Comella, Keiji Sato, S. Nordling, Wolgang Abenhardt, Shoji Shimose, M. Cajozzo, Mitsuo Ochi, Hiroyuki Tsuchiya, Giuseppe Frasci, Se Hoon Park, Amit Verma, Hideaki Toyoshima, Siddhartha Datta Gupta, Hiroshi Inoue, Hiroko Fukushima, J. Bennouna, C. Conill, E. Sperti, Eustachio Ruggieri, Barbara Vanni, Jatinder Kaur, R. Faggiuolo, Francesco Cognetti, Ornella Garrone, Marcella Occelli, Gerardo Botti, Norihiko Hayakawa, Tamotsu Sugai, Chih-Hung Hsu, Maurizio Di Bonito, M. Karthaus, J. Domingo-Domènech, S. Puig, J. Isola, Hidefumi Higashi, Laura Bertolotti, Takashi Sugita, Wen-Ling Tsai, Rakesh Rawal, Koji Tamakoshi, Zsuzsanna Kahán, Eric B. Haura, Yoshikazu Kagami, L. Palmeri, Jacqueline Whang-Peng, A. Mangiameli, S.V.S. Deo, E. Iannitto, Tadahiko Kubo, Edmondo Terzoli, Roland Greinwald, Makiko Ueda, Hiroshi Yatsuya, Daniel Fink, Sandro Barni, Fu-Min Fang, Dong Kyun Park, Chong-Jong Wang, F. Ferraù, D. Mayeur, Helmut Messmann, L. Capussotti, Michele Milella, M.C. Macaluso, Neal J. Meropol, Christina Liossi, Gabriel Civiello, Giorgio Palù, E. Dorval, A. Misino, J. Malvehy, Akinori Takagane, Bruce E. Johnson, P. Massucco, J. Lundin, Harald Ballo, Conrad Lee, Paolo Vallone, Hans-Jörg Senn, Yu-Chie Yu, Benedetta D'Attoma, Benny Zee, Ann-Lii Cheng, H. Perrier, S. Palmeri, Beena P. Patel, Scott J. Antonia, Kun-Huei Yeh, J.-P. Wiksten, M. Hebbar, Luciano Frontini, Yeonho Park, R. Thomas, Liliana Lapenta, Shilpi Soni, Rüdiger Behrens, Chi-Long Chen, Takaaki Kondo, Massimiliano D’Aiuto, Akiko Tamakoshi, Charles Williams, Anthony T.C. Chan, Patrick J. Loehrer, P. Barthélemy, Yoshihiro Ikura, Anna Mastrosimini, Masamichi Suzuki, Nitin Chakravarti, Carter W.N. Cheng, Shotaro Oro, Masaki Mori, Masafumi Ikeda, Yoshiyuki Watanabe, Nicola Marzano, M. Gatti, Dong Bok Shin, C. Martin, Shoichi Era, Roger von Moos, Vincenzo De Rosa, R. Martí, Pasquale Comella, Sadao Suzuki, V. Leonardi, Takehisa Suekane, Maria Gabriella Caruso, Miyuki Kawado, Tetsuo Hotta, Koji Suzuki, Manfred Kindler, G. Condemi, Anna-Lisa Stefani, Shinichi Tsutsui, Eric Francois, P. Gabriele, Serafino Conforti, Henry N. Wagner, Seok-Ah Im, Federica Cuppone, A. Magnino, Nootan Kumar Shukla, Alfred Rademaker, Paolo Carlini, Shunichi Tsujitani, Daniel K.H. Tong, Michihiko Hirayama, See Ching Chan, Ranju Ralhan, Ching-Yeh Hsiung, Karina Fincati, Alberto Chiappori, Jayesh A. Prajapati, Dietrich Braumann, Herng-Chia Chiu, M. Aglietta, Shinkan Tokudome, H. Bourgeois, J.Y. Douillard, and Yoriko Takezako

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2005
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8. 1041-94 Noninvasive evaluation of coronary artery flow using transthoracic color doppler echocardiograpy in patients with acute myocardial infarction in the emergency room

Author

Junichi Yoshikawa, Shiro Yanagi, Keiji Nagae, Michihiko Hirayama, Takahiro Ota, Kazuyoshi Hirota, Eiichi Nagashima, Hitomi Kawano, and Kenji Shimeno

Subjects
medicine.medical_specialty, business.industry, Electrocardiography in myocardial infarction, Color doppler, medicine.disease, medicine.anatomical_structure, Internal medicine, medicine, Cardiology, In patient, Radiology, Myocardial infarction, business, Cardiology and Cardiovascular Medicine, Artery
Published
2004
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