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765 results on '"Middeldorp, Jaap"'

1. Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest.

Author

Guimarães, Luiz F. F., Rodrigues, Bárbara A., Dias, Michelle H. F., Barcelos, Matheus G., Nascimento, Maria F. A., Moreira-Nascimento, Sâmick L., Afonso, Sofia L., Abreu, Barbara G. S., Middeldorp, Jaap M., Ntumngia, Francis B., Adams, John H., Fabbri, Camila, Lopes, Stefanie, Fernandes, Cor J. F., Kano, Flora S., and Carvalho, Luzia H.

Subjects
HUMORAL immunity, ANTIBODY formation, PLASMODIUM vivax, EPSTEIN-Barr virus, VACCINE effectiveness, IMMUNE response, CARRIER proteins
Abstract

Background: To develop an effective vaccine against Plasmodium vivax, the most widely dispersed human malaria parasite, it is critical to understand how coinfections with other pathogens could impact malaria-specific immune response. A recent conceptual study proposed that Epstein-Barr virus (EBV), a highly prevalent human herpesvirus that establishes lifelong persistent infection, may influence P. vivax antibody responses. Here, it was investigated whether EBV could impact the longevity of humoral immune response to P. vivax. Methodology/principal findings: A 14-year follow-up study was carried out among long-term P. vivax-exposed Amazonian individuals (272, median age 35 years), and included 9 cross-sectional surveys at periods of high and low malaria transmission. The experimental approach focused on monitoring antibodies to the major blood-stage P. vivax vaccine candidate, the Duffy binding protein region II (DBPII-Sal1), including a novel engineered DBPII-based vaccine targeting conserved epitopes (DEKnull-2). In parallel, the status of EBV infection was determined over time by the detection of circulating EBV DNA (EBV-DNAemia) and EBV-specific antibodies to lytic (VCAp18) or latent (EBNA1) antigens. Regardless of the malaria transmission period, the results demonstrated that one or multiple episodes of EBV-DNAemia did not influence the longevity of DBPII immune responses to both strain-specific (Sal-1) or strain-transcending (DEKnull-2) antibodies. Also, the average time in which DBPII-responders lost their antibodies was unrelated to the EBV serostatus. Considering all malaria cases detected during the study, there was a predominance of P. vivax mono-infection (76%), with a positive correlation between malaria infection and EBV-DNAemia. Conclusions/significance: In an immunocompetent P. vivax-exposed adult population neither sporadic episodes of EBV-DNAemia nor antibody responses to lytic/latent EBV antigens influence the longevity of both strain-specific and strain-transcending DBPII immune responses. Further studies should investigate the role of acute P. vivax infection in the activation of EBV replication cycle. [ABSTRACT FROM AUTHOR]

Published
2025
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2. Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Author

Lin, Weitao, Yip, Yim Ling, Jia, Lin, Deng, Wen, Zheng, Hong, Dai, Wei, Ko, Josephine Mun Yee, Lo, Kwok Wai, Chung, Grace Tin Yun, Yip, Kevin Y, Lee, Sau-Dan, Kwan, Johnny Sheung-Him, Zhang, Jun, Liu, Tengfei, Chan, Jimmy Yu-Wai, Kwong, Dora Lai-Wan, Lee, Victor Ho-Fun, Nicholls, John Malcolm, Busson, Pierre, Liu, Xuefeng, Chiang, Alan Kwok Shing, Hui, Kwai Fung, Kwok, Hin, Cheung, Siu Tim, Cheung, Yuk Chun, Chan, Chi Keung, Li, Bin, Cheung, Annie Lai-Man, Hau, Pok Man, Zhou, Yuan, Tsang, Chi Man, Middeldorp, Jaap, Chen, Honglin, Lung, Maria Li, and Tsao, Sai Wah

Subjects
Cell Line, Tumor, Animals, Mice, Inbred NOD, Humans, Mice, SCID, Herpesvirus 4, Human, Virion, Protein Kinase Inhibitors, Xenograft Model Antitumor Assays, Phylogeny, Virus Activation, Mutation, Genes, Viral, Adult, Aged, Middle Aged, Female, Male, rho-Associated Kinases, Nasopharyngeal Carcinoma, Cell Line, Tumor, Genes, Viral, Herpesvirus 4, Human, Mice, Inbred NOD, SCID
Abstract

The lack of representative nasopharyngeal carcinoma (NPC) models has seriously hampered research on EBV carcinogenesis and preclinical studies in NPC. Here we report the successful growth of five NPC patient-derived xenografts (PDXs) from fifty-eight attempts of transplantation of NPC specimens into NOD/SCID mice. The take rates for primary and recurrent NPC are 4.9% and 17.6%, respectively. Successful establishment of a new EBV-positive NPC cell line, NPC43, is achieved directly from patient NPC tissues by including Rho-associated coiled-coil containing kinases inhibitor (Y-27632) in culture medium. Spontaneous lytic reactivation of EBV can be observed in NPC43 upon withdrawal of Y-27632. Whole-exome sequencing (WES) reveals a close similarity in mutational profiles of these NPC PDXs with their corresponding patient NPC. Whole-genome sequencing (WGS) further delineates the genomic landscape and sequences of EBV genomes in these newly established NPC models, which supports their potential use in future studies of NPC.

Published
2018

3. PCR-Free Shallow Whole Genome Sequencing for Chromosomal Copy Number Detection from Plasma of Cancer Patients Is an Efficient Alternative to the Conventional PCR-Based Approach

Author

Beagan, Jamie J., Drees, Esther E.E., Stathi, Phylicia, Eijk, Paul P., Meulenbroeks, Laura, Kessler, Floortje, Middeldorp, Jaap M., Pegtel, D. Michiel, Zijlstra, Josée M., Sie, Daoud, Heideman, Daniëlle A.M., Thunnissen, Erik, Smit, Linda, de Jong, Daphne, Mouliere, Florent, Ylstra, Bauke, Roemer, Margaretha G.M., and van Dijk, Erik

Published
2021
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4. Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn 2+ -chelating function

Author

Jiang, Lijun, Lung, Hong Lok, Huang, Tao, Lan, Rongfeng, Zha, Shuai, Chan, Lai Sheung, Thor, Waygen, Tsoi, Tik-Hung, Chau, Ho-Fai, Boreström, Cecilia, Cobb, Steven L., Tsao, Sai Wah, Bian, Zhao-Xiang, Law, Ga-Lai, Wong, Wing-Tak, Tai, William Chi-Shing, Chau, Wai Yin, Du, Yujun, Tang, Lucas Hao Xi, Chiang, Alan Kwok Shing, Middeldorp, Jaap M., Lo, Kwok-Wai, Mak, Nai Ki, Long, Nicholas J., and Wong, Ka-Leung

Published
2019

6. Association Between Antibodies That Bind Epstein-Barr Virus (EBV) gp350 and gH/gL and Shedding of EBV in Saliva From Nasopharyngeal Carcinoma Multiplex Family Members in Taiwan.

Author

Liu, Kai-Lin, Hsu, Wan-Lun, Bu, Wei, Yu, Kelly J, Wang, Cheng-Ping, Chien, Yin-Chu, Chen, Tseng-Cheng, Chen, Chien-Jen, Hildesheim, Allan, Middeldorp, Jaap M, Waterboer, Tim, Cohen, Jeffrey I, Coghill, Anna E, and Liu, Zhiwei

Subjects
EPSTEIN-Barr virus, VIRAL DNA, NASOPHARYNX cancer, GLYCOPROTEINS, ODDS ratio
Abstract

Elevated levels of Epstein-Barr virus (EBV) gp350 and gH/gL antibodies have been associated with a lower risk of developing nasopharyngeal carcinoma (NPC), although the evidence remains inconclusive and unexplained. We conducted a longitudinal study within a high-risk Taiwanese cohort, analyzing total immunoglobulin against EBV-gp350 and -gH/gL in blood and EBV DNA shedding in saliva. Contrary to our hypothesis—that elevated levels of antibodies previously shown to be associated with a lower NPC risk should result in a decrease in EBV shedding in saliva—higher anti-gp350 antibodies at baseline were significantly associated with detectable EBV DNA in saliva at follow-up (odds ratio [OR], 1.99 [95% confidence interval {CI}, 1.03–3.97]; P =.04). Higher anti-EBV-gH/gL antibodies at baseline were not significantly associated with risk of detectable EBV DNA at follow-up (OR, 0.69 [95% CI,.35–1.32]; P =.26). These findings underscore the complexity of virus–host interactions and emphasize the need for further investigations into their role in EBV-associated diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression

Author

McHugh, Donal, Caduff, Nicole, Barros, Mario Henrique M., Rämer, Patrick C., Raykova, Ana, Murer, Anita, Landtwing, Vanessa, Quast, Isaak, Styles, Christine T., Spohn, Michael, Fowotade, Adeola, Delecluse, Henri-Jacques, Papoudou-Bai, Alexandra, Lee, Yong-Moon, Kim, Jin-Man, Middeldorp, Jaap, Schulz, Thomas F., Cesarman, Ethel, Zbinden, Andrea, Capaul, Riccarda, White, Robert E., Allday, Martin J., Niedobitek, Gerald, Blackbourn, David J., Grundhoff, Adam, and Münz, Christian

Published
2017
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12. Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Disease

Author

Middeldorp, Jaap M., Compans, Richard W, Series editor, Cooper, Max D., Series editor, Honjo, Tasuku, Series editor, Oldstone, Michael B. A., Series editor, Vogt, Peter K., Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Kawaoka, Yoshihiro, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Ahmed, Rafi, Series editor, and Münz, Christian, editor

Published
2015
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13. Epstein-Barr Virus and Malaria Interactions: Immunology Perspective

Author

Budiningsih, Insani, Middeldorp, Jaap M., Dachlan, Yoes Prijatna, Hadi, Usman, Pathology, and AII - Infectious diseases

Subjects
General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Abstract

Epstein-Barr Virus can cause various diseases, from acute inflammatory diseases such as fatal or chronic EBV infection, infectious mononucleosis as well as lymphoid and epithelial cancer, various autoimmune diseases, and also could interact with malaria. As EBV infects 95% of the world population, and more than 30% are infected with the protozoan parasite, with more than 500,000 deaths due to malaria cases. It is important to understand how EBV dysregulates the immune system, especially when the virus is interacting with other pathogens such as malaria parasites, causing more severe conditions in certain people like Burkitt Lymphoma. This review will be informative about the mechanism of how EBV interacts with malaria parasites and how it affects the immune system. Knowledge of various cytokines triggering the immune system which may provide links to control/minimize malaria disease severity.

Published
2022
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14. List of Contributors

Author

Au, Kwok Hung, primary, Baloche, Valentin, additional, Beadle, Beth M., additional, Blanchard, Pierre, additional, Busson, Pierre, additional, Chan, Jason W., additional, Chan, Jimmy Y.W., additional, Chan, Yap-Hang, additional, Chang, Amy T.Y., additional, Chen, Honglin, additional, Chen, Zhi-Jian, additional, Chiang, A.K.S., additional, Chiang, Chi Leung, additional, Choi, Horace C.W., additional, Chong, Vincent, additional, Chow, James C.H., additional, Dai, Wei, additional, Deng, W., additional, Futreal, Andy, additional, Han, Fei, additional, Ho, Sai-Yin, additional, Huang, S.C.M., additional, Huang, Shao Hui, additional, Hui, K.F., additional, Jain, Amit, additional, Ji, Mingfang, additional, Kam, Michael K.M., additional, Khong, Pek-Lan, additional, Khor, Damian, additional, Ko, Josephine Mun-Yee, additional, Kwong, Dora L.W., additional, Lai, Jessica W.Y., additional, Lam, Ka On, additional, Lam, Tai Chung, additional, Lam, Tai-Hing, additional, Le, Quynh-Thu, additional, Lee, Anne W.M., additional, Lee, Nancy Y., additional, Lee, Victor H.F., additional, Li, Kenneth W.S., additional, Lin, Jia-Huang, additional, Lin, W.T., additional, Liu, Fei-Fei, additional, Lo, K.W., additional, Lu, Taixiang, additional, Lung, H.L., additional, Li Lung, Maria, additional, Mai, Zhi-Ming, additional, Mak, N.K., additional, Middeldorp, Jaap M., additional, Ming Ip, Dennis Kai, additional, Ng, Alice W.Y., additional, Ng, Wai Tong, additional, Ngan, Roger K.C., additional, Nicholls, John M., additional, O'Sullivan, Brian, additional, Pan, Jian Ji, additional, Pignon, Jean Pierre, additional, Rickinson, A.B., additional, Rischin, Danny, additional, Rozali, Esdy, additional, Stanbridge, Eric, additional, Sze, Henry C.K., additional, Toh, Han Chong, additional, Tsang, C.M., additional, Tsao, S.W., additional, Vardhanabhuti, Vince, additional, Wang, Who-Whong, additional, Wei, William Ignace, additional, Ye, Weimin, additional, Yip, Timothy T.C., additional, Yip, Y.L., additional, Yom, Sue S., additional, Young, Lawrence S., additional, Yu, Yao, additional, Yuan, Hui, additional, Yuen, Kam Tong, additional, and Zong, Jing Feng, additional

Published
2019
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15. Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Author

Argirion, Ilona, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Middeldorp, Jaap M., Sarathkumara, Yomani D., Hsu, Wan-Lun, Chien, Yin-Chu, Lou, Pei-Jen, Wang, Cheng-Ping, Rothman, Nathaniel, Lan, Qing, Chen, Chien-Jen, Mbulaiteye, Sam M., Jarrett, Ruth F., Glimelius, Ingrid, Smedby, Karin E., Hjalgrim, Henrik, Hildesheim, Allan, Doolan, Denise L., Liu, Zhiwei, Argirion, Ilona, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Middeldorp, Jaap M., Sarathkumara, Yomani D., Hsu, Wan-Lun, Chien, Yin-Chu, Lou, Pei-Jen, Wang, Cheng-Ping, Rothman, Nathaniel, Lan, Qing, Chen, Chien-Jen, Mbulaiteye, Sam M., Jarrett, Ruth F., Glimelius, Ingrid, Smedby, Karin E., Hjalgrim, Henrik, Hildesheim, Allan, Doolan, Denise L., and Liu, Zhiwei

Abstract

Background: Epstein-Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL). Methods: Anti-EBV IgG and IgA antibody responses target-ing 202 sequences from 86 EBV proteins were measured using the same EBV whole proteome array across four case-control studies investigating EBV-positive cHL, eBL, NPC, and NKTCL (407 cases/620 controls). We grouped EBV-targeted antibodies into pathways by immunoglobulin type (IgA and IgG) and life-cycle stage (latent, immediate early lytic, early lytic, late lytic, and glycoprotein) and evaluated their associ-ation with each cancer type. In an additional analysis, we focused on the subset of 46 individual antibodies repre-senting the top candidates for each cancer and compared their associations across the four cancer types using multivariable linear regression models. Results: IgA antibody responses targeting all EBV life-cycle stages were associated with NPC but limited to anti-early lytic stage for cHL. NPC and eBL were associated with IgG antibodies across the viral life cycle; cHL with antibodies in the early lytic, late lytic and glyco-protein stages; and NKTCL with antibodies in the latent, immediate early lytic and early lytic phases. EBNA3A, BBLF1, BDLF4, and BLRF2 IgG antibodies were associated with all cancer types.Conclusions: Our observed similarities and differences across four EBV-associated cancers may inform EBV-related oncogenesis. Impact: Understanding the comparative humoral immune response across EBV-related cancers may aid in identifying shared etiologic roles of EBV proteins and inform unique pathogenic processes for each cancer.

Published
2023
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16. Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Author

Argirion, Ilona, primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Coghill, Anna E., primary, Yu, Kelly J., primary, Middeldorp, Jaap M., primary, Sarathkumara, Yomani D., primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Chen, Chien-Jen, primary, Mbulaiteye, Sam M., primary, Jarrett, Ruth F., primary, Glimelius, Ingrid, primary, Smedby, Karin E., primary, Hjalgrim, Henrik, primary, Hildesheim, Allan, primary, Doolan, Denise L., primary, and Liu, Zhiwei, primary

Published
2023
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17. Supplementary Table S2 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Author

Argirion, Ilona, primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Coghill, Anna E., primary, Yu, Kelly J., primary, Middeldorp, Jaap M., primary, Sarathkumara, Yomani D., primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Chen, Chien-Jen, primary, Mbulaiteye, Sam M., primary, Jarrett, Ruth F., primary, Glimelius, Ingrid, primary, Smedby, Karin E., primary, Hjalgrim, Henrik, primary, Hildesheim, Allan, primary, Doolan, Denise L., primary, and Liu, Zhiwei, primary

Published
2023
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18. Supplementary Methods S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Author

Argirion, Ilona, primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Coghill, Anna E., primary, Yu, Kelly J., primary, Middeldorp, Jaap M., primary, Sarathkumara, Yomani D., primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Rothman, Nathaniel, primary, Lan, Qing, primary, Chen, Chien-Jen, primary, Mbulaiteye, Sam M., primary, Jarrett, Ruth F., primary, Glimelius, Ingrid, primary, Smedby, Karin E., primary, Hjalgrim, Henrik, primary, Hildesheim, Allan, primary, Doolan, Denise L., primary, and Liu, Zhiwei, primary

Published
2023
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21. Sensing of latent EBV infection through exosomal transfer of 5′pppRNA

Author

Baglio, S. Rubina, van Eijndhoven, Monique A. J., Koppers-Lalic, Danijela, Berenguer, Jordi, Lougheed, Sinéad M., Gibbs, Susan, Léveillé, Nicolas, Rinkel, Rico N. P. M., Hopmans, Erik S., Swaminathan, Sankar, Verkuijlen, Sandra A. W. M., Scheffer, George L., van Kuppeveld, Frank J. M., de Gruijl, Tanja D., Bultink, Irene E. M., Jordanova, Ekaterina S., Hackenberg, Michael, Piersma, Sander R., Knol, Jaco C., Voskuyl, Alexandre E., Wurdinger, Thomas, Jiménez, Connie R., Middeldorp, Jaap M., and Pegtel, D. Michiel

Published
2016

22. Supplementary Figure 2 from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan

Author

Coghill, Anna E., primary, Hsu, Wan-Lun, primary, Pfeiffer, Ruth M., primary, Juwana, Hedy, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Chen, Jen-Yang, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap M., primary, and Hildesheim, Allan, primary

Published
2023
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23. Supplementary Figure Legend from Epstein-Barr Virus DNA Load in Nasopharyngeal Brushings and Whole Blood in Nasopharyngeal Carcinoma Patients before and after Treatment

Author

Adham, Marlinda, primary, Greijer, Astrid E., primary, Verkuijlen, Sandra A.W.M., primary, Juwana, Hedy, primary, Fleig, Sabine, primary, Rachmadi, Lisnawati, primary, Malik, Octavia, primary, Kurniawan, A.N., primary, Roezin, Averdi, primary, Gondhowiardjo, Soehartati, primary, Atmakusumah, Djumhana, primary, Stevens, Servi J.C., primary, Hermani, Bambang, primary, Tan, I. Bing, primary, and Middeldorp, Jaap M., primary

Published
2023
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24. Figure S3 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan

Author

Coghill, Anna E., primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lekieffre, Lea, primary, Krause, Lutz, primary, Teng, Andy, primary, Pablo, Jocelyn, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Liu, Zhiwei, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap, primary, Mulvenna, Jason, primary, Bethony, Jeff, primary, Hildesheim, Allan, primary, and Doolan, Denise L., primary

Published
2023
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25. Tables S2-S4 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan

Author

Coghill, Anna E., primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lekieffre, Lea, primary, Krause, Lutz, primary, Teng, Andy, primary, Pablo, Jocelyn, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Liu, Zhiwei, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap, primary, Mulvenna, Jason, primary, Bethony, Jeff, primary, Hildesheim, Allan, primary, and Doolan, Denise L., primary

Published
2023
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27. Supplemental Methods from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan

Author

Coghill, Anna E., primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lekieffre, Lea, primary, Krause, Lutz, primary, Teng, Andy, primary, Pablo, Jocelyn, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Liu, Zhiwei, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap, primary, Mulvenna, Jason, primary, Bethony, Jeff, primary, Hildesheim, Allan, primary, and Doolan, Denise L., primary

Published
2023
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28. Supplementary Figure Legends from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan

Author

Coghill, Anna E., primary, Hsu, Wan-Lun, primary, Pfeiffer, Ruth M., primary, Juwana, Hedy, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Chen, Jen-Yang, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap M., primary, and Hildesheim, Allan, primary

Published
2023
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29. Supplementary Table 1 from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan

Author

Coghill, Anna E., primary, Hsu, Wan-Lun, primary, Pfeiffer, Ruth M., primary, Juwana, Hedy, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Chen, Jen-Yang, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap M., primary, and Hildesheim, Allan, primary

Published
2023
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30. Supplementary Figure 1 from Epstein-Barr Virus DNA Load in Nasopharyngeal Brushings and Whole Blood in Nasopharyngeal Carcinoma Patients before and after Treatment

Author

Adham, Marlinda, primary, Greijer, Astrid E., primary, Verkuijlen, Sandra A.W.M., primary, Juwana, Hedy, primary, Fleig, Sabine, primary, Rachmadi, Lisnawati, primary, Malik, Octavia, primary, Kurniawan, A.N., primary, Roezin, Averdi, primary, Gondhowiardjo, Soehartati, primary, Atmakusumah, Djumhana, primary, Stevens, Servi J.C., primary, Hermani, Bambang, primary, Tan, I. Bing, primary, and Middeldorp, Jaap M., primary

Published
2023
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31. Supplementary Figure 1 from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan

Author

Coghill, Anna E., primary, Hsu, Wan-Lun, primary, Pfeiffer, Ruth M., primary, Juwana, Hedy, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Chen, Jen-Yang, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap M., primary, and Hildesheim, Allan, primary

Published
2023
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32. Data from Epstein–Barr Virus Serology as a Potential Screening Marker for Nasopharyngeal Carcinoma among High-Risk Individuals from Multiplex Families in Taiwan

Author

Coghill, Anna E., primary, Hsu, Wan-Lun, primary, Pfeiffer, Ruth M., primary, Juwana, Hedy, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Chen, Jen-Yang, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap M., primary, and Hildesheim, Allan, primary

Published
2023
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33. Table S1 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan

Author

Coghill, Anna E., primary, Pfeiffer, Ruth M., primary, Proietti, Carla, primary, Hsu, Wan-Lun, primary, Chien, Yin-Chu, primary, Lekieffre, Lea, primary, Krause, Lutz, primary, Teng, Andy, primary, Pablo, Jocelyn, primary, Yu, Kelly J., primary, Lou, Pei-Jen, primary, Wang, Cheng-Ping, primary, Liu, Zhiwei, primary, Chen, Chien-Jen, primary, Middeldorp, Jaap, primary, Mulvenna, Jason, primary, Bethony, Jeff, primary, Hildesheim, Allan, primary, and Doolan, Denise L., primary

Published
2023
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37. Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Author

Argirion, Ilona, primary, Pfeiffer, Ruth M., additional, Proietti, Carla, additional, Coghill, Anna E., additional, Yu, Kelly J., additional, Middeldorp, Jaap M., additional, Sarathkumara, Yomani D., additional, Hsu, Wan-Lun, additional, Chien, Yin-Chu, additional, Lou, Pei-Jen, additional, Wang, Cheng-Ping, additional, Rothman, Nathaniel, additional, Lan, Qing, additional, Chen, Chien-Jen, additional, Mbulaiteye, Sam M., additional, Jarrett, Ruth F., additional, Glimelius, Ingrid, additional, Smedby, Karin E., additional, Hjalgrim, Henrik, additional, Hildesheim, Allan, additional, Doolan, Denise L., additional, and Liu, Zhiwei, additional

Published
2023
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38. Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release

Author

Chao, Tsung-Yu, primary, Cheng, Yi-Ying, additional, Wang, Zi-Yun, additional, Fang, Tien-Fang, additional, Chang, Yu-Ruei, additional, Fuh, Chi-Shane, additional, Su, Mei-Tzu, additional, Su, Yuan-Wei, additional, Hsu, Pang-Hung, additional, Su, Yu-Chen, additional, Chang, Yu-Ching, additional, Lee, Ting-Yau, additional, Chou, Wei-Han, additional, Middeldorp, Jaap M., additional, Saraste, Jaakko, additional, and Chen, Mei-Ru, additional

Published
2023
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40. Can Epstein-Barr virus DNA load in nasopharyngeal brushings or whole blood predict recurrent nasopharyngeal carcinoma in a non-endemic region? A prospective nationwide study of the Dutch Head and Neck Oncology Cooperative Group

Author

Stoker, Sharon D., Wildeman, Maarten A., Novalic, Zlata, Fles, Renske, van der Noort, Vincent, de Bree, Remco, Braunius, Weibel W., van den Broek, Guido B., Kreike, Bas, Kross, Kenneth W., Juwana, Hedy, Ramayanti, Octavia, Verkuijlen, Sandra A. W. M., de Boer, Jan Paul, Greijer, Astrid E., Middeldorp, Jaap M., and Tan, I. Bing

Published
2016
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50. Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response

Author

Dias, Michelle H. F., primary, Guimarães, Luiz F. F., additional, Barcelos, Matheus G., additional, Moreira, Eduardo U. M., additional, do Nascimento, Maria F. A., additional, de Souza, Taís N., additional, Pires, Camilla V., additional, Monteiro, Talita A. F., additional, Middeldorp, Jaap M., additional, Soares, Irene S., additional, Fontes, Cor J. F., additional, Ntumngia, Francis B., additional, Adams, John H., additional, Kano, Flora S., additional, and Carvalho, Luzia H., additional

Published
2022
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